A secure routing approach based on league championship algorithm for wireless body sensor networks in healthcare.

Patients must always communicate with their doctor for checking their health status. In recent years, wireless body sensor networks (WBSNs) has an important contribution in Healthcare. In these applications, energy-efficient and secure routing is really critical because health data of individuals must be forwarded to the destination securely to avoid unauthorized access by malicious nodes. However, biosensors have limited resources, especially energy. Recently, energy-efficient solutions have been proposed. Nevertheless, designing lightweight security mechanisms has not been stated in many schemes. In this paper, we propose a secure routing approach based on the league championship algorithm (LCA) for wireless body sensor networks in healthcare. The purpose of this scheme is to create a tradeoff between energy consumption and security. Our approach involves two important algorithms: routing process and communication security. In the first algorithm, each cluster head node (CH) applies the league championship algorithm to choose the most suitable next-hop CH. The proposed fitness function includes parameters like distance from CHs to the sink node, remaining energy, and link quality. In the second algorithm, we employs a symmetric encryption strategy to build secure connection links within a cluster. Also, we utilize an asymmetric cryptography scheme for forming secure inter-cluster connections. Network simulator version 2 (NS2) is used to implement the proposed approach. The simulation results show that our method is efficient in terms of consumed energy and delay. In addition, our scheme has good throughput, high packet delivery rate, and low packet loss rate.

Pan-Cancer Analysis Reveals Functional Similarity of Three lncRNAs across Multiple Tumors.

Long non-coding RNAs (lncRNAs) are emerging as key regulators in many biological processes. The dysregulation of lncRNA expression has been associated with many diseases, including cancer. Mounting evidence suggests lncRNAs to be involved in cancer initiation, progression, and metastasis. Thus, understanding the functional implications of lncRNAs in tumorigenesis can aid in developing novel biomarkers and therapeutic targets. Rich cancer datasets, documenting genomic and transcriptomic alterations together with advancement in bioinformatics tools, have presented an opportunity to perform pan-cancer analyses across different cancer types. This study is aimed at conducting a pan-cancer analysis of lncRNAs by performing differential expression and functional analyses between tumor and non-neoplastic adjacent samples across eight cancer types. Among dysregulated lncRNAs, seven were shared across all cancer types. We focused on three lncRNAs, found to be consistently dysregulated among tumors. It has been observed that these three lncRNAs of interest are interacting with a wide range of genes across different tissues, yet enriching substantially similar biological processes, found to be implicated in cancer progression and proliferation.

A Q-learning-based routing scheme for smart air quality monitoring system using flying ad hoc networks.

Air pollution has changed ecosystem and atmosphere. It is dangerous for environment, human health, and other living creatures. This contamination is due to various industrial and chemical pollutants, which reduce air, water, and soil quality. Therefore, air quality monitoring is essential. Flying ad hoc networks (FANETs) are an effective solution for intelligent air quality monitoring and evaluation. A FANET-based air quality monitoring system uses unmanned aerial vehicles (UAVs) to measure air pollutants. Therefore, these systems have particular features, such as the movement of UAVs in three-dimensional area, high dynamism, quick topological changes, constrained resources, and low density of UAVs in the network. Therefore, the routing issue is a fundamental challenge in these systems. In this paper, we introduce a Q-learning-based routing method called QFAN for intelligent air quality monitoring systems. The proposed method consists of two parts: route discovery and route maintenance. In the part one, a Q-learning-based route discovery mechanism is designed. Also, we propose a filtering parameter to filter some UAVs in the network and restrict the search space. In the route maintenance phase, QFAN seeks to detect and correct the paths near to breakdown. Moreover, QFAN can quickly identify and replace the failed paths. Finally, QFAN is simulated using NS2 to assess its performance. The simulation results show that QFAN surpasses other routing approaches with regard to end-to-end delay, packet delivery ratio, energy consumption, and network lifetime. However, communication overhead has been increased slightly in QFAN.

Disentangling single-cell omics representation with a power spectral density-based feature extraction.

Emerging single-cell technologies provide high-resolution measurements of distinct cellular modalities opening new avenues for generating detailed cellular atlases of many and diverse tissues. The high dimensionality, sparsity, and inaccuracy of single cell sequencing measurements, however, can obscure discriminatory information, mask cellular subtype variations and complicate downstream analyses which can limit our understanding of cell function and tissue heterogeneity. Here, we present a novel pre-processing method (scPSD) inspired by power spectral density analysis that enhances the accuracy for cell subtype separation from large-scale single-cell omics data. We comprehensively benchmarked our method on a wide range of single-cell RNA-sequencing datasets and showed that scPSD pre-processing, while being fast and scalable, significantly reduces data complexity, enhances cell-type separation, and enables rare cell identification. Additionally, we applied scPSD to transcriptomics and chromatin accessibility cell atlases and demonstrated its capacity to discriminate over 100 cell types across the whole organism and across different modalities of single-cell omics data.

Dynamic Hybrid Model to Forecast the Spread of COVID-19 Using LSTM and Behavioral Models Under Uncertainty.

To accurately predict the regional spread of coronavirus disease 2019 (COVID-19) infection, this study proposes a novel hybrid model, which combines a long short-term memory (LSTM) artificial recurrent neural network with dynamic behavioral models. Several factors and control strategies affect the virus spread, and the uncertainty arising from confounding variables underlying the spread of the COVID-19 infection is substantial. The proposed model considers the effect of multiple factors to enhance the accuracy in predicting the number of cases and deaths across the top ten most-affected countries at the time of the study. The results show that the proposed model closely replicates the test data, such that not only it provides accurate predictions but it also replicates the daily behavior of the system under uncertainty. The hybrid model outperforms the LSTM model while accounting for data limitation. The parameters of the hybrid models are optimized using a genetic algorithm for each country to improve the prediction power while considering regional properties. Since the proposed model can accurately predict the short-term to medium-term daily spreading of the COVID-19 infection, it is capable of being used for policy assessment, planning, and decision making.

Stochastic Dual Simplex Algorithm: A Novel Heuristic Optimization Algorithm.

A new heuristic optimization algorithm is presented to solve the nonlinear optimization problems. The proposed algorithm utilizes a stochastic method to achieve the optimal point based on simplex techniques. A dual simplex is distributed stochastically in the search space to find the best optimal point. Simplexes share the best and worst vertices of one another to move better through search space. The proposed algorithm is applied to 25 well-known benchmarks, and its performance is compared with grey wolf optimizer (GWO), particle swarm optimization (PSO), Nelder-Mead simplex algorithm, hybrid GWO combined with pattern search (hGWO-PS), and hybrid GWO algorithm combined with random exploratory search algorithm (hGWO-RES). The numerical results show that the proposed algorithm, called stochastic dual simplex algorithm (SDSA), has a competitive performance in terms of accuracy and complexity.