BACKGROUND: Inguinal hernia repair is one of the most performed surgeries in the world. It is recognized that any surgery of the pelvic floor may represent a risk factor of male infertility. METHOD: Retrospective study of patients with azoospermia and a history of adult inguinal hernia repair surgery and referred to our center between January 1990 and January 2011 for infertility. RESULTS: Among 69 azoospermia patients with history of adult inguinal hernia repair surgery, 60 patients underwent surgical extraction of sperm that was successful in 75% (45/60). Positive extraction rate decreases in the subgroup of patients with risk factors for infertility (61.4%) as well as in the group with bilateral inguinal hernia (67.9%). There was no statistically significant difference in the positive rate of sperm retrieval according to surgical technique or according to the use of polypropylene mesh (P>0.05). CONCLUSION: The obstruction of the vas deferens due to an inguinal hernia repair was a potential iatrogenic cause of male infertility that was rare and underestimated. The influence of using a polypropylene mesh was not clearly demonstrated. The management of these patients is based on prevention in order to identify patients with risk factors of infertility in order to propose a presurgery cryopreservation of sperm. LEVEL OF EVIDENCE: 5.
Azoospermia/etiology , Hernia, Inguinal/surgery , Adult , Humans , Infertility, Male/etiology , Male , Retrospective Studies , Surgical Mesh , Vas Deferens
The conservative management of upper tract urothelial carcinoma (UTUC) has seen important developments over the last 10 years with advances in endoscopy. Our aim was to compare the available evidence regarding the impact of endoscopic nephron sparing procedures (NSP) and radical nephroureterectomy (RNU) on survival of upper tract urothelial carcinoma (UTUC). A critical review of Pubmed/Medline, Embase and the Cochrane Central Register of Controlled Trials was performed in July 2013 according to the preferred reporting items for systematic reviews and meta-analysis (PRISMA) statement. Overall, eight publications were selected for inclusion in this meta-analysis but all of them were retrospective or non-randomised comparative studies. The primary end points were the overall and cancer-specific survivals (OS and CSS) in the two treatment groups. We achieved to pool data on 1002 patients diagnosed with localised UTUC and treated either by endoscopic NSP (n = 322) or by RNU (n = 680). No significant difference was found in terms of OS and CSS between RNU and endoscopic NSP (HR = 1.47 and p = 0.31; HR = 0.96 and p = 0.91, respectively). However, the low level of evidence (3b) and the heterogeneity of the studies limited the quality of the results. In the absence of prospective and randomised studies, the equivalent oncologic control for endoscopic NSP and RNU is not provided by this meta-analysis. Multicentre prospective studies are urgently needed to assess the oncologic outcomes of UTUC with endoscopic management. In the next multicentre studies, the patients should be matched on the basis of the tumour stage (imaging) and grade (biopsy) at diagnosis.
Carcinoma, Transitional Cell/surgery , Kidney Neoplasms/surgery , Nephrectomy/methods , Ureteral Neoplasms/surgery , Ureteroscopy , Evidence-Based Medicine , Humans , Kidney Neoplasms/pathology , Neoplasm Recurrence, Local , Treatment Outcome , Ureteral Neoplasms/pathology
Managing patients with new oral anticoagulants in perioperative period is not yet well protocolized. We report a clinical case of a critical haematuria after prostate biopsies to a patient treated with RIVAROXABAN. Monitoring and treatment of the haematuria have been difficult due to the lack of biological control and antidote for this treatment.
Anticoagulants/adverse effects , Hematuria/etiology , Morpholines/adverse effects , Prostate/pathology , Thiophenes/adverse effects , Biopsy/adverse effects , Critical Illness , Humans , Male , Rivaroxaban
OBJECTIVE: To analyze the prognostic impact of lymphovascular invasion (LVI) in case of urothelial carcinoma of upper urinary tract (UUT-UC). PATIENTS AND METHODS: Retrospective study of 83 consecutive patients treated surgically for UUT-UC between January 1998 and October 2008. Prognostic interest of histopathological factors (stage, grade, LVI, CIS, tumor architecture, location, nodal status and surgical margins) was assessed in univariate and multivariate Cox regression model. Specific survival (SS), recurrence-free survival (RFS) and metastasis-free survival (MFS) were calculated using Kaplan-Meier method and Log-Rank test. RESULTS: LVI was observed in 26.5% of patients after histopathologic reviewing. The SS, RFS and MFS at 2 years were 93%, 76% and 96% respectively in group without LVI compared to 40%, 13% and 38% in group with LVI (P<0.001). In univariate analysis, pathological stage, LVI and margin status were predictive of SS (P<0.05). Pathological stage, LVI and surgical margin status were predictive of RFS (P<0.05). LVI, tumor architecture and status of surgical margins were predictive of MFS (P<0.05). LVI was the only independent predictive factor in multivariate analysis for all survival (P=0.002, 0.002 and 0.001 respectively for the SS, RFS and MFS). CONCLUSION: LVI was a poor prognostic factor in cases of UUT-UC. This criteria should be routinely sought and included in the pathology report.
Carcinoma, Transitional Cell/pathology , Carcinoma, Transitional Cell/secondary , Kidney Neoplasms/pathology , Ureteral Neoplasms/pathology , Vascular Neoplasms/pathology , Aged , Carcinoma, Transitional Cell/mortality , Female , Humans , Kidney Neoplasms/mortality , Lymphatic Metastasis , Male , Middle Aged , Neoplasm Invasiveness , Prognosis , Retrospective Studies , Survival Rate , Ureteral Neoplasms/mortality , Vascular Neoplasms/mortality
