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Zinc trifluorosulfonate [Zn(OTf)2] is considered as the most suitable zinc salt for aqueous Zn-ion batteries (AZIBs) but cannot support the long-term cycling of the Zn anode. Here, we reveal the micelle-like structure of the Zn(OTf)2 electrolyte and reunderstand the failing mechanism of the Zn anode. Since the solvated Zn2+ possesses a positive charge, it can spontaneously attract OTf- with the hydrophilic group of -SO3 and the hydrophobic group of -CF3 via electrostatic interaction and form a "micelle-like" structure, which is responsible for the poor desolvation kinetics and dendrite growth. To address these issues, an antimicelle-like structure is designed by using ethylene glycol monomethyl ether (EGME) as a cosolvent for highly reversible AZIBs. The modified electrolyte shows lower dissociation ability to Zn(OTf)2 and higher coordination tendency with Zn2+ compared to the Zn(OTf)2 electrolyte, resulting in the unique solvation structure of Zn2+(H2O)1.2(OTf-)2(EGME)2.8, which significantly reduces the charge of micelle, damages the micelle-like structure, and boosts the desolvation kinetics. Moreover, the reduction of EGME and OTf- can form a robust dual-layered SEI with high Zn2+ ion conductivity. Consequently, the Zn/Cu asymmetric coin cell using ZT-EGME can work at a high rate and a capacity of 50 mA cm-2 and 5 mA h cm-2 for more than 120 cycles, while its counterparts using ZT can barely work. Moreover, a 505.1 mA h pouch cell with practical parameters including a lean electrolyte supply of 15 mL A h-1 and an N/P ratio of â¼3.5 can work for 50 cycles.
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PURPOSE: We aimed to explore the relationship between bone mineral density (BMD), bone metabolism markers, and blood lipid-related indicators, body mass index (BMI) in elderly individuals. METHODS: A retrospective analysis was conducted on 710 patients. Patients' gender, age, height, weight, bone density values, T-scores, bone metabolism markers (including serum N-terminal propeptide of type I collagen (s-PINP), serum C-terminal telopeptide of type I collagen (s-CTX) and 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) and lipid-related indicators (including total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG) and Castelli index 1 (TC/HDL-C index) and Castelli index 2 (LDL-C/HDL-C index) were recorded. Correlations between variables were analyzed, and patients were grouped according to gender and T-score for intergroup comparisons. RESULTS: HDL-C negatively correlates with BMD and s-CTX. TG, Castelli index, and BMI positively correlate with BMD. BMI negatively correlates with s-PINP. 1,25(OH)2D3 negatively correlates with TC, LDL-C, and Castelli index. LDL-C positively correlates with BMD in males, and TC negatively correlates with s-PINP. In females, HDL-C negatively correlates with BMD, and s-CTX positively correlates with Castelli index. 1,25(OH)2D3 negatively correlates with TC, LDL-C, and Castelli index. TG and Castelli index were higher in normal bone mass group, while HDL-C is higher in the osteoporosis group. TG and BMI positively predicted bone mass density, while HDL-C negatively predicted bone mass density. CONCLUSIONS: HDL-C may have a predictive role in osteoporosis, particularly in women. The likelihood of osteoporosis is lower in individuals with high BMI or hyperlipidemia. Some lipid metabolism markers can be used to predict osteoporosis, and further research is needed.
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Densidad Ósea , Osteoporosis , Masculino , Humanos , Femenino , Anciano , LDL-Colesterol , Índice de Masa Corporal , Metabolismo de los Lípidos , Estudios Retrospectivos , Triglicéridos , Lípidos , Osteoporosis/diagnóstico por imagen , HDL-ColesterolRESUMEN
The inferior capacity and cyclic durability of V2 O5 caused by inadequate active sites and sluggish kinetics are the main problems to encumber the widespread industrial applications of vanadium-zinc batteries (VZBs). Herein, a cooperative redox chemistry (CRC) as "electron carrier" is proposed to facilitate the electron-transfer by capturing/providing electrons for the redox of V2 O5 . The increased oxygen vacancies in V2 O5 provoked in situ by CRC offers numerous Zn2+ storage sites and ion-diffusion paths and reduces the electrostatic interactions between vanadium-based cathode and intercalated Zn2+ , which enhance Zn2+ storage capability and structural stability. The feasibility of this strategy is fully verified by some CRCs. Noticeably, VZB with [Fe(CN)6 ]3- /[Fe(CN)6 ]4- as CRC displays conspicuous specific capacity (433.3 mAh g-1 ), ≈100% coulombic efficiency and superb cyclability (≈3500 cycles without capacity attenuation). Also, the mechanism and selection criteria of CRC are specifically unraveled in this work, which provides insightful perspectives for the development of high-efficiency energy-storage devices.
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π-conjugated organic compounds with a good charge transfer ability and rich redox functional groups are promising cathode candidates for air-rechargeable aqueous Zn-based batteries (AAZBs). However, the output voltage of even the state-of-the-art π-conjugated organic cathodes lies well below 0.8 V, resulting in insufficient energy density. Herein, we design a nonplanar π-conjugated sulfur heterocyclic quinone polymer (SHQP) as an advanced cathode material for AAZBs by polymerization 1,4-Benzoquinone (BQ) and S heteroatoms periodically. The extended π-conjugated plane and enhanced aromaticity endow SHQP with a more sensitive charge transfer ability and robust structure. Furthermore, the delocalized π electrons in the whole system are insufficient as the π orbit of the S heteroatom is not in the same plane with the π orbit of BQ due to its folded configuration, resulting in negligible variation of electron density around CâO after the polymerization. Thus, the output voltage of SHQP shows no significant decrease even though the thioether bond (-S-) functions as electron donor. Consequently, the Zn/SHQP AAZBs can deliver a record high midpoint discharging voltage (0.95 V), rate performance (119 mAh g-1 at 10 A g-1), and durability (98.7% capacity retention after 200 cycles) across a wide temperature range.
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As one of the receptors of the TAM family, AXL plays a vital role in stem cell maintenance, angiogenesis, immune escape of viruses and drug resistance against tumors. In this study, the truncated extracellular segment containing two immunoglobulin-like domains of human AXL (AXL-IG), which has been confirmed to bind growth arrest specific 6 (GAS6) by structural studies [1], was expressed in a prokaryotic expression system and then purified. Immunizing camelid with the purified AXL-IG as antigen could lead to the production of unique nanobodies composed of only variable domain of heavy chain of heavy-chain antibody (VHH), which are around 15 kD and stable. We screened out a nanobody A-LY01 specific binding to AXL-IG. We further determined the affinity of A-LY01 to AXL-IG and revealed that A-LY01 could specifically recognize full-length AXL on the surface of HEK 293T/17 cells. Our study provides appropriate support for the development of diagnostic reagents and antibody therapeutics targeting AXL.
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Escherichia coli , Neoplasias , Humanos , Escherichia coli/genética , Anticuerpos , Cadenas Pesadas de InmunoglobulinaRESUMEN
The disposal of wastewater sludge is one of the most challenging environmental problems for large cities. Wastewater sludge may be utilized as a feasible substitute for clay to sinter ceramics, given their similar mineralogical composition. However, the organics in sludge will be wasted, while their release during sintering will leave cracks in the ceramic products. In this research, after the thermal treatment for effective organic recovery, the thermally hydrolyzed sludge (THS) is incorporated with clay for the sintering of construction ceramics. The experimental results showed that a THS dosing ratio up to 40 % can be achieved for mixing with montmorillonite clay to make ceramic tiles. The sintered tiles (THS-40) had an intact shape and structure, and the tile performance was close to that made from single montmorillonite (THS-0), with water absorption of 0.4 % vs. 0.2 %, compressive strength of 136.8 vs. 140.7 MPa, and undetected heavy metal leaching. Further addition of THS would lead to a considerable deterioration of the quality of the tiles to a compressive strength of as low as 5.0 MPa for the THS only product (THS-100). Comparing with the tiles incorporated with raw sludge (RS-40), the THS-40 tiles had a more intact and denser structure with a 10 % improved compressive strength. Cristobalite, aluminum phosphate, mullite, and hematite dominated in the THS-born ceramics, which are typical components of ceramics, and the amount of hematite increased with the THS dosing ratio. Sintering at a high temperature of 1200 °C enabled efficient phase transformation from quartz to cristobalite and from muscovite to mullite, which ensured the toughness and compactness of the THS-born ceramic tiles.
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Based on the data of A-share listed companies in China from 2016 to 2020, this study empirically analyzes the relationship among corporate social responsibility, debt financing cost and enterprise innovation by constructing a regulated mediation effect model. The results show that enterprises perform social responsibility actively can enhance the level of enterprise innovation. Besides, debt financing cost plays a part of the intermediary role between corporate social responsibility and enterprise innovation. It is found that market competition degree positively regulates the relationship between corporate social responsibility and enterprise innovation, and market competition degree strengthens the part of the intermediary effect of debt financing cost. The conclusions not only help to reveal the impact mechanism of corporate social responsibility on enterprise innovation, but also provide empirical evidence for promoting enterprises to actively assume social responsibility, improve the level of innovation, and provide empirical evidence for the government to formulate corresponding policies according to the degree of competition in different markets.
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Gobierno , Responsabilidad Social , ChinaRESUMEN
C-C motif chemokine ligand 2 (CCL2) is a member of the monocyte chemokine protein family, which binds to its receptor CCR2 to induce monocyte infiltration and mediate inflammation. The CCL2/CCR2 signaling pathway participates in the transduction of neuroinflammatory information between all types of cells in the central nervous system. Animal studies and clinical trials have shown that CCL2/CCR2 mediate the pathological process of ischemic stroke, and a higher CCL2 level in serum is associated with a higher risk of any form of stroke. In the acute phase of cerebral ischemia-reperfusion, the expression of CCL2/CCR2 is increased in the ischemic penumbra, which promotes neuroinflammation and enhances brain injury. In the later phase, it participates in the migration of neuroblasts to the ischemic area and promotes the recovery of neurological function. CCL2/CCR2 gene knockout or activity inhibition can reduce the nerve inflammation and brain injury induced by cerebral ischemia-reperfusion, suggesting that the development of drugs regulating the activity of the CCL2/CCR2 signaling pathway could be used to prevent and treat the cell injury in the acute phase and promote the recovery of neurological function in the chronic phase in ischemic stroke patients.
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Experimentación Animal , Lesiones Encefálicas , Isquemia Encefálica , Accidente Cerebrovascular Isquémico , Daño por Reperfusión , Animales , Quimiocina CCL2/genética , Quimiocina CCL2/metabolismo , Quimiocinas , Humanos , Inflamación , Ligandos , Ratones , Ratones Endogámicos C57BL , Receptores CCR2/genética , Receptores CCR2/metabolismo , Daño por Reperfusión/metabolismoRESUMEN
In recent years, bromodomain-containing protein 4 (BRD4), a member of the bromodomain and extra terminal domain (BET) family, has been one of the most widely studied targets. BRD4 is a transcriptional regulation factor, which regulates cell transcription, marks mammalian biological mitosis, regulates cell cycle, and plays an important role in the biological process of cancer occurrence and development. It has been demonstrated that the imbalance or dysfunction of BRD4 expression leads to various types of cancers, including testicular gene nuclear protein melanoma, acute myeloid leukemia, colon cancer, breast cancer, liver cancer, and midline cancer. Therefore, inhibition of BRD4 has become a valuable approach in the treatment of these cancers. To date, there are numerous BRD4 inhibitors in preclinical development, some of which have entered human clinical trials. In this review, current progress in the development of privileged scaffolds designed as BRD4 inhibitors will be discussed by focusing on structure-activity relationship, selectivity, and mechanisms of action.
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Proteínas de Ciclo Celular , Factores de Transcripción , Proteínas de Ciclo Celular/antagonistas & inhibidores , Proteínas de Ciclo Celular/metabolismo , Humanos , Neoplasias , Dominios Proteicos , Factores de Transcripción/antagonistas & inhibidores , Factores de Transcripción/metabolismoRESUMEN
In the past, China, like other developing countries in the world, pursued the goal of rapid economic development at the expense of ecology and ignored the issue of environmental protection. But in recent decades, as environmental problems have become increasingly prominent, developing countries have begun to explore ways to coordinate economy and ecological environment. As the largest developing country, China has been actively exploring ecological governance plans, putting forward the concept of green development, setting the goal of building a "beautiful China" and placing the construction of ecological civilization in the ontological status of social systems and national goals. In order to accelerate the green development process of enterprises in developing countries, based on the actual situation in China, this paper constructs a tripartite evolutionary game model of environmental accounting information disclosure with enterprises, investors and media as the research objects, and analyzes the internal mechanism of environmental accounting information disclosure. The model finds that the equilibrium of the three parties is affected by multiple factors. Therefore, this study further uses system dynamics to explore the dynamic process of evolutionary games and the strategic choices among multiple agents, and explore the mechanism of three types of agents to promote environmental accounting information disclosure. The simulation results reveal that government incentives have a greater impact on guiding enterprises and the media to evolve in the direction of legal disclosure and participation in exposure strategies. In addition, the continuous reduction of the cumbersome degree of disclosure procedures and the difficulty of improving environmental performance can fundamentally promote companies to actively choose legal disclosure strategies, which will help improve the quality of environmental accounting information disclosure, boost investor confidence, and enhance government supervision.
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Conservación de los Recursos Naturales , Revelación , Teoría del Juego , Desarrollo Sostenible , China , Países en Desarrollo , Humanos , InternacionalidadRESUMEN
Obesity is related to energy imbalance and energy metabolism. In this study, we investigated the anti-obesity effects of Garcinia indica extract (GIE), Coleus forskohlii extract (CFE), and the combinations of these two extracts in a 3T3-L1 cells and high-fat diet (HFD)-induced obese mice. In vitro, GIE showed better effect on TG content than CFE, CFE showed better effect on glycerol released than GIE, and the combinations of GIE and CFE showed both effects compared with GIE and CFE alone. In vivo, GIE, LMIX (0.005% GIE + 0.025% CFE), and HMIX (0.01% GIE + 0.025% CFE) down-regulated adipogenesis-related transcription factors PPARγ and C/EBPα protein expression, CFE promoted lipolysis by up-regulated p-HSL and p-PKA protein expression, and four supplementations promoted fatty acid ß-oxidation by up-regulating CPT-1A and PPARα protein expression to decrease lipid accumulation in adipose tissue. Moreover, we found that CFE, LMIX and HMIX, except GIE exert increasing the abundance of Bacteroides caccae compared with HFD group. Overall, GIE, CFE, and the combinations of GIE and CFE were able to decrease body weight and adipocyte size by promoting fatty acid ß-oxidation and modulating gut microbiota in HFD-induced obese mice.
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Garcinia , Microbioma Gastrointestinal , Plectranthus , Animales , Bacteroides , Metabolismo Energético , Lípidos , Ratones , Ratones Obesos , Extractos Vegetales/farmacologíaRESUMEN
Core-shell silver nanoparticles@mesoporous silica spherical nanoparticles (Ag NPs@MSNs) were prepared by a two-step method. First, Ag NPs were synthesized by chemical reduction using silver nitrate (AgNO3) as the precursor, cetyl trimethyl ammonium bromide (CTAB) as the stabilizer, and sodium borohydride (NaBH4) as the reductant. Then, MSNs were obtained by employing CTABstabilized Ag NPs as the template and hydrolyzing tetraethoxysilane (TEOS) precursor in the presence of the alkaline precipitant, triethanolamine (TEOA). The effects of different preparation routes (core-first vs. shell-first), type of reductants as well as extraction methods and agents were studied. The obtained core-shell NPs were characterized by infrared spectroscopy (IR) and transmission electron microscopy (TEM). Our results showed that the core-first route was viable to produce uniform Ag NPs@MSNs with ordered mesostructures. Afterwards, those NPs were used as the catalyst to catalyze the reduction of rhodamine, a model dye compound representing organic pollutants in waste water, in the presence of NaBH4. It was found that Ag NPs@MSNs not only were efficient catalysts but also participated as coreductants in the reaction. Moreover, they exhibited almost no loss of catalytic efficacy after several reduction cycles, which indicated their promising future use as efficient recyclable catalysts for organic pollutant treatments.
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Nanoparticles, including Al2O3 and SiO2, and ultrasound were adopted to improve the solidification properties of water. The effects of nanoparticle concentration, contact angle, and ultrasonic intensity on the supercooling degree of water were investigated, as well as the dispersion stability of nanoparticles in water during solidification. Experimental results show that the supercooling degree of water is reduced under the combined effect of ultrasound and nanoparticles. Consequently, the reduction of supercooling degree increases with the increase of ultrasonic intensity and nanoparticle concentration and decrease of contact angle of nanoparticles. Moreover, the reduction of supercooling degree caused by ultrasound and nanoparticles together do not exceed the sum of the supercooling degree reductions caused by ultrasound and nanoparticles separately; the reduction is even smaller than that caused by ultrasound individually under certain conditions of controlled nanoparticle concentration and contact angle and ultrasonic intensity. The dispersion stability of nanoparticles during solidification can be maintained only when the nanoparticles and ultrasound together show a superior effect on reducing the supercooling degree of water to the single operation of ultrasound. Otherwise, the aggregation of nanoparticles appears in water solidification, which results in failure. The relationships among the meaningful nanoparticle concentration, contact angle, and ultrasonic intensity, at which the requirements of low supercooling and high stability could be satisfied, were obtained. The control mechanisms for these phenomena were analyzed.