Heterogeneity and tumoral origin of medulloblastoma in the single-cell era.

Medulloblastoma is one of the most common malignant pediatric brain tumors derived from posterior fossa. The current treatment includes maximal safe surgical resection, radiotherapy, whole cranio-spinal radiation and adjuvant with chemotherapy. However, it can only limitedly prolong the survival time with severe side effects and relapse. Defining the intratumoral heterogeneity, cellular origin and identifying the interaction network within tumor microenvironment are helpful for understanding the mechanisms of medulloblastoma tumorigenesis and relapse. Due to technological limitations, the mechanisms of cellular heterogeneity and tumor origin have not been fully understood. Recently, the emergence of single-cell technology has provided a powerful tool for achieving the goal of understanding the mechanisms of tumorigenesis. Several studies have demonstrated the intratumoral heterogeneity and tumor origin for each subtype of medulloblastoma utilizing the single-cell RNA-seq, which has not been uncovered before using conventional technologies. In this review, we present an overview of the current progress in understanding of cellular heterogeneity and tumor origin of medulloblastoma and discuss novel findings in the age of single-cell technologies.

Environmental economic co-benefits and offsets effects of China's unified energy-carbon market.

China pushed for the unification of markets for natural resources and emissions, wherein initial allocation mechanisms have a significant impact on how well the market functions. To identify how the market works well, this paper builds an integrated framework, comprised of permits initialization and reallocation processes. Additionally, we simulate variables by 2030 through scenario analysis and machine learning methods. At the unified energy-carbon market, GDP could increase by more than 49%, while the total energy consumption and the total carbon emission increase by around 410 million tons and 711 million tons, respectively, in China. This illustrates how joint trading markets favor economic growth and emission reduction simultaneously. Besides, most of China's provinces obtain improved energy consumption and carbon emission intensities, which proves the effectiveness and importance of the unified market. However, two rebound effects are found, one is that the increased investment is not always promoting positive effects, and the other is that provinces with higher GDPs have less incentive to cut their energy use. Further, the accumulated per capita initialization type favors energy conservation, while per GDP initialization benefits economic growth and carbon reduction. It's needed that simultaneously constructing an economic and efficient incentive mechanism while effectively playing up the government's role.

Water-climate change extended nexus contribution to social welfare and environment-related sustainable development goals in China.

Climate change exacerbates uncertainties in water resource management, water supply, and treatment that are energy intensive and then exert great pressure on climate change mitigation; hence, interrelated and contradictory characteristics within the water-climate change (WC) nexus system are needed to be studied. The nexus thinking and coordination of WC would impact many realistic practices and assist in sustainable socioeconomic development since traditional single-target policies have sometimes been out of function. Hence, the ability to direct water production and use as well as climate change mitigation has become a hotspot recently. Furthermore, we find that there has been no complete research on reviewing the impacts of the WC nexus in different areas on the Sustainable Development Goals (SDGs). Hence, this paper builds a core nexus of WC and then analyzes those effects on social and environmental aspects in many areas, including sewage treatment, energy transition, waste treatment, land management, and ocean management. This paper discusses how WC interlinkages are utilized to realize SDGs in those areas. Moreover, uncertainties derived from exogenous hydrology, climate change, and anthropogenic endogenous systems for realistic problems appeal to gradually increasing concern. Finally, implications offer valuable guidelines for integrated management of water and carbon emissions, as well as sustainable socioeconomic development in the future.

Towards carbon neutrality: what has been done and what needs to be done for carbon emission reduction?

Carbon emissions embodied in anthropogenic activities represent the major cause of global warming. Countries, regions, and cities have implemented comprehensive, multi-level and multi-scale measures to reduce emissions and move towards carbon neutrality. The demand for carbon emission reduction (CER) is made more challenging by different geographical locations, country-owned natural resources, and economic development stages. The main objectives of this paper are to conduct a bibliometric analysis to map the frontiers and directions of CER and to explore the paths and development models of CER from the perspective of spatio-temporal, multi-scale, multi-sectoral, and multi-responsible subjects. This study reveals that carbon emission evaluation and prediction, correlation and causal relationship analysis, and CER-related policy simulation and optimization are the most critical hotspots. Additionally, we point out the shortcomings of and future developments for the three study dimensions above. The bibliometric analysis also highlights the fact that a cooperative global value chain as well as amendable policies and mechanisms for CER will help with climate change mitigation and adaptation through the use of advanced carbon capture and storage technologies. We review the technical measures for and policy responses to CER adopted by different countries and industries at the theoretical and practical levels and provide new recommendations. Our work provides important information for climate actions in different countries and sectors and for developing more effective CER strategies and policies.

Spatial and dynamic effects of air pollution on under-five children's lower respiratory infections: an evidence from China 2006 to 2017.

Air pollution has been a deeply concerned issue posing an immediate and profound threat to human's lower respiratory health in China. The health of children under 5 years old, regarded as a key index of public health progress in a country, is closely related to the long-term human capital development. Hence, it is vital to investigate the potential association between air pollution and children's lower respiratory health outcomes and to explore related policy implications regarding the public health and the pollution regulation. As air pollutants diffuse across adjacent regions rather easily, considering the spatial spillover effect is meaningful in course of acquiring the aforementioned association. Based on the proposed province-level panel dataset of China during 2006-2017, this study constructs a dynamic spatial panel Durbin model to investigate the impact of air pollution on under-five children's lower respiratory infections. As a result, (1) both air pollution and children's respiratory health have obvious spatial spillover effects, and the latter has an outstanding characteristic of path dependence in time. (2) In the short term, air pollution presents significant negative impact on children's respiratory health, while in the long run, the impact decreases dramatically. (3) Regional comparison indicates that children in the western China are the most susceptible to air pollution followed by children in the central and eastern regions. (4) Other control variables have significant and varying impacts both in the short and long term. Particularly, this paper proves the existence of "siphon effect" in children healthcare system in China. From a broader and more comprehensive perspective, this study provides effective and constructive basis for policy making, in favor of improving children's health under air pollution and promoting sustainable development in China.

Characterization of complete mitochondrial genome of Hylarana guentheri (Anura: Ranidae) and its phylogenetic implication.

The Günther's frog (Hylarana guentheri) belongs to a member of the family Ranidae. We provide a complete mitogenome of H. guentheri and examine its phylogenetic position with other related species. Its mitogenome is a closed circular molecule 18,698 bp in length including 13 protein coding genes, 22 tRNA coding genes, two rRNA-coding genes, and a control region (CR) that are conserved in most Ranidae mitogenomes. The overall base composition of the H. guentheri mitogenome is 29.27% A, 30.45% T, 26.14% C, and 14.15% G, which is typical for Amphibious animals' mitochondrial genomes. The alignment of the Ranidae species control regions showed high levels of genetic variation and abundant AT content. Seven tandem repeats were found in the control region. Phylogenetic analysis with Bayesian inference and maximum likelihood based on 13 protein-coding genes indicated that H. guentheri is more closely related to Nidirana okinavana than to Babina subaspera and B. holsti. The complete mitogenome of H. guentheri provides a potentially useful resource for further exploration of the taxonomic status and phylogenetic relationships of Hylarana and related species.

Characteristics of the mitochondrial genome of Rana omeimontis and related species in Ranidae: Gene rearrangements and phylogenetic relationships.

The Omei wood frog (Rana omeimontis), endemic to central China, belongs to the family Ranidae. In this study, we achieved detail knowledge about the mitogenome of the species. The length of the genome is 20,120 bp, including 13 protein-coding genes (PCGs), 22 tRNA genes, two rRNA genes, and a noncoding control region. Similar to other amphibians, we found that only nine genes (ND6 and eight tRNA genes) are encoded on the light strand (L) and other genes on the heavy strand (H). Totally, The base composition of the mitochondrial genome included 27.29% A, 28.85% T, 28.87% C, and 15.00% G, respectively. The control regions among the Rana species were found to exhibit rich genetic variability and A + T content. R. omeimontis was clustered together with R. chaochiaoensis in phylogenetic tree. Compared to R. amurensis and R. kunyuensi, it was more closely related to R. chaochiaoensis, and a new way of gene rearrangement (ND6-trnE-Cytb-D-loop-trnL2 (CUN)-ND5-D-loop) was also found in the mitogenome of R. amurensis and R. kunyuensi. Our results about the mitochondrial genome of R. omeimontis will contribute to the future studies on phylogenetic relationship and the taxonomic status of Rana and related Ranidae species.

A Soft-Path Solution to Risk Reduction by Modeling Medical Waste Disposal Center Location-Allocation Optimization.

The risk of medical waste pollution and huge demand of daily medical waste disposal pose great difficulties to medical waste management. Establishing medical waste disposal centers (MWDCs) is considered one of the ways to reduce the environmental and public risk of medical waste pollution. However, how to serve the medical waste disposal demand in optimal MWDCs' locations is a key challenge due to the complexity of the whole system and relationships among stakeholders. This article develops a soft-path solution for reducing risks as well as mitigating the related costs by optimizing the MWDC location-allocation problem. A risk mitigation-oriented bilevel equilibrium optimization model is developed for modeling the Stackelberg game behavior between the local government and the medical institutions. The objectives of the local government are minimizing the total risk of loss, the subsidy costs, and the investment cost of building the MWDCs, while minimizing the disposal and transportation costs are the objectives at the medical institution level. Fuzzy random variables are introduced by combining insufficient historical data with expert knowledge via consulting surveys to describe the coexisting uncertainties in the data. To solve the model, a hybrid approach combined with the interactive fuzzy programming technique and an Entropy-Boltzmann selection-based genetic algorithm are designed and tested. The Chengdu Medical Waste Disposal Centers Planning Project is used as a practical application. The results show that it is possible to achieve a balanced market with higher economic efficiency and significantly reduced risk through an appropriate principle of interactive actions between the bilevel stakeholders.

An Improved Shapley Value Method for a Green Supply Chain Income Distribution Mechanism.

Low-carbon development and environmental remediation are key factors for green resource-based supply chains in China. With this aim in mind, by applying game theory under uncertain market demand, this paper incorporates low-carbon development and environmental remediation into a resource-based supply chain coordination model for decentralized and centralized markets. The results show that a centralized market can lead to improvement in total profit. Furthermore, based on an improved Shapley value method, a theoretical model for the centralized market income distribution mechanism is developed that incorporates three corrective risk factors, ecological investment, and technological level. Finally, a numerical analysis is conducted using a MATLAB simulation to obtain intuitive results, which, in turn, show the validity of incentive income distribution mechanisms for green supply chain development in China.

Processing Technology Selection for Municipal Sewage Treatment Based on a Multi-Objective Decision Model under Uncertainty.

This study considers the two factors of environmental protection and economic benefits to address municipal sewage treatment. Based on considerations regarding the sewage treatment plant construction site, processing technology, capital investment, operation costs, water pollutant emissions, water quality and other indicators, we establish a general multi-objective decision model for optimizing municipal sewage treatment plant construction. Using the construction of a sewage treatment plant in a suburb of Chengdu as an example, this paper tests the general model of multi-objective decision-making for the sewage treatment plant construction by implementing a genetic algorithm. The results show the applicability and effectiveness of the multi-objective decision model for the sewage treatment plant. This paper provides decision and technical support for the optimization of municipal sewage treatment.

Joint Attributes and Event Analysis for Multimedia Event Detection.

Semantic attributes have been increasingly used the past few years for multimedia event detection (MED) with promising results. The motivation is that multimedia events generally consist of lower level components such as objects, scenes, and actions. By characterizing multimedia event videos with semantic attributes, one could exploit more informative cues for improved detection results. Much existing work obtains semantic attributes from images, which may be suboptimal for video analysis since these image-inferred attributes do not carry dynamic information that is essential for videos. To address this issue, we propose to learn semantic attributes from external videos using their semantic labels. We name them video attributes in this paper. In contrast with multimedia event videos, these external videos depict lower level contents such as objects, scenes, and actions. To harness video attributes, we propose an algorithm established on a correlation vector that correlates them to a target event. Consequently, we could incorporate video attributes latently as extra information into the event detector learnt from multimedia event videos in a joint framework. To validate our method, we perform experiments on the real-world large-scale TRECVID MED 2013 and 2014 data sets and compare our method with several state-of-the-art algorithms. The experiments show that our method is advantageous for MED.