Correlation research between fear of disease progression and quality of life in patients with lung cancer.

BACKGROUND: Lung cancer has the highest incidence rate and mortality rate of all malignancies. In recent years, the therapeutic effect of lung cancer has been greatly improved, but the fear of disease progression still directly affects the quality of life (QOL) of patients. The aim of this study was to evaluate the factors affecting the progression of fear of disease and its impact on the quality of life in patients with lung cancer. METHODS: From December 2019 to February 2020, 102 patients with lung cancer in the Department of Thoracic Oncology of a top three hospital were investigated by using the simplified fear of disease progression scale (FoP-Q-SF) and the quality-of-life scale for cancer patients (FACT-G). Data were collected and statistically analyzed by SPSS25.0 software. RESULTS: A total of 110 questionnaires were distributed and 102 valid questionnaires were recovered, indicating a recovery rate of 92.7%. The results of multiple stepwise regression analyses showed that blood group, monthly income, and mood state were the influencing factors for the progression of phobic diseases in cancer patients (P<0.05), and the score of progression of phobic disease was negatively correlated with the quality-of-life score (r=-0.382). CONCLUSIONS: The progress of phobic diseases in patients with lung cancer seriously affects their QOL, and further attention by medical staff in providing health education, psychological counseling, social support, and other measures is required.

[Determination of 33 pesticides in tea by accelerated solvent extraction-gel permeation and solid-phase extraction purification-gas chromatography-mass spectrometry].

A method has been developed for the determination of 33 pesticide residues in tea, including organophosphorous, organochlorine and pyrethroid pesticides. The target analytes were extracted with the solution of acetone/dichloromethane (1:1, v/v) using accelerated solvent extraction (ASE) and then purified using gel permeation chromatography (GPC) to eliminate most of the coextracts, such as pigments, lipids and waxes. They were further purified using Carb-NH2 and Florisil solid-phase extraction (SPE) cartridges prior to the identification using gas chromatography-mass spectrometry (GC-MS). The quantitative analysis was performed with flame photometric detector (FPD) for organophosphorous pesticides and electron capture detector (ECD) for organochlorine and pyrethroid pesticides. At the spiked level of 0.05 mg/kg, the recoveries for most pesticides were between 70%-120%; the relative standard deviations were less than 20%; the limits of detection varied from 0.005 to 0.05 mg/kg (defined in terms of 10 times of the baseline noise). This method is precise, sensitive and highly efficient in extraction. After routine applications, the results indicated that this method is suitable for the determination of pesticide residues in the tea for export.