The investigation showed that reamberin application in the complex treatment of patients with severe disintegrated fractures of pelvic bones is pathogenetically grounded. Despite polyetiological origin of critical conditions in the organism in this case, all these have a common pathophysiological basis of three main processes: hypoxia, intoxication, and immunosuppression. Succinic acid, which is contained in reamberin, is a substrate antihypoxant that stimulates the synthesis of restorative equivalents in the cell. A modifying effect of succinic acid on the processes of tissue metabolism, including cell respiration, LPO/AOS system, and synthesis of proteins, is the basis of pathophysiological ground of reamberin application in a complex treatment of patients with disintegrated fractures of pelvic bones.
Fractures, Bone/drug therapy , Hypoxia/drug therapy , Meglumine/analogs & derivatives , Pelvic Bones/drug effects , Succinates/therapeutic use , Ceruloplasmin/metabolism , Female , Fractures, Bone/blood , Fractures, Bone/immunology , Fractures, Bone/physiopathology , Humans , Hypoxia/blood , Hypoxia/immunology , Hypoxia/physiopathology , Immunocompromised Host , Lipid Peroxidation/drug effects , Male , Malondialdehyde/blood , Meglumine/therapeutic use , Pelvic Bones/immunology , Pelvic Bones/metabolism , Vitamin E/blood
Health of a nation is a sensitive barometer of the environmental situation, especially in the North, where vulnerable nature cannot resist intensive industrial development. The geographical location and severe climatic conditions of the Republic of Sakha (Yakutia) significantly sharpen any negative impact of industrial activity on the state of the environment. The impact of ecological factors on the health of population has been studied in the case of a diamond province (Vilyuy region), where a complex of chemical pollutants from diamond mining, products of wood decay in places of flooding of the water reservoir for the Vilyuisk power station, highly mineralised underground waters and consequences of underground explosions have caused a substantial negative effect on the environment and people. Studies on the health of the population in the Vilyuy region has shown that sickness and morbidity rates of viral hepatitis, tuberculosis, pathologies during pregnancy and other diseases are higher in comparison to rates in the Republic as a whole, a feature which has been attributed to environmental degradation in the area.
Ecology , Environmental Pollution , Health Status Indicators , Population Surveillance , Humans , Mining , Siberia/epidemiology
Presented are the results of antioxidant status of inhabitants of Yakutia. The intensity of lipid peroxydation depends on professional factors: influence of the quartz dust and smoking. Miners and smokers have high concentration of malonil dialdegide in blood. The SOD and catalase levels did not statistically depend on sex and nationality, but increased in miners and smokers. Insufficiency of vitamins C, A and E combined with immunoglobulins deviations. It should be noticed that country-people have more deviations in vitamin and immune status than towns-people.
Antioxidants , Ascorbic Acid Deficiency/diagnosis , Catalase/blood , Lipid Peroxidation , Malondialdehyde/blood , Superoxide Dismutase/blood , Vitamin E Deficiency/diagnosis , Adolescent , Adult , Data Interpretation, Statistical , Dust/adverse effects , Female , Humans , Immunodiffusion , Male , Middle Aged , Mining , Rural Population , Siberia , Smoking/adverse effects , Urban Population
