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1.
Aerosol Sci Technol ; 56(5): 413-424, 2022.
Article En | MEDLINE | ID: mdl-36311996

Aerosol particles generated by dental procedures could facilitate the transmission of infectious diseases and contain carcinogen particles. Such particles can penetrate common surgical masks and reach the lungs, leading to increased risk for dental care professionals. However, the risk of inhaling contaminated aerosol and the effectiveness of aerosol reduction measures in dental offices remain unclear. The present study aimed to quantify aerosols produced by drilling and scaling procedures and to evaluate present recommendations for aerosol reduction. The concentration of aerosol particles released from the mock scaling and drilling procedures on dental mannequin were measured using a TSI Optical Particle Sizer (OPS 3330) during 15-min sessions carried out in a single-patient examination room. Using a drilling procedure as the aerosol source, the aerosol reduction performance of two types of high-volume evacuators (HVEs) and a commercial off-the-shelf air purifier was evaluated in a simulated clinical setting. Using either HVEs or the air purifier individually reduced the aerosol accumulated over the course of a 15-minutes drilling procedure at a reduction rate of 94.8 to 97.6%. Using both measures simultaneously raised the reduction rate to 99.6%. The results show that existing HVEs can effectively reduce aerosol concentration generated by a drilling procedure and can be further improved by using an air purifier. Following current regulatory guidelines can ensure a low risk of inhaling contaminated aerosol for dentists, assistants, and patients.

2.
Evid Based Dent ; 2022 Jul 08.
Article En | MEDLINE | ID: mdl-35804195

Introduction The COVID-19 pandemic has urged healthcare systems to develop new ways to safely provide care. Telehealth has become a compelling alternative. Our purpose was to evaluate the accuracy and effectiveness of teledentistry for screening, diagnosis and therapeutic management of dental care in children and adults.Methods We conducted a systematic review (SR) of systematic reviews. Multiple databases, the grey literature and conference archives were searched. Eligible SRs included those reporting virtual screening, diagnostic investigations and therapeutic interventions. Two investigators independently reviewed abstracts, articles, critically appraised SRs and extracted the data.Results We identified 817 citations and included six SRs. The accepted SRs involved >7,000 participants, used primarily asynchronous communication for diagnostic/screening outcomes and used synchronous communication for treatment outcomes. SRs were of low quality and included 30 primary studies of our interest. Sensitivity and specificity for dental referrals and diagnostic treatment planning were higher than other index/reference tests, ranging from 80-88% and 73-95%, respectively. Treatment outcome measured patient compliance and professional supervision.Conclusion This SR provides the best existing evidence for clinical decision-making involving teledentistry. Current evidence supports teledentistry as an effective means for dental referrals, treatment planning and compliance and treatment viability. Asynchronous communication and the adoption of smartphones for image capturing are feasible and convenient for the implementation of teledentistry.

3.
Disabil Rehabil Assist Technol ; 17(8): 916-926, 2022 11.
Article En | MEDLINE | ID: mdl-32988252

PURPOSE: Activities of daily living including oral care may be challenging after stroke. Some stroke survivors are not able to complete oral care independently and need assistance from healthcare professionals and care partners. Poor oral hygiene may impact stroke recovery and rehabilitation possibly incurring issues such as aspiration pneumonia, malnutrition, and social isolation. The objective of this paper is to outline practical ways to apply oral care technology in daily use for stroke survivors. MATERIALS AND METHODS: We reviewed the literature on i) stroke-related impairments impacting oral care, ii) oral hygiene dental devices, and iii) technology for oral care education. RESULTS: Oral care activities involve integrated skills in the areas of motivation, energy, planning, body movement and sensation, and mental acuity and health. Post-stroke impairments such as fatigue, hemiparesis, and mental impairments may impact oral care activities. Technology may help survivors and caregivers overcome some barriers. Three types of technologies are available for facilitating post-stroke oral care: i) non-powered tools and adaptations; ii) powered oral care tools, and; iii) electronic aids to guide oral care activities. Particular choices should maximise patient safety and autonomy while ensuring accessibility and comfort during oral care tasks. CONCLUSION: The available device and technologies may help substantially with the accommodations needed for post-stroke oral care, improving the oral health of stroke survivors. Good oral health confers benefit to overall health and well-being and could enhance recovery and rehabilitation outcomes. Nonetheless, more research is necessary to demonstrate the feasibility and effectiveness of technology in stroke contexts.IMPLICATIONS FOR REHABILITATIONOral care may be challenging after stroke due to patient fatigue, hemiparesis, cognitive impairments, and other impaired body functions.Poor oral hygiene may impact stroke recovery and rehabilitation due to risk of aspiration pneumonia, malnutrition, and social isolation.Powered oral care tools, non-powered tools, and adaptations to non-powered tools are some of the technology available to help overcome post-stroke barriers for oral care.Computer programs and online resources for education and guidance for oral care activities may help improve recommendation uptake and compliance.


Malnutrition , Pneumonia, Aspiration , Stroke Rehabilitation , Stroke , Activities of Daily Living , Fatigue , Humans , Paresis , Patient-Centered Care , Technology
4.
RSC Adv ; 11(25): 15284-15289, 2021 Apr 21.
Article En | MEDLINE | ID: mdl-35424078

Iron-catalysed hydroboration of imines and nitriles has been developed under low catalyst loading (1 mol%) in the presence of HBpin. A wide scope of substrate was found to smoothly undergo hydroboration, including electron releasing/withdrawing and halogen substitution patterns and cyclic substrates which all afforded the corresponding amines in good to excellent yields. Dihydroboration of nitriles was achieved conveniently under solvent free and additive free conditions. Promisingly, this catalytic system is also capable of the hydroboration of challenging ketimine substrates. Preliminary kinetic analysis of imine hydroboration reveals a first-order dependence on catalyst concentration. Both HBpin and 4-fluorophenyl-N-phenylmethanimine (1b) appear to exhibit saturation kinetics with first order dependence up to 0.5 mmol HBpin and 0.75 mmol imine, respectively. Temperature-dependent rate experiments for imine hydroboration have also been explored. Activation parameters for the hydroboration of FPhC[double bond, length as m-dash]NPh (1b) were determined from the Eyring and Arrhenius plots with ΔS ≠, ΔH ≠, and E a values of -28.69 (±0.3) e.u., 12.95 (±0.04) kcal mol-1, and 15.22 (±0.09) kcal mol-1, respectively.

5.
Geriatr Nurs ; 40(2): 197-204, 2019.
Article En | MEDLINE | ID: mdl-30528781

Inadequate oral care in long-term care (LTC) facilities compromises the quality of life of residents. This study assessed oral care knowledge of, and challenges experienced by, nurses and allied nursing staff (ANS) in a LTC facility in Canada. Dentists and nursing staff used the findings to implement strategies for improved care. Using a sequential mixed method design, data on oral care knowledge and practices were collected using self-administered questionnaires (n = 114) and focused groups (n = 39). Data were analyzed using descriptive statistics and thematic analysis. While participants (>80%) felt knowledgeable and confident in providing oral care, they desired improved skills to overcome resistive behavior, communication, and wanted adapted oral care materials. Implemented strategies included skills-acquisition workshop, oral care posters, and oral health champion. Overall, our interprofessional collaboration increased awareness of the need for oral care training, and implemented strategies to help nursing staff overcome barriers in providing care.


Cooperative Behavior , Dentistry , Long-Term Care , Nursing Staff/education , Oral Health/education , Adult , Canada , Female , Focus Groups , Health Knowledge, Attitudes, Practice , Humans , Male , Nursing Assistants/education , Nursing Homes , Surveys and Questionnaires
6.
mBio ; 9(4)2018 08 28.
Article En | MEDLINE | ID: mdl-30154261

Rathayibacter toxicus is a species of Gram-positive, corynetoxin-producing bacteria that causes annual ryegrass toxicity, a disease often fatal to grazing animals. A phylogenomic approach was employed to model the evolution of R. toxicus to explain the low genetic diversity observed among isolates collected during a 30-year period of sampling in three regions of Australia, gain insight into the taxonomy of Rathayibacter, and provide a framework for studying these bacteria. Analyses of a data set of more than 100 sequenced Rathayibacter genomes indicated that Rathayibacter forms nine species-level groups. R. toxicus is the most genetically distant, and evidence suggested that this species experienced a dramatic event in its evolution. Its genome is significantly reduced in size but is colinear to those of sister species. Moreover, R. toxicus has low intergroup genomic diversity and almost no intragroup genomic diversity between ecologically separated isolates. R. toxicus is the only species of the genus that encodes a clustered regularly interspaced short palindromic repeat (CRISPR) locus and that is known to host a bacteriophage parasite. The spacers, which represent a chronological history of infections, were characterized for information on past events. We propose a three-stage process that emphasizes the importance of the bacteriophage and CRISPR in the genome reduction and low genetic diversity of the R. toxicus species.IMPORTANCERathayibacter toxicus is a toxin-producing species found in Australia and is often fatal to grazing animals. The threat of introduction of the species into the United States led to its inclusion in the Federal Select Agent Program, which makes R. toxicus a highly regulated species. This work provides novel insights into the evolution of R. toxicusR. toxicus is the only species in the genus to have acquired a CRISPR adaptive immune system to protect against bacteriophages. Results suggest that coexistence with the bacteriophage NCPPB3778 led to the massive shrinkage of the R. toxicus genome, species divergence, and the maintenance of low genetic diversity in extant bacterial groups. This work contributes to an understanding of the evolution and ecology of an agriculturally important species of bacteria.


Actinobacteria/classification , Actinobacteria/genetics , Biological Warfare Agents , Evolution, Molecular , Genetic Variation , Actinobacteria/isolation & purification , Actinobacteria/virology , Animal Diseases/microbiology , Animals , Australia , Bacteriophages/genetics , Clustered Regularly Interspaced Short Palindromic Repeats , Genome, Bacterial , Genotype
7.
Compend Contin Educ Dent ; 38(8): 529-534; quiz 535, 2017 Sep.
Article En | MEDLINE | ID: mdl-28862468

Palliative care dentistry is the management of patients with progressive, far-advanced disease for whom the oral cavity has been compromised either by disease or by treatment. The focus of care is on the immediate quality of life. Typically, the palliative care team neglects to include a dentist despite many patients under its care, including those with cancer, exhibiting oral problems such as xerostomia, candidiasis, mucositis, and loss of masticatory function. This article will discuss the oral care of patients with terminal illnesses, many of whom have oral maladies that negatively impact quality of life. Treatment options for these patients will be outlined.


Dental Care/methods , Mouth Diseases/therapy , Palliative Care , Quality of Life , Terminally Ill , Tooth Diseases/therapy , Humans
8.
Surg Innov ; 20(5): 444-53, 2013 Oct.
Article En | MEDLINE | ID: mdl-23154636

The Mozart Effect is a phenomenon whereby certain pieces of music induce temporary enhancement in "spatial temporal reasoning." To determine whether the Mozart Effect can improve surgical performance, 55 male volunteers (mean age = 20.6 years, range = 16-27), novice to surgery, were timed as they completed an activity course on a laparoscopic simulator. Subjects were then randomized for exposure to 1 of 2 musical pieces by Mozart (n = 21) and Dream Theater (n = 19), after which they repeated the course. Following a 15-minute exposure to a nonmusical piece, subjects were exposed to one of the pieces and performed the activity course a third time. An additional group (n = 15) that was not corandomized performed the tasks without any exposure to music. The percent improvements in completion time between 3 successive trials were calculated for each subject and group means compared. In 2 of the tasks, subjects exposed to the Dream Theater piece achieved approximately 30% more improvement (26.7 ± 8.3%) than those exposed to the Mozart piece (20.2 ± 7.8%, P = .021) or to no music (20.4 ± 9.1%, P = .049). Distinct patterns of covariance between baseline performance and subsequent improvement were observed for the different musical conditions and tasks. The data confirm the existence of a Mozart Effect and demonstrate for the first time its practical applicability. Prior exposure to certain pieces may enhance performance in practical skills requiring spatial temporal reasoning.


Laparoscopy/education , Music , Psychomotor Performance/physiology , Robotics/education , Task Performance and Analysis , Adolescent , Adult , Humans , Laparoscopy/instrumentation , Male , Robotics/instrumentation , Young Adult
9.
Cent Eur J Public Health ; 19(2): 79-83, 2011 Jun.
Article En | MEDLINE | ID: mdl-21739896

PURPOSE: A short HIV/AIDS risk behaviour knowledge index based on questions about HIV transmission and prevention of HIV infection during sexual intercourse and intravenous drug use is proposed and implemented for an HIV average risk population in Munich. METHODS: Knowledge levels about HIV/AIDS risk behaviour was assessed in a group of people (n = 210) in sexually active age range of 18-49 years which was at an average risk of contracting HIV. Four questions about HIV transmission by unprotected vaginal, anal, or oral sexual intercourse, and by needle sharing, and two questions about HIV prevention by condom use, and the single use of needles and syringes were chosen from ten others for making a four level risk behaviour knowledge index (HIV/AIDS Transmission through Sex and Intravenous Drug Use, HATSIDU) internally consistent according to Cronbach's alpha. RESULTS: HATSIDU index (mean 3.0, SD +/- 1.18) was not associated (p>0.05) with sex and marital status, but depended (p < 0.05) on age, education and social status. General population of Munich in a sexually active age group of 40-49 years, or those without further education or the unemployed, had a significantly lower knowledge of HIV risk behaviour. CONCLUSION: The HATSIDU is a simple and usable index for the assessment of HIV/AIDS risk behaviour knowledge in a population with an average risk of HIV infection.


HIV Infections/prevention & control , HIV Infections/transmission , Health Knowledge, Attitudes, Practice , Sexual Behavior , Substance Abuse, Intravenous/complications , Adolescent , Adult , Age Factors , Educational Status , Female , Germany , Humans , Male , Marital Status , Middle Aged , Risk-Taking , Social Class , Surveys and Questionnaires , Young Adult
10.
Soc Secur Bull ; 70(2): 1-29, 2010.
Article En | MEDLINE | ID: mdl-20560301

The Supplemental Security Income (SSI) program is the nation's safety net for the aged, blind, and disabled. SSI receipt is often not reported by individuals interviewed in the Current Population Survey (CPS), the statistical base for the Census Bureau's annual estimates of poverty rates. In an earlier article, we explored the effect on estimated poverty rates in 2002 of adjusting CPS income reports using administrative data on earnings and benefits from the SSI and Old-Age, Survivors, and Disability Insurance programs. We assessed poverty using both the official standard and a "relative" standard based on half of median pretax, posttransfer income. This article extends that work through 2005. We find that including administrative data presents challenges, but under the methodology we adopt, such adjustments lower estimated official poverty overall and increase estimated poverty rates for elderly SSI recipients. Relative poverty rates are much higher than official poverty rates. By any of the applied standards and procedures for income adjustment, poverty changed little over the 2002-2005 interval.


Government Programs/economics , Pensions/statistics & numerical data , Poverty/economics , Social Security/economics , Adolescent , Adult , Age Factors , Aged , Child , Child, Preschool , Data Collection , Data Interpretation, Statistical , Government Programs/statistics & numerical data , Humans , Infant , Infant, Newborn , Insurance, Disability/economics , Insurance, Disability/statistics & numerical data , Middle Aged , Poverty/statistics & numerical data , Social Security/statistics & numerical data , Socioeconomic Factors , United States , United States Social Security Administration , Young Adult
11.
Soc Secur Bull ; 69(1): 45-73, 2009.
Article En | MEDLINE | ID: mdl-19579530

In the United States, poverty is generally assessed on the basis of income, as reported in the Current Population Survey's (CPS's) Annual Social and Economic Supplement (ASEC), using an official poverty standard established in the 1960s. The prevalence of receipt of means-tested transfers is underreported in the CPS, with uncertain consequences for the measurement of poverty rates by both the official standard and by using alternative "relative" measures linked to the contemporaneous income distribution. The article reports results estimating the prevalence of poverty in 2002. We complete this effort by using a version of the 2003 CPS/ASEC for which a substantial majority (76 percent) of respondents have individual records matching administrative data from the Social Security Administration on earnings and receipt of income from the Old-Age, Survivors, and Disability Insurance and Supplemental Security Income (SSI) programs. Adjustment of the CPS income data with administrative data substantially improves coverage of SSI receipt. The consequence for general poverty is sensitive to the merge procedures employed, but under both sets of merge procedures considered, the estimated poverty rate among all elderly persons and among elderly SSI recipients is substantially less than rates estimated using the unadjusted CPS. The effect of the administrative adjustment is less significant for perception of relative poverty than for absolute poverty. We emphasize the effect of these adjustments on perception of poverty among the elderly in general and elderly SSI recipients in particular.


Insurance, Disability/economics , Poverty/economics , Public Assistance/economics , Social Security/economics , Adolescent , Adult , Age Factors , Aged , Child , Child, Preschool , Eligibility Determination , Humans , Infant , Infant, Newborn , Insurance Benefits/economics , Insurance Coverage/economics , Insurance, Disability/trends , Middle Aged , Models, Economic , Poverty/trends , Public Assistance/trends , United States , Young Adult
12.
Soc Secur Bull ; 68(2): 53-67, 2008.
Article En | MEDLINE | ID: mdl-19102138

Recently various analysts have called attention to the apparent success of the Canadian social assistance system in reducing poverty among the elderly and have suggested that there may be lessons to be drawn from the Canadian experience that are relevant to the evolution of the U.S. Supplemental Security Income (SSI) program. This article profiles the Canadian system, compares the system to the U.S. SSI program, reviews the consequences for elderly poverty rates, assesses system costs, and then comments on pertinence of the Canadian experience to SSI policy. The Canadian minimum income guarantee for the elderly is substantially more generous than what is provided by the United States, but it is misleading to claim that the Canadian system costs only "slightly more" than the U.S. program. Such a judgment overlooks a key and costly part of the Canadian system, the Old Age Security demogrant. We estimate the total costs to Canada of providing income support for elderly persons receiving a Guaranteed Income Supplement (GIS) in 2004 to be approximately C$13.3 billion (roughly US $11.1 billion), slightly more than 1 percent of gross domestic product (GDP) and almost fourteen times the U.S. allocation for SSI and food stamps for elderly SSI recipients. The significance of this commitment is underscored when it is recognized that in 2004 Canadian GDP per capita was just 80 percent of the U.S. level. The Canadian example suggests U.S. policymakers consider better integration of SSI with basic Social Security benefits, experimenting with alternatives to restricting SSI eligibility to individuals with very few assets, and reducing barriers to program access.


Government Programs/economics , Income , Pensions , Retirement/economics , Safety/economics , Aged , Aged, 80 and over , Canada , Humans , Poverty/prevention & control , Poverty/statistics & numerical data , Public Policy , Socioeconomic Factors , United States , United States Social Security Administration
13.
J Can Dent Assoc ; 74(8): 715-20, 2008 Oct.
Article En | MEDLINE | ID: mdl-18845061

Recognizing abuse is paramount to protecting the increasing proportion of seniors in the Canadian population. Dentists are in an ideal position to identify and signal suspected abuse, as they perform a thorough examination of the head and neck region and generally see their patients twice a year. Good communication skills are necessary to improve dialogue with the patient. This article is intended to provide the dentist with tools to identify abuse and a decision tree to manage and monitor the suspected abused elder. With increased awareness, dentists will play an important role in helping protect seniors from abuse.


Dentists , Elder Abuse/diagnosis , Professional Role , Aged , Canada , Decision Trees , Dentist-Patient Relations , Geriatric Assessment , Humans , Mandatory Reporting
14.
Spec Care Dentist ; 28(2): 58-60, 2008.
Article En | MEDLINE | ID: mdl-18402618

The dentist's role following the death of a patient in his/her practice has received little attention in the literature. This study determined the prevalence of death within a dental practice. It also investigated methods by which dentists supported grieving survivors, and how frequently dentists received formal bereavement education in dental school. A perceived need for training in death and dying was also investigated. A survey was mailed to 200 randomly selected general dental practitioners in Ontario, Canada. It was found that (1) the vast majority of respondents (86%) had experienced the death of a patient within the past 12 months; (2) support methods included sending sympathy cards (79.3%), sending flowers (34.5%), attending the funeral or wake (23%), or visiting/calling survivors (11.5%); (3) only 4% of respondents reported receiving formal bereavement education during dental school; and (4) 61% believed bereavement education should be included in the dental school curricula. While the majority of dentists in this study provided bereavement support and believed they could effectively comfort grieving persons, these dentists experienced significant stress when dealing with issues of death and bereavement. The stress may be explained by inadequate education and exposure to the issues of death and dying.


Bereavement , Death , Dentist-Patient Relations , Dentists/psychology , Adult , Aged , Attitude of Health Personnel , Curriculum , Education, Dental , Female , Humans , Male , Middle Aged , Surveys and Questionnaires
15.
Bone ; 40(2): 444-50, 2007 Feb.
Article En | MEDLINE | ID: mdl-16965947

The aim of this cross-sectional analysis was to examine the skeletal effects of low-dose monophasic oral contraceptive (OC) use in a cohort of 248 young Caucasian women aged 18-24 years. Areal bone mineral density (BMD) of the femoral neck and lumbar spine was evaluated by dual-energy X-ray absorptiometry. Volumetric BMD, bone mineral content (BMC), and bone geometry were assessed in the tibia by peripheral quantitative computed tomography (pQCT). The women were allocated into ever or never OC users, and also into 5 different OC groups according to duration and time of initiation of OC use. Women with >2 years of OC use and OC initiation within 3 years after menarche were characterized by 10% lower femoral neck areal BMD (P<0.001), 5% lower spine areal BMD (not significant, P=0.101), 7% lower distal tibial total BMC (P<0.05), and 6% lower total BMC at the tibial shaft (P<0.05) relative to never users. In addition, women who had ever used OCs had lower bone mass at the femoral neck and tibial shaft, despite similar age, height, weight, BMI, hours of exercise, and calcium intake compared with never users. At the tibial shaft, OC users showed reduced total cross-sectional area, and increased cortical BMD. In conclusion, our data suggest that OC use is associated with a detrimental effect on bone mass in young women, and provide further insight into the pathophysiological mechanisms involved.


Bone Density/drug effects , Contraceptives, Oral/adverse effects , Femur Neck/drug effects , Lumbar Vertebrae/drug effects , Absorptiometry, Photon , Adolescent , Adult , Contraceptives, Oral/administration & dosage , Cross-Sectional Studies , Female , Femur Neck/diagnostic imaging , Humans , Lumbar Vertebrae/diagnostic imaging
16.
Soc Secur Bull ; 67(4): 71-87, 2007.
Article En | MEDLINE | ID: mdl-18777670

The Food Stamp Program (FSP) and Supplemental Security Income (SSI) are important parts of national public assistance policy, and there is considerable overlap in the populations that the programs serve. About half of all SSI recipients reside in FSP recipient households. This article uses Social Security administrative data and the Food Stamp Quality Control samples for federal fiscal years 2001-2006 to study the prevalence of food stamp receipt among households with SSI recipients, the contribution of FSP to household income, and the importance of various FSP features in contributing to the well-being of recipient households. The prevalence of FSP participation among households that include SSI recipients is estimated to have grown steadily over the entire 2001-2006 period, rising from 47.4 percent in 2001 to 55.6 percent in 2006. This growth has occurred across all age groups of SSI recipients. The FSP contribution to household income has grown as well. In 2001, FSP increased the income of the households of SSI/FSP recipients by 13 percent; by 2006 the increase was 16.8 percent. Almost 80 percent of the food stamp recipient households that include SSI recipients receive increased benefits because of excess housing costs. In 2006, 44 percent of SSI recipients lived in households that did not receive food stamps. Given available information, it is difficult to gauge the FSP eligibility of nonparticipating households and, therefore, to assess the potential benefit of outreach efforts. Currently available measures of FSP take-up probably overstate participation among eligible households that include SSI recipients, and there is some evidence that enhanced state promotion of the FSP raises participation among households with SSI recipients. We conclude with recommendation for review and renewal of collaboration between the Food and Nutrition Service of the U.S. Department of Agriculture (the agency responsible for administering the FSP) and the Social Security Administration in ensuring that eligible SSI recipients utilize FSP benefits.


Government Regulation , Income , Pensions , Public Assistance/economics , Adolescent , Adult , Aged , Eligibility Determination , Female , Food Services/economics , Humans , Male , Middle Aged , Poverty/economics , Program Evaluation , Public Assistance/legislation & jurisprudence , Social Security/economics , United States , United States Social Security Administration , Young Adult
17.
Contraception ; 74(5): 367-75, 2006 Nov.
Article En | MEDLINE | ID: mdl-17046377

AIM: This 12-month study was conducted to evaluate the skeletal effects of two monophasic oral contraceptives containing 20 mug of ethinylestradiol and 100 mug of levonorgestrel (LEVO) or 150 mug of desogestrel (DESO). METHODS: Fifty-two women (18-24 years) were randomized into the DESO group or the LEVO group; 36 women served as controls. The areal bone mineral density (aBMD) of the femoral neck and the lumbar spine was evaluated by DXA, and parameters of bone geometry and volumetric bone mineral density (vBMD) were assessed by peripheral quantitative computed tomography at the distal radius and the tibia. RESULTS: The LEVO group did not lose vertebral aBMD, whereas women in the DESO group lost 1.5%. At the distal radius and the tibia (shank level, 14%), LEVO induced an increase in total cross-sectional area, indicating increased periosteal bone formation. Radial trabecular vBMD declined by 1.4+/-1.8% in the DESO group, while it remained unchanged in the LEVO group. CONCLUSION: Our study suggests that the skeletal effects of OC preparations may be influenced by progestogenic components in young women.


Bone Density/drug effects , Bone and Bones/drug effects , Contraceptives, Oral, Synthetic/pharmacology , Desogestrel/pharmacology , Levonorgestrel/pharmacology , Absorptiometry, Photon , Adolescent , Adult , Alkaline Phosphatase/blood , Bone and Bones/metabolism , Collagen Type I/blood , Contraceptives, Oral, Synthetic/administration & dosage , Desogestrel/administration & dosage , Female , Humans , Levonorgestrel/administration & dosage , Longitudinal Studies , Lumbar Vertebrae/drug effects , Osteocalcin/blood , Peptides/blood , Radius/drug effects , Tibia/drug effects , Tomography, X-Ray Computed
18.
Tissue Eng ; 12(6): 1617-26, 2006 Jun.
Article En | MEDLINE | ID: mdl-16846357

This study investigated the hypothesis that spraying autologous mesenchymal stem cells (MSCs) onto grooved hydroxyapatite (HA) coated collars of segmental bone tumor implants would increase bone growth and contact to the implant surface in an ovine model. Autologous MSCs were isolated from bone marrow, grown in culture and during surgery implants in group 1 were sprayed with MSCs, suspended within fibrin glue. Implants in group 2 received no MSC therapy and acted as control. Implants remained in vivo for 6 months. New bone area and contact to the implant was quantified on radiographs and histologically. Radiographic analysis demonstrated greater total bone area in the MSC treated group in both ML (MSC = 79.738 mm2 +/- 22.964; control = 30.135 mm2 +/- 6.717) (p = 0.018) and AP (MSC = 90.338 +/- 19.361 mm2; control = 57.384 +/- 9.035 mm2 (p = 0.074) radiographs at 6 months. Results demonstrated significantly increased bone growth in the MSC group at 2 (p = 0.03) and 3 months (p < 0.05). Histological analysis demonstrated significantly greater bone area adjacent to the collars in the treated group (53.994 +/- 10.641 mm2) when compared with the control group 21.069 +/- 7.339 mm2 (p = 0.020). Increased bone contact in the MSC group (19.833 +/- 8.729 %) was observed when compared with controls (8.667 +/- 8.667%). This novel application of spraying MSCs onto the implant surface has significant implications for the future of successful implant fixation.


Bone Neoplasms/surgery , Bone Regeneration/physiology , Mesenchymal Stem Cells/physiology , Prostheses and Implants , Stem Cell Transplantation , Animals , Bone Neoplasms/pathology , Cell Proliferation , Cell Survival/physiology , Cells, Cultured , Female , Femur , Sheep , Transplantation, Autologous
19.
J Can Dent Assoc ; 72(5): 453-8, 2006 Jun.
Article En | MEDLINE | ID: mdl-16772071

Palliative care patients require special dental attention, ranging from operative and preventive care to support for emotional needs. The dentist"s role in palliative care is to improve quality of life of the patient. This paper describes some common problems encountered in palliative care dentistry for adults with terminal cancer and the appropriate treatment of these problems.


Dental Care for Chronically Ill/methods , Mouth Diseases/drug therapy , Neoplasms/therapy , Palliative Care , Antifungal Agents/therapeutic use , Antineoplastic Agents/adverse effects , Candidiasis, Oral/complications , Candidiasis, Oral/drug therapy , Cranial Irradiation/adverse effects , Depression/complications , Humans , Mouth Diseases/complications , Nausea/drug therapy , Nausea/etiology , Neoplasms/complications , Nutritional Physiological Phenomena , Oral Hygiene , Quality of Life , Stomatitis/drug therapy , Stomatitis/etiology , Xerostomia/drug therapy , Xerostomia/etiology
20.
Soc Secur Bull ; 66(4): 21-36, 2005.
Article En | MEDLINE | ID: mdl-17590982

Interactions and overlap of social assistance programs across clients interest policymakers because such interactions affect both the clients' well-being and the programs' efficiency. This article investigates the connections between Supplemental Security Income (SSI) and Temporary Assistance for Needy Families (TANF) and TANF's predecessor, the Aid to Families with Dependent Children (AFDC) program. Connections between receipt of TANF and SSI are widely discussed in both disability policy and poverty research literatures because many families receiving TANF report disabilities. For both states and the individuals involved, it is generally financially advantageous for adults and children with disabilities to transfer from TANF to SSI. States gain because the federal government pays for the SSI benefit, and states can then use the TANF savings for other purposes. The families gain because the SSI benefits they acquire are greater than the TANF benefits they lose. The payoff to states from transferring welfare recipients to SSI was substantially increased when Congress replaced AFDC with TANF in 1996. States retained less than half of any savings achieved through such transfers under AFDC, but they retain all of the savings under TANF. Also, the work participation requirements under TANF have obligated states to address the work support needs of adults with disabilities who remain in TANF, and states can avoid these costs if adults have disabilities that satisfy SSI eligibility requirements. The incentive for TANF recipients to apply for SSI has increased over time as inflation has caused real TANF benefits to fall relative to payments received by SSI recipients. Trends in the financial incentives for transfer to SSI have not been studied in detail, and reliable general data on the extent of the interaction between TANF and SSI are scarce. In addition, some estimates of the prevalence of TANF receipt among SSI awardees are flawed because they fail to include adults receiving benefits in TANF-related Separate State Programs (SSPs). SSPs are assistance programs that are administered by TANF agencies but are paid for wholly from state funds. When the programs are conducted in a manner consistent with federal regulations, the money states spend on SSPs counts toward federal maintenance-of-effort (MOE) requirements, under which states must sustain a certain level of contribution to the costs of TANF and approved related activities. SSPs are used for a variety of purposes, including support of families who are in the process of applying for SSI. Until very recently, families receiving cash benefits through SSPs were not subject to TANF's work participation requirements. This article contributes to analysis of the interaction between TANF and SSI by evaluating the financial consequences of TANF-to-SSI transfer and developing new estimates of both the prevalence of receipt of SSI benefits among families receiving cash assistance from TANF and the proportion of new SSI awards that go to adults and children residing in families receiving TANF or TANF-related benefits in SSPs. Using data from the Urban Institute's Welfare Rules Database, we find that by 2003 an SSI award for a child in a three-person family dependent on TANF increased family income by 103.5 percent on average across states; an award to the adult in such a family increased income by 115.4 percent. The gain from both child and adult transfers increased by about 6 percent between 1996 (the eve of the welfare reform that produced TANF) and 2003. Using data from the Department of Health and Human Services' TANF/SSP Recipient Family Characteristics Survey, we estimate that 16 percent of families receiving TANF/SSP support in federal fiscal year 2003 included an adult or child SSI recipient. This proportion has increased slightly since fiscal year 2000. The Social Security Administration's current procedures for tabulating characteristics of new SSI awardees do not recognize SSP receipt as TANF We use differences in reported TANF-to-SSI flows between states with and without Separate State Programs to estimate the understatement of the prevalence of TANF-related SSI awards in states with SSPs. The results indicate that the absolute number of awards to AFDC (and subsequently) TANF/SSP recipients has declined by 42 percent for children and 25 percent for adults since the early 1990s. This result is a product of the decline in welfare caseloads. However, the monthly incidence of such awards has gone up-from less than 1 per 1,000 child recipients in calendar years 1991-1993 to 1.3 per 1,000 in 2001-2003 and, for adult recipients, from 1.6 per 1,000 in 1991-1993 to 4 per 1,000 in 2001-2003. From these results we conclude that a significant proportion of each year's SSI awards to disabled nonelderly people go to TANF/SSP recipients, and many families that receive TANF/SSP support include adults, children, or both who receive SSI. Given the Social Security Administration's efforts to improve eligibility assessment for applicants, to ensure timely access to SSI benefits for those who qualify, and to improve prospects for eventual employment of the disabled, there is definitely a basis for working with TANF authorities both nationally and locally on service coordination and on smoothing the process of SSI eligibility assessment. The Deficit Reduction Act of 2005 reauthorized TANF through fiscal year 2010, but with some rules changes that are important in light of the analysis presented in this article. The new law substantially increases effective federal requirements for work participation by adult TANF recipients and mandates that adults in Separate State Programs be included in participation requirements beginning in fiscal year 2007. Thus SSPs will no longer provide a means for exempting from work requirements families that are in the process of applying for SSI, and the increased emphasis on work participation could result in more SSI applications from adult TANF recipients.


Aid to Families with Dependent Children/trends , Social Security/trends , Adolescent , Adult , Aid to Families with Dependent Children/statistics & numerical data , Female , Humans , Middle Aged , Motivation , Social Security/statistics & numerical data , United States
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