RESUMEN
Zika virus (ZIKV) was first detected in the Americas in Brazil in 2015, with a rapid spread to surrounding countries. In Panama, the outbreak began in November 2015 in an indigenous community located on the Caribbean side of the country. Zika virus is typically associated with a diffuse rash, fever, and conjunctivitis. It can rarely cause neurologic manifestations, most commonly microcephaly and Guillain-Barré syndrome. Encephalitis and acute encephalomyelitis are known complications, but ZIKV-associated cerebellitis has yet to be reported in the literature. Herein, we report a case of cerebellitis in a patient infected with ZIKV. This patient developed severe frontal headache and vertigo on the third day of illness, and dysarthria and ataxia on the fifth day. After 1 week of hospitalization, the patient completely recovered. The laboratory serological diagnosis was complicated because of the detection of antibodies against dengue, suggesting a secondary flavivirus infection.
Asunto(s)
Enfermedades Cerebelosas/diagnóstico por imagen , Enfermedades Cerebelosas/virología , Infección por el Virus Zika/complicaciones , Adulto , Anticuerpos Antivirales/sangre , Ataxia/virología , Brasil , Enfermedades Cerebelosas/terapia , Coinfección/diagnóstico , Coinfección/virología , Dengue/diagnóstico , Femenino , Infecciones por Flavivirus/diagnóstico , Cefalea/virología , Hospitalización , Humanos , Reacción en Cadena de la Polimerasa , ARN Viral/genética , Tomografía Computarizada por Rayos X , Resultado del Tratamiento , Vértigo/virología , Virus Zika/genética , Virus Zika/aislamiento & purificación , Infección por el Virus Zika/diagnósticoRESUMEN
Acute cerebellitis can occur in association with varicella-zoster virus, enterovirus, mumps, mycoplasma, and other infective organisms. Acute cerebellitis is a rare complication of Epstein-Barr virus (EBV) infection. We report the case of a 21-year-old woman with a 12-day history of nausea and vomiting, gait and limbs ataxia, myoclonus, tremor of head and all four limbs, opsoclonus and cutaneous rash. Anti-EBV IgG and IgM antibodies against antiviral capsid were positive and anti-EBV against virus-associated nuclear antigen was also positive. EBV infection in association with neurological findings can occur without the classic signs and symptoms of infectious mononucleosis.
Asunto(s)
Enfermedades Cerebelosas/virología , Encefalitis Viral/complicaciones , Infecciones por Virus de Epstein-Barr/complicaciones , Herpesvirus Humano 4/aislamiento & purificación , Enfermedad Aguda , Adulto , Antiinflamatorios/uso terapéutico , Anticuerpos Antivirales/aislamiento & purificación , Enfermedades Cerebelosas/tratamiento farmacológico , Dexametasona/uso terapéutico , Encefalitis Viral/tratamiento farmacológico , Infecciones por Virus de Epstein-Barr/tratamiento farmacológico , Femenino , Herpesvirus Humano 4/inmunología , HumanosRESUMEN
A cerebelite aguda pode ocorrer em associação a infecção pelo vírus da varicela-zoster, enterovirus, caxumba, micoplasma e outros agentes infecciosos. A cerebelite aguda é uma complicação rara da infecção pelo vírus Epstein-Barr (EBV). Relatamos o caso de uma mulher de 21 anos com história de 12 dias de evolução com náuseas, vômitos, ataxia de marcha e membros, tremor cefálico e de membros, opsoclono, mioclonias e rash cutâneo. Sorologia para EBV foi positiva. A infecção pelo EBV, com complicações neurológicas, pode não se apresentar com os sinais e sintomas clássicos da mononucleose infeciosa.