Eficacia de la netilmicina en infecciones de vías urinarias / Effectivenes of netilmycin in infections of urinary tract

Se estudiaron 20 pacientes de ambos sexos, de edades primedio de 39 años, con infección no complicada de las vías urinarias, sintomáticos y con bacteriuria, causada por gérmenes susceptibles "in vitro" a < 1.25 mcg/ml de netilmicina. El aminoglucósido se administró en una dosis única diaria intramuscular de 3 mg/kg de peso corporal durante 14 días. Antes de aplicar el esquema terapéutico, durante la ejecución del mismo ya continuación se reañozarpm estidops de ñabpratprop ára evaluar las funciones renal, hepática y hematopoyética, asi como audiometrías y pruebas calóricas para valorar las funciones coclear y vestibular del VII nervio craneal. Se determinó la biodisponibilidad del antimicrobiano en el plasma de los pacientes los días 2, 5, 9 y 14 de tratamiento.

Respiratory Activity of the Mycelium of Eremothecium ashbyii.

The respiratory activity of the mycelium of Eremothecium ashbyii from submerged cultures was manometrically determined at different stages of its development and the results were statistically analyzed. The experiments were performed in a manner designed to diminish the endogenous respiration without affecting the response to the addition of an exogenous substrate. Lactose was the carbohydrate tested that produced the lowest oxygen consumption. The oxidation of maltose, which was high at 24 hr, decreased by more than 50% at 48 and 55 hr. Glucose and sucrose were actively oxidized by mycelium of three ages. From the intermediates of carbohydrate metabolism, 24-hr mycelium did not produce oxygen consumption with malate, lactate, citrate, fumarate, and alpha-ketoglutarate. At 48 hr, mycelium did not oxidize either lactate or citrate; 55-hr mycelium showed oxygen consumption with all intermediates tested. Acetate and pyruvate always produced high oxygen consumption. Ethyl alcohol produced high oxygen consumption with mycelium of all tested ages.