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1.
BMC Psychiatry ; 24(1): 89, 2024 Jan 31.
Artículo en Inglés | MEDLINE | ID: mdl-38297274

RESUMEN

AIM: Although there are many scales that measure stigma, there is no scale with the necessary adequacy to measure stigma in the perinatal period. The study aims to develop the stigma scale for women with mental illness in the perinatal period and test its validity and reliability. MATERIALS AND METHODS: Participants were reached via patients, visitors, and hospital staff who applied to Sakarya Training and Research Hospital between 01/06/2022 and 01/12/2022. Two hundred people (female n = 134, male n = 66) aged 18-65 participated in the study and "Sociodemographic data form," "Perinatal Mental Illness Stigma Scale (PMISS)," "Social Distance Scale," and "Beliefs Towards Mental Illness Scale" were used to collect data. Data were analyzed using SPSS 22 and the AMOS 26 program. RESULTS: The Content Validity Index of the scale items was between 0.80-1. Cronbach's alpha coefficient score of the general scale was 0.94, the "Discrimination and Prejudice" sub-dimension was 0.93, and the "Labeling" sub-dimension was 0.88. It was determined that item-total score correlations varied between 0.410 and 0.799. P value calculated < 0.05 in Barlett's test and 0.94 in the Kaiser-Meyer Olkin test. These values show that factor analysis can be applied to the scale. According to the Exploratory Factor Analysis result, the scale has a 2-factor structure, explaining 60% of the total variance. The Guttman Split-Half coefficient of the scale was 0.882, and the Spearman-Brown coefficient was 0.883. The scale was reapplied to 30 participants with an interval of three weeks. The correlation coefficient between the two measurements was 0.91, indicating that the scale satisfies the invariance principle over time. CONCLUSION: The PMISS is a reliable measurement tool that can be used to investigate stigma towards mental illness during the perinatal period in the Turkish population.


Asunto(s)
Trastornos Mentales , Estigma Social , Embarazo , Humanos , Masculino , Femenino , Reproducibilidad de los Resultados , Psicometría , Trastornos Mentales/diagnóstico , Prejuicio , Encuestas y Cuestionarios
2.
Ann Clin Psychiatry ; 35(4): 260-271, 2023 11.
Artículo en Inglés | MEDLINE | ID: mdl-37850996

RESUMEN

BACKGROUND: The aims of this study were to develop a mobile mental health application (app) to scan the symptoms of anxiety, depression, and related factors during pregnancy; examine the effect of the app on pregnant women; and determine the factors related to using such an app. METHODS: A software platform called Perinatal Anxiety Depression Monitoring Platform (PADIP) was developed. This study included 320 pregnant women: 160 in the PADIP group and 160 in the control group. The PADIP group was screened monthly for 3 months for depression, anxiety, and sleep quality, and instant feedback was provided on scale scores. RESULTS: During the follow-up period, there was a significant decrease in depression and anxiety scale scores in the PADIP group but no significant difference in scale scores in the control group. The interface used for the app was important for scale scores. It was preferred by pregnant women with a high education level, higher Perinatal Anxiety Screening Scale scores, and lower sleep quality scores. CONCLUSIONS: PADIP use was associated with a decrease in depression and anxiety scores of pregnant women. It was more useful for patients with higher education levels and a history of a psychiatric disorder, but further research is needed to develop a more comprehensive model.


Asunto(s)
Depresión , Trastorno Depresivo , Femenino , Embarazo , Humanos , Depresión/diagnóstico , Depresión/terapia , Depresión/psicología , Ansiedad/psicología , Mujeres Embarazadas/psicología , Trastornos de Ansiedad , Trastorno Depresivo/diagnóstico , Trastorno Depresivo/terapia , Trastorno Depresivo/psicología
3.
Comput Biol Med ; 161: 107003, 2023 07.
Artículo en Inglés | MEDLINE | ID: mdl-37224599

RESUMEN

Undiagnosed prenatal anxiety and depression have the potential to worsen and have an adverse effect on both the mother and the infant. Although the diagnosis is made by specialist doctors, it is unclear which parameters are more effective. Especially in medicine, it is crucial to diagnose disease with high accuracy. For this reason, in this study, a questionnaire study was first conducted on pregnant women, and real original data were collected. Then, the Marine Predators Algorithm (MPA), one of the current metaheuristic algorithms inspired by nature, was combined with K-Nearest Neighbors (kNN) to determine high-priority features in the collected data. As a result, five of the 147 features selected by the proposed method were determined as high priority and approved by the doctors. In addition, the proposed method is compared with the Chi-square method, which is one of the filter-based feature selection methods. Thanks to the proposed feature selection method based on MPA and kNN, it has been observed that the classification gives more successful results in a shorter time with 98.11% success, and the model supports the diagnosis stage of the doctors.


Asunto(s)
Algoritmos , Depresión , Embarazo , Humanos , Femenino , Depresión/diagnóstico , Ansiedad/diagnóstico , Análisis por Conglomerados , Recolección de Datos
4.
Chem Biodivers ; 20(5): e202201190, 2023 May.
Artículo en Inglés | MEDLINE | ID: mdl-37005228

RESUMEN

The pathophysiological mechanism behind the link between antipsychotic drugs and sexual dysfunction is still unknown. The goal of this research is to compare the potential effects of antipsychotics on the male reproductive system. Fifty rats were randomly assigned into the five groups indicated: Control, Haloperidol, Risperidone, Quetiapine and Aripiprazole. Sperm parameters were significantly impaired in all antipsychotics-treated groups. Haloperidol and Risperidone significantly decreased the level of testosterone. All antipsychotics had significantly reduced inhibin B level. A significant reduction was observed in SOD activity in all antipsychotics-treated groups. While GSH levels diminished, MDA levels were rising in the Haloperidol and Risperidone groups. Also, the GSH level was significantly elevated in the Quetiapine and Aripiprazole groups. By causing oxidative stress and altering hormone levels, Haloperidol and Risperidone are damaging to male reproductivity. This study represents useful starting point for exploring further aspects of the underlying mechanisms reproductive toxicity of antipsychotics.


Asunto(s)
Antipsicóticos , Masculino , Ratas , Animales , Antipsicóticos/toxicidad , Antipsicóticos/uso terapéutico , Risperidona/toxicidad , Risperidona/uso terapéutico , Haloperidol/toxicidad , Haloperidol/uso terapéutico , Fumarato de Quetiapina , Aripiprazol , Semen
5.
Drug Alcohol Depend ; 238: 109577, 2022 09 01.
Artículo en Inglés | MEDLINE | ID: mdl-35905593

RESUMEN

BACKGROUND: Aggression and craving are common and important withdrawal symptoms in cannabis use disorder. The present study investigated the association between appetite-regulating hormones, aggression, and craving during cannabis withdrawal syndrome (CWS). METHODS: Fifty-six male subjects diagnosed with cannabis withdrawal and 45 healthy males were included in the study. The Substance Craving Scale, the Buss-Perry Aggression Questionnaire, and the State-Trait Anxiety Inventory were implemented at baseline. Blood samples were drawn to measure ghrelin, leptin, adiponectin, and resistin levels in the serum. Then, the Point Subtraction Aggression Paradigm (PSAP) was applied. Bloodwork and psychometric assessment procedures were re-implemented after the PSAP. At the 7-day follow-up, psychometric assessments and hormone measurements were repeated in the CWS group. RESULTS: Baseline serum ghrelin and adiponectin levels were lower in the CWS group than controls at baseline. After PSAP, there was a significant increase in ghrelin levels of patients with CWS compared to controls. Patients yielded higher aggression scores, while there was no significant correlation between hormonal changes and PSAP findings. At 7-day follow, ghrelin and resistin levels significantly increased, while serum leptin decreased in patients with CWS. Finally, there was a positive association between craving and resistin levels. CONCLUSIONS: Our results present the changes in appetite-regulating hormones. Long-term follow-up studies are needed to shed light on neuroendocrinological aspects of cannabis withdrawal.


Asunto(s)
Abuso de Marihuana , Síndrome de Abstinencia a Sustancias , Adiponectina , Agresión , Apetito , Ansia , Ghrelina , Humanos , Leptina , Masculino , Resistina
6.
Indian J Clin Biochem ; 37(2): 139-148, 2022 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-35463111

RESUMEN

Klotho and neurotropic factors have recently been shown to be related to some psychiatric disorders and neurocognitive disorders, but there is no study on this issue within substance users. In this study, brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), glial derived neurotrophic factor (GDNF) and klotho serum levels of a patient group consisting of 27 chronic cannabis users according to the DSM-V and 27 healthy volunteers were compared, and their relationships with other the clinical features of other patients were evaluated. Clinical scales, the Buss-Perry Aggression Scale, and the Substance Craving Scale were repeated on the first day of hospitalisation and on the seventh day of withdrawal. BDNF, GDNF, NGF and klotho levels were analysed using the ELISA method. There was no differences between the cannabinoid use disorder group and the control group regarding their klotho and other neurotrophic levels, but initiation age of cannabis use was negatively correlated with these levels. In addition, there was a relationship between verbal aggression scores and BDNF and NGF levels. There was a positive correlation between klotho and neurotrophic factors in all groups (patient group Day 1, patient group Day 7, control group) (p < 0.01). When comparing the difference between the correlations using the cocor (a comprehensive solution for the statistical comparison of correlations), the klotho-GDNF and klotho-NGF correlations for the first day of the patient group and the control group were different. In this study, rather than a difference in klotho levels and neurotropic factors, a significant relationship between these markers and each other and clinical parameters was demonstrated; further studies are needed to understand the exact mechanism.

7.
J Yeungnam Med Sci ; 39(1): 58-61, 2022 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-35067008

RESUMEN

Mega cisterna magna (MCM), one of the members of the Dandy-Walker complex, is a developmental malformation of the posterior fossa that is larger than 10 mm but morphologically does not affect the vermis and cerebellar hemispheres. Reports of psychiatric disorders associated with this anomaly are rare. We present the case of a patient with MCM who presented with a psychotic manic attack and was diagnosed with bipolar disorder. A 28-year-old female, single housewife, university graduate, presented with irritability, decreased sleep and appetite, distraction, and agitation. The patient also had a delusion of reference. In the clinical follow-up, an increase in energy and an increase in the amount of speech were observed. Her neurological examination was normal, and cranial magnetic resonance imaging revealed an MCM. The relationship and clinical significance of MCM with psychosis and mood disorders have not yet been fully elucidated. It is not known whether this association is accidental or based on etiological commonality. The purpose of this case report is to review the relationship between the cerebellum and psychiatric symptoms and to contribute to the literature.

8.
North Clin Istanb ; 8(5): 443-453, 2021.
Artículo en Inglés | MEDLINE | ID: mdl-34909582

RESUMEN

OBJECTIVE: Epidemic and pandemic outbreak periods are as stressful for psychiatric symptoms as well as the physical symptoms of the epidemic disease and can trigger and aggravate psychiatric symptoms, especially anxiety. There is no scale specific to the outbreak period and which can be used in other outbreaks. In this study, it was planned to develop a scale to evaluate the anxiety associated with epidemic disease, especially during the epidemic period. METHODS: In this study, a Likert type scale with 15 items was developed by our research team to evaluate outbreak disease anxiety, and the scale form created was transferred to online use and the reliability of validity was evaluated by obtaining the results of 311 participants in the online environment. The internal consistency of the scale was assessed with Cronbach's Alpha coefficients. Split-half reliability was estimated using Spearman-Brown coefficients unequel length. Explanatory factor analysis, confirmatory factor analysis in AMOS, correlation analysis, and construct validity analysis (convergent validity and discriminant validity) were conducted. Beck Anxiety Inventory and Health Anxiety Inventory was used to evaluate concurrent and discriminant validity. RESULTS: The Cronbach Alpha coefficient calculated for the evaluation of the internal consistency (homogeneity) of the outbreak anxiety scale was determined as 0.94 and this value shows that the scale has high reliability. With the results of this study, the scale's content validity and construct validity, discrimination, and criterion validity were evaluated and it was shown to have acceptable valid features in all. CONCLUSION: Outbreak anxiety scale is a valid and reliable tool to evaluate anxiety related with outbreak of epidemic and pandemic disease.

9.
BMC Psychiatry ; 21(1): 562, 2021 11 11.
Artículo en Inglés | MEDLINE | ID: mdl-34763683

RESUMEN

BACKGROUND: Klotho and its relationship with neurotrophic factors and cognition in schizophrenia has not yet been investigated. In this study, the hypothesis that the blood serum levels of BDNF, GDNF, NGF and Klotho in schizophrenia patients and healthy controls would be related to cognitive functions was investigated. METHODS: In this study, two groups were assessed: schizophrenia patients (case group) who were hospitalised in the Psychiatry Clinic of Sakarya University Training and Research Hospital and healthy volunteers (control group). The patients were evaluated on the 1st and 20th days of their hospitalisation with the Positive and Negative Syndrome Scale (PANSS), the Brief Psychiatric Rating Scale (BPRS), the General Assessment of Functioning Scale (GAF) and the Clinical Global Impression Scale (CGI). For cognitive assessment, both groups were evaluated with the Wechsler Memory Scale-Visual Production Subtest (Wechsler Memory Scale III-Visual Reproduction Subtest) and the Stroop test. RESULTS: BDNF, GDNF, NGF and Klotho levels were lower in schizophrenia patients than in healthy controls. In the schizophrenia patients, on the 20th day of treatment, there was a statistically significant increase in BDNF compared to the 1st day of treatment. BDNF, GDNF and Klotho showed positive correlations with some cognitive functions in the healthy controls. BDNF, GDNF, NGF and Klotho levels were intercorrelated and predictive of each other in both groups. CONCLUSION: This study suggests a relationship between cognitive functions, neurotrophic factors and Klotho. Most of the results are the first of their kind in the extant literature, while other results are either similar to or divergent from those generated in previous studies. Therefore, new, enhanced studies are needed to clarify the role of Klotho and neurotrophic factors in schizophrenia.


Asunto(s)
Factor Neurotrófico Derivado del Encéfalo , Esquizofrenia , Cognición , Factor Neurotrófico Derivado de la Línea Celular Glial , Humanos , Proteínas Klotho , Factor de Crecimiento Nervioso
10.
Nord J Psychiatry ; 75(8): 596-606, 2021 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-33906561

RESUMEN

AIM: Preventing relapses in addiction and related factors are still being investigated. There is inadequate data, specifically, on the effects of expressed emotion (EE) among key relatives of patients with alcohol and substance use disorder (ASUD), the personality traits of patients, and the clinical features of addiction on relapses. MATERIAL AND METHOD: This study was conducted with patients with ASUD (n = 102, 98 male) and their relatives (n = 102, 44 male). The Dependency Profile Index, and the Temperament and Character Inventory were applied to the patients, while the EE scale was applied to key relatives. Relapse rates were evaluated six months later. RESULTS: EE levels among key relatives of patients were found to be associated with early relapse rates (p = 0.002). In addition, the individuals the patients lived with (p = 0.041), income level (p = 0.048), working status (p = 0.039), time spent in profession (p = 0.007), and severity of addiction (p = 0.016) were all found to be significantly associated with relapses. The personality traits of patients were not related to early relapses. In logistic regression analysis, EE and time spent in a profession were found to be significantly associated with relapses (p = 0.014, 0.043 respectively), while other variables were not significant. CONCLUSION: The relationship between relapse in the early period of abstaining from substance use and EE levels of key relatives seems to be a greater determinant for ongoing success than several other variables in patients with ASUD, including addiction severity. The research suggests that families be involved in programs that help prevent relapses.


Asunto(s)
Emoción Expresada , Trastornos Relacionados con Sustancias , Carácter , Estudios de Seguimiento , Humanos , Masculino , Pronóstico
11.
Psychiatry Investig ; 18(2): 140-146, 2021 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-33601873

RESUMEN

OBJECTIVE: The COVID-19 outbreak has negatively affected children in many ways. This study aimed to compare the psychological responses of children exposed to different levels of stress during the COVID-19 outbreak. METHODS: The anxiety levels, negative thoughts, and quality of life of COVID-19-positive children with COVID-19-positive parents (Child+ group, n=17), COVID-19-negative children who are separated from COVID-19-positive parents (Parent+ group, n=59), and a control group (n=64) were compared. The participants completed the Screen for Child Anxiety and Related Disorders (SCARED), Children's Negative Cognitive Errors Questionnaire (CNCEQ), and Pediatric Quality of Life Inventory (PedsQL). RESULTS: The statistical analysis revealed that the Parent+ group recorded higher SCARED and CNCEQ scores and lower PedsQL scores in comparison with the control group. No statistically significant difference was found between the scores of the Child+ and control groups. Furthermore, high CNCEQ scores and low PedsQL scores in the Parent+ group predicted an increase in their SCARED scores. CONCLUSION: Our study indicates that separating children from their parents during the COVID-19 outbreak negatively influences their mental health and increases their anxiety levels.

12.
Turk J Med Sci ; 51(3): 898-911, 2021 06 28.
Artículo en Inglés | MEDLINE | ID: mdl-33306335

RESUMEN

Background/aim: During the intense periods of the COVID-19 pandemic, legal measures were taken for its containment. However, since legal precautions cannot be implemented continuously, hand washing, mask usage and obeying social distance rules are important in combating the pandemic. Complying with these rules is mostly individual decisions. The behavior of individuals has a prominent place in the course of the pandemic. In this study, we aimed to develop a scale which could measure compliance with outbreak measures. Materials and methods: This study was conducted in two stages after evaluation of the content validity of the item pool formed by the research group by experts. For construct validity, the scale subdimensions were determined in 250 people between the ages of 18-70 years at the first stage and the definitive version of the 20-item scale was constructed. In the second stage, exploratory factor analysis was repeated in a group of 484 people, and confirmatory factor analysis was performed. Cronbach's alpha coefficients, Spearman-Brown coefficients, test-retest methods were used to determine reliability. Results: The variance explanation of the scale consisting of 20 items and two subdimensions in the explanatory factor analysis is 63.434% (n = 484). Confirmatory factor analysis resulted in CMIN/DF = 3.540, RMR = 0.043, NFI Delta 1 = 0.928, TLI rho 2 = 0.939, CFI = 0.947, RMSEA = 0.072, SRMR = 0.0368. Cronbach's alpha value of the scale is 0.95; and the Spearman Brown coefficient equal length analysis resulted in 0.928. The temporal consistency of the scale was evaluated with the test-retest method (P = 0.893). The structure, content validity, temporal consistency, item discrimination, and internal consistency were evaluated and found to have acceptable valid, reliable properties. Conclusion: The outbreak prevention recommendation compliance scale is a valid and reliable tool with which compliance with the prevention plans can be evaluated.


Asunto(s)
COVID-19/prevención & control , Pandemias/prevención & control , Cooperación del Paciente , Psicometría/métodos , SARS-CoV-2 , Adolescente , Adulto , Anciano , COVID-19/epidemiología , Femenino , Humanos , Masculino , Persona de Mediana Edad , Reproducibilidad de los Resultados , Estudios Retrospectivos , Encuestas y Cuestionarios , Turquía/epidemiología , Adulto Joven
13.
Psychiatry Clin Psychopharmacol ; 31(2): 189-197, 2021 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-38765231

RESUMEN

Background: The COVID-19 outbreak affects both the physical and mental health of individuals and society. This study investigates the factors related to health anxiety in COVID-19 patients and explores their sociodemographic-, disease-, and treatment-related factors, trait anxiety, and characteristics of secure or insecure attachment. Methods: The sample consisted of 420 individuals aged 18-65 years and diagnosed with COVID-19 between March 15 and May 15, 2020. The participants completed a sociodemographic data form and the Health Anxiety Inventory (HAI), Adult Attachment Scale (AAS), and State-Trait Anxiety Inventory (STAI). Results: Hierarchical regression analysis revealed that female gender, presence of chronic physical diseases, presence of mental health problems, and high AAS insecure attachment scores significantly predicted high HAI scores. Moreover, results indicated that the model explained approximately 21% of variance in HAI scores. Conclusions: Factors such as gender, presence of chronic physical diseases, presence of mental health problems, and attachment style influence health anxiety. Determining the appropriate factors that cause health anxiety can contribute to the implementation of protective measures for mental health and to the application of effective interventions for individuals who develop mental problems.

14.
J Clin Neurosci ; 65: 11-16, 2019 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-31076249

RESUMEN

Schizophrenia (SCH) and drug addiction are chronic disorders that are frequently accompanied by physical diseases, poor nutrition and reduced self-care, all of which are likely to result in vitamin deficiencies. The objective of this study was to compare vitamin levels in SCH patients, substance use disorder (SUD) patients and healthy controls (HCs). The study included 189 SCH patients, 119 SUD patients and 109 HCs. Information on vitamin B12, folic acid and vitamin D levels were retrieved from the hospital's database, and mean values and deficiency/insufficiency were evaluated. Vitamin D deficiency (<30 ng/ml) was more common in the SCH group than in the SUD and HC groups (88.4%, 74.8% and 86.4%, respectively). Although there were no significant differences in folic acid deficiency (<3.0 ng/ml) in the SUD and SCH groups (15.1% and 8.5%, respectively), the incidence of folic acid deficiency was significantly higher in both groups as compared with that in the HC group (5.8%). Significantly higher numbers of patients in the SCH group than in the SUD group had vitamin B12 deficiency (45.5% vs. 28.3%). The prevalence of vitamin B12 deficiency in the SUD group was significantly higher than that the HC group (28.3% vs.11.5%). As compared with the HC group, vitamin D and B12 levels were significantly lower in SCH group, and folic acid and B12 levels were significantly lower in the SUD group. Several vitamin deficiencies appear to be common in both SCH and SUD. Possible reasons should be investigated.


Asunto(s)
Deficiencia de Ácido Fólico/epidemiología , Esquizofrenia/sangre , Trastornos Relacionados con Sustancias/sangre , Deficiencia de Vitamina B 12/epidemiología , Deficiencia de Vitamina D/epidemiología , Adulto , Femenino , Ácido Fólico/sangre , Humanos , Incidencia , Masculino , Persona de Mediana Edad , Prevalencia , Vitamina B 12/sangre , Vitamina D/sangre
15.
Ment Illn ; 11(1): 7988, 2019 Mar 22.
Artículo en Inglés | MEDLINE | ID: mdl-31007882

RESUMEN

The aim of this study was to determine the prevalence of complementary and alternative medical applications (CAM) and non-drug treatments of women during their pregnancies, postpartum periods and the changes between these periods. The Screening Form for Non-pharmacologic Methods Used during Pregnancy and Postpartum period was administered to the participants. Passiflora (Incarnata), Hypericum perforatum (St. John's Wort), omega 3 supplements, bright light treatment, transmagnetic stimulation, S-adenosyl- methionine, herbal teas, biofeedback/neurofeedback, amulets, exercise, acupuncture and psychotherapy were investigated. The ratio of the use of one of the CAM methods for psychiatric complaints during people's lifetime was found to be 33.3% (n=162). Herbal teas were the main practice used during pregnancy (58.8%) and the postpartum. The use of CAM according to the utilization periods of the participants statistically significantly decreased in those who were currently pregnant (Cochran's Q=298.007; P<0.05). The use of participants' non-drug treatments in the periodical follow-up decreased in those who are currently pregnant and increased during the postpartum period.

16.
Nord J Psychiatry ; 73(3): 178-184, 2019 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-30896269

RESUMEN

AIM: Neurodegenerative processes are effective in schizophrenia. However, the underlying causes of the symptoms and associated factors have not yet been fully elucidated. Recent research has focused on the relationship between neurodegeneration and vitamin D, Klotho and homocysteine levels. In this study, we aimed to investigate this relationship in schizophrenia. METHOD: This study included 30 schizophrenic inpatients, 30 schizophrenic outpatients in remission and 28 healthy volunteers as the control group. The psychiatric diagnoses of our patients were evaluated according to DSM-IV criteria. The Positive and Negative Syndrome Scale (PANSS), the Global Assessment of Functioning (GAF) scale and the Clinical Global Impression (CGI) scale were used for clinical measurements. Serum Klotho, homocysteine, vitamin D, vitamin B12 and folic acid levels were analyzed using ELISA and compared with clinical properties. RESULTS: The PANSS scores and CGI scores were higher in schizophrenic inpatients than outpatients, and the GAF scores were lower (p < 0.05). Three groups were compared for Klotho, homocysteine and vitamin D serum levels; Klotho levels were elevated but the difference was not statistically significant (p > 0.05). However, vitamin B12, folic acid and homocysteine levels were higher in schizophrenic patients than the control group (p < 0.05). CONCLUSIONS: Higher levels of homocysteine with concomitant higher levels of vitamin B12 and folic acid suggest a relationship of this pathway with schizophrenia. Differences in Klotho levels were elevated but it was not significant. Replication studies to investigate probable associations with larger samples are needed.


Asunto(s)
Glucuronidasa/sangre , Homocisteína/sangre , Esquizofrenia/sangre , Vitamina D/sangre , Enfermedad Aguda , Adulto , Anciano , Estudios de Casos y Controles , Ensayo de Inmunoadsorción Enzimática , Femenino , Ácido Fólico/sangre , Humanos , Proteínas Klotho , Masculino , Persona de Mediana Edad , Escalas de Valoración Psiquiátrica , Esquizofrenia/diagnóstico , Vitamina B 12/sangre , Adulto Joven
17.
Clin Psychopharmacol Neurosci ; 16(3): 302-309, 2018 Aug 31.
Artículo en Inglés | MEDLINE | ID: mdl-30121980

RESUMEN

OBJECTIVE: Suicide is a major cause of death in patients with schizophrenia; thus, predicting and preventing suicide in patients with schizophrenia is examined in various studies. Affective temperaments which are accepted as precursors of mood disorders may be an important factor in predicting suicidality. This study investigated the relationship between affective temperaments of relatives of schizophrenia patients and suicidal thoughts and other clinical correlates of patients with schizophrenia. METHODS: Patients with schizophrenia and their first degree relatives are included to the study. All of the participants were evaluated with Structured Clinical Interview for DSM-IV axis I disorders and relatives with active psychiatric diagnosis were excluded. Positive and Negative Symptom Scale, Clinical Global Impression Scale, Turkish version of cognitive assessment interview were administered congruently to the patients. Relatives of the patients were evaluated with Temperament Evaluation of Memphis, Pisa, Paris and San Diego-Auto-questionnaire. RESULTS: Depressive temperament scores of relatives of schizophrenic patients who had suicidal thoughts were higher than the scores of the relatives of the patients who did not have suicidal thoughts. Depressive temperament also predicted number of suicide attempts in regression analysis. Number of suicide attempts was also related with number of hospitalization and functionality of the patient. CONCLUSION: Suicidality in schizophrenia is related with relatives' affective temperaments and patients' own positive symptom scores. The relationship between suicidal thoughts and depressive temperament is high lightened in this study.

18.
Neuropsychiatr Dis Treat ; 14: 1855-1860, 2018.
Artículo en Inglés | MEDLINE | ID: mdl-30038496

RESUMEN

OBJECTIVES: Interactions between neuropeptides and psychiatric disorders have been investigated for many years. The aim of this study was to evaluate oxytocin (OXT), arginine-vasopressin (AVP), and atrial natriuretic peptide (ANP) and assess their interactions with each other, as well as investigate these changes with the manifestations of schizophrenia. PARTICIPANTS AND METHODS: Thirty-four individuals having acute schizophrenia and 24 healthy individuals as the control group were included in the study. Positive and Negative Syndrome Scales, Global Assessment of Functionality score, and Clinical Global Impression (CGI) scores were measured. Serum hormone levels were analyzed using enzyme-linked immunosorbent assay and were compared with the clinical findings. RESULTS: OXT levels were significantly lower and AVP levels were significantly higher in patients having acute schizophrenia than the control group. OXT was negatively correlated with Positive and Negative Syndrome Scales positive score and CGI score, while it was positively correlated with Global Assessment of Functionality score. AVP was negatively correlated with CGI score. ANP levels of the patients having schizophrenia were lower than the control group; however, there was no significant correlation with clinical findings. CONCLUSION: The obtained data indicate that the AVP level was higher, but OXT and ANP levels were lower in the patients having acute schizophrenia. Specifically OXT is related with reduced disease severity and increased functionality.

19.
J Atten Disord ; 22(13): 1200-1206, 2018 11.
Artículo en Inglés | MEDLINE | ID: mdl-25515679

RESUMEN

OBJECTIVE: This study investigates the relationship between ADHD and the personalities of parents of children with ADHD. METHOD: Personality traits of parents of children with ADHD (study group; n = 135) and parents of children without ADHD (control group; n = 122) were compared. Psychiatric comorbidities were excluded with Structured Clinical Interview for DSM-IV Axis I Disorders, Clinical Version [SCID-I-CV]. Personality is assessed with Temperament and Character Inventory, and inattention (IA) and hyperactivity (HI) are assessed with Turgay Scale. RESULTS: Harm avoidance and persistence scores were higher, and self-directedness (SD) scores were lower in the study group than the control group. Being in ADHD group predicted lower SD scores. Positive correlations were found between harm avoidance and IA and HI, and between persistence and HI. Negative correlations were found between SD and both IA and HI. CONCLUSION: Our data suggest that there is relationship between ADHD in children's and parents' personalities. Common etiologic properties and personalized psychoeducation and treatment options for families should be discussed.


Asunto(s)
Trastorno por Déficit de Atención con Hiperactividad , Padres , Temperamento , Trastorno por Déficit de Atención con Hiperactividad/psicología , Carácter , Niño , Comorbilidad , Manual Diagnóstico y Estadístico de los Trastornos Mentales , Femenino , Humanos , Masculino , Relaciones Padres-Hijo , Padres/psicología , Personalidad , Trastornos de la Personalidad/epidemiología , Inventario de Personalidad
20.
Gynecol Endocrinol ; 34(3): 265-269, 2018 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-29073788

RESUMEN

BACKGROUND: Pregnancy and postpartum periods are the main reproductive periods during which women experience mood disorders. Affective temperaments are known antecedents of mood disorders and their importance is increasing in time for early diagnosis and determining risky groups. But data about affective temperaments during perinatal period is limited. METHODS: Women during pregnancy and perinatal period and healthy controls who are not in perinatal period are included in the study. 83 pregnant women in 1st trimester, 94 pregnant women in 2nd trimester and 115 pregnant women in 3rd trimester; 32 women in 1st month postpartum and 89 women in 2nd month postpartum; and 88 healthy non-pregnant women with similar ages were evaluated regarding their temperament evaluation of Memphis, Pisa, Paris and San Diego auto-questionnaire (TEMPS-A) scores. RESULTS: Women in perinatal period had higher scores of hyperthymic temperaments than the control group. Women in the 2nd month of postpartum period had also higher anxious temperament scores. And women in the second trimester had the highest hyperthymic temperament scores. CONCLUSION: Pregnancy and postpartum periods correlate with hyperthymic temperament characteristics in women without active psychiatric diagnosis. Future studies will help to understand if this is a mental quietness or increased risk for bipolarity.


Asunto(s)
Afecto/fisiología , Ansiedad/psicología , Genio Irritable/fisiología , Trastornos del Humor/diagnóstico , Periodo Posparto/psicología , Temperamento/fisiología , Adulto , Femenino , Humanos , Trastornos del Humor/psicología , Embarazo , Psicometría , Encuestas y Cuestionarios
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