Cortical atrophy in early-stage patients with anti-NMDA receptor encephalitis: a machine-learning MRI study with various feature extraction.

Conventional brain magnetic resonance imaging (MRI) of anti-N-methyl-D-aspartate-receptor encephalitis (NMDARE) is non-specific, thus showing little differential diagnostic value, especially for MRI-negative patients. To characterize patterns of structural alterations and facilitate the diagnosis of MRI-negative NMDARE patients, we build two support vector machine models (NMDARE versus healthy controls [HC] model and NMDARE versus viral encephalitis [VE] model) based on radiomics features extracted from brain MRI. A total of 109 MRI-negative NMDARE patients in the acute phase, 108 HCs and 84 acute MRI-negative VE cases were included for training. Another 29 NMDARE patients, 28 HCs and 26 VE cases were included for validation. Eighty features discriminated NMDARE patients from HCs, with area under the receiver operating characteristic curve (AUC) of 0.963 in validation set. NMDARE patients presented with significantly lower thickness, area, and volume and higher mean curvature than HCs. Potential atrophy predominately presented in the frontal lobe (cumulative weight = 4.3725, contribution rate of 29.86%), and temporal lobe (cumulative weight = 2.573, contribution rate of 17.57%). The NMDARE versus VE model achieved certain diagnostic power, with AUC of 0.879 in validation set. Our research shows potential atrophy across the entire cerebral cortex in acute NMDARE patients, and MRI machine learning model has a potential to facilitate the diagnosis MRI-negative NMDARE.

Efficient Binary Weight Convolutional Network Accelerator for Speech Recognition.

Speech recognition has progressed tremendously in the area of artificial intelligence (AI). However, the performance of the real-time offline Chinese speech recognition neural network accelerator for edge AI needs to be improved. This paper proposes a configurable convolutional neural network accelerator based on a lightweight speech recognition model, which can dramatically reduce hardware resource consumption while guaranteeing an acceptable error rate. For convolutional layers, the weights are binarized to reduce the number of model parameters and improve computational and storage efficiency. A multichannel shared computation (MCSC) architecture is proposed to maximize the reuse of weight and feature map data. The binary weight-sharing processing engine (PE) is designed to avoid limiting the number of multipliers. A custom instruction set is established according to the variable length of voice input to configure parameters for adapting to different network structures. Finally, the ping-pong storage method is used when the feature map is an input. We implemented this accelerator on Xilinx ZYNQ XC7Z035 under the working frequency of 150 MHz. The processing time for 2.24 s and 8 s of speech was 69.8 ms and 189.51 ms, respectively, and the convolution performance reached 35.66 GOPS/W. Compared with other computing platforms, accelerators perform better in terms of energy efficiency, power consumption and hardware resource consumption.

Real-Time Pedestrian Tracking Terminal Based on Adaptive Zero Velocity Update.

In the field of pedestrian dead reckoning (PDR), the zero velocity update (ZUPT) method with an inertial measurement unit (IMU) is a mature technology to calibrate dead reckoning. However, due to the complex walking modes of different individuals, it is essential and challenging to determine the ZUPT conditions, which has a direct and significant influence on the tracking accuracy. In this research, we adopted an adaptive zero velocity update (AZUPT) method based on convolution neural networks to classify the ZUPT conditions. The AZUPT model was robust regardless of the different motion types of various individuals. AZUPT was then implemented on the Zynq-7000 SoC platform to work in real time to validate its computational efficiency and performance superiority. Extensive real-world experiments were conducted by 60 different individuals in three different scenarios. It was demonstrated that the proposed system could work equally well in different environments, making it portable for PDR to be widely performed in various real-world situations.