α-Arylsulfonyloxyacrylates: attractive O-centered electrophiles for synthesis of α-substituted acrylates via Pd-catalysed Suzuki reactions.

We herein report α-arylsulfonyloxyacrylates as a kind of useful and attractive O-centered electrophiles for Suzuki cross-coupling reactions. A range of α-(hetero)aryl substituted acrylates has been prepared via the palladium-catalysed C-C cross-coupling reactions between potassium (hetero)aryltrifluoroborates and α-arylsulfonyloxyacrylates. Moreover, α-arylsulfonyloxyacrylate could also react with B-alkyl-9-BBN to produce α-alkyl substituted acrylates. The synthetic application of this new method was demonstrated by the preparation of the intermediate for synthesis of retinoid X receptors-selective retinoids. These Suzuki reaction-based protocols feature broad substrate scope, generality, and mild reaction conditions.

The risk surveillance of schistosomiasis in Yunnan, 2021 / 中国热带医学

@#Abstract: Objective　To evaluate the potential transmission risk of schistosomiasis in Yunnan Province, and to provide strategic basis for the prevention and control. Methods　Based on the prevalence of schistosomiasis, the social and environmental factors that may lead to the epidemic, 1-3 villages from 3 provincial-level and 15 county-level counties (cities and districts) were selected as the evaluated villages in 2021. The risk of schistosomiasis spread was analyzed comprehensively by consulting, reviewing and collecting routine surveillance data of schistosomiasis in the villages, combined with snail and wild feces survey. The risk level was evaluated for the positive snails, positive wild feces, resident infection, average density of live snails and snail frame occurrence rate. Results　Totally 7 snail counties schistosomiasis transmission was blocked of 18 epidemic counties and the rest were eliminated counties. A total of 152 447 snail frames were investigated and 3 043 frames with snails, 15 895 snails were captured and included 15 727 live snails in the 32 evaluated villages. The total area of snail was 58.87 hm2 and the area of reoccurrence was 34.19 hm2 with snail frame occurrence rate of 2.00% and average density of live snails 0.103 2/0.11 m2, and no positive snails were found by loop-mediated isothermal amplification (LAMP) assay. A total of 1 374 wild feces were collected in 27 evaluated villages of 14 epidemic counties, mainly from cattle, dogs, sheep, equine animals, pigs and so on, all of which were negative. According to the risk assessment of epidemic spread, Yongle Village and Yongsheng Village in Eryuan County, Zhiming Village in Chuxiong City were Ⅱ risk, and the rest were Ⅲ risk. Conclusions　Although the risk of transmission is low in Yunnan Province, the risk of transmission and spread still exists. It is necessary to strengthen the risk monitoring, control of snail and effective management of livestock to prevent the rebound of the epidemic.

Interfacial Shear Performance of Epoxy Adhesive Joints of Prefabricated Elements Made of Ultra-High-Performance Concrete.

Application of ultra-high-performance concrete (UHPC) in joints can improve the impact resistance, crack resistance, and durability of structures. In this paper, the direct shear performance of ultra-high-performance concrete (UHPC) adhesive joints was experimentally studied. Twenty-four direct shear loading tests of UHPC adhesive joints were carried out considering different interface types and constraint states. The failure modes and load-slip curves of different interfaces were studied. Results indicated that passive confinement could enhance the strength and ductility of the interface; the average ultimate bearing capacity of the smooth, rough, grooved, and keyway specimens with passive restraint were, respectively, increased by 11.92%, 8.91%, 11.93%, and 17.766% compared with the unrestrained ones. The passive constraint force changes with the loading and finally tends to be stable. The epoxy adhesive has high reliability as a coating for the UHPC interface. The adhesive layer is not cracked before the failure of the specimen, which is also different from the common failure mode of adhesive joints. Failure of all specimens occurred in the UHPC layer, and the convex part of the groove interface shows the UHPC matrix peeling failure; the keyway interface is the shear damage of the key-tooth root, and the rest of the keyway showed UHPC surface peeling failure. According to the failure mode, the shear capacity of UHPC keyway adhesive joints under passive restraint is mainly provided by the shear resistance of key teeth, the friction force of the joint surface, and the bonding force of the UHPC surface. The friction coefficient was determined based on the test results, and the high-precision fitting formula between the shear strength of the UHPC surface and the passive constraint force was established. According to the Mohr stress circle theory, the proposed formula for direct shear strength of UHPC bonded joints under passive constraint was established. The average ratio of the proposed UHPC adhesive joint calculation formula to the test results was 0.99, and the standard deviation was 0.027.