RESUMEN
PURPOSE: In clinical practice the assessment of the "vocal cord-arytenoid unit" (VCAU) mobility is crucial in the staging, prognosis, and choice of treatment of laryngeal squamous cell carcinoma (LSCC). The aim of the present study was to measure repeatability and reliability of clinical assessment of VCAU mobility and radiologic analysis of posterior laryngeal extension. METHODS: In this multi-institutional retrospective study, patients with LSCC-induced impairment of VCAU mobility who received curative treatment were included; pre-treatment endoscopy and contrast-enhanced imaging were collected and evaluated by raters. According to their evaluations, concordance, number of assigned categories, and inter- and intra-rater agreement were calculated. RESULTS: Twenty-two otorhinolaryngologists evaluated 366 videolaryngoscopies (total evaluations: 2170) and 6 radiologists evaluated 237 imaging studies (total evaluations: 477). The concordance of clinical rating was excellent in only 22.7% of cases. Overall, inter- and intra-rater agreement was weak. Supraglottic cancers and transoral endoscopy were associated with the lowest inter-observer reliability values. Radiologic inter-rater agreement was low and did not vary with imaging technique. Intra-rater reliability of radiologic evaluation was optimal. CONCLUSIONS: The current methods to assess VCAU mobility and posterior extension of LSCC are flawed by weak inter-observer agreement and reliability. Radiologic evaluation was characterized by very high intra-rater agreement, but weak inter-observer reliability. The relevance of VCAU mobility assessment in laryngeal oncology should be re-weighted. Patients affected by LSCC requiring imaging should be referred to dedicated radiologists with experience in head and neck oncology.
Asunto(s)
Neoplasias Laríngeas , Pliegues Vocales , Humanos , Neoplasias Laríngeas/diagnóstico por imagen , Neoplasias Laríngeas/patología , Masculino , Femenino , Persona de Mediana Edad , Anciano , Estudios Retrospectivos , Pliegues Vocales/diagnóstico por imagen , Pliegues Vocales/fisiopatología , Adulto , Reproducibilidad de los Resultados , Anciano de 80 o más Años , Laringoscopía/métodos , Carcinoma de Células Escamosas/diagnóstico por imagen , Carcinoma de Células Escamosas/patologíaRESUMEN
BACKGROUND AND PURPOSE: Tractography of the facial nerve based on single-shell diffusion MR imaging is thought to be helpful before surgery for resection of vestibular schwannoma. However, this paradigm can be vitiated by the isotropic diffusion of the CSF, the convoluted path of the facial nerve, and its crossing with other bundles. Here we propose a multishell diffusion MR imaging acquisition scheme combined with probabilistic tractography that has the potential to provide a presurgical facial nerve reconstruction uncontaminated by such effects. MATERIALS AND METHODS: Five patients scheduled for vestibular schwannoma resection underwent multishell diffusion MR imaging (b-values = 0, 300, 1000, 2000 s/mm2). Facial nerve tractography was performed with a probabilistic algorithm and anatomic seeds located in the brain stem, cerebellopontine cistern, and internal auditory canal. A single-shell diffusion MR imaging (b-value = 0, 1000 s/mm2) subset was extrapolated from the multishell diffusion MR imaging data. The quality of the facial nerve reconstruction based on both multishell diffusion MR imaging and single-shell diffusion MR imaging sequences was assessed against intraoperative videos recorded during the operation. RESULTS: Single-shell diffusion MR imaging-based tractography was characterized by failures in facial nerve tracking (2/5 cases) and inaccurate facial nerve reconstructions displaying false-positives and partial volume effects. In contrast, multishell diffusion MR imaging-based tractography provided accurate facial nerve reconstructions (4/5 cases), even in the presence of ostensibly complex patterns. CONCLUSIONS: In comparison with single-shell diffusion MR imaging, the combination of multishell diffusion MR imaging-based tractography and probabilistic algorithms is a more valuable aid for surgeons before vestibular schwannoma resection, providing more accurate facial nerve reconstructions, which may ultimately improve the postsurgical patient's outcome.
Asunto(s)
Imagen de Difusión Tensora/métodos , Nervio Facial/diagnóstico por imagen , Interpretación de Imagen Asistida por Computador/métodos , Neuroma Acústico/cirugía , Cirugía Asistida por Computador/métodos , Algoritmos , Femenino , Humanos , Masculino , Persona de Mediana Edad , Procedimientos Neuroquirúrgicos/métodosRESUMEN
BACKGROUND: A post-auricular cutaneous mastoid fistula is a rare condition that can occur following radical mastoid surgery, chronic suppurative otitis media or spontaneous exteriorisation of cholesteatoma from the mastoid through the post-auricular skin surface. Management of a post-auricular cutaneous mastoid fistula can be challenging for the surgeon. OBJECTIVE: This paper describes a surgical refinement for post-auricular cutaneous mastoid fistula closure, involving a fibro-muscular-periosteal flap to cover the mastoid cavity, combined with a bilobed flap from the mastoid and lateral neck regions for skin closure. METHOD AND RESULTS: A case of a post-auricular cutaneous mastoid fistula developed after revision tympanoplasty for a cholesteatoma. The condition was successfully treated with the presented technique. Pre- and post-operative photographs are provided for demonstration. CONCLUSION: The fibro-muscular-periosteal flap combined with a bilobed flap from the mastoid and lateral neck regions, in our view, can be considered a valid option for post-auricular cutaneous mastoid fistula closure.
Asunto(s)
Colesteatoma del Oído Medio/cirugía , Fístula Cutánea/cirugía , Apófisis Mastoides/cirugía , Timpanoplastia/efectos adversos , Adulto , Fístula Cutánea/etiología , Humanos , Masculino , Colgajos Quirúrgicos , Resultado del TratamientoAsunto(s)
Neoplasias Meníngeas/cirugía , Meningioma/cirugía , Procedimientos Neuroquirúrgicos/métodos , Neoplasias de la Base del Cráneo/cirugía , Base del Cráneo/cirugía , Adulto , Anciano , Estudios de Cohortes , Endoscopía , Femenino , Pérdida Auditiva/cirugía , Humanos , Imagen por Resonancia Magnética , Masculino , Apófisis Mastoides , Persona de Mediana Edad , Neuroma Acústico/cirugía , Estudios Retrospectivos , Base del Cráneo/anatomía & histología , Hueso Temporal , Adulto JovenRESUMEN
The current treatment options for acoustic neuromas (AN) - observation, microsurgery and radiotherapy - should assure no additional morbidity on cranial nerves VII and VIII. Outcomes in terms of disease control and facial function are similar, while the main difference lies in hearing. From 2012 to 2016, 91 of 169 patients (54%) met inclusion criteria for the present study, being diagnosed with unilateral, sporadic, intrameatal or extrameatal AN up to 1 cm in the cerebello-pontine angle; the remaining 78 patients (46%) had larger AN and were all addressed to surgery. The treatment protocol for small AN included observation, translabyrinthine surgery, hearing preservation surgery (HPS) and radiotherapy. Hearing function was assessed according to the Tokyo classification and the American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNS) classification. Sixty-one patients (71%) underwent observation, 19 (22%) HPS and 6 (7%) translabyrinthine surgery; 5 patients were lost to follow-up. Median follow-up was 25 months. In the observation group, 24.6% of patients abandoned the wait-and-see policy for an active treatment; the risk of switching from observation to active treatment was significant for tumour growth (p = 0.0035) at multivariate analysis. Hearing deteriorated in 28% of cases without correlation with tumour growth; the rate of hearing preservation for classes C-D was higher than for classes A-B (p = 0.032). Patients submitted to HPS maintained an overall preoperative hearing class of Tokyo and AAO-HNS in 63% and 68% of cases, respectively. Hearing preservation rate was significantly higher for patients presenting with preoperative favourable conditions (in-protocol) (p = 0.046). A multi-option management for small AN appeared to be an effective strategy in terms of hearing outcomes.
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Neuroma Acústico/terapia , Terapia Combinada , Femenino , Audición , Humanos , Masculino , Persona de Mediana Edad , Neuroma Acústico/patología , Neuroma Acústico/fisiopatología , Estudios ProspectivosRESUMEN
Endolymphatic sac tumour (ELST) is infrequent, as emerges from small series reported in the literature. It is a slow-growing malignancy with local aggressiveness and a low risk of distant metastases. It is often misdiagnosed because of the late onset of symptoms and difficulty in obtaining a biopsy. Its frequency is higher in von Hippel-Lindau (VHL) disease (a genetic systemic syndrome involving multiple tumours), with a prevalence of around 25%. The diagnosis is based on radiology, with specific patterns on contrast-enhanced MRI and typical petrous bone erosion on bone CT scan. Our experience of ELST in the years between 2012-2015 concerns 7 cases, one of which was bilateral, in patients with VHL disease. Four of the 7 patients underwent 5 surgical procedures at our institution. Each case is described in detail, including clinical symptoms, and the intervals between symptom onset, diagnosis and therapy. Postoperative morbidity was low after early surgery on small tumours, whereas extensive surgery for large tumours was associated with loss of cranial nerve function (especially VII, IX, X). The critical sites coinciding with loss of neurological function were the fallopian canal, jugular foramen, petrous apex and intradural extension into the posterior cranial fossa. Early surgery on small ELST is advocated for patients with VHL disease, in whom screening enables a prompt diagnosis and consequently good prognosis.
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Neoplasias del Oído/complicaciones , Saco Endolinfático , Enfermedad de von Hippel-Lindau/complicaciones , Adulto , Neoplasias del Oído/diagnóstico , Neoplasias del Oído/terapia , Femenino , Humanos , Masculino , Persona de Mediana Edad , Estudios RetrospectivosRESUMEN
In the last 20 years, neonatal survival has progressively increased due to the constant amelioration of neonatal medical treatment and surgical techniques. Thus, the number of children with congenital malformations and severe chronic pathologies who need rehabilitative care has progressively increased. Rehabilitation programs for paediatric patients with disorders of voice, speech and language, communication and hearing, deglutition and breathing are not widely available in hospital settings or in long-term care facilities. In most countries, the number of physicians and technicians is still inadequate; moreover, multidisciplinary teams dedicated to paediatric patients are quite rare. The aim of the present study is to present some new trends in ENT paediatric rehabilitation.
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Enfermedades Otorrinolaringológicas/rehabilitación , Niño , Humanos , Rehabilitación/tendenciasRESUMEN
Intracochlear schwannomas can occur either as an extension of a larger tumor from the internal auditory canal, or as a solitary labyrinthine tumor. They are currently removed via a translabyrinthine approach extended to the basal turn, adding a transotic approach for tumors lying beyond the basal turn. Facial bridge cochleostomy may be associated with the translabyrinthine approach to enable the whole cochlea to be approached without sacrificing the external auditory canal and tympanum. We describe seven cases, five of which underwent cochlear schwannoma resection with facial bridge cochleostomy, one case with the same procedure for a suspect tumor and one, previously subjected to radical tympanomastoidectomy, who underwent schwannoma resection via a transotic approach. Facial bridge cochleostomy involved removing the bone between the labyrinthine and tympanic portions of the fallopian canal, and exposing the cochlea from the basal to the apical turn. Patients' recovery was uneventful, and long-term magnetic resonance imaging showed no residual tumor. Facial bridge cochleostomy can be a flexible extension of the translabyrinthine approach for tumors extending from the internal auditory canal to the cochlea. The transcanal approach is suitable for the primary exclusive intralabyrinthine tumor. The indications for the different approaches are discussed.
Asunto(s)
Neoplasias del Oído , Neurilemoma , Neuroma Acústico , Procedimientos Quirúrgicos Otológicos , Adulto , Disección/efectos adversos , Disección/métodos , Conducto Auditivo Externo/cirugía , Neoplasias del Oído/patología , Neoplasias del Oído/cirugía , Oído Interno/diagnóstico por imagen , Oído Interno/patología , Oído Interno/cirugía , Femenino , Humanos , Italia , Imagen por Resonancia Magnética/métodos , Masculino , Persona de Mediana Edad , Invasividad Neoplásica , Neoplasia Residual/diagnóstico , Neoplasia Residual/prevención & control , Neurilemoma/patología , Neurilemoma/cirugía , Neuroma Acústico/patología , Neuroma Acústico/cirugía , Procedimientos Quirúrgicos Otológicos/efectos adversos , Procedimientos Quirúrgicos Otológicos/métodos , Evaluación de Procesos y Resultados en Atención de Salud , Estudios Retrospectivos , Membrana Timpánica/cirugíaRESUMEN
Closure of the sigmoid-jugular complex is generally planned during various surgical procedures on the skull base, either to repair a jugular foramen lesion or as the oncological boundary of the resection. A series of 218 cases of skull base tumour surgeries was analysed in which closure of the sigmoid-jugular complex was systematically planned (bilaterally in one case) in patients treated for jugular foramen paragangliomas, squamous cell carcinomas and other temporal bone tumours. Surgery was performed via a petro-occipital trans-sigmoid approach in 61 cases, an infratemporal A in 128, en bloc subtotal temporal bone resections in 10 and other approaches in 20. In our experience, planned unilateral (and, in one case, bilateral) closure of the sigmoid-jugular complex had no clinical consequences. The vicarious drainage of the skull base was always assessed preoperatively, revealing no contraindications to intraoperative sinus closure. Given the scarcity of literature on this subject, the present report shows that the procedure is associated with low morbidity and helps to improve our understanding of cerebral venous discharge.
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Carcinoma de Células Escamosas/cirugía , Tumor del Glomo Yugular/cirugía , Neoplasias de la Base del Cráneo/cirugía , Humanos , Venas Yugulares , Procedimientos Quirúrgicos Otorrinolaringológicos/métodosRESUMEN
Temporal bone carcinoma is an uncommon aggressive malignancy. Its low incidence and the absence of a globally accepted staging system still make it difficult to compare different centers' approaches and results. In this review of the main available studies dealing with temporal bone carcinoma since 1995, we consider its rational preoperative staging and assessment, compare the effectiveness of different treatments by tumor stage, and outline the main actuarial prognostic factors.
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Neoplasias Craneales/terapia , Hueso Temporal/patología , Biomarcadores de Tumor , Humanos , Estadificación de Neoplasias , Pronóstico , Procedimientos de Cirugía Plástica , Neoplasias Craneales/diagnóstico , Neoplasias Craneales/mortalidad , Neoplasias Craneales/patologíaRESUMEN
This study was conducted on patients with squamous cell carcinoma of the external auditory canal and temporal bone treated with surgery alone or surgery plus postoperative radiotherapy. It was designed as a retrospective investigation with complete long-term follow-up covering the years from 1983 to 2008. The setting was a tertiary referral centre. Forty-one consecutive cases underwent surgery involving en bloc lateral or subtotal temporal bone resection, parotidectomy and neck dissection plus radiotherapy in advanced cases. The Pittsburgh staging system was adopted. No cases were lost to follow-up, which ranged from 2 to 220 months, while for survivors ranged from 60 to 220 months and included clinical examinations and imaging. Outcome was expressed as NED (no evidence of disease), DOC (dead of other causes), DOD (dead of disease), AWD (alive with disease), disease-free survival (DFS) and disease-specific survival (DSS). Results were expressed with raw data and Kaplan Meyer curves. Patients with T1 and T2 disease had a DFS of 67% and a DSS of 92%. For T3 and T4 cases, the DFS was 41% and DSS was 48%. All treatment failures were due to local recurrences. The cases classified as T4 because the lesion extended from the cartilage canal to the periauricular soft tissues, or from the anterior wall to the parotid space, had a better outcome than the other T4 cases: this different prognosis suggests the need to stage tumours differently. Nodal disease coincided with a worse outcome due to local recurrence.
Asunto(s)
Carcinoma de Células Escamosas/cirugía , Conducto Auditivo Externo , Neoplasias del Oído/cirugía , Humanos , Estudios Retrospectivos , Factores de Tiempo , Resultado del TratamientoRESUMEN
Long-term hearing was examined in 200 patients operated on during 1976-2000 with removal of acoustic neuroma with a retrosigmoid approach and hearing preservation technique. Ninety-four cases preserved hearing, and 91 cases were followed-up for at least 6 years (range 6 to 21 years). Hearing was measured with the PTA 0.5 KHz to 4 KHz and the SDS, and followed the guidelines of the American Academy of Otolaryngology and Head Neck Surgery (AAOHNS classification). Change (or stability) of the short to long-term class was the main outcome measure. Postoperative hearing of class A and B was preserved at long-term and within class B in 87% of cases. A total of 13% presented a decrease of class to C or D. Small size and good preoperative hearing correlated with good short- and long-term hearing [corrected].
Asunto(s)
Audición , Neuroma Acústico/cirugía , Estudios de Seguimiento , Pérdida Auditiva/prevención & control , Humanos , Procedimientos Quirúrgicos Otológicos/métodos , Factores de Tiempo , Resultado del TratamientoRESUMEN
Progress in the study of skull base anatomy and the different lesions involving it has led to more and more precise knowledge of the site. New diagnostic tools have allowed better definition of various diseases, and the use of an operative microscope and modern surgical instruments have all contributed to the development of microsurgery of the skull base. Refinements in microsurgical techniques have led to the description of multiple approaches to the skull base. Lateral approaches to the skull base have been described by pioneering surgeons who created the basis of this surgery and further contributed with their own experience. Refinements and modifications to the original technique have taken place over years, to the point that nowadays the large number of approaches described by oto- and neurosurgeons have led to some confusion. We have attempted to simplify this by retracing it to the original, basic steps based on the most representative publications and personal experience.
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Microcirugia/métodos , Base del Cráneo/cirugía , HumanosRESUMEN
Quality and rate of preserved hearing are crucial to make hearing preservation surgery a viable treatment. A long-term experience with hearing preservation surgery, with tumour size and hearing as admission criteria, was evaluated to assess which size and hearing allowed a high rate of success. The hearing outcome in relation to size of tumour and pre-operative hearing was retrospectively reviewed in a consecutive series of 115 cases of sporadic acoustic neuroma which were operated on with hearing preservation surgery. Inclusion criteria were hearing with ≤ 30 dB pure tone average and ≥ 70% Speech Discrimination Score. The size was ≤ 15 mm in the first series of 51 cases, and ≤ 10 mm in the second series of 64 cases. Pre-operative and post-operative pure tone average were measured at 0.5 to 4.0 KHz, and speech discrimination score at ≤ 40 dB above perception. Post-operative hearing within 30 dB pure tone average and 70% speech discrimination score was considered socially useful hearing and successful outcome. The change to 40 dB pure tone average and 60% speech discrimination score from a pre-operative 30 pure tone average/70% speech discrimination score was considered an acceptable outcome. Patients with a tumour of ≤ 10 mm size in the cerebello-pontine-angle and hearing within 20 dB pure tone average/80% speech discrimination score had a success rate of 76%. Patients with hearing between the 20 dB pure tone average/80% speech discrimination score and 30 dB pure tone average/ 70% speech discrimination score had a success rate of 41%, which increased to 53% if the limit to success was set at 40 dB pure tone average/60% speech discrimination score. Patients with a tumour larger than 10 mm or hearing worse than 30 dB pure tone average/70% speech discrimination score had a poor preservation rate. In conclusion, hearing preservation surgery on a ≤ 10 mm acoustic neuroma with good hearing had a high rate of success and appeared to be a realistic treatment option which could be integrated with observation and radiotherapy in updated guidelines of treatment.
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Pérdida Auditiva/prevención & control , Neuroma Acústico/cirugía , Complicaciones Posoperatorias/prevención & control , Adulto , Femenino , Humanos , Masculino , Persona de Mediana Edad , Estudios RetrospectivosRESUMEN
In a retrospective study of our cases of recurrent paralysis of the facial nerve of tumoural and non-tumoural origin, a tumour-like lesion of the intra-temporal course of the facial nerve, mimicking facial nerve schwannoma, was found and investigated in 4 cases. This was defined as, pseudotumoral hypertrophic neuritis of the facial nerve. The picture was one of recurrent acute facial palsy with incomplete recovery and imaging of a benign tumour. It was different from the well-known recurrent neuritis, hypertrophic neuropathy and perineuroma. A portion of the intra-temporal course of the nerve with concurrent dilatation of the osseous walls was diagnosed pre-operatively as facial nerve schwannoma. The pathological picture showed inflammatory hypertrophy which was not a schwannoma but was likely of viral origin, with degeneration-regeneration of fibres and new connective tissue. Resection of the involved portion of the facial nerve and autologous graft in two cases was performed, decompression with biopsy in the other two. No recurrence of new episodes of paralysis after surgery was observed.
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Enfermedades del Nervio Facial/patología , Nervio Facial/patología , Granuloma de Células Plasmáticas/patología , Adolescente , Adulto , Enfermedades del Nervio Facial/complicaciones , Parálisis Facial/etiología , Granuloma de Células Plasmáticas/complicaciones , Humanos , Hipertrofia/complicaciones , Hipertrofia/patología , Imagen por Resonancia Magnética , MasculinoRESUMEN
Experimental research conducted on normal subjects and on perennial rhinitis sufferers demonstrates that the application of metacholine stimulates nasal secretions and that this effect is inhibited by pretreatment with ipratropium bromide. Using the Baroody et al. method, a group of 20 healthy volunteers was used to check the effect metacholine and ipratropium/metacholine had on nasal secretions. At the same time a study was performed to determine whether these treatments modify other nasal functions: turbinate blood flow, nasal resistance, mucociliar transport. The data confirm earlier observations regarding the effect of metacholine and ipratropium on nasal secretions. A parallel effect is also seen in mucociliary transport time, most likely linked to modifications in the rheological characteristics of the mucous. On the other hand, no significant difference was found in the other functions studied: turbinate blood flow and nasal resistance. We can consider metacholine and ipratropium selective and specific, acting on the secretory function of the nasal mucosa.