Expression of COX-1 and COX-2 in the Platelet of Iron Deficiency Anemia Women at Childbearing Age and Its Clinical Significance / 中国实验血液学杂志

<p><b>OBJECTIVE</b>To detect the expression level of cyclooxygenase-1（COX-1） and cyclooxygenase-2（COX-2） in the platelet of iron deficiency anemia（IDA）women at childbearing age and to explore its correlation with the different indexes of anemia and platelets.</p><p><b>METHODS</b>Forty female IDA patients at childbearing age and 35 healthy controls were enrolled in this study. The Flow cytometry was used to detect the expression of platelet COX-1 and COX-2，the platelet aggregation function as examined by turbidimetric method，and the levels of serum ferritin were analyzed by electrochemical luminescence method，the leval of serum iron was determined by ELISA，and the correlation of different indexes was analyzed.</p><p><b>RESULTS</b>Compared with healthy controls，the levels of platelet COX-1 and COX-2 were significantly lower in female IDA patients at Childbearing age（P<0.05），but platelet count（Plt），mean platelet volume（MPV） and platelet aggregation rate（PAgT）were not statistically different between the 2 groups（P > 0.05）. The expression level of platelet COX-1 positively correlated with those of Hb（r =0.623，P<0.01），serum iron（r =0.321，P<0.05） and HCT（r=0.305，P<0.05）. but the platelet COX-2 expression did not corelate with these indexs.</p><p><b>CONCLUSION</b>The expression of platelet COX-1 and COX-2 in female IDA patients at Childbearing age markedly decrease，and the expression level of platelet COX-1 closely relates with the severity of anemia，that possesses reference value for clinical diagnosis of female IDA patients at Childbearing age..</p>

[Establishment of a monitoring database of historical Oncomelania hupensis environments at grass - root level for schistosomiasis prevention based on Google Earth].

OBJECTIVE: To establish a monitoring database of historical Oncomelania hupensis environments at grass-root level for schistosomiasis prevention based on Google Earth (GE), so as to improve the management efficiency of historical O. hupensis environments. METHODS: GE was labeled with the information about the historical O. hupensis environments through adding landmark, path and polygon. Meanwhile, POCO web album was used to storage the practice situation pictures of the environments, which could be imported into GE so that the environments could be monitored dynamically. RESULTS: There were 553 historical O. hupensis snail environments in Yangjian Town, Xishan District, Wuxi City and the accumulative area was 506 000 m2. Among these environments, 224 (40.5%) were Class IV environments, accounting for 40.5% of accumulative area. CONCLUSIONS: The monitoring database of historical O. hupensis environments based on GE at country level is established successfully and it can be used to manage the historical snail environments visually and monitor the changes dynamically.