Ambient temperature, humidity, and urinary system diseases: a population-based study in Western China.

Climate has received an increasing attention due to its adverse effects on human health, but the effects on the urinary system are still short of enough evidence. Therefore, we carry out this study to analyze the relationship between meteorological factors and urinary system health in arid areas of western China. In this study, the daily numbers of outpatients with the urinary system diseases from multiple hospitals in three cities in Gansu province (Lanzhou, Zhangye, and Tianshui city) were collected and used for analysis. The distributed lag non-linear models (DLNM) with a quasi-Poisson distribution were used to estimate the associations between meteorological factors and daily outpatients for urinary system diseases in these three cities, and then a multivariate meta-analysis was applied to pool the estimates of city-specific effects. We found that the ambient temperature (AT) and relative humidity (RH) were significantly associated with the outpatient visits of urinary system diseases. The effects of meteorological factors on outpatients with urinary system diseases for both males and females were statistically significant at different lag days. The higher AT and lower RH were associated with the higher risk of urinary system diseases. We also observed substantial lag effects of meteorological factors on outpatients for both males and females. Among all disease types, renal tubule-interstitial diseases had the strongest relationships with meteorological factors. Our results indicate that the higher AT and lower RH may increase the outpatient visits for urinary system diseases, with significant lag effects in semi-arid areas.

[The protective effects of vitamin E on lung injury caused by high temperature and PM2.5 in COPD rats].

OBJECTIVE: To investigate the effects of vitamin E on the respiratory function impairment in rats with chronic obstructive pulmonary disease (COPD) after exposed to high temperature and PM2.5. METHODS: Fifty-four 7-week-old SPF male Wistar rats were randomly divided into 9 experimental groups (n=6). The rat COPD model was established by lipopolysaccharide (LPS) and smoke exposure. After modeled, the rats were tracheal instilled with PM2.5 (0 mg/ml, 3.2 mg/ml) and intraperitoneally injected with vitamin E at the dose of 40 mg/kg (20 mg/ml). Part of rats (high temperature groups) were then exposed to high temperature (40℃), once (8 h) a day for three consecutive days. After the last exposure, the lung function of rats was detected. The expression levels of inducible nitric oxide synthase (iNOS), tumor necrosis factor-α (TNF-α) and monocyte chemotactic protein-1 (MCP-1) were detected by corresponding ELISA kits. RESULTS: Compared with the control group, exposure of high temperature and PM2.5 could inhibit the lung function of COPD rats significantly (P＜0.05); the level of MCP-1 was increased significantly in PM2.5-exposure groups (P＜0.05); iNOS was increased significantly in the groups of high temperature (P＜0.05). Compared with the single-PM2.5 exposure groups, TNF-α in lung was decreased in the normal temperature health group and high temperature COPD group (P＜0.05) after treated with vitamin E; MCP-1 was decreased in all vitamin E-treated groups (P＜0.05); the decreased iNOS only appeared in the group of high temperature with vitamin E treatment. CONCLUSION: High temperature and PM2.5 could aggravate the inflammation of COPD rats. As an antioxidant, vitamin E may protect the lung from the damage effects.