The Effect of Iodine-125 Radioactive Particle Stent with Doxorubicin-loaded Nano-tetrahedrons Combined with Transarterial Chemoembolization on Survival and Prognosis of Patients with Cholangiocarcinoma.

This study was to analyze the application of doxorubicin-loaded DNA nano-tetrahedral Iodine-125 (I-125) radioactive particle stent (doxorubicin-loaded 125I stent) combined with transarterial chemoembolization (TACE) in improving the prognosis of patients with cholangiocarcinoma (CC). The doxorubicin-loaded DNA nano-tetrahedrons were constructed, the preparation plan was optimized, and the toxicity test was performed. The prepared doxorubicin-loaded DNA nano-tetrahedrons were applied to 85 cases in the K1 group (doxorubicin-loaded 125I + TACE), 85 cases in the K2 group (doxorubicin-loaded 125I), and 85 cases in K3 group (TACE). It was found that the optimal initial concentration of doxorubicin for the preparation of DNA-loaded nano-tetrahedrons was 200 mmol, and the optimal reaction time was 7 hours. The serum total bilirubin (TBIL) level in the K1 group at 30 days after operation was lower than that in the K2 and K3 groups at 7, 14 and 21 days. (P< 0.05). The alkaline phosphatase (ALP) level in the K1 group was lower in contrast to that in the other two groups at 7, 14, and 21 days after surgery (P< 0.05); and the five-year survival rate of patients in the K1 group was greater in contrast to the rate in K2 and K3 groups (P< 0.05). In short, the implantation of a doxorubicin-loaded 125I stent combined with TACE could effectively improve the five-year survival rate of patients with CC and improve the prognosis effect of the patients.

Computed Tomography Perfusion Imaging Quality Affected by Different Input Arteries in Patients of Internal Carotid Artery Stenosis.

BACKGROUND The aim of this study was to explore the influence of different input arteries on the parameters of computed tomography (CT) perfusion imaging for patients with different degree of stenosis of internal carotid artery (ICA). MATERIAL AND METHODS Forty patients were enrolled in the present study and divided into mild, moderate, severe stenosis and occlusion groups respectively with each 10 patients in each group. In reconstruction of cerebral CT perfusion (CTP) images, each raw perfusion image was reconstructed 3 times based on different reference input artery, including bilateral middle cerebral artery (MCA) and basilar arteries (BA). Region of interest (ROI) was drawn in the central territories of bilateral anterior cerebral artery, middle cerebral artery and posterior cerebral artery. And regional cerebral blood flow (rCBF) regional cerebral blood volume (rCBV), mean transit time (MTT), time to peak (TTP) and delay time (DT) were obtained from those ROI corresponding perfusion images. RESULTS In patients with mild and moderate ICA stenosis, there was no significant difference of perfusion parameters based on different input arteries (P>0.05). However, in severe ICA stenosis and occlusion CBF, MTT, and DT were significant different in affect side of the MCA group compared to the others (P<0.05). CONCLUSIONS Large intracranial artery can be selected as the input artery for patients with mild to moderate ICA stenosis, while for patients with severe stenosis and occlusion of ICA, the contra lateral middle cerebral artery or basilar artery would be better choice.