Hypodontia phenotype in patients with epithelial ovarian cancer.

BACKGROUND: Ovarian cancer is usually diagnosed in an advanced stage and the present clinical and diagnostic molecular markers for early OC screening are insufficient. The aim of this study was to identify potential relationship between the hypodontia and epithelial ovarian cancer (EOC). PATIENTS AND METHODS: A retrospective study was conducted on 120 patients with EOC treated at the Department of Gynaecologic and Breast Oncology at the University Clinical Centre and 120 gynaecological healthy women (control group) of the same mean age. Women in both groups were reviewed for the presence of hypodontia and the patients with EOC also for clinicopathological characteristics of EOC according to hypodontia phenotype. RESULTS: Hypodontia was diagnosed in 23 (19.2%) of patients with EOC and 8 (6.7%) controls (p = 0.004; odds ratio [OR] = 3.32; confidence interval [CI], 1.42-7.76). There was no statistically significant difference in patients with EOC with or without hypodontia regarding histological subtype (p = 0.220); they differed in regard to FIGO stage (p = 0.014; OR =3.26; CI, 1.23-8.64) and tumour differentiation grade (p = 0.042; OR = 3.1; CI, 1.01-9.53). Also, bilateral occurrence of EOC was more common than unilateral occurrence in women with hypodontia (p = 0.021; OR = 2.9; CI, 1.15-7.36). We also found statistically significant difference between the ovarian cancer group and control group in presence of other malignant tumours in subjects (p < 0.001). CONCLUSIONS: The results of the study suggest a statistical association between EOC and hypodontia phenotype. Hypodontia might serve as a risk factor for EOC detection.

Temporomandibular joint involvement caused by Borrelia Burgdorferi.

BACKGROUND: Lyme borreliosis is an endemic disease in Slovenia with an incidence of around 150 patients per 100,000 inhabitants. Although the large joints are most typically affected in Lyme borreliosis, there are also periods of disease activity with arthritis or arthralgias involving smaller joints, including the temporo-mandibular joint. PATIENTS: During the years between 2000 and 2003, two patients with Lyme borreliosis affecting the temporo-mandibular joints were treated. The patients presented with fatigue and pain in diverse muscle groups accompanied by arthralgia, which was most pronounced in the temporomandibular joint area. None of the patients were febrile or had joint effusions. METHODS: Both patients were examined by means of biochemical and serological examinations for Borrelia burgdorferi using ELISA assay and Western blot test (both for IgM and IgG), plain radiographs, MR and CT scans, and scinti-scan of the temporo-mandibular joints They both had positive serum markers for an acute B. burgdorferi infection and were treated with intravenous ceftriaxone. RESULTS: None of the patients had clinical or laboratory signs of chronic Lyme disease activity two and four years following therapy, respectively. Roentgenographic and nuclear magnetic resonance imaging of the temporo-mandibular joints had not shown any persistent sign of acute inflammation. CONCLUSION: There are only few reports of patients with manifest temporo-mandibular joint involvement of Lyme borreliosis in the literature. This report emphasizes the importance of differential diagnosis of acute temporo-mandibular joint arthralgia, of early diagnosis of Lyme borreliosis, and of the necessity for prompt antibiotic treatment.

The Ljubljana classification - its application to grading oral epithelial hyperplasia.

INTRODUCTION: The diagnosis, prognosis and treatment of particular pathologic entities of the oral mucosa depend almost exclusively on the histologic changes in the epithelium. The basis for the classification of oral epithelial hyperplastic lesions should be their propensity to progress to invasive cancer. MATERIAL AND METHODS: In a retrospective study, 135 biopsies of oral epithelial hyperplastic lesions from 115 patients were classified according to the Ljubljana classification, which has recently been introduced for the grading of laryngeal hyperplastic epithelial lesions. RESULTS: Seventy nine cases (59%) showed simple, 42 (31%) abnormal and 11 (8%) atypical hyperplasia; carcinoma in situ was found in three cases (2%). During the follow-up, ranging from 3 months to 6 years (median 1 year), two cases of atypical hyperplasia progressed to invasive cancer, whereas none of the cases classified as simple or abnormal hyperplasia showed progression. CONCLUSION: The present study suggests that the Ljubljana classification can be reliably applied for classifying oral epithelial hyperplastic lesions into different risk groups, which is essential for prognosis in order to plan therapy.