Printable and flexible integrated sensing systems for wireless healthcare.

The rapid development of wearable sensing devices and artificial intelligence has enabled portable and wireless tracking of human health, fulfilling the promise of digitalized healthcare applications. To achieve versatile design and integration of multi-functional modules including sensors and data transmission units onto various flexible platforms, printable technologies emerged as some of the most promising strategies. This review first introduces the commonly utilized printing technologies, followed by discussion of the printable ink formulations and flexible substrates to ensure reliable device fabrication and system integration. The advances of printable sensors for body status monitoring are then discussed. Moreover, the integration of wireless data transmission via printable approaches is also presented. Finally, the challenges in achieving printable sensing devices and wireless integrated systems with competitive performances are considered, so as to realize their practical applications for personalized healthcare.

A monolithically integrated in-textile wristband for wireless epidermal biosensing.

Textile bioelectronics that allow comfortable epidermal contact hold great promise in noninvasive biosensing. However, their applications are limited mainly because of the large intrinsic electrical resistance and low compatibility for electronics integration. We report an integrated wristband that consists of multifunctional modules in a single piece of textile to realize wireless epidermal biosensing. The in-textile metallic patterning and reliable interconnect encapsulation contribute to the excellent electrical conductivity, mechanical robustness, and waterproofness that are competitive with conventional flexible devices. Moreover, the well-maintained porous textile architectures deliver air permeability of 79 mm s-1 and moisture permeability of 270 g m-2 day-1, which are more than one order of magnitude higher than medical tapes, thus ensuring superior wearing comfort. The integrated in-textile wristband performed continuous sweat potassium monitoring in the range of 0.3 to 40 mM with long-term stability, demonstrating its great potential for wearable fitness monitoring and point-of-care testing.

Fully Integrated Patch Based on Lamellar Porous Film Assisted GaN Optopairs for Wireless Intelligent Respiratory Monitoring.

Respiratory pattern is one of the most crucial indicators for accessing human health, but there has been limited success in implementing fast-responsive, affordable, and miniaturized platforms with the capability for smart recognition. Herein, a fully integrated and flexible patch for wireless intelligent respiratory monitoring based on a lamellar porous film functionalized GaN optoelectronic chip with a desirable response to relative humidity (RH) variation is reported. The submillimeter-sized GaN device exhibits a high sensitivity of 13.2 nA/%RH at 2-70%RH and 61.5 nA/%RH at 70-90%RH, and a fast response/recovery time of 12.5 s/6 s. With the integration of a wireless data transmission module and the assistance of machine learning based on 1-D convolutional neural networks, seven breathing patterns are identified with an overall classification accuracy of >96%. This integrated and flexible on-mask sensing platform successfully demonstrates real-time and intelligent respiratory monitoring capability, showing great promise for practical healthcare applications.

Corn Steep Liquor: Green Biological Resources for Bioindustry.

Corn steep liquor (CSL) is a by-product of the wet milling process and contains mostly crude proteins, amino acids, minerals, vitamins, reducing sugars, organic acids, enzymes and other nutrients. The concentration of organic matter in the CSL is high and the yield is large. If directly discharged into the integrated wastewater treatment system, the load and cost of wastewater treatment will be greatly increased. On the other hand, most of the organic matter in the CSL is a valuable resource that can be reused and recovered, and has a significant resource potential. How to develop and utilize CSL has become a major problem faced by enterprises and society. In recent years, people have done a lot of research on the comprehensive utilization of CSL. CSL is commonly used as an inexpensive source of nitrogen, carbon or vitamins in the production of glutamate, antibiotics, lactic acid and other biotechnologies. This article reviews the active ingredients of CSL and their analytical methods, as well as its use for microbial culture medium, low-cost animal feed, biosurfactant, and biostimulant.

Reduced graphene oxide-based highly sensitive pressure sensor for wearable electronics via an ordered structure and enhanced interlayer interaction mechanism.

Compressible carbon materials have promising applications in various wearable devices. However, it is still difficult to prepare a carbon material with superior mechanical properties, stable strain-electrical signal response, and high linear sensitivity. In this study, a compressible and conductive carbon aerogel with excellent properties is obtained by designing an ordered wavy layered structure with enhanced interactions between carbon layers. Bidirectional freezing is used to produce a wavy layered structure. Cellulose nanocrystals (CNC) and lignin play important roles in enhancing the interactions between reduced graphene oxide (rGO) layers. Due to the design of the carbon aerogel structure and interlayer interactions, the prepared carbon aerogel exhibits supercompressibility (up to 99% ultimate strain), excellent elasticity and fatigue resistance (91.3% height retention after 10 000 cycles at a strain of 30%), and stable strain-current response. Moreover, the carbon aerogel demonstrated an ultrahigh sensitivity of 190.94 kPa-1, a wide linear range (within strain of 0-80%), and a low detection limit for pressure (0.875 Pa). These advantages suggest that this carbon aerogel has great application potential in wearable devices.