INTRODUCTION: Fluid and electrolyte disorders such as diabetes insipidus, salt wasting syndrome (SWS) and syndrome of inappropriate antidiuretic hormone secretion (SIADH) can appear in the immediate postoperative period after surgery for brain tumors. Early diagnosis and treatment are important to prevent the potential adverse effects of these disorders on the central nervous system (CNS). OBJECTIVES: To determine the incidence and characteristics of fluid and electrolyte disorders in the immediate postoperative period after surgery for CNS tumors in children treated in our hospital. MATERIAL AND METHODS: We retrospectively analyzed clinical and laboratory data in all infants and children who underwent surgery for CNS tumors in our hospital from January 1998 to June 2005 and who met the laboratory criteria for diabetes insipidus, SWS or SIADH. RESULTS: Twenty-three electrolyte disorders were identified in 149 surgical patients (an incidence of 15.4%). The median age was 5 years and 3 months (from 6 months to 17 years) and 48.7% of the patients were male. The most frequent electrolyte disturbance was diabetes insipidus (65.2% of all electrolyte disorders). On average, onset of diabetes insipidus occurred 19 hours after surgery. Treatment with desmopressin was administrated in all patients. On average, diabetes insipidus was resolved 73 hours after diagnosis, except in one patient with permanent diabetes insipidus due to a surgical lesion of the hypothalamic-pituitary axis. The second most frequent electrolyte disturbance was SWS (26.1%) with a mean time of onset of 50.4 hours after surgery. On average, SWS was resolved 57.6 hours after administration of saline solutions. Only two patients developed SIADH, which was treated with water restriction and adequate sodium supply. Both cases of SIADH resolved spontaneously in the first 36 hours after diagnosis. At discharge, none of the patients showed neurological disturbances due to an electrolytic disorder. CONCLUSIONS: In our series, the most frequent electrolyte disorder after surgery for CNS tumors was diabetes insipidus. Early treatment with desmopressin almost always prevents hypernatremia. Unless there is a surgical lesion of the hypothalamic-pituitary axis, spontaneous resolution will take place in 3 days on average. The management of SWS and SIADH requires close monitoring of plasma sodium due to the risk of hyponatremia.
Brain Neoplasms/surgery , Postoperative Complications/epidemiology , Water-Electrolyte Imbalance/epidemiology , Adolescent , Child , Child, Preschool , Female , Humans , Incidence , Infant , Infant, Newborn , Male , Postoperative Complications/therapy , Retrospective Studies , Water-Electrolyte Imbalance/therapy
Introducción Entre las complicaciones que pueden aparecer en el postoperatorio inmediato de los tumores cerebrales destacan los trastornos hidroelectrolíticos (diabetes insípida, síndrome pierde sal y síndrome de secreción inadecuada de hormona antidiurética [SIADH]). Es importante su diagnóstico y tratamiento precoz de cara a prevenir los posibles efectos negativos que pueden tener sobre el propio sistema nervioso central (SNC). Objetivos Valorar la incidencia y características de los trastornos electrolíticos aparecidos en el postoperatorio inmediato de los niños intervenidos de tumores del SNC en nuestro centro. Material y métodos Análisis retrospectivo de las historias clínicas de niños intervenidos de tumores del SNC en nuestro centro entre enero de 1998 y junio de 2005, que en el postoperatorio cumplieron criterios analíticos de diabetes insípida, síndrome pierde sal o SIADH. Resultados Se detectaron 23 trastornos hidroelectrolíticos en 149 intervenciones (15,4 %). El 47,8 % fueron varones. La mediana de edad fue de 5 años y 3 meses (rango de 6 meses a 17 años). La alteración electrolítica más frecuente fue diabetes insípida (65,2 %). El trastorno apareció en una media de 19 h tras la cirugía. Se administró desmopresina en todos los casos, con resolución del cuadro en una media de 73 h tras el diagnóstico, excepto un caso de diabetes insípida permanente por lesión quirúrgica del eje hipotálamo- hipofisario. El síndrome pierde sal, con un 26,1 % de los casos, fue el segundo trastorno hidroelectrolítico en frecuencia. El tiempo medio de aparición tras la cirugía fue de 50,4 h. Se adecuó el aporte hidrosalino en todos los casos. El trastorno se resolvió en una media de 57,6 h tras su aparición. Sólo se detectaron 2 casos de SIADH que se trataron con restricción hídrica y adecuación de aportes de sodio. Ambos casos se resolvieron espontáneamente en las primeras 36 h tras el diagnóstico. Al alta ningún paciente presentaba alteraciones neurológicas secundarias al trastorno hidroelectrolítico. Conclusiones El trastorno hidroelectrolítico más frecuente en postoperados de tumores cerebrales en nuestra serie ha sido la diabetes insípida. El tratamiento precoz con desmopresina evita en la mayor parte de los casos la aparición de hipernatremia. Si no existe lesión quirúrgica del eje hipotálamo- hipofisario la resolución espontánea se produce en una media de 3 días. El manejo del síndrome pierde sal y el SIADH requiere una estrecha monitorización del sodio plasmático por la gran tendencia a la hiponatremia
Introduction Fluid and electrolyte disorders such as diabetes insipidus, salt wasting syndrome (SWS) and syndrome of inappropriate antidiuretic hormone secretion (SIADH) can appear in the immediate postoperative period after surgery for brain tumors. Early diagnosis and treatment are important to prevent the potential adverse effects of these disorders on the central nervous system (CNS). Objectives To determine the incidence and characteristics of fluid and electrolyte disorders in the immediate postoperative period after surgery for CNS tumors in children treated in our hospital. Material and methods We retrospectively analyzed clinical and laboratory data in all infants and children who underwent surgery for CNS tumors in our hospital from January 1998 to June 2005 and who met the laboratory criteria for diabetes insipidus, SWS or SIADH. Results Twenty-three electrolyte disorders were identified in 149 surgical patients (an incidence of 15.4 %). The median age was 5 years and 3 months (from 6 months to 17 years) and 48.7 % of the patients were male. The most frequent electrolyte disturbance was diabetes insipidus (65.2 % of all electrolyte disorders). On average, onset of diabetes insipidus occurred 19 hours after surgery. Treatment with desmopressin was administrated in all patients. On average, diabetes insipidus was resolved 73 hours after diagnosis, except in one patient with permanent diabetes insipidus due to a surgical lesion of the hypothalamic-pituitary axis. The second most frequent electrolyte disturbance was SWS (26.1 %) with a mean time of onset of 50.4 hours after surgery. On average, SWS was resolved 57.6 hours after administration of saline solutions. Only two patients developed SIADH, which was treated with water restriction and adequate sodium supply. Both cases of SIADH resolved spontaneously in the first 36 hours after diagnosis. At discharge, none of the patients showed neurological disturbances due to an electrolytic disorder. Conclusions In our series, the most frequent electrolyte disorder after surgery for CNS tumors was diabetes insipidus. Early treatment with desmopressin almost always prevents hypernatremia. Unless there is a surgical lesion of the hypothalamic- pituitary axis, spontaneous resolution will take place in 3 days on average. The management of SWS and SIADH requires close monitoring of plasma sodium due to the risk of hyponatremia
Male , Female , Infant , Child, Preschool , Child , Adolescent , Humans , Water-Electrolyte Imbalance/diagnosis , Water-Electrolyte Imbalance/etiology , Postoperative Complications , Brain Neoplasms/surgery , Inappropriate ADH Syndrome/diagnosis , Inappropriate ADH Syndrome/etiology , Retrospective Studies , Diabetes Insipidus/diagnosis , Diabetes Insipidus/etiology , Incidence
Purpura fulminans (PF) is an infrequent complication of varicella characterized by the progressive development of purpuric or painful ecchymotic lesions associated with biochemical alternations typical of consumption coagulopathy. Activation of coagulation is due to a marked and prolonged decrease in protein S, which is probably secondary to the formation of antiprotein S antibodies. The mechanism responsible for the synthesis of these autoantibodies is unknown. We present three cases of postvaricella PF and review the clinical and biochemical characteristics of this entity, as well as current diagnostic and therapeutic recommendations.
Chickenpox/complications , IgA Vasculitis/etiology , Antibodies , Autoantibodies , Chickenpox/immunology , Child , Child, Preschool , Female , Humans , IgA Vasculitis/diagnosis , Male , Protein S/immunology
La púrpura fulminante es una complicación rara de la varicela que se caracteriza por la aparición progresiva de lesiones purpúricas o equimóticas dolorosas asociado a una alteración analítica propia de una coagulopatía de consumo. La activación de la coagulación es debida a un descenso marcado y prolongado de la proteína S, que probablemente es secundario a la formación de anticuerpos antiproteína S. El mecanismo responsable de la síntesis de estos autoanticuerpos es desconocido. Se presentan 3 casos de púrpura fulminante posvaricelosa y se revisan las características clinicoanalíticas y las recomendaciones diagnosticoterapéuticas actuales de esta entidad (AU)
Child , Child, Preschool , Female , Humans , Male , Autoantibodies , Chickenpox , Antibodies , Protein S , IgA Vasculitis
