Multistage Competitive Opinion Maximization With Q-Learning-Based Method in Social Networks.

Competitive opinion maximization (COM) aims to determine some individuals (i.e., seed nodes) from social networks, propagating the desired opinions toward a target entity to their neighbors through social relationships when facing with its competitors (components) and maximize the opinion spread after the specific time. Current studies on COM are still in its infancy, while the only work merely considers the scenario that the strategy of competitors is known but ignores the unknown scenario. In addition, previous studies on COM cannot easily address the situation where some users might dynamically change their opinions. To address the COM issue, we investigate the multistage COM and propose a brand-new Q-learning-based opinion maximization framework (QOMF). Our QOMF consists of two components: dynamic opinion propagation and seeding process. We formulate the COM problem by maximizing relative effective opinions. To produce a dynamic opinion series more realistically, we design an opinion propagation model by joining the activation process and a dynamic opinion process. Moreover, we also verify that the opinion propagation model can reach convergence within finite iterations. To acquire the seed nodes, we design a multistage Q-learning seeding scheme by considering known and unknown competitor strategies, respectively. Experimental results on three real datasets demonstrate that the proposed method outperforms the benchmarks on reaching relatively effective opinions.

Classification of high-grade glioblastoma and single brain metastases using a new SCAT-inception model trained with MRI images.

Background and objectives: Glioblastoma (GBM) and brain metastasis (MET) are the two most common intracranial tumors. However, the different pathogenesis of the two tumors leads to completely different treatment options. In terms of magnetic resonance imaging (MRI), GBM and MET are extremely similar, which makes differentiation by imaging extremely challenging. Therefore, this study explores an improved deep learning algorithm to assist in the differentiation of GBM and MET. Materials and methods: For this study, axial contrast-enhanced T1 weight (ceT1W) MRI images from 321 cases of high-grade gliomas and solitary brain metastasis were collected. Among these, 251 out of 270 cases were selected for the experimental dataset (127 glioblastomas and 124 metastases), 207 cases were chosen as the training dataset, and 44 cases as the testing dataset. We designed a new deep learning algorithm called SCAT-inception (Spatial Convolutional Attention inception) and used five-fold cross-validation to verify the results. Results: By employing the newly designed SCAT-inception model to predict glioblastomas and brain metastasis, the prediction accuracy reached 92.3%, and the sensitivity and specificity reached 93.5 and 91.1%, respectively. On the external testing dataset, our model achieved an accuracy of 91.5%, which surpasses other model performances such as VGG, UNet, and GoogLeNet. Conclusion: This study demonstrated that the SCAT-inception architecture could extract more subtle features from ceT1W images, provide state-of-the-art performance in the differentiation of GBM and MET, and surpass most existing approaches.

Effects of clinical nursing pathway on the surgical site wound infection in patients undergoing knee or hip replacement surgery: A meta-analysis.

To explore the effect of clinical nursing pathway on wound infection in patients undergoing knee or hip replacement surgery. Computerised searches of PubMed, Web of Science, Cochrane Library, Embase, Wanfang, China Biomedical Literature Database, China National Knowledge Infrastructure databases were conducted, from database inception to September 2023, on the randomised controlled trials (RCTs) of application of clinical nursing pathway to patients undergoing knee and hip arthroplasty. Literature was screened and evaluated by two researchers based on inclusion and exclusion criteria, and data were extracted from the final included literature. RevMan 5.4 software was employed for data analysis. Overall, 48 RCTs involving 4139 surgical patients were included, including 2072 and 2067 in the clinical nursing pathway and routine nursing groups, respectively. The results revealed, compared with routine nursing, the use of clinical nursing pathways was effective in reducing the rate of complications (OR = 0.17, 95%CI: 0.14-0.21, p < 0.001) and wound infections (OR = 0.29, 95%CI: 0.16-0.51, p < 0.001), shortens the hospital length of stay (MD = -4.11, 95%CI: -5.40 to -2.83, p < 0.001) and improves wound pain (MD = -1.34, 95%CI: -1.98 to -0.70, p < 0.001); it also improve patient satisfaction (OR = 7.13, 95%CI: 4.69-10.85, p < 0.001). The implementation of clinical nursing pathways in clinical care after knee or hip arthroplasty can effectively reduce the incidence of complications and wound infections, and also improve the wound pain, while also improving treatment satisfaction so that patients can be discharged from the hospital as soon as possible.

Channel Adaptive and Sparsity Personalized Federated Learning for Privacy Protection in Smart Healthcare Systems.

With the booming development of Smart Healthcare Systems (SHSs), employing federated learning (FL) in SHS devices has become a research hotspot. FL, as a distributed learning framework, can train models without sharing the original data among users, and then protect the user privacy. Existing research has proposed many methods to improve the security and efficiency of FL, which may not fully consider the characteristics of SHSs. Specifically, the requirements of privacy protection and efficiency pose significant challenges to FL. Current studies have struggled to balance privacy security and efficiency, and the degradation of model training efficiency in SHSs can be critical to patient health. Therefore, to improve the privacy protection of healthcare data and ensure communication efficiency, this work proposes a novel personalized FL framework based on Communication quality and Adaptive Sparsification (pFedCAS). In order to achieve privacy protection, a control unit is proposed and introduced to adjust the sparsity of the local model adaptively. To further improve the training efficiency, a selection unit is added during global model aggregation to select suitable clients for parameter updates. Finally, we validate the proposed method operated on the HAM10000 dataset. Simulation results validate that pFedCAS can not only improve privacy protection, but also gain an improvement of 15% in training accuracy and a reduction of 30% in training costs based on communication quality. The simulation results also validate the excellent robustness of pFedCAS to non-iid data.

Effects of evidence-based nursing in preventing pressure ulcers in intensive care unit patients: A meta-analysis.

To systematically analyse the effects of evidence-based nursing (EBN) in preventing the development of pressure ulcers (PUs) in intensive care unit (ICU) patients. We conducted a computerised search of the Embase, PubMed, Cochrane Library, Web of Science, China National Knowledge Infrastructure and Wanfang databases for randomised controlled trials on the prevention of PUs in ICU patients by EBN, published before the respective databases were established until September 2023. Two investigators independently performed literature screening, data extraction and quality assessment. A meta-analysis was performed using Stata 17.0. Eighteen papers were included, comprising 2593 patients, of whom 1297 and 1296 received EBN and conventional nursing, respectively. The incidence of PUs was 2.70% and 12.04% in the EBN and conventional nursing groups, respectively. Meta-analysis showed a statistically significantly lower incidence of PUs in the EBN group than that in the conventional nursing group (risk ratio = 0.22, 95% confidence interval: 0.16-0.32, p < 0.001). EBN interventions are more effective than conventional nursing in preventing PUs in ICU patients. However, since the literature included in this study was from China, the conclusions require further confirmation via higher-quality studies.

C2BNet: A Deep Learning Architecture with Coupled Composite Backbone for Parasitic EGG Detection in Microscopic Images.

Internet of Medical Things (IoMT) enabled by artificial intelligence (AI) technologies can facilitate automatic diagnosis and management of chronic diseases (e.g., intestinal parasitic infection) based on two-dimensional (2D) microscopic images. To improve the model performance of object detection challenged by microscopic image characteristics (e.g., focus failure, motion blur, and whether zoomed or not), we propose Coupled Composite Backbone Network (C2BNet) to execute the parasitic egg detection task using 2D microscopic images. In particular, the C2BNet backbone adopts a two-path structure-based backbone and leverages model heterogeneity to learn object features from different perspectives. A novel feature composition style is proposed to flow the feature within the coupled composite backbone, and ensure mutual enhancement of feature representation ability among the different paths of the backbone. To further improve the accuracy of the detection results, we propose Multiscale Weighted Box Fusion (WBF) to fuse the location and confidence scores of all bounding boxes predicted from the multiscale feature maps, and iteratively refine the box coordinates to form the final prediction. Experimental results on Chula-ParasiteEgg-11 dataset demonstrate that the C2BNet not only performs satisfactorily compared with state-of-the-art methods, but also can focus more on learning detailed morphology features and abundant semantic features, resulting in more precise detection for parasitic eggs located in the 2D microscopic image.

Low-Latency Federated Learning via Dynamic Model Partitioning for Healthcare IoT.

Federated learning (FL) is receiving much attention in the Healthcare Internet of Things (H-IoT) to support various instantaneous E-health services. Today, the deployment of FL suffers from several challenges, such as high training latency and data privacy leakage risks, especially for resource-constrained medical devices. In this article, we develop a three-layer FL architecture to decrease training latency by introducing split learning into FL. We formulate a long-term optimization problem to minimize the local model training latency while preserving the privacy of the original medical data in H-IoT. Specially, a Privacy-ware Model Partitioning Algorithm (PMPA) is proposed to solve the formulated problem based on the Lyapunov optimization theory. In PMPA, the local model is partitioned properly between a resource-constrained medical end device and an edge server, which meets privacy requirements and energy consumption constraints. The proposed PMPA is separated into two phases. In the first phase, a partition point set is obtained using Kullback-Leibler (KL) divergence to meet the privacy requirement. In the second phase, we employ the model partitioning function, derived through Lyapunov optimization, to select the partition point from the partition point set that that satisfies the energy consumption constraints. Simulation results show that compared with traditional FL, the proposed algorithm can significantly reduce the local training latency. Moreover, the proposed algorithm improves the efficiency of medical image classification while ensuring medical data security.

Big Data Analytics on Lung Cancer Diagnosis Framework With Deep Learning.

As the segment of diseased tissue in PET images is time-consuming, laborious and low accuracy, this work proposes an automated framework for PET image screening, denoising and diseased tissue segmentation. First, taking into account the characteristics of PET images, the framework uses a differential activation filter to select whole-body images containing lesion tissue. Second, a new neural network containing residual connections which has powerful generalization performance compared with normal FCN network is proposed for PET image reconstruction and denoising. Finally, in the segmentation of lesion tissues, a custom clustering algorithm based on the density is used to distinguishe the lesion tissue part from the normal tissue. Tests on real medical PET images show that the whole automated framework has good performance and time cost in PET lesion image screening, image denoising and lesion tissue segmentation compared with other algorithms. The framework shows promising scientific study and application prospects.

A Simple Federated Learning-Based Scheme for Security Enhancement Over Internet of Medical Things.

Nowadays, Federated Learning (FL) over Internet of Medical Things (IoMT) devices has become a current research hotspot. As a new architecture, FL can well protect the data privacy of IoMT devices, but the security of neural network model transmission can not be guaranteed. On the other hand, the sizes of current popular neural network models are usually relatively extensive, and how to deploy them on the IoMT devices has become a challenge. One promising approach to these problems is to reduce the network scale by quantizing the parameters of the neural networks, which can greatly improve the security of data transmission and reduce the transmission cost. In the previous literature, the fixed-point quantizer with stochastic rounding has been shown to have better performance than other quantization methods. However, how to design such quantizer to achieve the minimum square quantization error is still unknown. In addition, how to apply this quantizer in the FL framework also needs investigation. To address these questions, in this paper, we propose FedMSQE - Federated Learning with Minimum Square Quantization Error, that achieves the smallest quantization error for each individual client in the FL setting. Through numerical experiments in both single-node and FL scenarios, we prove that our proposed algorithm can achieve higher accuracy and lower quantization error than other quantization methods.

Conditional Anonymous Remote Healthcare Data Sharing Over Blockchain.

As an important carrier of healthcare data, Electronic Medical Records (EMRs) generated from various sensors, i.e., wearable, implantable, are extremely valuable research materials for artificial intelligence and machine learning. The efficient circulation of EMRs can improve remote medical services and promote the development of the related healthcare industry. However, in traditional centralized data sharing architectures, the balance between privacy and traceability still cannot be well handled. To address the issue that malicious users cannot be locked in the fully anonymous sharing schemes, we propose a trackable anonymous remote healthcare data storing and sharing scheme over decentralized consortium blockchain. Through an "on-chain & off-chain" model, it relieves the massive data storage pressure of medical blockchain. By introducing an improved proxy re-encryption mechanism, the proposed scheme realizes the fine-gained access control of the outsourced data, and can also prevent the collusion between semi-trusted cloud servers and data requestors who try to reveal EMRs without authorization. Compared with the existing schemes, our solution can provide a lower computational overhead in repeated EMRs sharing, resulting in a more efficient overall performance.

Toward real-time and efficient cardiovascular monitoring for COVID-19 patients by 5G-enabled wearable medical devices: a deep learning approach.

Patients with deaths from COVID-19 often have co-morbid cardiovascular disease. Real-time cardiovascular disease monitoring based on wearable medical devices may effectively reduce COVID-19 mortality rates. However, due to technical limitations, there are three main issues. First, the traditional wireless communication technology for wearable medical devices is difficult to satisfy the real-time requirements fully. Second, current monitoring platforms lack efficient streaming data processing mechanisms to cope with the large amount of cardiovascular data generated in real time. Third, the diagnosis of the monitoring platform is usually manual, which is challenging to ensure that enough doctors online to provide a timely, efficient, and accurate diagnosis. To address these issues, this paper proposes a 5G-enabled real-time cardiovascular monitoring system for COVID-19 patients using deep learning. Firstly, we employ 5G to send and receive data from wearable medical devices. Secondly, Flink streaming data processing framework is applied to access electrocardiogram data. Finally, we use convolutional neural networks and long short-term memory networks model to obtain automatically predict the COVID-19 patient's cardiovascular health. Theoretical analysis and experimental results show that our proposal can well solve the above issues and improve the prediction accuracy of cardiovascular disease to 99.29%.

An Efficient Ciphertext-Policy Weighted Attribute-Based Encryption for the Internet of Health Things.

The Internet of Health Things (IoHT) is a medical concept that describes uniquely identifiable devices connected to the Internet that can communicate with each other. As one of the most important components of smart health monitoring and improvement systems, the IoHT presents numerous challenges, among which cybersecurity is a priority. As a well-received security solution to achieve fine-grained access control, ciphertext-policy weighted attribute-based encryption (CP-WABE) has the potential to ensure data security in the IoHT. However, many issues remain, such as inflexibility, poor computational capability, and insufficient storage efficiency in attributes comparison. To address these issues, we propose a novel access policy expression method using 0-1 coding technology. Based on this method, a flexible and efficient CP-WABE is constructed for the IoHT. Our scheme supports not only weighted attributes but also any form of comparison of weighted attributes. Furthermore, we use offline/online encryption and outsourced decryption technology to ensure that the scheme can run on an inefficient IoT terminal. Both theoretical and experimental analyses show that our scheme is more efficient and feasible than other schemes. Moreover, security analysis indicates that our scheme achieves security against a chosen-plaintext attack.

Clouds Proportionate Medical Data Stream Analytics for Internet of Things-Based Healthcare Systems.

Internet of Things (IoT) assisted healthcare systems are designed for providing ubiquitous access and recommendations for personal and distributed electronic health services. The heterogeneous IoT platform assists healthcare services with reliable data management through dedicated computing devices. Healthcare services' reliability depends upon the efficient handling of heterogeneous data streams due to variations and errors. A Proportionate Data Analytics (PDA) for heterogeneous healthcare data stream processing is introduced in this manuscript. This analytics method differentiates the data streams based on variations and errors for satisfying the service responses. The classification is streamlined using linear regression for segregating errors from the variations in different time intervals. The time intervals are differentiated recurrently after detecting errors in the stream's variation. This process of differentiation and classification retains a high response ratio for healthcare services through spontaneous regressions. The proposed method's performance is analyzed using the metrics accuracy, identification ratio, delivery, variation factor, and processing time.

Enhancing Cancer Driver Gene Prediction by Protein-Protein Interaction Network.

With the advances in gene sequencing technologies, millions of somatic mutations have been reported in the past decades, but mining cancer driver genes with oncogenic mutations from these data remains a critical and challenging area of research. In this study, we proposed a network-based classification method for identifying cancer driver genes with merging the multi-biological information. In this method, we construct a cancer specific genetic network from the human protein-protein interactome (PPI) to mine the network structure attributes, and combine biological information such as mutation frequency and differential expression of genes to achieve accurate prediction of cancer driver genes. Across seven different cancer types, the proposed algorithm always achieves high prediction accuracy, which is superior to the existing advanced methods. In the analysis of the predicted results, about 40 percent of the top 10 candidate genes overlap with the Cancer Gene Census database. Interestingly, the feature comparison indicates that the network based features are still more important than the biological features, including the mutation frequency and genetic differential expression. Further analyses also show that the integration of network structure attributes and biological information is valuable for predicting new cancer driver genes.

AI-Driven Synthetic Biology for Non-Small Cell Lung Cancer Drug Effectiveness-Cost Analysis in Intelligent Assisted Medical Systems.

According to statistics, in the 185 countries' 36 types of cancer, the morbidity and mortality of lung cancer take the first place, and non-small cell lung cancer (NSCLC) accounts for 85% of lung cancer (International Agency for Research on Cancer, 2018), (Bray et al., 2018). Significantly in many developing countries, limited medical resources and excess population seriously affect the diagnosis and treatment of alung cancer patients. The 21st century is an era of life medicine, big data, and information technology. Synthetic biology is known as the driving force of natural product innovation and research in this era. Based on the research of NSCLC targeted drugs, through the cross-fusion of synthetic biology and artificial intelligence, using the idea of bioengineering, we construct an artificial intelligence assisted medical system and propose a drug selection framework for the personalized selection of NSCLC patients. Under the premise of ensuring the efficacy, considering the economic cost of targeted drugs as an auxiliary decision-making factor, the system predicts the drug effectiveness-cost then. The experiment shows that our method can rely on the provided clinical data to screen drug treatment programs suitable for the patient's conditions and assist doctors in making an efficient diagnosis.

Hybrid Intelligence-Driven Medical Image Recognition for Remote Patient Diagnosis in Internet of Medical Things.

In ear of smart cities, intelligent medical image recognition technique has become a promising way to solve remote patient diagnosis in IoMT. Although deep learning-based recognition approaches have received great development during the past decade, explainability always acts as a main obstacle to promote recognition approaches to higher levels. Because it is always hard to clearly grasp internal principles of deep learning models. In contrast, the conventional machine learning (CML)-based methods are well explainable, as they give relatively certain meanings to parameters. Motivated by the above view, this paper combines deep learning with the CML, and proposes a hybrid intelligence-driven medical image recognition framework in IoMT. On the one hand, the convolution neural network is utilized to extract deep and abstract features for initial images. On the other hand, the CML-based techniques are employed to reduce dimensions for extracted features and construct a strong classifier that output recognition results. A real dataset about pathologic myopia is selected to establish simulative scenario, in order to assess the proposed recognition framework. Results reveal that the proposal that improves recognition accuracy about two to three percent.

PEDF relieves kidney injury in type 2 diabetic nephropathy mice by reducing macrophage infiltration.

INTRODUCTION: Pigment epithelium-derived factor (PEDF) is a multifunctional protein with anti-angiogenic, antioxidant and anti-inflammatory properties. PEDF is involved in the pathogenesis of diabetic retinopathy, but its exact role in diabetic kidneys remains unclear. P78-PEDF is an active peptide sequence consisting of 44 amino acids with biological activity similar to that of PEDF. The present study aimed to investigate whether PEDF can alleviate renal damage in type 2 diabetic nephropathy mice by inhibiting macrophage infiltration. MATERIAL AND METHODS: The db/db mice were randomly divided into a diabetes PEDF intervention group (DM-P78-PEDF), a diabetes empty carrier intervention group (DM-Vehicle), and a diabetes mellitus group (DM). Subsequently, they were injected subcutaneously P78-PEDF (0.3 µg/g/d) and PBS for 6 weeks. The ratio of kidney weight to body weight was observed in the mice. An automatic biochemical analyser was used to determine fasting blood glucose (GLU), blood urea nitrogen (UREA), serum creatinine (CREA), and haemoglobin (Hb) content. Histological and ultrastructural pathological changes in the kidneys were examined through H&E and PAS staining. Kidney tissue levels of interleukin-1ß (IL-1ß), interleukin 6 (IL-6), tumour necrosis factor alpha (TNF-α), and interferon gamma (IFN-γ) were determined by ELISA. Expression of the macrophage infiltration and typing as well as that of PEDF, NF-kB, and TLR4 was evaluated in the kidneys. RESULTS: PEDF was located in glomeruli, and the expression of PEDF protein and mRNA in the kidney of diabetic mice declined significantly. Compared with diabetic mice treated with vehicle, continuous infusion of P78-PEDF could reduce blood urea nitrogen, serum creatinine (CREA), renal macrophage recruitment, inflammatory cytokines, and histological changes and restore the expression of TLR4/NF-κB signalling pathway-related factors in diabetic mice. CONCLUSION: These findings highlight the importance of P78-PEDF peptide as a potential treatment in the occurrence and development of diabetic renal injury.

Anhuienoside C Attenuates Podocyte Injury in Diabetic Nephropathy Rats.

OBJECTIVE: The present study evaluated the nephroprotective effects of anhuienoside C (AC) against diabetic nephropathy (DN) in rats. MATERIAL AND METHODS: Diabetic nephropathy was induced by administration of a high-fat diet (HFD) for 8 weeks and intraperitoneal administration of streptozotocin (STZ; 30 mg/kg) at the end of the fourth week of this protocol. Effects of AC on blood glucose levels, renal function markers, and mediators of inflammation in the serum of DN rats were assessed. RESULTS: Anhuienoside C treatment reduced the blood glucose levels and attenuated the increased levels of renal injury markers in DN rats. Anhuienoside C also increased podocyte counts; alleviated the changes in podocin, desmin, and nephrin protein levels; and ameliorated the altered pathophysiology in the kidney tissues induced by DN. Compared with the DN group, the levels of inflammatory markers and mediators of oxidative stress were reduced in the serum and kidney tissues of the AC-treated groups. Moreover, treatment with AC ameliorates the altered expression of podocin, nephrin, and desmin proteins in the renal tissue of HFD/STZ-induced kidney-injured rats. CONCLUSION: In conclusion, AC protected against podocyte injury by regulating nuclear factor kappa-light-chain-enhancer of activated B cells/protein kinase B pathway in a rat model of DN.

Deep Spectral-Spatial Features of Near Infrared Hyperspectral Images for Pixel-Wise Classification of Food Products.

Hyperspectral imaging (HSI) emerges as a non-destructive and rapid analytical tool for assessing food quality, safety, and authenticity. This work aims to investigate the potential of combining the spectral and spatial features of HSI data with the aid of deep learning approach for the pixel-wise classification of food products. We applied two strategies for extracting spatial-spectral features: (1) directly applying three-dimensional convolution neural network (3-D CNN) model; (2) first performing principal component analysis (PCA) and then developing 2-D CNN model from the first few PCs. These two methods were compared in terms of efficiency and accuracy, exemplified through two case studies, i.e., classification of four sweet products and differentiation between white stripe ("myocommata") and red muscle ("myotome") pixels on salmon fillets. Results showed that combining spectral-spatial features significantly enhanced the overall accuracy for sweet dataset, compared to partial least square discriminant analysis (PLSDA) and support vector machine (SVM). Results also demonstrated that spectral pre-processing techniques prior to CNN model development can enhance the classification performance. This work will open the door for more research in the area of practical applications in food industry.

Association between MC4R rs17782313 genotype and obesity: A meta-analysis.

BACKGROUND: Obesity is a huge burden of the world. It is commonly recognized that dietary structure and physical inactivity is essential in the progress of obesity. However, some individuals still face the trouble of obese even though they live a healthy life. Except for the combination of diseases, the operation of both lifestyle and genetic features contributes to obesity. Melanocortin-4-receptor (MC4R) gene is one of the known hereditary factors of obesity. rs17782313, a single nucleotide variant in MC4R gene, has been reported unclear results in whether it plays a role in obesity. This meta-analysis is to estimate the association between MC4R rs17782313 genotype and obesity. METHOD: A systematic literature retrieval was conducted in four databases: PubMed, Embase, Web of Science and Cochrane Library with specific search strategy. Select qualified studies to identify relevant studies. Odds ratios (ORs) with 95% confidence intervals (CI), P value and I2 value were used to assess the strength of the association in meta-analysis and adjusted with ethnicity, quality and single nucleotide polymorphism (SNP) testing method. RESULT: 6 eligible studies involving 3133 obese cases and 3123 normal-weight participants were selected from 378 articles. Allele B of MC4R rs17782313 present a statistically significant association with obesity under allele contrast model (OR = 1.325, 95%CI: 1.219-1.439), dominant model (OR = 1.320, 95%CI: 1.184-1.472), recessive model (OR = 1.690, 95%CI: 1.420-2.011) and homozygous type of co-dominant model (OR = 1.925, 95%CI: 1.590-2.330), respectively, and P < 0.05. CONCLUSION: Mutated MC4R rs17782313 is associated with higher risk of obesity. People with homozygous mutant genotype of MC4R rs17782313 would be more likely to suffer from obesity, while heterozygous mutant genotype needs further studies to clarify.