Light Absorption Analysis and Optimization of Ag@TiO2 Core-Shell Nanospheroid and Nanorod.

For photothermal therapy of cancer, it is necessary to find Ag @TiO2 core-shell nanoparticles that can freely tune the resonance wavelength within the near-infrared biological window. In this paper, the finite element method and the size-dependent refractive index of metal nanoparticles were used to theoretically investigate the effects of the core material, core length, core aspect ratio, shell thickness, refractive index of the surrounding medium, and the particle orientation on the light absorption properties of Ag@TiO2 core-shell nanospheroid and nanorod. The calculations show that the position and intensity of the light absorption resonance peaks can be freely tuned within the first and second biological windows by changing the above-mentioned parameters. Two laser wavelengths commonly used in photothermal therapy, 808 nm (first biological window) and 1064 nm (second biological window), were selected to optimize the core length and aspect ratio of Ag@TiO2 core-shell nanospheroid and nanorod. It was found that the optimized Ag@TiO2 core-shell nanospheroid has a stronger light absorption capacity at the laser wavelengths of 808 nm and 1064 nm. The optimized Ag@TiO2 core-shell nanoparticles can be used as ideal therapeutic agents in photothermal therapy.

Inversion of the Complex Refractive Index of Au-Ag Alloy Nanospheres Based on the Contour Intersection Method.

The contour intersection method is a new method used to invert the complex refractive index of small particles. Research has yet to be reported on using this method to invert the complex refractive index of nanoparticles. This paper reports the feasibility and reliability of the contour intersection method in the inversion of the complex refractive index of nanoparticles using Au-Ag alloy nanospheres. The Mie theory and the size-dependent dielectric function are used to calculate the light scattering and absorption efficiency of Au-Ag alloy nanospheres corresponding to the complex refractive index. The complex refractive index of the particles is obtained by inversion with the contour intersection method. The backscattering efficiency constraint method is used to determine the unique solution when multiple valid solutions from the contour intersection method appear. The effects of the Au component percentage, particle size, and measurement errors on the inversion results are quantitatively analyzed. Finally, the inversion accuracy is compared and analyzed with the traditional iterative method. The results show that as long as the light scattering efficiency, light absorption efficiency, and backscattering efficiency of Au nanospheres can be measured, the accurate complex refractive index can also be calculated by inversion using the contour intersection method. The accuracy of the inversion results can be ensured when the measurement error is less than 5%. The results of inversion using the contour intersection method are better than those of the iterative methods under the same conditions. This study provides a simple and reliable inversion method for measuring the complex refractive index of Au-Ag alloy nanospheres.