RESUMEN
We report a case of neonatal subdural empyema caused by Mycoplasma hominis. The infant sustained severe birth-related eye injury and subsequently developed multiple subdural empyemata. This report illustrates the clinical presentation of this unusual infection and the crucial role of neurosurgical intervention and specific antimicrobial therapy for its successful management.
Asunto(s)
Antibacterianos/uso terapéutico , Empiema Subdural/tratamiento farmacológico , Minociclina/uso terapéutico , Infecciones por Mycoplasma/tratamiento farmacológico , Mycoplasma hominis/aislamiento & purificación , Traumatismos del Nacimiento/etiología , Traumatismos del Nacimiento/microbiología , Traumatismos del Nacimiento/patología , Empiema Subdural/microbiología , Empiema Subdural/patología , Lesiones Oculares/etiología , Lesiones Oculares/microbiología , Lesiones Oculares/patología , Femenino , Humanos , Recién Nacido , Inyecciones Intravenosas , Pruebas de Sensibilidad Microbiana , Infecciones por Mycoplasma/complicaciones , Infecciones por Mycoplasma/patología , Mycoplasma hominis/fisiología , Forceps Obstétrico/efectos adversos , Resultado del TratamientoRESUMEN
The limited available evidence supports a strong association of chorioamnionitis with neonatal encephalopathy and CP in the term infant. The association of chorioamnionitis with depressed Apgar scores or neonatal seizures and with CP is equivocal in the preterm infant. Different study results may be related to differences in study populations, perhaps specifically to differences in susceptibility by stages of neurologic development as well as differences in gene frequencies associated with inflammation and thrombophilia. We require further understanding of the normal roles of cytokines in brain development, pregnancy, and inflammatory homeostasis before clinical interventions directed at cytokines, their receptors, or the inflammatory process are considered.
Asunto(s)
Traumatismos del Nacimiento/microbiología , Lesiones Encefálicas/congénito , Lesiones Encefálicas/microbiología , Parálisis Cerebral/congénito , Parálisis Cerebral/microbiología , Corioamnionitis/complicaciones , Hipoxia-Isquemia Encefálica/congénito , Hipoxia-Isquemia Encefálica/microbiología , Antibacterianos/uso terapéutico , Corioamnionitis/diagnóstico , Corioamnionitis/microbiología , Corioamnionitis/prevención & control , Femenino , Predisposición Genética a la Enfermedad/genética , Humanos , Recién Nacido , Enfermedades del Prematuro/microbiología , Inflamación , Tamizaje Masivo/métodos , Embarazo , Factores de Riesgo , Sensibilidad y EspecificidadRESUMEN
Antimicrobial therapy can ameliorate infection and prevent long-term morbidity caused by several pathogens that infect the fetus and neonate. Ultimately, however, preventive strategies need to be developed and incorporated into routine preconceptional care. The future of prevention lies in immunizations, and if past and current successes with smallpox, polio, rubella, and measles vaccination programs are any indication, the future is bright for the developing fetus.
