Evaluating the Biomechanical Effects of Pedicle Subtraction Osteotomy at Different Lumbar Levels: A Finite Element Investigation.

BACKGROUND: Pedicle subtraction osteotomy (PSO) is effective for correcting spinal malalignment but is associated with high complication rates. The biomechanical effect of different PSO levels remains unclear, and no finite element (FE) analysis has compared L2-, L3-, L4-, and L5-PSOs. PURPOSE: To assess the effects of PSO level on the spine's global range of motion, stresses on posterior instrumentation, load sharing with the anterior column, and proximal junctional stresses. STUDY DESIGN: A computational biomechanical analysis. METHODS: A validated 3D spinopelvic FE model (T10-Pelvis) was used to perform PSOs at L2, L3, L4 and L5. Each model was instrumented with a four-rod configuration (primary rods + in-line satellite rods) from T11-Pelvis. Simulation included a 2-step analysis; (1) applying 300 N to thoracic, 400 N to lumbar, and 400 N to sacrum, and (2) applying a 7.5 Nm moment to the top endplate of the T10 vertebral body. Acetabulum surfaces were fixed in all degrees of freedom. The range of motion, spinopelvic parameters (lumbar lordosis (LL), sacral slope (SS), pelvic incidence (PI), and pelvic tilt (PT)), PSO force, and von Mises stresses were measured. All models were compared with the L3-PSO model and percentage differences were captured. RESULTS: Compared to the intact alignment: LL increased by 48%, 45%, 59%, and 56% in the L2-, L3-, L4-, and L5-PSO models; SS increased by 25%, 15%, and 11% while PT decreased by 76%, 53%, and 45% in L2-, L3-, and L4-PSOs (SS and PT approximated intact model in L5-PSO); Lumbar osteotomy did not affect the PI. Compared to L3-PSO: L2-, L4-, and L5-PSOs showed up to 32%, 34%, and 34% lower global ROM. The least T10-T11 ROM was observed in L5-PSO. The left and right SIJ ROM were approximately similar in each model. Amongst all, the L5-PSO model showed the least ROM at the SIJ. Compared to L3-PSO, the L2-, L4-, and L5-PSO models showed up to 67%, 61%, and 78% reduced stresses at the UIV, respectively. Minimum stress at UIV+ was observed in the L3-PSO model. The L2-and L3-PSOs showed the maximum PSO force. The L5-PSO model showed the lowest stresses on the primary rods in all motions. CONCLUSION: Our FE investigation indicates that L5-PSO results in the greatest lumbar lordosis and lowest global, SIJ, and T10-T11 ROMs and stresses on the primary rods, suggesting potential mechanical benefits in reducing the risk of rod breakage. However, L4- and L5-PSOs led to the least force across the osteotomy site, which may increase the risk of pseudarthrosis. These findings provide biomechanical insights that may inform surgical planning, though further clinical investigation is essential to determine the optimal PSO level and validate these results. CLINICAL SIGNIFICANCE: Understanding the biomechanical impact of PSO level is crucial for optimizing surgical outcomes and minimizing the risks of post-operative complications.

Lumbar Disc Degeneration Affects the Risk of Rod Fracture Following PSO; A Finite Element Study.

STUDY DESIGN: Finite element (FE) study. OBJECTIVE: Pedicle subtraction osteotomy (PSO) is a surgical method to correct sagittal plane deformities. In this study, we aimed to investigate the biomechanical effects of lumbar disc degeneration on the instrumentation following PSO and assess the effects of using interbody spacers adjacent to the PSO level in a long instrumented spinal construct. METHODS: A spinopelvic model (T10-pelvis) with PSO at the L3 level was used to generate 3 different simplified grades of degenerated lumbar discs (mild (Pfirrmann grade III), moderate (Pfirrmann grade IV), and severe (Pfirrmann grade V)). Instrumentation included eighteen pedicle screws and bilateral primary rods. To investigate the effect of interbody spacers, the model with normal disc height was modified to accommodate 2 interbody spacers adjacent to the PSO level through a lateral approach. For the models, the rods' stress distribution, PSO site force values, and the spine range of motion (ROM) were recorded. RESULTS: The mildly, moderately, and severely degenerated models indicated approximately 10%, 26%, and 40% decrease in flexion/extension motion, respectively. Supplementing the instrumented spinopelvic PSO model using interbody spacers reduced the ROM by 22%, 21%, 4%, and 11% in flexion, extension, lateral bending, and axial rotation, respectively. The FE results illustrated lower von Mises stress on the rods and higher forces at the PSO site at higher degeneration grades and while using the interbody spacers. CONCLUSIONS: Larger and less degenerated discs adjacent to the PSO site may warrant consideration for interbody cage instrumentation to decrease the risk of rod fracture and PSO site non-union.

Biomechanical comparison of multi-rod constructs by satellite rod configurations (in-line vs. lateral) and screw types (monoaxial vs. polyaxial) spanning a lumbar pedicle subtraction osteotomy (PSO): is there an optimal configuration?

PURPOSE: Multi-rod constructs are used commonly to stabilize pedicle subtraction osteotomies (PSO). This study aimed to evaluate biomechanical properties of different satellite rod configurations and effects of screw-type spanning a PSO. METHODS: A validated 3D spinopelvic finite element model with a L3 PSO (30°) was used to evaluate 5 models: (1) Control (T10-pelvis + 2 rods); (2) lateral satellite rods connected via offsets to monoaxial screws (LatSat-Mono) or (3) polyaxial screws (LatSat-Poly); (4) in-line satellite rods connected to monoaxial screws (InSat-Mono) or (4) polyaxial screws (InSat-Poly). Global and PSO range of motions (ROM) were recorded. Rods' von Mises stresses and PSO forces were recorded and the percent differences from Control were calculated. RESULTS: All satellite rods (save InSat-Mono) increased PSO ROM and decreased primary rods' von Mises stresses at the PSO. Lateral rods increased PSO forces (LatSat-Mono:347.1 N; LatSat-Poly:348.6 N; Control:336 N) and had relatively lower stresses, while in-line rods decreased PSO forces (InSat-Mono:280.1 N; InSat-Poly:330.7 N) and had relatively higher stresses. Relative to polyaxial screws, monoaxial screws further decreased PSO ROM, increased satellite rods' stresses, and decreased PSO forces for in-line rods, but did not change PSO forces for lateral rods. CONCLUSION: Multi-rod constructs using in-line and lateral satellite rods across a PSO reduced primary rods' stresses. Subtle differences in biomechanics suggest lateral satellite rods, irrespective of screw type, increase PSO forces and lower rod stresses compared to in-line satellite rods, which had a high degree of posterior instrumentation stress shielding and lower PSO forces. Clinical studies are warranted to determine if these findings influence clinical outcomes.

Iatrogenic muscle damage in transforaminal lumbar interbody fusion and adjacent segment degeneration: a comparative finite element analysis of open and minimally invasive surgeries.

PURPOSE: Lumbar procedures for Transforaminal Lumbar Interbody Fusion (TLIF) range from open (OS) to minimally invasive surgeries (MIS) to preserve paraspinal musculature. We quantify the biomechanics of cross-sectional area (CSA) reduction of paraspinal muscles following TLIF on the adjacent segments. METHODS: ROM was acquired from a thoracolumbar ribcage finite element (FE) model across each FSU for flexion-extension. A L4-L5 TLIF model was created. The ROM in the TLIF model was used to predict muscle forces via OpenSim. Muscle fiber CSA at L4 and L5 were reduced from 4.8%, 20.7%, and 90% to simulate muscle damage. The predicted muscle forces and ROM were applied to the TLIF model for flexion-extension. Stresses were recorded for each model. RESULTS: Increased ROM was present at the cephalad (L3-L4) and L2-L3 level in the TLIF model compared to the intact model. Graded changes in paraspinal muscles were seen, the largest being in the quadratus lumborum and multifidus. Likewise, intradiscal pressures and annulus stresses at the cephalad level increased with increasing CSA reduction. CONCLUSIONS: CSA reduction during the TLIF procedure can lead to adjacent segment alterations in the spinal element stresses and potential for continued back pain, postoperatively. Therefore, minimally invasive techniques may benefit the patient.

Spinal Balance/Alignment - Clinical Relevance and Biomechanics.

In the normal spine due to its curvature in various regions, C7 plumb line (C7PL) passes through the sacrum so that the head is centered over the pelvis-ball and socket hip joints and ankle joints. This configuration leads to the least muscular activities to maintain the spinal balance. For any reason like deformity, scoliosis, kyphosis, trauma, and/or surgery this optimal configuration gets disturbed requiring higher muscular activity to maintain the posture and balance. Several parameters like the thoracic kyphosis (TK), lumbar lordosis (LL), pelvic incidence (PI), sacral slope (SS), Hip- and leg position influence the sagittal balance and thus the optimal configuration of spinal alignment. Global sagittal imbalance is energy consuming and often painful compensatory mechanisms are developed, that in turn negatively influence the quality of life. This review looks at the clinical aspects of spinal imbalance, and the biomechanics of spinal balance as dictated by the deformities- ankylosing spondylitis, scoliosis and kyphosis; surgical corrections- pedicle subtraction osteotomies and long segment stabilizations and consequent postural complications like the proximal and distal junctional kyphosis. This review suggests several potential research topics as well.

Optimal satellite rod constructs to mitigate rod failure following pedicle subtraction osteotomy (PSO): a finite element study.

BACKGROUND CONTEXT: Pedicle subtraction osteotomy (PSO) is a challenging restoration technique for sagittal imbalance and is associated with significant complications. One of the major complications is rod fracture and there exists a need for a biomechanical assessment of this complication for various instrumentation configurations. PURPOSE: To evaluate and compare the global range of motion (ROM), rod stress distribution, and the forces on the pedicle subtraction site in various instrumentation configurations using finite element analysis. STUDY DESIGN/SETTING: A computational biomechanical analysis. METHODS: A previously validated osseoligamentous three-dimensional spinopelvic finite element model (T10-pelvis) was used to develop a 30° PSO at the L3 level. In addition to the standard bilateral cobalt chromium primary rod instrumentation of the PSO model, various multirod configurations including constructs with medially, laterally, and posteriorly affixed satellite rods and the short-rod technique were assessed in spinal physiological motions. T10-S1 global ROM, maximum von Mises stress on the rods and at the PSO level, factor of safety (yield stress of the rod material/maximum actual stress in the rod) and the load acting across the PSO site were compared between various instrumentation configurations. The higher the factor of safety the lesser the chances of rod failure. RESULTS: Among all multirod constructs, posteriorly affixed satellite rod construct showed the greatest motion reduction compared to the standard bilateral rod configuration followed by medially and laterally affixed satellite rod constructs. Compared to the standard bilateral rod configuration, recessed short-rod technique resulted in 4% to 49% reduction in T10-S1 ROM recorded in extension and lateral bending motions, respectively, while the axial rotation motion increased by approximately 31%. Considering the maximum stress values on the rods, the recessed short-rod technique showed the greatest factor of safety (FOS = 4.1) followed by posteriorly (FOS = 3.9), medially (FOS = 3), laterally affixed satellite rod constructs (FOS = 2.8), and finally the standard bilateral rod construct (FOS = 2.7). By adding satellite rods, the maximum von Mises stress at the PSO level of the rods also reduced significantly and at this level resulted in the greatest FOS in the posteriorly affixed satellite rod construct. Compared to the standard bilateral rod construct, the load magnitude acting on the osteotomy site decreased by 11%, 16%, and 37% in the laterally, medially, and posteriorly affixed satellite rod constructs, respectively, and did not change with the short-rod technique. CONCLUSIONS: Adding satellite rods increases the rigidity of the construct, which results in an increase in the stability and the reduction of the global ROM. Additionally, having satellite rods reduces the stress on the primary rods at the PSO level and shifts the stresses from this PSO region to areas adjacent to the side-by-side connectors. The data suggest a significant benefit in supplementing medial over lateral satellite rods at the PSO by reducing stress on the primary rods. Except the recessed short-rod technique, all other multirod constructs decrease the magnitude of the load acting across the osteotomy region, which could cause a delayed or non-union at the PSO site. CLINICAL SIGNIFICANCE: The study evaluates the mechanical performance of various satellite rod instrumentation configurations following PSO to predict the risk factors for rod fracture and thereby mitigate the rate of clinically relevant failures.

Treatment of the Fractional Curve of Adult Scoliosis With Circumferential Minimally Invasive Surgery Versus Traditional, Open Surgery: An Analysis of Surgical Outcomes.

STUDY DESIGN: Retrospective, multicenter review of adult scoliosis patients with minimum 2-year follow-up. OBJECTIVE: Because the fractional curve (FC) of adult scoliosis can cause radiculopathy, we evaluated patients treated with either circumferential minimally invasive surgery (cMIS) or open surgery. METHODS: A multicenter retrospective adult deformity review was performed. Patients included: age >18 years with FC >10°, ≥3 levels of instrumentation, 2-year follow-up, and one of the following: coronal Cobb angle (CCA) > 20°, pelvic incidence and lumbar lordosis (PI-LL) > 10°, pelvic tilt (PT) > 20°, and sagittal vertical axis (SVA) > 5 cm. RESULTS: The FC was treated in 118 patients, 79 open and 39 cMIS. The FCs had similar coronal Cobb angles preoperative (17° cMIS, 19.6° open) and postoperative (7° cMIS, 8.1° open), but open had more levels treated (12.1 vs 5.7). cMIS patients had greater reduction in VAS leg (6.4 to 1.8) than open (4.3 to 2.5). With propensity matching 40 patients for levels treated (cMIS: 6.6 levels, N = 20; open: 7.3 levels, N = 20), both groups had similar FC correction (18° in both preoperative, 6.9° in cMIS and 8.5° postoperative). Open had more posterior decompressions (80% vs 22.2%, P < .001). Both groups had similar preoperative (Visual Analogue Scale [VAS] leg 6.1 cMIS and 5.4 open) and postoperative (VAS leg 1.6 cMIS and 3.1 open) leg pain. All cMIS patients had interbody grafts; 35% of open did. There was no difference in change of primary CCA, PI-LL, LL, Oswestry Disability Index, or VAS Back. CONCLUSION: Patients' FCs treated with cMIS had comparable reduction of leg pain compared with those treated with open surgery, despite significantly fewer cMIS patients undergoing direct decompression.

The impact of age on surgical goals for spinopelvic alignment in minimally invasive surgery for adult spinal deformity.

OBJECTIVEAchieving appropriate spinopelvic alignment in deformity surgery has been correlated with improvement in pain and disability. Minimally invasive surgery (MIS) techniques have been used to treat adult spinal deformity (ASD); however, there is concern for inadequate sagittal plane correction. Because age can influence the degree of sagittal correction required, the purpose of this study was to analyze whether obtaining optimal spinopelvic alignment is required in the elderly to obtain clinical improvement.METHODSA multicenter database of ASD patients was queried. Inclusion criteria were age ≥ 18 years; an MIS component as part of the index procedure; at least one of the following: pelvic tilt (PT) > 20°, sagittal vertical axis (SVA) > 50 mm, pelvic incidence to lumbar lordosis (PI-LL) mismatch > 10°, or coronal curve > 20°; and minimum follow-up of 2 years. Patients were stratified into younger (< 65 years) and older (≥ 65 years) cohorts. Within each cohort, patients were categorized into aligned (AL) or mal-aligned (MAL) subgroups based on postoperative radiographic measurements. Mal-alignment was defined as a PI-LL > 10° or SVA > 50 mm. Pre- and postoperative radiographic and clinical outcomes were compared.RESULTSOf the 185 patients, 107 were in the younger cohort and 78 in the older cohort. Based on postoperative radiographs, 36 (33.6%) of the younger patients were in the AL subgroup and 71 (66.4%) were in the MAL subgroup. The older patients were divided into 2 subgroups based on alignment; there were 26 (33.3%) patients in the AL and 52 (66.7%) in the MAL subgroups. Overall, patients within both younger and older cohorts significantly improved with regard to postoperative visual analog scale (VAS) scores for back and leg pain and Oswestry Disability Index (ODI) scores. In the younger cohort, there were no significant differences in postoperative VAS back and leg pain scores between the AL and MAL subgroups. However, the postoperative ODI score of 37.9 in the MAL subgroup was significantly worse than the ODI score of 28.5 in the AL subgroup (p = 0.019). In the older cohort, there were no significant differences in postoperative VAS back and leg pain score or ODI between the AL and MAL subgroups.CONCLUSIONSMIS techniques did not achieve optimal spinopelvic alignment in most cases. However, age appears to impact the degree of sagittal correction required. In older patients, optimal spinopelvic alignment thresholds did not need to be achieved to obtain similar symptomatic improvement. Conversely, in younger patients stricter adherence to optimal spinopelvic alignment thresholds may be needed.https://thejns.org/doi/abs/10.3171/2018.4.SPINE171153.

Curve Laterality for Lateral Lumbar Interbody Fusion in Adult Scoliosis Surgery: The Concave Versus Convex Controversy.

BACKGROUND: Minimally invasive lateral lumbar interbody fusion (LLIF) is an effective adjunct in adult degenerative scoliosis (ADS) surgery. LLIF approaches performed from the concavity or convexity have inherent approach-related risks and benefits. OBJECTIVE: To analyze LLIF approach-related complications and radiographic and clinical outcomes in patients with ADS. METHODS: A multicenter retrospective review of a minimally invasive adult spinal deformity database was queried with a minimum of 2-yr follow-up. Patients were divided into 2 groups as determined by the side of the curve from which the LLIF was performed: concave or convex. RESULTS: No differences between groups were noted in demographic, and preoperative or postoperative radiographic parameters (all P > .05). There were 8 total complications in the convex group (34.8%) and 21 complications in the concave group (52.5%; P = .17). A subgroup analysis was performed in 49 patients in whom L4-5 was in the primary curve and not in the fractional curve. In this subset of patients, there were 6 complications in the convex group (31.6%) compared to 19 in the concave group (63.3%; P < .05) and both groups experienced significant improvements in coronal Cobb angle, Oswestry Disability Index, and Visual Analog Scale score with no difference between groups. CONCLUSION: Patients undergoing LLIF for ADS had no statistically significant clinical or operative complication rates regardless of a concave or convex approach to the curve. Clinical outcomes and coronal plane deformity improved regardless of approach side. However, in cases wherein L4-5 is in the primary curve, approaching the fractional curve at L4-5 from the concavity may be associated with a higher complication rate compared to a convex approach.

Patients with High Pelvic Tilt Achieve the Same Clinical Success as Those with Low Pelvic Tilt After Minimally Invasive Adult Deformity Surgery.

BACKGROUND: Pelvic tilt (PT) is a compensatory mechanism for adult spinal deformity patients to mitigate sagittal imbalance. The association between preop PT and postop clinical and radiographic outcomes has not been well studied in patients undergoing minimally invasive adult deformity surgery. OBJECTIVE: To evaluate clinical and radiographic outcomes in adult spinal deformity patients with high and low preoperative PT treated surgically using less invasive techniques. METHODS: Retrospective case-control, institutional review board-approved study. A multicenter, minimally invasive surgery spinal deformity patient database was queried for 2-yr follow-up with complete radiographic and health-related quality of life (HRQOL) data. Hybrid surgery patients were excluded. Inclusion criteria were as follows: age > 18 and either coronal Cobb angle > 20, sagittal vertical axis > 5 cm, pelvic incidence-lumbar lordosis (PI-LL) > 10 or PT > 20. Patients were stratified by preop PT as per Schwab classification: low (PT< 20), mid (PT 20-30), or high (>30). Postoperative radiographic alignment parameters (PT, PI, LL, Cobb angle, sagittal vertical axis) and HRQOL data (Visual Analog Scale Back/Leg, Oswestry Disability Index) were evaluated and analyzed. RESULTS: One hundred sixty-five patients had complete 2-yr outcomes data, and 64 patients met inclusion criteria (25 low, 21 mid, 18 high PT). High PT group had higher preop PI-LL mismatch (32.1 vs 4.7; P < .001). At last follow-up, 76.5% of patients in the high PT group had continued PI-LL mismatch compared to 34.8% in the low PT group (P < .006). There was a difference between groups in terms of postop changes of PT (-3.9 vs 1.9), LL (8.7 vs 0.5), and PI-LL (-9.5 vs 0.1). Postoperatively, HRQOL data (Oswestry Disability Index and Visual Analog Scale) were significantly improved in both groups (P < .001). CONCLUSION: Adult deformity patients with high preoperative PT treated with minimally invasive surgical techniques had less radiographic success but equivalent clinical outcomes as patients with low PT.

Impact of case type, length of stay, institution type, and comorbidities on Medicare diagnosis-related group reimbursement for adult spinal deformity surgery.

OBJECTIVE The aim of this study was to educate medical professionals about potential financial impacts of improper diagnosis-related group (DRG) coding in adult spinal deformity (ASD) surgery. METHODS Medicare's Inpatient Prospective Payment System PC Pricer database was used to collect 2015 reimbursement data for ASD procedures from 12 hospitals. Case type, hospital type/location, number of operative levels, proper coding, length of stay, and complications/comorbidities (CCs) were analyzed for effects on reimbursement. DRGs were used to categorize cases into 3 types: 1) anterior or posterior only fusion, 2) anterior fusion with posterior percutaneous fixation with no dorsal fusion, and 3) combined anterior and posterior fixation and fusion. RESULTS Pooling institutions, cases were reimbursed the same for single-level and multilevel ASD surgery. Longer stay, from 3 to 8 days, resulted in an additional $1400 per stay. Posterior fusion was an additional $6588, while CCs increased reimbursement by approximately $13,000. Academic institutions received higher reimbursement than private institutions, i.e., approximately $14,000 (Case Types 1 and 2) and approximately $16,000 (Case Type 3). Urban institutions received higher reimbursement than suburban institutions, i.e., approximately $3000 (Case Types 1 and 2) and approximately $3500 (Case Type 3). Longer stay, from 3 to 8 days, increased reimbursement between $208 and $494 for private institutions and between $1397 and $1879 for academic institutions per stay. CONCLUSIONS Reimbursement is based on many factors not controlled by surgeons or hospitals, but proper DRG coding can significantly impact the financial health of hospitals and availability of quality patient care.

Does Spanning a Lateral Lumbar Interbody Cage Across the Vertebral Ring Apophysis Increase Loads Required for Failure and Mitigate Endplate Violation.

STUDY DESIGN: Randomized Biomechanical Cadaveric Study-Level II. OBJECTIVE: We aimed to elucidate that placing lateral lumbar interbody cages that span the stronger ring apophysis will require increasing loads for failure, decreasing rates of subsidence, regardless of bone density or endplate integrity. SUMMARY OF BACKGROUND DATA: There are several reports regarding the rates and grades of cage subsidence when utilizing the lateral lumbar interbody fusion technique. However, there is limited data on how spanning the lateral cage across the ring apophysis can prevent it. METHODS: Eight fresh-frozen human spines (L1-L5) were utilized. Each vertebra was placed with their endplates horizontal in an MTS actuator. A total of 40 specimens were randomized into Groups:Load displacement data was collected at 5 Hz until failure. RESULTS: Longer cages spanning the ring apophysis provided more strength in compression with less subsidence relative to shorter cages, regardless of endplate integrity.Longer cages, spanning the ring apophysis, resting on intact endplates (G2) had a significant (P < 0.05) increase in strength and less subsidence when compared with the smaller cage group resting on intact endplates (G1) (P = 0.003).Longer cages spanning the ring apophysis of intact endplates (G2) showed a significant (P < 0.05) increase in strength and resistance to subsidence when compared with similar length cages resting on decorticated endplates (G4) (P = 0.028). CONCLUSION: Spanning the ring apophysis increased the load to failure by 40% with intact endplates and by 30% with decorticated endplates in this osteoporotic cadaveric model. Larger cages that span the endplate ring apophysis could improve the compressive strength and decrease subsidence at the operative level despite endplate violation or osteoporosis. LEVEL OF EVIDENCE: 2.

Cardiac Emboli Documented by Intraoperative Transesophageal Echocardiogram During Administration of a Topical Hemostatic Agent Prior to Pedicle Subtraction Osteotomy.

STUDY DESIGN: This is a case report. OBJECTIVE: Describe the occurrence of cardiac emboli recorded on transesophageal echocardiogram (TEE) after the injection of a topical hemostatic agent into a vertebra prior to performing a pedicle subtraction osteotomy (PSO). SUMMARY OF BACKGROUND DATA: Hemostasis during spinal surgery is critical for adequate visualization and to reduce the risk of perioperative complications. Adult spinal deformity surgery can involve performing PSOs which are useful in cases of fixed spinal deformities and are associated with increased blood loss secondary to epidural and cancellous bleeding. Prior to performing a PSO, a topical hemostatic agent can be injected into the vertebra through the pedicle screw pilot holes in an attempt to decrease cancellous bleeding. Injected hemostatic agents can pressurize the vertebral body similar to cementation in vertebroplasty and during fracture reaming and prosthetic implantation in the femur. Patients with cardiac defects such as patent foramen ovale or atrial septal defect may be more prone to systemic embolic events resulting in morbidity or mortality. METHODS: We injected a topical hemostatic matrix agent through the pedicle screw pilot holes into the L1 vertebral body prior to performing a PSO while simultaneously recording with TEE. RESULTS: The TEE recorded large visible emboli traveling through the heart into the pulmonary vasculature. The patient remained stable throughout the remainder of the case and a postoperative spiral computed tomography (CT) scan was negative for filling defects. The patient had an uneventful hospital course. CONCLUSION: Questions remain about the exact consistency of these emboli, when they are most likely to occur, how much cardiopulmonary insult can be tolerated without resulting in complications, or how to prevent their occurrence. Patients undergoing spinal surgery with the plan to inject hemostatic matrix agents into the vertebral body may benefit from a preoperative TEE to reduce the risk of complications associated with embolic events, especially in patients with undiagnosed patent foramen ovale or atrial septal defect. LEVEL OF EVIDENCE: 5.

Verification of nerve decompression using mechanomyography.

BACKGROUND CONTEXT: Assessment of nerve root decompression in surgery is largely based on visualization and tactile feedback. Often times, visualization can be limited, such as in minimally invasive surgery, and tactile feedback is a subjective assessment that makes the evaluation of successful nerve decompression difficult. Electromyography (EMG) has been proposed as an assessment tool, but EMG responses are often difficult to quantify. Alternatively, mechanomyography (MMG) provides a quantifiable response with high signal-to-noise ratio compared with EMG. MMG provides a sensitive tool to accurately quantify mechanical responses to motor action potentials generated by electrical stimulus, allowing more reliable assessment of nerve decompression. PURPOSE: The aim of this study was to assess the ability of MMG to quantitatively demonstrate successful nerve root decompression. STUDY DESIGN: Prospective cohort, Therapeutic Level III, Urban Level I Trauma Center. PATIENT SAMPLE: A total of 46 patients (72 affected nerve roots) undergoing decompression procedures for lower extremity radiculopathy caused by nerve root compression were enrolled in the study. The study population included 15 patients with herniated nucleus pulposus (HNP) and 31 with lateral recess stenosis (LRS). OUTCOME MEASURE: Visual analog scale (VAS) score. METHODS: A total of 72 nerves roots in 46 patients undergoing lumbar decompression procedures, for lower extremity radicular symptoms, were tested using MMG. Nerves were stimulated upstream from the compression site, and the lowest threshold current needed to generate a muscle response was determined. Signal response sizes were recorded before and after decompression. VAS scores were collected pre- and postoperatively. RESULTS: Of the patients, 90% (65/72) had elevated stimulation thresholds (>1 milliamp [mA]) before decompression. After decompression, 98% of patients (64/65) with elevated current thresholds exhibited a drop in threshold of ≥1 mA (p<.001). A postdecompression increase in response amplitude was recorded in all patients. VAS scores improved postdecompression (6.8 vs. 1.1, p<.001) with a positive correlation between decreased stimulation thresholds and degree of improvement in VAS scores (p<.001). CONCLUSION: MMG is an effective tool that can be used to differentiate normal and compressed nerves by quantifying the mechanomyographic response to a stimulating current. MMG allows one to measure the effect of decompression, judge its effectiveness in real time, and eliminate the subjectivity seen in tactile feedback methods. When the adequacy of decompression is uncertain, MMG can guide the surgeon toward additional or alternative procedures to ensure complete nerve root decompression.

Comparison of Ocular Radiation Exposure Utilizing Three Types of Leaded Glasses.

STUDY DESIGN: Anthropomorphic phantoms were used to measure radiation exposure to the surgeon phantom's eye. Groups analyzed were: Group 1-no glasses (None); Group 2-leaded lenses without lead sides (WOLS); Group 3-leaded lenses with lead sides (WLS); and Group 4-sport wraparound leaded glasses (Sport). Glasses were 0.75 mm lead equivalent. OBJECTIVE: To evaluate the efficacy of three types of leaded eyeglasses at reducing radiation exposure to the lens during typical views of minimally invasive spine surgery. SUMMARY OF BACKGROUND DATA: Minimally invasive spine surgery relies upon fluoroscopic x-ray. Ocular radiation exposure is associated with cataract formation. Leaded glasses can reduce ocular radiation exposure. METHODS: Fifteen individual 20-second exposures with the fluoroscopic C-arm in the anteroposterior (AP) and lateral positions, with phantom head positioned at 0, 45, and 90 degrees to the fluoroscope were performed. Radiation was measured using a solid-state dosimeter. Student t test was used to calculate significance. RESULTS: All glasses (WOLS, WLS, and Sport) had significant reductions in ocular radiation versus no glasses, at all individual head positions (P ≤ 1.31 × 10). Sport had significantly lower ocular radiation dose than WLS at all head positions except at 90 degrees AP (P = 0.001). WOLS had significantly lower ocular radiation dose than Sport in three out of six cases including phantom head at 0 degrees AP (P = 0.0003), 90 degrees AP (P = 4.46 × 10), and 90 degrees lateral (P = 7.38 × 10). WOLS had significantly lower radiation dosage at all head positions than WLS except at 45 degrees AP (P = 0.303). All glasses resulted in a significant reduction in total radiation dose from all head positions over no glasses (P ≤ 8.37 × 10). CONCLUSION: We demonstrate a significant reduction in ocular radiation exposure with all three types of leaded glasses. Lead glasses, WOLS and Sport, were the most effective at reducing ocular radiation. LEVEL OF EVIDENCE: 3.

Guillain-Barré syndrome after pelvic fracture fixation: a rare cause of postoperative paralysis.

STUDY DESIGN: Case report. OBJECTIVE: To describe the important epidemiology, clinical presentation, and pathophysiology of Guillain-Barré syndrome (GBS) after orthopedic surgery in a trauma patient. SUMMARY OF BACKGROUND DATA: Little in the orthopedic literature describes trauma as an etiology of GBS. We report a case of post-traumatic GBS in a 52-year-old male who developed ascending weakness after experiencing pelvic trauma that required 2 separate orthopedic procedures for pelvic stabilization after a fall from a height of 12 ft. After the index operative procedure, the patient complained of left S1 numbness. Computed tomographic scan demonstrated the pelvic screw approximating the left S1 neuroforamen and correlated with the patient's immediate postoperative symptoms. A secondary procedure to reposition the screw alleviated the patient's left S1 numbness. Two weeks postoperatively, the patient developed profound ascending lower extremity weakness. This case highlights the importance of considering all etiologies, no matter how uncommon, in the differential diagnosis of lower extremity weakness. METHODS: Case report with literature search on GBS in orthopedic trauma patient. RESULTS: We propose that direct neural trauma from poorly positioned hardware resulting in clinical neurological symptoms may have been the inciting event that caused GBS in this trauma patient. CONCLUSION: Post-traumatic GBS is a rare, potentially life-threatening cause of weakness. Once mechanical causes are ruled out with appropriate imaging, all etiologies in the differential diagnosis must be explored. If the image findings cannot explain the clinical examination, other biologic causes of weakness, including GBS, must be explored. The causes of GBS in the postoperative trauma patient include infection, trauma, surgery, or direct neural injury. LEVEL OF EVIDENCE: 4.

Disease severity and treatment in adolescent idiopathic scoliosis: the impact of race and economic status.

BACKGROUND CONTEXT: Ethnic disparities have been documented in the incidence and treatment of many diseases. Additionally, race and socioeconomic status (SES) have been shown to affect disease severity and access to care in the recent orthopedic literature. PURPOSE: To assess the role, if any, that race, SES, and health insurance type play in disease severity and treatment decisions in patients with adolescent idiopathic scoliosis. STUDY DESIGN: Retrospective chart review. PATIENT SAMPLE: Pediatric patients seen in a single surgeon's practice over 6 years (2004-2009). OUTCOME MEASURES: Treatment modality (observation, bracing, or surgery). METHODS: Data were obtained from 403 patients seen over 6 years (2004-2009). A patient-reported questionnaire was used to collect race, age, family income, and parent marital status data. Race was self-reported as "Asian," "black or African American," "Hispanic or Latino," "white or Caucasian," or "Other." Socioeconomic status was determined using family income and type of health insurance as indicators. Major curve magnitude and prescribed initial treatment (observation, brace, or surgery) were assessed from physician records. An independent sample t test was used to detect differences in curve magnitude of the different racial groups. A Pearson chi-square analysis was used to detect group differences for curves in surgical patients, defined as curves greater than 40°, and their initial treatment. RESULTS: Patients self-identified with one of the following racial groups: white (N=219), black (N=86), Hispanic (N=44), Asian (N=37), or Other (N=17). Mean curve magnitude was greater in black than in white patients (33° vs. 28°, p<.05). Black patients were more likely to present with curves in the surgical range (34% vs. 24%, p<.05) and were more likely to have surgery as their initial treatment than white patients (34% vs. 19%, p<.05). Black patients had more limited health care plans and lower incomes compared with whites (p<.001). Patients with higher access insurance plans presented at a younger age than patients with more limited access plans, irrespective of race (13.6 vs. 14.1, p<.05). There was no difference in Cobb angle at presentation by income or type of insurance. CONCLUSIONS: Curve magnitude and percentage of patients with curves in the surgical range were greater in black than in white patients. There was no difference in age on presentation or treatment offered across all racial groups. Black patients were more likely to have surgery as their initial treatment than white patients. While race did have an impact on disease severity in this single surgeon's practice, SES did not.

Lateral lumbar interbody fusion for the correction of spondylolisthesis and adult degenerative scoliosis in high-risk patients: early radiographic results and complications.

BACKGROUND: Lateral lumbar interbody fusion (LLIF) is not associated with many of the complications seen in other interbody fusion techniques. This study used computed tomography (CT) scans, the radiographic gold standard, to assess interbody fusion rates achieved utilizing the LLIF technique in high-risk patients. METHODS: We performed a retrospective review of patients who underwent LLIF between January 2008 and July 2013. Forty-nine patients underwent nonstaged or staged LLIF on 119 levels with posterior correction and augmentation. Per protocol, patients received CT scans at their 1-year follow-up. Of the 49 patients, 21 patients with LLIF intervention on 54 levels met inclusion criteria. Two board-certified musculoskeletal radiologists and the senior surgeon (JZ) assessed fusion. RESULTS: Of the 21 patients, 6 patients had had previous lumbar surgery, and the cohort's comorbidities included osteoporosis, diabetes, obesity, and smoking, among others. Postoperative complications occurred in 12 (57.1%) patients and included anterior thigh pain and weakness in 6 patients, all of which resolved by 6 months. Two cases of proximal junctional kyphosis occurred, along with 1 case of hardware pullout. Two cases of abdominal atonia occurred. By CT scan assessment, each radiologist found fusion was achieved in 53 of 54 levels (98%). The radiologists' findings were in agreement with the senior surgeon. CONCLUSION: Several studies have evaluated LLIF fusion and reported fusion rates between 88%-96%. Our results demonstrate high fusion rates using this technique, despite multiple comorbidities in the patient population. Spanning the ring apophysis with large LLIF cages along with supplemental posterior pedicle screw augmentation can enhance stability of the fusion segment and increase fusion rates.

Establishing a role for vancomycin powder application for prosthetic joint infection prevention-results of a wear simulation study.

Topical vancomycin powder (VP) has shown efficacy and safety in decreasing post-operative spine infections. VP use in arthroplasty has not been established. Concerns remain for third-body wear with the addition of crystalline substrate at the implant interface. The study's purpose was to compare wear behavior of CoCr on UHMWPE to identical wear couples with VP. A six-station wear simulator was utilized and cyclic articulations were run for 10 million cycles (Mc). UHMWPE wear was measured using photography, stereomicroscopy, and gravimetric measurement. There were no differences in wear mark length (P = 0.43), width (P = 0.49), or gravimetric wear at 10 Mc (P = 0.98). VP and control groups lost 0.32 and 0.33 mg, respectively. VP may have a role in PJI prevention. A well-designed clinical study is needed.

Novel concepts in the evaluation and treatment of high-dysplastic spondylolisthesis.

The classification system of spondylolisthesis proposed by Marchetti and Bartolozzi is the most practical regarding prognosis and treatment and includes the description of both low- and high-dysplastic developmental spondylolisthesis (HDDS). Unfortunately, it does not provide strict criteria on how to differentiate between these two subtypes. The accepted treatment for HDDS is surgical. However, there is no consensus on how to surgically stabilize this subtype of spondylolisthesis, and although the concept of reducing spinal deformity before fusion is attractive, the issue of surgical reduction versus in situ fusion remains controversial, especially for HDDS (Meyerding Grades III and IV). The purpose of this study was (1) to describe the severity index (SI) as a simple method that can be used in the identification of low-dysplastic developmental spondylolisthesis from HDDS allowing earlier surgical stabilization to prevent slip progression, (2) to provide guidelines for using the unstable zone for the inclusion of L4 in stabilization, and (3) to describe a surgical technique in the reduction and stabilization of this challenging surgical entity in an attempt to decrease the risk of iatrogenic L5 neurologic injury. The concepts of SI and unstable zone in the evaluation and treatment of HDDS are relatively new. In our study, patients with an SI value >20% were classified as having HDDS and surgical stabilization was offered. In addition, all vertebrae that were contained in the defined unstable zone were surgically instrumented and fused with attempts at anatomic reduction. This case series involved the retrospective radiological review of 25 consecutive patients surgically treated for HDDS between April 2000 and September 2004 by two senior surgeons. All 25 patients had a minimum 3-year follow-up. Reduction of slip, lumbosacral kyphosis, sacral inclination, fusion rate, maintenance of reduction, and iatrogenic L5 neurologic injury were evaluated. Twenty-two patients underwent a single-level L5-S1 fusion. Three patients had extension of the L5-S1 fusion to include L4 because it fell into the unstable zone. Slip improved from 67.2 to 13.6%, focal L5-S1 kyphosis improved from +17.5 degrees to -6.4 degrees . There were no pseudoarthroses and all patients had radiographic evidence of solid bony fusion at latest follow-up. To date, there have been no re-operations secondary to progression of deformity or loss of fixation. Two re-operations were performed, one for a superficial wound infection, the other for further laparoscopic decompression for continued L5 nerve root symptoms after the index surgery. One patient developed an iatrogenic L5 radiculopathy with dysaesthesiae 3 days postoperatively which completely resolved over 6 weeks. HDDS is best treated surgically. Early identification and stabilization of this challenging surgical entity could prevent the progression of slip and deformity making the index surgery less technically demanding. Vertebrae that are contained in the unstable zone can be instrumented and stabilized so that progression of the deformity and re-operation might be avoided. The authors suggested surgical technique can provide a way to restore sagittal balance, provide an environment for successful fusion, and decrease the risk of iatrogenic L5 neurologic injury.