RESUMEN
OBJECTIVE: Cutaneous adverse events (CAE) from FreeStyle Libre include allergic contact dermatitis (ACD) caused by the allergen isobornyl acrylate (IBOA). We aim to report CAE from this glucose sensor, ACD to IBOA in particular, and the outcome of using barrier films as a prevention. RESEARCH DESIGN AND METHODS: A monocentric, retrospective review of medical files from adult and pediatric patients with diabetes using Freestyle Libre, in the period between December 2016 and April 2019, was performed with a focus on CAE. RESULTS: Fifty-seven of 1,036 patients with diabetes (5.5%) were referred to our dermatology department because of CAE from FreeStyle Libre. Thirty-nine of 1,036 (3.8%) had ACD due to IBOA. Only two patients, of whom one sensitized to IBOA, had a benefit from using barrier films. CONCLUSIONS: CAE occurred in 5.5% of FreeStyle Libre users, and 3.8% suffered from ACD due to IBOA. Barrier films had limited value in the prevention.
Asunto(s)
Acrilatos/inmunología , Canfanos/inmunología , Dermatitis Alérgica por Contacto/sangre , Dermatitis Alérgica por Contacto/epidemiología , Diabetes Mellitus/sangre , Diabetes Mellitus/epidemiología , Equipos y Suministros/efectos adversos , Sistemas de Infusión de Insulina/efectos adversos , Acrilatos/química , Adolescente , Adulto , Glucemia/análisis , Automonitorización de la Glucosa Sanguínea/efectos adversos , Automonitorización de la Glucosa Sanguínea/instrumentación , Canfanos/química , Niño , Dermatitis Alérgica por Contacto/etiología , Dermatitis Alérgica por Contacto/prevención & control , Diabetes Mellitus/tratamiento farmacológico , Femenino , Humanos , Insulina/administración & dosificación , Masculino , Persona de Mediana Edad , Prevalencia , Estudios Retrospectivos , Adulto JovenAsunto(s)
Acrilatos/inmunología , Canfanos/inmunología , Dermatitis Alérgica por Contacto/diagnóstico , Dermatitis Alérgica por Contacto/etiología , Equipos y Suministros/efectos adversos , Bombas de Infusión/efectos adversos , Pruebas del Parche/métodos , Adolescente , Adulto , Alérgenos/inmunología , Glucemia/análisis , Niño , Estudios de Cohortes , Femenino , Humanos , Incidencia , Insulina/administración & dosificación , Masculino , Persona de Mediana Edad , Pronóstico , Medición de RiesgoRESUMEN
The production of 2-methylisoborneol (MIB) by certain fungi and algae can contribute musty off-flavors to foods and water supplies if uncontrolled. The goal of this research was to develop a nonsensory simple method for the detection of MIB. Anti-MIB monoclonal antibodies were produced by immunizing mice with borneol-conjugated protein and selecting positive clones with an MIB-protein conjugate. An indirect competitive immunoassay developed using this antibody had a detection limit of 0.6 microg L(-)(1) and an I(50) value of 5 microg L(-)(1). Detection was relatively specific for MIB and showed 20% cross-reactivity with borneol or isoborneol and 4-5% cross-reactivity with camphor. No cross-reactivity to geosmin was observed.
