[Cutaneous healing after topical application of nebacetin and gingilone to infected wounds. Clinical and histological study in rats]. / Cicatrização cutânea após aplicação tópica de nebacetin e gingilone em feridas infectadas. Estudo clínico e histológico em ratos.

It was performed a study to examine the cutaneous cicatrization of infected wound of skin after daily topic application of Nebacetin and Gingilone. Following clinical observations the animals were sacrificed after 4, 10 and 17 post-operative days. The pieces were treated, analyzed, in an optical microscope. The topic application of Nebacetin showed to be more efficient in the epithelial reparation comparatively to the Gingilone and control group.

Topical antibiotics in chronic sickle cell leg ulcers.

A randomized, controlled, trial of a topical antibiotic preparation (neomycin, bacitracin, and polymyxin B) was performed in 30 patients with homozygous sickle cell (SS) disease and chronic leg ulceration. Over a period of 8 weeks, the reduction in ulcer size was significantly (P less than 0.05) greater in the treatment group than in the control group. The results suggest that these topical antibiotics may contribute to the therapy of chronic leg ulceration associated with sickle cell disease.

Estudo comparativo entre o uso tópico de fusidato de sódio a 2%, cloranfenicol, associaçäo neomicina/bacitracina e eritromicina (oral) no tratamento do impetigo estafilocócico do recém-nascido / Comparative study between the topical use of sodium fusiate at 2%, chloramphenicol, combination neomycin/bacitracin and erytromycin (oral) in the treatment of staphylococcal impetigo in newborn infants

Quarenta e oito recém-nascidos portadores de impetigo estafilocócico foram tratados com uso tópico de fusidato de sódio a 2%, cloranfenicol, associaçäo neomicina/bacitracina e eritromicina oral, aleatoriamente, e avaliados no 5§, 7§ e 10§ dia de tratamento, sendo significativa a eficácia do fusidato de sódio a 2% na cura desta infecçäo cutânea

Efficacy of topical antibiotic therapy in acute conjunctivitis in children.

We studied 102 children aged 1 month to 18 years in a randomized, double-blind trial designed to determine both the natural history of bacterial conjunctivitis and whether topical antibiotic therapy is beneficial. Affected eyes were treated four times a day for 7 days with drug (polymyxin-bacitracin ophthalmic ointment) or placebo. Eighty-four patients had proved bacterial conjunctivitis (Haemophilus influenzae 61, Streptococcus pneumoniae 22, both one); 66 of these received only topical therapy. By 3 to 5 days, 21 of 34 (62%) patients receiving topical antibiotic were clinically cured, whereas only nine of 32 (28%) patients given placebo were cured (P less than 0.02). By 8 to 10 days, 31 (91%) of the patients given antibiotic and 23 (72%) of the placebo group were cured (P = NS). The bacterial pathogen was eradicated by day 3 to 5 in 71% and by day 8 to 10 in 79% of patients given antibiotic, compared to 19% and 31% of the placebo group (P less than 0.001). Acute bacterial conjunctivitis is a self-limited disease, but topical antibiotic therapy with polymyxin-bacitracin shortens the duration of clinical disease and enhances eradication of the causative organism from the conjunctiva.

The use of prophylactic systemic antibiotics in compound depressed skull fractures in infancy and childhood.

The authors described their experience with the use of prophylactic antibiotics in children with compound depressed skull fractures. The analysis of the results of the treatment of patients with or without systemic antibiotics and with or without the replacement of the bone fragments showed no difference in the infection rate, any one was the method used.