Correction: Integrated silicon photonic MEMS.

[This corrects the article DOI: 10.1038/s41378-023-00498-z.].

Association of systemic complications with mortality in coronavirus disease of 2019: A cohort study on intensive care unit patients.

Background: Since the beginning of the coronavirus disease of 2019 (COVID-19) pandemic, concerns raised by the growing number of deaths worldwide. Acute respiratory distress syndrome (ARDS) and extrapulmonary complications can correlate with prognosis in COVID-19 patients. This study evaluated the association of systemic complications with mortality in severely affected COVID-19 patients. Materials and Methods: This retrospective study was done on 51 intensive care unit (ICU)-admitted COVID-19 adult patients who were admitted to the ICU ward of Khorshid hospital, affiliated with Isfahan University of Medical Sciences. Only the patients who had a definite hospitalization outcome (dead vs. survivors) were included in the study. Daily clinical and paraclinical records were used to diagnose in-hospital complications in these patients. Results: The sample was comprised of 37 males (72.5%) and 14 females (27.4%). The median age of patients was 63 years (Min: 20, Max: 84), with the mortality rate of 47.1%. In total, 70.6% of patients had at least one coexisting disorder. Chronic kidney disease was associated with the worse outcome (29.16% of dead patients against 3.70 of survived ones). Mechanical ventilation was used in 58.8% of patients. Patients who had received invasive ventilation were more likely to die (87.50% of dead patients against 7.40 of survivors), Complications including sepsis and secondary infections (odds ratio: 8.05, confidence interval: 2.11-30.63) was the strongest predictors of mortality. Conclusion: Complications including sepsis and secondary infections can increase the risk of death in ICU-admitted COVID-19 patients. Therefore, it is substantial that the physicians consider preventing or controlling these complications.

Heart rate and cardiovascular events: a nested case-control in Isfahan Cohort Study.

INTRODUCTION: Elevated heart rate (HR) is known to be a risk factor. The aim of the present study was to investigate the association of HR with the incidence of cardiovascular disease (CVD) in Iranian adults. METHODS: The Isfahan cohort study (ICS) was a longitudinal study started in 2001 on 6504 adults aged ≥ 35 years in urban and rural areas of central Iran. In a nested case control study, a control was randomly selected for each CVD event occurring during 7 years of follow up using density sampling method. HR at baseline was assessed by electrocardiogram. CVD was defined as incident coronary heart disease (myocardial infarction, unstable angina and sudden cardiac death) and stroke. The odds ratios (OR) were estimated by conditional logistic regression. RESULTS: 432 participants with CVD events in the case group and 401 participants free of CVD in the control group were included in the analysis. While HR did not show any significant relationship with CVD events in the crude model (P = 0.208), it was detrimentally associated with them when age was included (OR = 1.01, 95% CI: 1.00 - 1.02, P = 0.024). A dose response effect of quintiles of HR was seen in which significant association with CVD events started at third quintile [OR = 1.98 (1.15 - 3.41)] and increased toward fifth quintile [OR = 2.53 (1.47 - 4.36)] in the adjusted model for age, sex and HR-lowering drugs (P for trend = 0.001). This association remained statistically significant when other traditional risk factors were included in the model. CONCLUSIONS: An elevated heart rate was associated with the occurrence of cardiovascular events. It can be considered as a predictor of cardiovascular disease independently of other risk factors in Iranian adults.

Highly tunable nanoscale metal-insulator-metal split ring core ring resonators (SRCRRs).

A class of nano-scale wavelength-selective optical filters is proposed where the core of a metal-insulator-metal square ring is replaced with a split-ring core (SRC). The proposed resonator supports split-ring-resonator-like (SRR-like) resonant modes that are characteristics of the structure. These resonant modes are highly adjustable, via the gap size of the split-ring core, over a range of hundreds of nanometers. The proposed resonator can also incorporate tunable materials localized in the gap of the SRC or placed throughout the resonating path. By varying the refractive index (1 to 2) of the material in the gap of the SRC, first and second SRR-like modes can be tuned over ~200 and 300 nm, respectively. A circuit model based on transmission-line theory is proposed for the structure and used to derive the resonance conditions of the split-ring-resonator-like modes; the model compares favorably to the numerical results. The proposed resonator has the potential to be utilized effectively in integrated nano-scale optical switches and tunable filters.

Selective-mode optical nanofilters based on plasmonic complementary split-ring resonators.

A nanoplasmonic optical filtering technique based on a complementary split-ring resonator structure is proposed. The basic and modal properties of the square-nanoring are studied using the group theory. Degeneracy and non-degeneracy of the possible TM odd- and even-modes are characterized based on the symmetry elements of the ring structure. Distinctively, the proposed technique allows selecting and exciting the proper plasmonic modes of the nanoring in the side-coupled arrangement. It is found that the non-integer modes can be excited due to the presence of a metallic nano-wall. These modes are highly sensitive to the nano-wall dimensions, in contrast to the regular integer modes. Moreover, the transmission-line theory is used to derive the resonance condition of the modes. The results show the optical transmission spectrum of the investigated filter can be efficiently modified and tuned either by manipulation of the position or by variation of the width of the employed nano-wall inside the ring. The numerical results support the theoretical analysis.