[Effect of laser acupuncture on the pulmonary vascular resistance in patients with obstructive chronic lung diseases]. / Vliianie lazeropunktury na legochnoe sosudistoe soprotivlenie u bol'nykh khronicheskimi obstruktivnymi zabolevaniiami legkikh.

Clinical pattern of the disease, systolic pressure in the pulmonary artery, external respiration, central hemodynamics were assessed in 111 patients (50 with chronic obstructive bronchitis and 61 with bronchial asthma) to study the effect of laser puncture. The treatment course consisted of 10 sessions performed with application of Uzor apparatus in pulse regimen with 890 nm wave length, 1500 Hz frequency and 2 mW mean radiation rate. The results indicate a positive response to infra-red laser acupuncture evident from improved bronchial patency, enhanced bronchial sensitivity to sympathomimetics, reduced systolic pressure in the pulmonary artery. The promise of the laser puncture is attributed to its separate broncholytic effect and the ability to lower pulmonary vascular resistance.

[State of the atrial myocardium in patients with paroxysmal form of fibrillation arrhythmia]. / Sostoianie miokarda predserdii u bolnykh s paroksizmal'noi formoi mertsiatel'noi aritmii.

Seven two patients with coronary heart disease complicated with paroxysmal atrial fibrillation were studied by using accelerated atrial vector cardiography and M-mode echocardiography. Vector cardiography made it possible to reveal the signs of left atrial hyperfunction with normal left atrial echocardiographic dimensions. There were lower values for left ventricular myocardial contractility in parallel with higher echocardiographic dimensions of the left atrium. In the patients examined, progression of cardiosclerosis was accompanied by decreased amplitude values for the P loop on the vector cardiogram strip along with slower intraatrial conduction with an increase in the size of the left atrial cavity.

[Significance of echo- and vectorcardiographic studies of the heart atrium in the assessment of intracardiac hemodynamics and myocardial contractility]. / Znachenie ékho- i vektorkardiograficheskogo issledovaniia predserdii v otsenke vnutriserdechnoi gemodinamiki i sokratimosti miokarda.

Seventy three patients with coronary heart disease (CHD) complicated by paroxysmal atrial fibrillation (PAF) were examined. Vectorcardiography developed by I. A. Akulinichev and M-mode echocardiography were used to assess the status of left atrial and ventricular myocardia. An interrelationship was examined between the electrophysiological and echocardiographic parameters of myocardial performance, depending on the stage of circulatory insufficiency (CI). The patients with PAF-complicated CHD, unlike those with CHD alone, showed more severe myocardial conduction abnormalities despite the stage of CI. There were signs of compensatory left ventricular overload in the absence of clinical signs of CI. Comparison of ultrasound examination findings with high performance atrial vectorcardiographic ones increases the possibility of accurately assessing the cardiac performance by using noninvasive tools of examinations.

[Clinico-immunologic aspects of using mildronate in patients with bronchopulmonary diseases]. / Kliniko-immunologicheskie aspekty primeneniia mildronata u bol'nykh s bronkholegochnymi zabolevaniiami.

The immunity status of 35 patients with chronic bronchitis and infectious and allergic bronchial asthma was studied. Defects in the humoral immunity were revealed. To correct the immunity status, all the patients were treated with mildronate. The immunomodulatory effect of mildronate was found in all the groups of the patients. Mildronate was shown to increase the activity of a secondary immune response and the bronchial potency in the persons with infectious and allergic asthma.

[Effectiveness of depin-E in patients with chronic bronchitis]. / Effektivnost' depina-E u bol'nykh khronicheskim bronkhitom.

Acute course and long-term regimens of depin-E administration were evaluated clinically and pharmacologically in 50 patients with chronic obstructive bronchitis (COB) and chronic cor pulmonale (CCP). The drug has three mechanisms of action: arteriolovenodilating, bronchodilating, direct pulmonary vascular. Therapeutic effect was achieved in 80% and 60% of COB and CCP patients, respectively. No response was demonstrated for patients with severe cardiac failure. Depin-E can be recommended for prophylaxis and treatment of CCP, to arrest hypertension crises in lesser circulation, to improve pulmonary circulation, central hemodynamics, exercise tolerance.

[A case of successful antibiotic therapy of legionnaires' disease with lesions of the lungs and heart]. / Sluchai uspeshnoi antibiotikoterapii bolezni legionerov s porazheniem legkikh i serdtsa.

Pulmonary affections in patients with legionellosis are the main ones. The affections of the heart, gastrointestinal tract and other organs and systems are less frequent. Some characteristic features of the legionellosis clinical process in the case described are indicated. The torpid process of chronic bronchitis, the two-phase pattern of the disease, dyspnea at 3-4 month intervals, intermissions, edema and failure of complex therapy with antibiotics and cardiac glycosides provided a tentative diagnosis of Legionella pneumonia with affection of the myocardium. The importance of early serological diagnosis (enzyme immunoassay) was shown. A new approach to the treatment of legionellosis with cefuroxime was of interest.

[The pharmacodynamics and pharmacokinetics of bonnecor in patients with different disorders of the heart rhythm]. / Farmakodinamika i farmakokinetika bonnekora u bol'nykh s razlichnymi narusheniiami ritma serdtsa.

The clinical pharmacokinetics and the effect of bonnecor on parameters of the pharmacodynamics were studied in 53 patients with cardiac rhythm disorders, including 23 patients in the acute period of myocardial infarction. At intravenous administration of bonnecor in a dose of 0.4-0.6 mg/kg there was noted a pronounced antiarrhythmic effect with respect to both ventricular and supraventricular cardiac rhythm disorders. Bonnecor exerted no significant effect on the hemodynamic parameters. The pharmacokinetic parameters of bonnecor possess a great variability, the mean values of the parameters are close to the corresponding ones for ethacizine. Along with the unchanged drug one can detect in the blood mono-N-demethylated metabolite. The ranges of effective concentrations and those inducing side effects of the drug are given.

[Effectiveness of using semiconductor laser in the complex treatment of patients with obstructive forms of chronic nonspecific lung diseases]. / Effektivnost' primeneniia poluprovodnikovogo lazera v kompleksnom lechenii bol'nykh s obstruktivnymi formami khronicheskikh nespetsificheskikh zabolevanii legkikh.

Laser puncture (LJ) using semiconductor gallium-arsenide apparatus Uzor (wave-length 890 nm) was made in 30 patients with chronic obstructive diseases of the lungs. The results were compared to the response in acupuncture. The study covered pulmonary volumes pattern, changes in bronchial permeability and partial oxygen pressure in capillary blood. A berotek pharmacological test evaluated LP effect on bronchial adrenoreceptors function. LP was found to promote the benefit of the standard treatment, to improve bronchial permeability, enhance oxygenation of arterial blood, reduce dyspnea and cough, to stimulate expectoration, normalize sleep and appetite. Lower doses or discontinuation of sympathomimetics became feasible.

[Evaluation of external respiratory function in patients with chronic obstructive bronchitis using radionuclide methods]. / Otsenka funktsii vneshnego dykhaniia u bo'lnykh khronicheskim obstruktivnym bronkhitom s pomo'shchiu radionuklidnykh metodov.

A trial was designed to study shifts in various mechanisms of external respiration (ER) distress in chronic obstructive bronchitis by type of respiration insufficiency (RI). Combined clinicoroentgenological, spirographic, endoscopic and radionuclide (133Xe radiopneumography and 99Tc scintigraphy) examinations were conducted in 66 patients (41 males and 25 females aged 20-60 with 2-17-year history of chronic obstructive bronchitis) versus 30 healthy controls. ER parameters assessed in 4 groups of patients (with-out resting RI, with obstructive and mixed RI variants) by+radiopneugraphy and scintigraphy were found abnormal for either lung and both lungs as a whole. The abnormalities recorded correlated with RI variant. The following parameters appeared most informative in studying ER in the bronchitis patients with radionuclide techniques: the volume of ventilated alveoli, respiratory capacity, total and functional residual lung capacity, index ventilation/blood flow, capillary blood flow, time of half elimination of Xe from the alveoli and vascular bed. The above parameters change for the worse with progressive deterioration of external respiration.

[Use of ethacizine tablets in paroxysms of atrial flutter and fibrillation]. / Opyt ispo'lzovaniia étatsizina v tabletkakh pri pariksi'zmakh trepetaniia i mertsaniia predserdii.

Tablets of ethacizine (a phenothiazine series agent) were used for relieving paroxysms of atrial fibrillation and flutter in 30 patients during 103 attacks. The agent produced a favourable effect in 15 patients in 80 paroxysms of atrial fibrillation. The mean time of sinus rhythm recovery was 1.9 hours. It is effective when given in a single dose of 100 mg with its subsequent administration 6 hours later in the absence of the effect. This agent administered in 50 mg dose produced no results. This scheme of relieving paroxysms of atrial flutter was useful when they lasted not more than 7 days; it is not recommended in initial disturbances of intraventricular conduction. Ethacizine tablets can be used both under hospital and outpatient conditions.