PURPOSE: It is important to differentiate between radiation injury (RI) and tumor recurrence (TR) in patients with glioma after surgery and radiotherapy. Our objective was to evaluate the use of dynamic susceptibility contrast-enhanced perfusion-weighted imaging to distinguish between TR and RI in patients with glioma. METHODS: Relevant studies published until October 2021 were identified in the PubMed, Embase, and Cochrane Library databases. Stata v12.0 and RevMan 5.3 were used for meta-analysis. RESULTS: In total, the meta-analysis incorporated 13 retrospective studies that included 513 patients with 522 lesions. Among the 522 lesions, 329 lesions were TRs and 193 lesions were RIs. The pooled relative cerebral blood volume value was significantly greater in the TR group ( P < 0.00001) with significant heterogeneity ( I2 = 88%). The pooled sensitivity, specificity, positive likelihood ratio (PLR), and negative likelihood ratio (NLR) were 83% (95 confidence interval [CI], 77%-88%), 85% (95 CI, 77%-91%), 5.60 (95 CI, 3.61-8.70), and 0.20 (95% CI, 0.14-0.27), respectively. The heterogeneity of sensitivity ( I2 = 33.18%), specificity ( I2 = 24.01%), PLR ( I2 = 0.00%), and NLR ( I2 = 6.68%) is not significant. The area under the receiver operating characteristic curve was 0.91 (95% CI, 0.88-0.93). The 3.0 T magnetic resonance imaging, high-grade glioma, and Europe/America patient subgroups showed PLR greater than 5 and NLR less than 0.2. There was no significant indication of publication bias in the analysis ( P = 0.496). CONCLUSIONS: It is concluded that dynamic susceptibility contrast-enhanced perfusion-weighted imaging is effective for the diagnostic differentiation between TR and RI in patients with glioma.
Glioma , Neuroblastoma , Radiation Injuries , Humans , Retrospective Studies , Radiation Injuries/diagnostic imaging , Glioma/diagnostic imaging , Glioma/surgery , Magnetic Resonance Angiography , Perfusion
ABSTRACT: We aim to compare the diagnostic accuracy, safety, and radiation exposure between low-dose and standard-dose computed tomography (CT)-guided cutting needle biopsy (CNB) for lung nodules.From January 2016 to August 2017, all consecutive patients admitted with lung nodule underwent low-dose or standard-dose CT-guided CNB procedure in our center. Diagnostic accuracy and radiation dose were compared.A total of 67 and 69 patients who underwent low-dose and standard-dose CT-guided CNB procedure were included in this study. Each patient underwent CT-guided CNB for 1 nodule. The technical success rates were 100% in both groups. The sensitivity, specificity, and overall diagnostic accuracy were 97.7%, 100%, and 98.5% for low-dose group and 91.5%, 100%, and 94.2% for standard-dose group. There was no significant difference in diagnostic accuracy (Pâ=â.380) between 2 groups. Pneumothorax was found in 8 and 15 patients in the low-dose and standard-dose groups, respectively (11.9% vs 21.7%, Pâ=â.127). Hemoptysis was found in 10 and 10 patients in the low-dose and standard-dose groups, respectively (14.9% vs 14.5%, Pâ=â.943). The mean dose-length product was 38.2â±â17.2âmGy-cm and 375.3â±â115.7âmGy-cm in the low-dose and standard-dose groups (Pâ<â.001). The mean dose-length product was 38.2â±â17.2âmGy-cm and 375.3â±â115.7âmGy-cm in the low-dose and standard-dose groups, respectively (Pâ<â.001). The mean effective dose was 0.5â±â0.2 mSv and 5.3â±â1.6 mSv in the low-dose and standard-dose groups, respectively (Pâ<â.001).Low-dose CT-guided CNB of lung nodules significantly decreased radiation dose compared with standard-dose CT. The low-dose protocol could provide similar diagnostic accuracy and safety as standard-dose CT-guided CNB for lung nodules.
Biopsy, Needle/methods , Early Detection of Cancer/methods , Image-Guided Biopsy/methods , Lung Neoplasms/diagnosis , Radiation Dosage , Tomography, X-Ray Computed , Aged , Biopsy, Needle/adverse effects , Female , Hemoptysis/etiology , Humans , Image-Guided Biopsy/adverse effects , Lung/pathology , Male , Middle Aged , Pneumothorax/etiology , Radiation Exposure/adverse effects , Radiation Exposure/analysis , Radiation Injuries/etiology , Retrospective Studies , Sensitivity and Specificity
This study focused on the fabrication and characterization of ammonium metatungstate hydrate (AMT) combined with cobalt(III) acetylacetonate (Co(acac)3)-loaded electrospun micro-nanofibers. The morphologies, structures, element distribution, through-pore size, and through-pore size distribution of AMT/Co(acac)3-loaded PAN/PS micro-nanofibers were investigated by a combination of field emission scanning electron microscopy (FESEM), flourier transformation infrared (FTIR) spectroscopy, energy disperse spectroscopy (EDS), through-pore size analyzer, and so on. These micro-nanofibers have many advantages in their potential application as electro-catalysts. The porous and large thorough-pore will benefit for effective electrolyte penetration, in addition to promoting gas bubbles evolving and releasing from catalyst surface timely.
