Oscillation and self-propulsion of Leidenfrost droplets enclosed in cylindrical cavities.

Leidenfrost droplets can be considered as soft engines capable of directly transforming heat into mechanical energy. Despite remarkable advancements in understanding the propulsion of Leidenfrost droplets on asymmetric structures, the complex dynamics of droplets in enclosed structures is not fully understood. To address this fundamental gap, we investigated the dynamics of Leidenfrost droplets restricted by metal disks. The disk alters the accumulation and release of the vapour generated by the droplet, and substantially changes its dynamic characteristics. Our experiments reveal the formation of oscillating multi-lobed structures when restricting the droplet within a disk. In comparison, patterning offset radial grooves on the surface of the disk rectifies the vapour flow and facilitates the self-propulsion of the droplet along the edge of the disk. Our work offers opportunities for developing soft and short-living actuators, which can operate at high temperatures.

Corrigendum: A multi-functional bubble-based microfluidic system.

This corrects the article DOI: 10.1038/srep09942.

A multi-functional bubble-based microfluidic system.

Recently, the bubble-based systems have offered a new paradigm in microfluidics. Gas bubbles are highly flexible, controllable and barely mix with liquids, and thus can be used for the creation of reconfigurable microfluidic systems. In this work, a hydrodynamically actuated bubble-based microfluidic system is introduced. This system enables the precise movement of air bubbles via axillary feeder channels to alter the geometry of the main channel and consequently the flow characteristics of the system. Mixing of neighbouring streams is demonstrated by oscillating the bubble at desired displacements and frequencies. Flow control is achieved by pushing the bubble to partially or fully close the main channel. Patterning of suspended particles is also demonstrated by creating a large bubble along the sidewalls. Rigorous analytical and numerical calculations are presented to describe the operation of the system. The examples presented in this paper highlight the versatility of the developed bubble-based actuator for a variety of applications; thus providing a vision that can be expanded for future highly reconfigurable microfluidics.

Using dielectrophoresis to study the dynamic response of single budding yeast cells to Lyticase.

Budding yeast cells are quick and easy to grow and represent a versatile model of eukaryotic cells for a variety of cellular studies, largely because their genome has been widely studied and links can be drawn with higher eukaryotes. Therefore, the efficient separation, immobilization, and conversion of budding yeasts into spheroplast or protoplast can provide valuable insight for many fundamentals investigations in cell biology at a single cell level. Dielectrophoresis, the induced motion of particles in non-uniform electric fields, possesses a great versatility for manipulation of cells in microfluidic platforms. Despite this, dielectrophoresis has been largely utilized for studying of non-budding yeast cells and has rarely been used for manipulation of budding cells. Here, we utilize dielectrophoresis for studying the dynamic response of budding cells to different concentrations of Lyticase. This involves separation of the budding yeasts from a background of non-budding cells and their subsequent immobilization onto the microelectrodes at desired densities down to single cell level. The immobilized yeasts are then stimulated with Lyticase to remove the cell wall and convert them into spheroplasts, in a highly dynamic process that depends on the concentration of Lyticase. We also introduce a novel method for immobilization of the cell organelles released from the lysed cells by patterning multi-walled carbon nanotubes (MWCNTs) between the microelectrodes.

PDMS nanocomposites for heat transfer enhancement in microfluidic platforms.

Increasing the thermal conductivity of PDMS (polydimethylsiloxane) based microfluidics is an important issue for the thermal management of hot spots produced by embedding electronic circuits in such systems. This paper presents a solution for enhancing the thermal conductivity of such PDMS based microfluidics by introducing thermally conductive alumina (Al2O3) nanoparticles, forming PDMS/Al2O3 nanocomposites. The materials are fully characterized for different concentrations of Al2O3 in PDMS for experiments which are conducted at different flow rates. Our results suggest that incorporation of Al2O3 nanoparticles at 10% w/w in the PDMS based nanocomposite significantly enhances the heat conduction from hot spots by enhancing the thermal conductivity, while maintaining the flexibility and decreasing the specific heat capacity of the developed materials. This proof-of-concept study offers potential for a practical solution for the cooling of future embedded electronic systems.

Investigation of different nanoparticles for magnetophoretically enabled nanofin heat sinks in microfluidics.

Assembled nanofin heat sinks, nanostructures which are formed via external forces in a cooling microfluidic to remove heat from hot spots, are a new concept that has recently been introduced. In this work, we investigate nanofin structures formed by CrO2 and Fe2O3 magnetic nanoparticles and compare their performance. Thermal imaging is used for comparison of three cases including: (i) DI water as the coolant liquid, (ii) suspension of magnetic particles in DI water, and (iii) suspension of magnetic particles in DI water in the presence of a magnetic field. For each case, the experiments are conducted at three different flow rates of 10, 40 and 120 µl min(-1). Our results suggest that the high thermal conductivity of the nanofins composed of CrO2 significantly enhances the heat exchange across the microchannel. The proof-of-concept magnetophoretic system can offer a practical solution for the cooling of future compact electronics.

Reorientation of microfluidic channel enables versatile dielectrophoretic platforms for cell manipulations.

Dielectrophoresis is a versatile tool for the sorting, immobilization, and characterization of cells in microfluidic systems. The performance of dielectrophoretic systems strongly relies on the configuration of microelectrodes, which produce a nonuniform electric field. However, once fabricated, the microelectrodes cannot be reconfigured to change the characteristics of the system. Here, we show that the reorientation of the microfluidic channel with respect to the microelectrodes can be readily utilized to alter the characteristics of the system. This enables us to change the location and density of immobilized viable cells across the channel, release viable cells along customized numbers of streams within the channel, change the deflection pattern of nonviable cells along the channel, and improve the sorting of viable and nonviable cells in terms of flow throughput and efficiency of the system. We demonstrate that the reorientation of the microfluidic channel is an effective tool to create versatile dielectrophoretic platforms using the same microelectrode design.

Thermal analysis of nanofluids in microfluidics using an infrared camera.

We present the thermal analysis of liquid containing Al(2)O(3) nanoparticles in a microfluidic platform using an infrared camera. The small dimensions of the microchannel along with the low flow rates (less than 120 µl min(-1)) provide very low Reynolds numbers of less than 17.5, reflecting practical parameters for a microfluidic cooling platform. The heat analysis of nanofluids has never been investigated in such a regime, due to the deficiencies of conventional thermal measurement systems. The infrared camera allows non-contact, three dimensional and high resolution capability for temperature profiling. The system was studied at different w/w concentrations of thermally conductive Al(2)O(3) nanoparticles and the experiments were in excellent agreement with the computational fluid dynamics (CFD) simulations.