Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 4 de 4
Filtrar
Más filtros











Base de datos
Intervalo de año de publicación
2.
Notf Rett Med ; 23(8): 578-586, 2020.
Artículo en Alemán | MEDLINE | ID: mdl-32837305

RESUMEN

Due to the increasing number of COVID-19 infections worldwide, all hospitals are faced with the challenge associated with the pandemic. In particular, emergency rooms must prepare and implement completely new workflows. This applies in particular to patient screening and selection (triage). Close cooperation with other specialist areas such as hygiene, infectiology or virology is also necessary in order to implement appropriate treatment concepts before, during and after the diagnosis is completed. In addition, communication and quality and risk management are highly relevant in addition to the clinical aspects. This article uses COVID-19 as an example to describe how emergency rooms can prepare for a pandemic.

3.
Nat Commun ; 7: 13404, 2016 11 21.
Artículo en Inglés | MEDLINE | ID: mdl-27869121

RESUMEN

Although mutations may represent attractive targets for immunotherapy, direct identification of mutated peptide ligands isolated from human leucocyte antigens (HLA) on the surface of native tumour tissue has so far not been successful. Using advanced mass spectrometry (MS) analysis, we survey the melanoma-associated immunopeptidome to a depth of 95,500 patient-presented peptides. We thereby discover a large spectrum of attractive target antigen candidates including cancer testis antigens and phosphopeptides. Most importantly, we identify peptide ligands presented on native tumour tissue samples harbouring somatic mutations. Four of eleven mutated ligands prove to be immunogenic by neoantigen-specific T-cell responses. Moreover, tumour-reactive T cells with specificity for selected neoantigens identified by MS are detected in the patient's tumour and peripheral blood. We conclude that direct identification of mutated peptide ligands from primary tumour material by MS is possible and yields true neoepitopes with high relevance for immunotherapeutic strategies in cancer.


Asunto(s)
Epítopos/metabolismo , Melanoma/metabolismo , Presentación de Antígeno , Antígenos de Neoplasias , Secuencia de Bases , Clonación Molecular , Epítopos/genética , Regulación Neoplásica de la Expresión Génica , Humanos , Ligandos , Espectrometría de Masas , Melanoma/inmunología , Mutación , Péptidos/metabolismo
4.
Surg Technol Int ; IX: 193-203, 2000 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-12219296

RESUMEN

Chronic leg ulceration affects about 1 to 2 % of the European population. Although the pathogenesis of venous ulceration is not completely understood, it is generally agreed that the transmission of high ambulatory pressures through incompetent perforating veins plays a major role. There are only limited data available to assess the long-term prognosis for leg ulcer patients.

SELECCIÓN DE REFERENCIAS
DETALLE DE LA BÚSQUEDA