RESUMEN
The authors present the first case of a pure osteosarcoma arising in a long-standing uterine leiomyoma along with a literature review of all heterologous sarcomas arising in uterine leiomyoma. Most cases present with abnormal vaginal bleeding and symptoms related to a rapidly enlarged pelvic mass in postmenopausal women with a long-standing history of uterine leiomyoma. The histological finding of the case in this study revealed a relatively well-circumscribed tumor with a peripheral ring of leiomyoma and a central osteosarcoma. The case in this study further supported a possible pathogenesis involving the p53 gene. The prognosis may be better with low-stage tumor; however, cases with advanced stages, larger tumor size at presentation, and histological type of epithelioid angiosarcoma had poorer prognosis despite aggressive therapy.
Asunto(s)
Transformación Celular Neoplásica/patología , Leiomioma/patología , Osteosarcoma/patología , Neoplasias Uterinas/patología , Femenino , Humanos , Persona de Mediana EdadRESUMEN
Carcinoma ex pleomorphic adenoma affects glandular structures, occurring mostly in major salivary glands and less commonly in the lacrimal gland. We present a rare case in the lacrimal gland. We highlight the importance of keeping this rare tumor in mind and the early detection of symptoms because such a malignant transformation could occur in pleomorphic adenomas, with the proportion dependent on the duration of the tumor.
Asunto(s)
Adenocarcinoma/diagnóstico , Adenoma Pleomórfico/diagnóstico , Neoplasias del Ojo/diagnóstico , Enfermedades del Aparato Lagrimal/diagnóstico , Adenocarcinoma/patología , Adenocarcinoma/cirugía , Adenoma Pleomórfico/patología , Adenoma Pleomórfico/cirugía , Anciano de 80 o más Años , Neoplasias del Ojo/patología , Neoplasias del Ojo/cirugía , Humanos , Enfermedades del Aparato Lagrimal/patología , Enfermedades del Aparato Lagrimal/cirugía , Masculino , Tomografía Computarizada por Rayos XRESUMEN
We report a case of Denys-Drash syndrome, a disorder characterized by male pseudohermaphroditism, congenital nephrotic syndrome, and early renal failure. The patient received dialysis therapy from 15 days of age until his death at the age of 6 months. DNA analysis was performed on the WT1 gene, and a missense point mutation was detected in exon 8 (R366H). After prenatal confirmation of normal WT1 gene in the family's next child, they had a healthy baby 14 months after the patient's death.