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In order to analyze the similarities and differences of chemical compositions between the roots and stems and leaves of Isodon japonicus(IJ), this study utilized UPLC-Q-TOF-MS technology to systematically characterize its chemical compositions, analyzed and identified the structure of its main compounds, and established a method for simultaneous determination of its content by refe-rence substance. A total of 34 major compounds in IJ, including 14 reference compounds, were identified or predicted online. Moreover, an UPLC-UV content determination method was developed for 11 compounds [danshensu, caffeic acid, vicenin-2,(1S,2S)-globoidnan B, rutin,(+)-rabdosiin,(-)-rabdosiin,(1S,2S)-rabdosiin, shimobashiric acid C, rosmarinic acid, and pedalitin]. The method exhibited excellent separation, stability, and repeatability, with a wide linear range(0.10-520.00 µg·mL~(-1)) and high linearity(R~2>0.999). The average recovery rates ranged from 94.72% to 104.2%. The principal component analysis(PCA) demonstrated a clear difference between the roots and stems and leaves of IJ, indicating good separation by cluster. Furthermore, the orthogonal partial least squares discriminant analysis(OPLS-DA) model was employed, and six main differentially identified compounds were identified: rosmarinic acid, shimobashiric acid C, epinodosin, pedalitin, rutin, and(1S,2S)-rabdosiin. In summary, this study established a strategy and method for distinguishing different parts of IJ, providing a valuable tool for quality control of IJ and a basis for the ratio-nal utilization and sustainable development of IJ.
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Quimiometría , Medicamentos Herbarios Chinos , Isodon , Espectrometría de Masas , Hojas de la Planta , Cromatografía Líquida de Alta Presión/métodos , Isodon/química , Espectrometría de Masas/métodos , Quimiometría/métodos , Hojas de la Planta/química , Medicamentos Herbarios Chinos/química , Medicamentos Herbarios Chinos/análisis , Raíces de Plantas/química , Tallos de la Planta/químicaRESUMEN
PURPOSE: To systematically evaluate the relationship between cutaneous immunerelated adverse events (cirAEs) and the efficacy of PD-1/PD-L1 in the treatment of non-small cell lung cancer (NSCLC) and to provide an evidence-based reference for the clinical application of PD-1/PD-L1 and safety evaluation. METHODS: Electronic databases (PubMed, Embase, Medline, Web of Science, and the Cochrane Library) were screened systematically to collect prospective or retrospective cohort studies on the correlation between cirAEs and efficacy of PD-1/PD-L1 in the treatment of NSCLC. RESULTS: A total of 3514 participants were included in 13 cohort studies (enclosing an ambidirectional cohort study). Outcomes revealed that compared with those patients with non cirAEs, patients suffering cirAEs were associated with significantly higher objective response rate (ORR) [risk ratio (RR): 1.74, 95% confidence interval (CI): 1.42-2.14, P<0.00001], longer progressionfree survival (PFS) [RR: 0.52, 95% CI: 0.45-0.60, P<0.00001], and longer overall survival (OS) [RR:0.46, 95% CI: 0.38-0.56]. Sensitivity analyses through the exclusion of one study at a time did not significantly influence the outcomes, indicating that the meta-analysis results were relatively robust. Furthermore, subgroup analyses revealed consistent results in the study design (prospective or retrospective cohort studies), as well as in the endpoint results (PFS and OS) of Kaplan-Meier curves or Cox proportional hazards regression for evaluable patients. CONCLUSION: Currently, evidence reveals that cirAEs development may be associated with a good prognosis and can be an early predictor of the efficacy of PD-1/PD-L1 in the treatment of NSCLC patients.
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BACKGROUND: Laparoscopic radical gastrectomy is widely used, and perioperative complications have become a highly concerned issue. AIM: To develop a predictive model for complications in laparoscopic radical gastrectomy for gastric cancer to better predict the likelihood of complications in gastric cancer patients within 30 days after surgery, guide perioperative treatment strategies for gastric cancer patients, and prevent serious complications. METHODS: In total, 998 patients who underwent laparoscopic radical gastrectomy for gastric cancer at 16 Chinese medical centers were included in the training group for the complication model, and 398 patients were included in the validation group. The clinicopathological data and 30-d postoperative complications of gastric cancer patients were collected. Three machine learning methods, lasso regression, random forest, and artificial neural networks, were used to construct postoperative complication prediction models for laparoscopic distal gastrectomy and laparoscopic total gastrectomy, and their prediction efficacy and accuracy were evaluated. RESULTS: The constructed complication model, particularly the random forest model, could better predict serious complications in gastric cancer patients undergoing laparoscopic radical gastrectomy. It exhibited stable performance in external validation and is worthy of further promotion in more centers. CONCLUSION: Using the risk factors identified in multicenter datasets, highly sensitive risk prediction models for complications following laparoscopic radical gastrectomy were established. We hope to facilitate the diagnosis and treatment of preoperative and postoperative decision-making by using these models.
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Laparoscopía , Neoplasias Gástricas , Humanos , Neoplasias Gástricas/patología , Estudios Retrospectivos , Complicaciones Posoperatorias/epidemiología , Complicaciones Posoperatorias/etiología , Complicaciones Posoperatorias/cirugía , Laparoscopía/efectos adversos , Gastrectomía/efectos adversos , Gastrectomía/métodos , Resultado del TratamientoRESUMEN
C. vulgaris has a positive effect on the removal of nutrients from pig farm biogas slurry. However, swine wastewater often contains heavy metal ions, such as Cu (II), which may have impacts on the nutrient removal performance of C. vulgaris. Additionally, the heavy metal ions in wastewater can be adsorbed by microalgae. In this study, the stress effect of Cu (II) on the growth of Chlorella vulgaris, the Cu (II) removal by microalgae, and the effect of different concentrations of Cu (II) on the nutrient removal efficiency of C. vulgaris in biogas slurries were explored. The results showed that the microalgae biomass of microalgae on the sixth day of the experiment was the highest in the treatment with a Cu (II) concentration of 0.5 mg/L, which was 30.1% higher than that of the 2.5 mg/L group. C. vulgaris had higher removal efficiencies of Cu (II) at a Cu (II) concentration of 0.1~1.5 mg/L. The-OH, C=O, -COOH, and C-O groups on the surface of the algal cells play a significant role in the removal of Cu (II). The removal rates of COD, NH3-N, TN, and TP by C. vulgaris at a Cu (II) concentration of 0.5 mg/L were the highest, which were 89.0%, 53.7%, 69.6%, and 47.3%, respectively.
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CONTEXT: Shenxiang Suhe pill (SXSH), a traditional Chinese medicine, is clinically effective against coronary heart disease, but the mechanism of cardiac-protective function is unclear. OBJECTIVE: We investigated the cardiac-protective mechanism of SXSH via modulating gut microbiota and metabolite profiles. MATERIALS AND METHODS: Sprague-Dawley (SD) male rats were randomly divided into 6 groups (n = 8): Sham, Model, SXSH (Low, 0.063 g/kg; Medium, 0.126 g/kg; High, 0.252 g/kg), and Ato (atorvastatin, 20 mg/kg). Besides the Sham group, rats were modelled with acute myocardial infarction (AMI) by ligating the anterior descending branch of the left coronary artery (LAD). After 3, 7, 14 days' administration, ultrasound, H&E staining, serum enzymic assay, 16S rRNA sequencing were conducted to investigate the SXSH efficacy. Afterwards, five groups of rats: Sham, Model, Model-ABX (AMI with antibiotics-feeding), SXSH (0.126 g/kg), SXSH-ABX were administrated for 14 days to evaluate the gut microbiota-dependent SXSH efficacy, and serum untargeted metabolomics test was performed. RESULTS: 0.126 g/kg of SXSH intervention for 14 days increased ejection fraction (EF, 78.22%), fractional shortening (FS, 109.07%), and aortic valve flow velocities (AV, 21.62%), reduced lesion area, and decreased serum LDH (8.49%) and CK-MB (10.79%). Meanwhile, SXSH upregulated the abundance of Muribaculaceae (199.71%), Allobaculum (1744.09%), and downregulated Lactobacillus (65.51%). The cardiac-protective effect of SXSH was disrupted by antibiotics administration. SXSH altered serum metabolites levels, such as downregulation of 2-n-tetrahydrothiophenecarboxylic acid (THTC, 1.73%), and lysophosphatidylcholine (lysoPC, 4.61%). DISCUSSION AND CONCLUSION: The cardiac-protective effect and suggested mechanism of SXSH could provide a theoretical basis for expanding its application in clinic.
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Microbioma Gastrointestinal , Infarto del Miocardio , Ratas , Masculino , Animales , Ratas Sprague-Dawley , ARN Ribosómico 16S , Infarto del Miocardio/tratamiento farmacológico , Infarto del Miocardio/metabolismo , Antibacterianos/farmacologíaRESUMEN
Background: Current clinical treatments for gastric cancer (GC), particularly advanced GC, lack infallible therapeutic targets. The 3'-untranslated region (3'-UTR) has attracted increasing attention as a drug target. Methods: In vitro and in vivo experiments were conducted to determine the function of FN1 3'-UTR and FN1 protein in invasion and metastasis. RNA pull-down assay and high-throughput sequencing were used to screen the factors regulated by FN1 3'-UTR and construct the regulatory network. Western blotting and polymerase chain reaction were used to examine the correlation of intermolecular expression levels. RNA-binding protein immunoprecipitation was used to verify the correlation between FN1 3'-UTR and target mRNAs. Results: The FN1 3'-UTR may have stronger prognostic implications than the FN1 protein in GC patients. Upregulation of FN1 3'-UTR significantly promoted the invasive and metastatic abilities of GC cells to a greater extent than FN1 protein in vitro and in vivo. A novel regulatory network was constructed based on the FN1 3'-UTR-let-7i-5p-THBS1 axis, wherein FN1 3'-UTR displayed stronger oncogenic effects than the FN1 protein. Conclusions: FN1 3'-UTR may be a better therapeutic target for constructing targeted drugs in GC than the FN1 protein.
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Fibronectinas , MicroARNs , Neoplasias Gástricas , Humanos , Regiones no Traducidas 3'/genética , Línea Celular Tumoral , Movimiento Celular/genética , Proliferación Celular/genética , Fibronectinas/genética , Fibronectinas/metabolismo , Regulación Neoplásica de la Expresión Génica , MicroARNs/genética , MicroARNs/metabolismo , ARN Mensajero/genética , Neoplasias Gástricas/patologíaRESUMEN
Accurate carbon price prediction is a crucial task for the carbon trading market. Previous studies have ignored the impact of online data and are limited to point predictions, which brings challenges to the accurate forecasting of carbon prices. To address those issues, this paper proposes an interval-valued carbon price forecasting method based on web search data and social media sentiment. First, we collect web search data and social media sentiment to improve prediction performance by synthesizing multiple types of data information. Second, we employ principal component analysis (PCA) to preprocess high-dimensional web search data, and utilize BosonNLP for quantifying social media information, thereby enhancing the predictability of the dataset. Subsequently, a variational mode decomposition (VMD) is applied to the carbon price and online data, followed by utilizing particle swarm optimization support vector regression (PSO-SVR) to predict each sub-modes and summing them up to obtain the ultimate forecasting outcome. Finally, using carbon prices in Guangdong and Hubei provinces as case studies, the experimental results demonstrate that web search data and social media sentiment significantly enhance the predictive accuracy of interval-valued carbon prices. Furthermore, the proposed VMD-PSO-SVR outperforms other comparative models in the accuracy and reliability of interval-valued forecasting.
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Medios de Comunicación Sociales , Humanos , Carbono , Reproducibilidad de los Resultados , Predicción , ActitudRESUMEN
Accurate quantitative analysis of trace analytes in a complicated matrix is a challenge in modern analytical chemistry. An appropriate analytical method is considered to be one of the most common gaps during the whole process. In this study, a green and efficient strategy based on miniaturized matrix solid-phase dispersion and solid-phase extraction combined with capillary electrophoresis was first proposed for extracting, purifying and determining target analytes from complicated matrix, using Wubi Shanyao Pill as an example. In detail, 60 mg of samples were dispersed on MCM-48 to obtain high yields of analytes, then the extract was purified with a solid-phase extraction cartridge. Finally, four analytes in the purified sample solution were determined by capillary electrophoresis. The parameters affecting the extraction efficiency of matrix solid-phase dispersion, purification efficiency of solid-phase extraction and separation effect of capillary electrophoresis were investigated. Under the optimized conditions, all analytes demonstrated satisfactory linearity (R2 >0.9983). What's more, the superior green potential of the developed method for the determination of complex samples was confirmed by the Analytical GREEnness Metric Approach. The established method was successfully applied in the accurate determination of target analytes in Wubi Shanyao Pill and thus provided reliable, sensitive, and efficient strategy support for its quality control.
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Electroforesis Capilar , Extracción en Fase Sólida , Extracción en Fase Sólida/métodos , Cromatografía Líquida de Alta PresiónRESUMEN
Self-assembled short peptides have intrigued scientists due to the convenience of synthesis, good biocompatibility, low toxicity, inherent biodegradability and fast response to change in the physiological environment. Therefore, it is necessary to present a comprehensive summary of the recent advances in the last decade regarding the construction, route of administration and application of self-assembled short peptides based on the knowledge on their unique and specific ability of self-assembly. Herein, we firstly explored the molecular mechanisms of self-assembly of short peptides, such as non-modified amino acids, as well as Fmoc-modified, N-functionalized, and C-functionalized peptides. Next, cell penetration, fusion, and peptide targeting in peptide-based drug delivery were characterized. Then, the common administration routes and the potential pharmaceutical applications (drug delivery, antibacterial activity, stabilizers, imaging agents, and applications in bioengineering) of peptide drugs were respectively summarized. Last but not least, some general conclusions and future perspectives in the relevant fields were briefly listed. Although with certain challenges, great opportunities are offered by self-assembled short peptides to the fascinating area of drug development.
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Gel polymer electrolytes (GPE) are promising next-generation electrolytes for high-energy batteries, combining the multiple advantages of liquid and all-solid-state electrolytes. Herein, we a synthesized GPE using poly(ethylene glycol)acrylate (PEGDA) in order to understand how the GPE efficiently inhibits lithium dendrite formation and growth. The effects of PEGDA on the solvation shell structure of the lithium ion are investigated using density functional theory (DFT) and abâ initio molecular dynamics (AIMD) simulations, which are also supported by Raman spectroscopy. The GPE electrolytes with optimal PEGDA concentration exhibit high transference numbers (t Li + ${{_{{\rm Li}{^{+}}}}}$ =0.72) and ionic conductivity (σ=3.24â mS cm-1 ). A symmetric lithium ion battery using GPE can be stably cycled for 1200â h in comparison to 320â h in a liquid electrolyte (LE), possibly owing to the high content of LiF (17.9 %) in the solid-electrolyte interphase film of the GPE cell. The observed concentration/electric field gradient observed through the finite element method also accounts for the good cycling performance. In addition, a LiCoO2 |GPE|Li cell demonstrates excellent capacity retention of 87.09 % for 200â cycles; this approach could present promising guidelines for the design of high-energy lithium batteries.
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Single-atom catalysts have been paid more attention to improving sluggish reaction kinetics and anchoring polysulfide for lithium-sulfur (Li-S) batteries. It has been demonstrated that d-block single-atom elements in the fourth period can chemically interact with the local environment, leading to effective adsorption and catalytic activity toward lithium polysulfides. Enlightened by theoretical screening, for the first time, we design novel single-atom Nb catalysts toward improved sulfur immobilization and catalyzation. Calculations reveal that Nb-N4 active moiety possesses abundant unfilled antibonding orbitals, which promotes d-p hybridization and enhances anchoring capability toward lithium polysulfides via a "trapping-coupling-conversion" mechanism. The Nb-SAs@NC cell exhibits a high capacity retention of over 85% after 1000 cycles, a superior rate performance of 740 mA h g-1 at 7 C, and a competitive areal capacity of 5.2 mAh cm-2 (5.6 mg cm-2). Our work provides a new perspective to extend cathodes enabling high-energy-density Li-S batteries.
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In this brief, we define a self-limiting control term, which has the function of guaranteeing the boundedness of variables. Then, we apply it to a finite-time stability control problem. For nonstrict feedback nonlinear systems, a finite-time adaptive control scheme, which contains a piecewise differentiable function, is proposed. This scheme can eliminate the singularity of derivative of a fractional exponential function. By adding a self-limiting term to the controller and the virtual control law of each subsystem, the boundedness of the overall system state is guaranteed. Then the unknown continuous functions are estimated by neural networks (NNs). The output of the closed-loop system tracks the desired trajectory, and the tracking error converges to a small neighborhood of the equilibrium point in finite time. The theoretical results are illustrated by a simulation example.
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OBJECTIVE: This study was conducted to determine the optimal dose of novel iron amino acid complexes (Fe-Lys-Glu) by measuring laying performance, egg quality, egg iron (Fe) concentrations, and blood biochemical parameters in laying hens. METHODS: A total of 1,260 18-week-old healthy Beijing White laying hens were randomly divided into 7 groups with 12 replicates of 15 birds each. After a 2-wk acclimation to the basal diet, hens were fed diets supplemented with 0 (negative control, the analyzed innate iron content was 75.06 mg/kg), 15, 30, 45, 60, and 75 mg Fe/kg as Fe-Lys-Glu or 45 mg Fe/kg from FeSO4 (positive control) for 24 wk. RESULTS: Results showed that compared with the negative and positive control groups, dietary supplementation with 30 to 75 mg Fe/kg from Fe-Lys-Glu significantly (linear and quadratic, p<0.05) increased the laying rate (LR) and average daily egg weight (ADEW); hens administered 45 to 75 mg Fe/kg as Fe-Lys-Glu showed a remarkable (linear, p<0.05) decrease in feed conversion ratio. There were no significant differences among all groups in egg quality. The iron concentrations in egg yolk and serum were elevated by increasing Fe-Lys-Glu levels, and the highest iron content was found in 75 mg Fe/kg group. In addition, hens fed 45 mg Fe/kg from Fe-Lys-Glu had (linear and quadratic, p<0.05) higher yolk Fe contents than that with the same dosage of FeSO4 supplementation. The red blood cell (RBC) count and hemoglobin content (linear and quadratic, p<0.05) increased obviously in the groups fed with 30 to 75 mg Fe/kg as Fe-Lys-Glu in comparison with the control group. Fe-Lys-Glu supplementation also (linear and quadratic, p<0.05) enhanced the activity of copper/zinc-superoxide dismutase (Cu/Zn-SOD) in serum, as a result, the serum malonaldehyde content (linear and quadratic, p<0.05) decreased in hens received 60 to 75 mg Fe/kg as Fe-Lys-Glu. CONCLUSION: Supplementation Fe-Lys-Glu in laying hens could substitute for FeSO4 and the optimal additive levels of Fe-Lys-Glu are 45 mg Fe/kg in layers diets based on the quadratic regression analysis of LR, ADEW, RBC, and Cu/Zn-SOD.
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The purpose of this paper is centred on the kinetics of removal of main pollutants in wastewater and to compared different hydraulic loading conditions of the constructed rapid infiltration system (CRI system) in terms of removal efficiencies, effluent concentrations, mass removal rate (MRR), and the first-order removal rate coefficient (k) of COD, TOC, NH4+-N, TN, and TP. The results showed that the higher the hydraulic loading, the higher the effluent concentration. The results that synthesized hydraulic loading, effluent concentrations, removal efficiencies, and other conditions showed that the best hydraulic loading was 40â cm/d. When the hydraulic load was 40â cm/d, the effluent average concentrations of COD, TOC, NH4+-N, TN, TP, Cu2+ and the removal efficiencies were 27.31 ± 16.40â mg/L, 86.11%, 10.55 ± 5.25â mg/L, 84.64%, 0.59 ± 0.87â mg/L, 99.60%, 143.31 ± 14.77â mg/L, 7.04%, 5.64 ± 1.38â mg/L, 79.20%, and 0.13 ± 0.47â mg/L, 97.51%, respectively. According to a kinetic study of the primary pollutants, the MRR increased with an increase in the hydraulic loading, except for ammonia nitrogen. CRI-3, CRI-4 were high significant correlated with ammonia nitrogen (with R2 = 93.65% and R2 = 95.03%, respectively), while CRI-2, CRI-3, and CRI-4 were high significant correlated with total nitrogen (with R2 = 94.56%, R2 = 96.70% and R2 = 96.56% respectively).
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Eliminación de Residuos Líquidos , Aguas Residuales , Animales , Porcinos , Eliminación de Residuos Líquidos/métodos , Amoníaco , Cinética , NitrógenoRESUMEN
Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase and an adaptor protein that primarily regulates adhesion signaling and cell migration. FAK promotes cell survival in response to stress. Increasing evidence has shown that at the pathological level, FAK is highly expressed in multiple tumors in several systems (including lung, liver, gastric, and colorectal cancers) and correlates with tumor aggressiveness and patient prognosis. At the molecular level, FAK promotes tumor progression mainly by altering survival signals, invasive capacity, epithelial-mesenchymal transition, the tumor microenvironment, the Warburg effect, and stemness of tumor cells. Many effective drugs have been developed based on the comprehensive role of FAK in tumor cells. In addition, its potential as a tumor marker cannot be ignored. Here, we discuss the pathological and pre-clinical evidence of the role of FAK in cancer development; we hope that these findings will assist in FAK-based clinical studies.
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In this study, an (A-R)TiO2 catalyst (ART) was prepared via the sol-gel method, and g-C3N4 (CN) was used as an amendment to prepare the g-C3N4/(A-R)TiO2 composite catalyst (ARTCN). X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), Raman spectroscopy, N2 adsorption-desorption curves (BET), UV-Vis diffuse absorption spectroscopy (UV-Vis DRS), and fluorescence spectroscopy (PL) were used to evaluate the structure, morphology, specific surface area, optical properties, and photocarrier separation ability of the catalysts. The results showed that when the modifier CN content was 0.5 g, the dispersion of the ARTCN composite catalyst was better, with stronger light absorption performance, and the forbidden band width was smaller. Moreover, the photogenerated electrons in the conduction band of ART transferred to the valence band of CN and combined with the holes in the valence band of CN, forming Z-type heterostructures that significantly improved the efficiency of the photogenerated electron-hole migration and separation, thus increasing the reaction rate. Gaseous and liquid ammonia were used as the target pollutants to investigate the activity of the prepared catalysts, and the results showed that the air wetness and initial concentration of ammonia had a great influence on the degradation of gaseous ammonia. When the initial concentration of ammonia was 50 mg/m3 and the flow rate of the moist air was 0.9 mL/min, the degradation rate of gaseous ammonia by ARTCN-0.5 reached 88.86%, and it had good repeatability. When the catalytic dose was 50 mg and the initial concentration of NH4+ was 100 mg/L, the degradation rate of liquid ammonia by ARTCN-0.5 was 71.60% after 3 h of reaction, and small amounts of NO3- and NO2- were generated. The superoxide anion radical (·O2-) and hydroxyl radical (·OH) were the main active components in the photocatalytic reaction process.
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Amoníaco , Gases , Luz , CatálisisRESUMEN
In order to analyze the intervention effect of integrating mental health knowledge into ideological and political teaching on college students' employment and entrepreneurship mentality, this paper proposes a study to predict the effect of integrated intervention. This research mainly investigates the ideological and psychological conditions of college students from divorced families through questionnaires, compares and analyzes the classification and statistical results of the survey data between groups and within groups, and analyzes the reasons for the ideological and psychological problems of college students. The experimental results show that 30% of college students from divorced families and college students from non-divorced families responded that they do not feel comfortable in places with many people, and the difference between the groups is not significant. Regarding the concept of entrepreneurship, 64.63% of college students from divorced families in urban areas believe that entrepreneurship is a form of learning and should be encouraged. 63.27% of college students from divorced families in rural areas believe that learning should be the first priority and that a business should not be started. 20.41% of college students from divorced families in rural areas and 25.61% of college students from divorced families in urban areas believe that because entrepreneurship provides economic income, it can reduce the burden on families, but the difference is not obvious. In short, this study can provide reference for the ideological and psychological status of college students from divorced families.
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{001}TiO2/TiOF2 photocatalytic composites with a high activity {001} crystal plane were prepared by one-step hydrothermal methods using butyl titanate as a titanium source and hydrofluoric acid as a fluorine source. X-ray diffraction (XRD), scanning electron microscopy (SEM), high-resolution transmission electron microscopy (HRTEM), raman spectroscopy, N2 adsorption-desorption curve (BET), UV-Vis diffuse absorption spectroscopy (UV-Vis DRS), X-ray photoelectron spectroscopy (XPS), and fluorescence spectroscopy (PL) were used to evaluate the structure, morphology, specific surface area, optical properties, and photocarrier separation ability of {001}TiO2/TiOF2. Ammonia nitrogen was taken as the target pollutant, and the degradation performance of the catalyst was investigated. The results show that hydrofluoric acid improves the content of {001} crystal plane of TiO2 with high activity; it also improves the specific surface area and dispersion of the composite material and adjusts the ratio of {001}TiO2 to TiOF2 in the composite material to enhance the absorption capacity of the composite material and reduce the band gap width of the composite material. The degradation rate of ammonia nitrogen by 100 mg F15 is 93.19% when the initial concentration of ammonia nitrogen is 100 mg/L and pH is 10. Throughout the reaction process, the {001}TiO2/TiOF2 composite produces superoxide anion radical (·O2-) and hydroxyl radical (·OH) to oxidize NH3·H2O and generate N2 accompanied by a small amount of NO3- and NO2-.