1.
Chem Commun (Camb)
; 59(53): 8250-8253, 2023 Jun 29.
Artículo
en Inglés
| MEDLINE
| ID: mdl-37313723
RESUMEN
Using newly designed α-imino amide surrogates and azlactones as amphiphilic reactants, catalyzed by a chiral bifunctional guanidine, the construction of chiral 3,4-diaminopyrrolidine-2,5-diones and their derivatives was realized via formal [3+2]-cyclization. The role of guanidine as a multiple hydrogen bond donor was demonstrated by DFT calculations.