RESUMEN
BACKGROUND: Despite good manufacturing practice and quality control, consumer products can become contaminated. In some cases, this can result in severe and life-threatening intoxication with potentially fatal consequences. CASE DESCRIPTION: A 27-year-old man and a 28-year-old pregnant woman presented to the Emergency Department with severe anticholinergic syndrome after using a marshmallow root (Althaea officinalis) herbal remedy, mixed into hot chocolate drink, to reduce symptoms of common cold. After a short stay in Intensive Care, the symptoms diminished and the patients could be released from hospital. The herbs were found to be contaminated with atropine, most probably derived from deadly nightshade (Atropa belladonna). Analyses of the contaminated product indicated that the patients were exposed to 20-200 mg atropine, while a dose of 2 mg is already considered mildly toxic. CONCLUSION: Consultation of the Dutch National Poisons Information Center resulted in rapid detection of the contamination; close collaboration with the Netherlands Food and Consumer Product Safety Authority and the manufacturer of the product allowed rapid identification of the source of contamination and facilitated the prevention of an epidemic.
Asunto(s)
Síndrome Anticolinérgico/etiología , Atropina/efectos adversos , Contaminación de Medicamentos , Tés de Hierbas , Adulto , Animales , Atropa belladonna/efectos adversos , Atropa belladonna/química , Atropina/análisis , Antagonistas Colinérgicos/efectos adversos , Antagonistas Colinérgicos/análisis , Femenino , Humanos , Masculino , Países Bajos , Tés de Hierbas/efectos adversos , Tés de Hierbas/análisisAsunto(s)
Atropa belladonna/efectos adversos , Antagonistas Colinérgicos/efectos adversos , Cólico/tratamiento farmacológico , Fitoterapia/efectos adversos , Síndrome de Wolff-Parkinson-White/inducido químicamente , Antagonistas Colinérgicos/administración & dosificación , Electrocardiografía , Humanos , Lactante , Recién Nacido , Masculino , Fitoterapia/métodosRESUMEN
We present a case of a 63-year-old woman who presented to an ED with bifrontal headache, nausea and vomiting and reduced visual acuity. Examination revealed bilateral elevated intraocular pressures, corneal haze, shallow anterior chambers and poorly reactive, mid-dilated pupils. Diagnosis was made of simultaneous bilateral acute angle closure glaucoma. A complete drug history revealed that she had been using an over-the-counter cold and flu remedy whose active ingredients included atropa belladonna, an herb with anticholinergic properties. It is likely that drug-induced dilatation of the individual's pupils precipitated this angle closure emergency. In the report we discuss the risk factors for angle closure glaucoma, and review the local and systemic drugs known to trigger this sight-threatening emergency.
Asunto(s)
Atropa belladonna/efectos adversos , Glaucoma de Ángulo Cerrado/inducido químicamente , Medicamentos Compuestos contra Resfriado, Gripe y Alergia/efectos adversos , Preparaciones de Plantas/efectos adversos , Acetazolamida/uso terapéutico , Antagonistas Adrenérgicos beta/uso terapéutico , Resfriado Común , Diuréticos/uso terapéutico , Femenino , Glaucoma de Ángulo Cerrado/tratamiento farmacológico , Humanos , Gripe Humana , Persona de Mediana Edad , Agonistas Muscarínicos/uso terapéutico , Pilocarpina/uso terapéutico , Factores de Riesgo , Factores de Tiempo , Timolol/uso terapéuticoRESUMEN
Deadly nightshade (Atropa belladonna) intoxication has been infrequently reported in both children and adults in the literature. In this article, the clinical and laboratory findings of 49 children with acute deadly nightshade intoxication are reviewed. Our purpose was to enlighten the findings of deadly nightshade intoxication in childhood. The most common observed symptoms and signs were meaningless speech, tachycardia, mydriasis, and flushing. None of the children required mechanical ventilation or died in our series. The patients were categorized into two groups, mild/moderate and severe intoxication. Children with and without encephalopathy were accepted as severe and mild/moderate intoxication, respectively. While 43 children were placed in the group of mild/moderate intoxication, six were in severe intoxication group. We found that meaningless speech, lethargy, and coma were more common, but tachycardia was less common in the severe intoxication group (children with encephalopathy) (P < 0.05). In the treatment, neostigmine was used in all children because of no available physostigmine in our country. In conclusion, our findings showed that the initial signs and symptoms of acute deadly nightshade intoxication might be severe in some children, but no permanent sequel and death were seen in children. We also showed that meaningless speech, lethargy, coma, and absence of tachycardia were ominous signs in deadly nightshade intoxication in childhood. Lastly, we suggest that neostigmine may be used in cases of deadly nightshade intoxication if physostigmine cannot be available.
Asunto(s)
Atropa belladonna/efectos adversos , Niño , Intoxicación por Plantas/diagnóstico , Atropa belladonna/química , Pruebas de Química Clínica , Técnicas de Laboratorio Clínico , Coma/inducido químicamente , Femenino , Humanos , Masculino , Registros Médicos , Intoxicación por Plantas/sangre , Intoxicación por Plantas/fisiopatología , Estudios Retrospectivos , Índice de Severidad de la Enfermedad , Fases del Sueño/efectos de los fármacos , Habla/efectos de los fármacos , TurquíaAsunto(s)
Atropina/efectos adversos , Dermatitis Alérgica por Contacto/etiología , Midriáticos/efectos adversos , Soluciones Oftálmicas/efectos adversos , Adulto , Atropa belladonna/efectos adversos , Humanos , Masculino , Pruebas del Parche , Escopolamina/efectos adversos , Tropanos/efectos adversos , Tropicamida/efectos adversosRESUMEN
AIM: Pupillary dilatation with alcaloids from the Atropa belladonna plant have been used since antiquity. It is less known that the wood of the plant contains an even higher concentration of alkaloids than the ripe fruit. METHODS: Clinical case. RESULTS: A 32-year-old patient presented with a foreign body sensation after a splinter got in his eye while chopping wood of an Atropa belladonna bush in the underbrush. Ophthalmic examination showed a visual acuity of 0.9 s.c. (1.0 with pinhole) and a pupil in a fixed mydriasis without any visible rupture of the sphincter muscle. After a 3-day follow-up the pupil returned to normal size and visual acuity recovered to 1.25 s.c. CONCLUSION: The wood of the Atropa belladonna plant contains a very high concentration of alkaloids. A well-directed history may help to discover this less well-known cause of an accidental mydriasis.
Asunto(s)
Alcaloides de Belladona/efectos adversos , Cuerpos Extraños en el Ojo/fisiopatología , Midriasis/inducido químicamente , Adulto , Atropa belladonna/efectos adversos , Humanos , Masculino , Plantas Medicinales , Plantas Tóxicas , Remisión Espontánea , Agudeza Visual/efectos de los fármacos , MaderaAsunto(s)
Antiparkinsonianos/efectos adversos , Enfermedad Iatrogénica/inducido químicamente , Enfermedad de Parkinson/tratamiento farmacológico , Amantadina/efectos adversos , Anestésicos , Antibacterianos/efectos adversos , Antidepresivos/efectos adversos , Antihipertensivos/efectos adversos , Atropa belladonna/efectos adversos , Depresión/tratamiento farmacológico , Dihidroxifenilalanina/efectos adversos , Relación Dosis-Respuesta a Droga , Quimioterapia Combinada , Humanos , Hipertensión/tratamiento farmacológico , Parasimpatolíticos/efectos adversos , Plantas Medicinales , Plantas Tóxicas , Piridoxina/efectos adversos , Simpatomiméticos/efectos adversos , Tranquilizantes/efectos adversos , Tropanos/efectos adversosAsunto(s)
Efectos Colaterales y Reacciones Adversas Relacionados con Medicamentos , Glaucoma/inducido químicamente , Alcaloides/efectos adversos , Anfetamina/efectos adversos , Cámara Anterior/anatomía & histología , Antropometría , Antiparkinsonianos/efectos adversos , Atropa belladonna/efectos adversos , Glaucoma/congénito , Glaucoma/diagnóstico , Antagonistas de los Receptores Histamínicos H1/efectos adversos , Humanos , Presión Intraocular/efectos de los fármacos , Persona de Mediana Edad , Inhibidores de la Monoaminooxidasa/efectos adversos , Oftalmoscopía , Parasimpatolíticos/efectos adversos , Plantas Medicinales , Plantas Tóxicas , Simpatomiméticos/efectos adversosAsunto(s)
Anestesia , Glaucoma/cirugía , Anestesia por Inhalación , Anestesia Local , Anestésicos/farmacología , Animales , Atropa belladonna/efectos adversos , Gatos , Niño , Humanos , Lactante , Recién Nacido , Presión Intraocular/efectos de los fármacos , Intubación , Manitol/efectos adversos , Manitol/farmacología , Nariz , Faringe , Plantas Medicinales , Plantas Tóxicas , Complicaciones Posoperatorias , Potasio/sangre , Medicación Preanestésica , Respiración Artificial , Escopolamina/efectos adversos , Succinilcolina/farmacología , Ventiladores MecánicosRESUMEN
A controlled single-blind trial has been carried out to determine the value of long-term anticholinergic therapy in duodenal ulcer. Of 106 male patients with symptomatic and radiologically proven duodenal ulcer admitted to the trial, 91 completed the study. Patients were divided randomly into three groups. They received either glycopyrronium, or 1-hyoscyamine in a sustained-release form, or inert tablets for one year. Progress was judged on the basis of frequency and severity of symptoms, monthly assessments by patients, antacid consumption, and radiology. By all criteria, glycopyrronium and 1-hyoscyamine were not significantly superior to placebo. Symptomatic improvement, both subjective and objective, occurred in approximately 80% of all patients during the year of observation; there was no significant difference between the groups.