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Bioorg Med Chem Lett
; 22(14): 4599-604, 2012 Jul 15.
Artículo
en Inglés
| MEDLINE
| ID: mdl-22727640
RESUMEN
Novel substituted benzylidene-1,3-thiazolidine-2,4-diones (TZDs) have been identified as potent and highly selective inhibitors of the PIM kinases. The synthesis and SAR of these compounds are described, along with X-ray crystallographic, anti-proliferative, and selectivity data.