1.
Angew Chem Int Ed Engl
; 57(46): 15096-15100, 2018 Nov 12.
Artículo
en Inglés
| MEDLINE
| ID: mdl-30211963
RESUMEN
We prepared a new class of chiral C2 -symmetric bicyclic bisborane catalysts by addition reactions of internal dienes with the Piers borane, HB(C6 F5 )2 , and an analogue, HB(p-C6 F4 H)2 . The dependence of the addition pattern on the reaction temperature allowed us to selectively prepare two diastereomeric catalysts from a single diene precursor. The bisboranes prepared in situ exhibited excellent activity (turnover numbers up to 200 at -40 °C) and enantioselectivity (up to 95 %â ee) in imine hydrogenation reactions.