1.
Chem Commun (Camb)
; 55(1): 119-122, 2018 Dec 18.
Artículo
en Inglés
| MEDLINE
| ID: mdl-30516178
RESUMEN
Transition-metal-free α-arylation of α-nitroketones with diaryliodonium salts has been realized for the first time. As an application of this methodology, a concise synthesis of the clinical drug tiletamine was also achieved via a three-step procedure from 2-nitrocyclohexanone without the isolation of intermediates.