RESUMEN
OBJECTIVE: To develop an asleep motor mapping paradigm for accurate detection of the corticospinal tract during glioma surgery and compare outcomes with awake patients undergoing glioma resection. METHODS: A consecutive cohort of adult patients undergoing craniotomy for suspected diffuse glioma with tumor in a perirolandic location who had awake or asleep cortical and subcortical motor mapping with positive areas of motor stimulation were assessed for postoperative extent of resection (EOR), permanent neurological deficit, and proximity of stimulation to diffusion tensor imaging-based corticospinal tract depiction on preoperative magnetic resonance imaging. Outcome data were compared between asleep and awake groups. RESULTS: In the asleep group, all 16 patients had improved or no change in motor function at last follow-up (minimum 3 months of follow-up). In the awake group, all 23 patients had improved function or no change at last follow-up. EOR was greater in the asleep group (mean [SD] EOR 88.71% [17.56%]) versus the awake group (mean [SD] EOR 80.62% [24.44%]), although this difference was not statistically significant (P = 0.3802). Linear regression comparing distance from stimulation to corticospinal tract in asleep (n = 14) and awake (n = 4) patients was r = -0.3759, R2 = 0.1413, P = 0.1853, and 95% confidence interval = -0.4453 to 0.09611 and r = 0.7326, R2 = 0.5367, P = 0.2674, and 95% confidence interval = -7.042 to 14.75, respectively. CONCLUSION: In this small patient series, asleep motor mapping using commonly available motor evoked potential hardware appears to be safe and efficacious in regard to EOR and functional outcomes.
Asunto(s)
Anestesia General/métodos , Mapeo Encefálico/métodos , Encéfalo/cirugía , Sedación Consciente/métodos , Craneotomía/métodos , Vigilia/fisiología , Adulto , Anciano , Anestesia General/tendencias , Encéfalo/diagnóstico por imagen , Mapeo Encefálico/tendencias , Neoplasias Encefálicas/diagnóstico por imagen , Neoplasias Encefálicas/cirugía , Sedación Consciente/tendencias , Craneotomía/tendencias , Imagen de Difusión Tensora/métodos , Imagen de Difusión Tensora/tendencias , Potenciales Evocados Motores/fisiología , Femenino , Glioma/diagnóstico por imagen , Glioma/cirugía , Humanos , Monitorización Neurofisiológica Intraoperatoria/métodos , Monitorización Neurofisiológica Intraoperatoria/tendencias , Masculino , Persona de Mediana Edad , Adulto JovenRESUMEN
BACKGROUND: Non-human primates are commonly used in neuroimaging research for which general anaesthesia or sedation is typically required for data acquisition. In this analysis, the cumulative effects of exposure to ketamine, Telazol® (tiletamine and zolazepam), and the inhaled anaesthetic isoflurane on early brain development were evaluated in two independent cohorts of typically developing rhesus macaques. METHODS: Diffusion MRI scans were analysed from 43 rhesus macaques (20 females and 23 males) at either 12 or 18 months of age from two separate primate colonies. RESULTS: Significant, widespread reductions in fractional anisotropy with corresponding increased axial, mean, and radial diffusivity were observed across the brain as a result of repeated anaesthesia exposures. These effects were dose dependent and remained after accounting for age and sex at time of exposure in a generalised linear model. Decreases of up to 40% in fractional anisotropy were detected in some brain regions. CONCLUSIONS: Multiple exposures to commonly used anaesthetics were associated with marked changes in white matter microstructure. This study is amongst the first to examine clinically relevant anaesthesia exposures on the developing primate brain. It will be important to examine if, or to what degree, the maturing brain can recover from these white matter changes.
Asunto(s)
Anestesia General/efectos adversos , Encéfalo/efectos de los fármacos , Encéfalo/diagnóstico por imagen , Sustancia Blanca/efectos de los fármacos , Sustancia Blanca/diagnóstico por imagen , Animales , Animales Recién Nacidos , Encéfalo/metabolismo , Imagen de Difusión Tensora/tendencias , Femenino , Macaca mulatta , MasculinoRESUMEN
Previous diffusion tensor imaging (DTI) studies have reported that both mild cognitive impairment (MCI) and Alzheimer's disease (AD) revealed microstructural changes [fractional anisotropy (FA)]. However, these results were not conclusive. The purpose of this meta-analysis was to identify the consistent FA alterations and the differences between MCI and AD. Case-control studies investigating MCI and AD using FA were searched in the online databases. The quantitative FA value of cognition-related brain regions was extracted and the standardized mean difference (SMD) with 95% confidence interval (CI) was calculated using fixed or random effect models. Twenty six studies with a total of 1,021 patients were included in this meta-analysis. Significantly decreased FA in patients with AD were identified in the left frontal lobe, corpus callosum (CC), fornix, hippocampus (HP), cingulate gyrus (CG), cingulate bundle (CB), uncinate fasciculus (UF), superior longitudinal fasciculus(SLF), the inferior fronto-occipital fascicles (IFOF), and the inferior longitudinal fasciculus(ILF) relative to MCI in this meta-analysis. This study provides objective and quantitative evidence that AD is associated with FA alteration within left frontal lobe, CC, FX, HP, CG, CB, and UF may suggest the key regions of the process from MCI to AD.
Asunto(s)
Enfermedad de Alzheimer/diagnóstico por imagen , Disfunción Cognitiva/diagnóstico por imagen , Imagen de Difusión Tensora/tendencias , Progresión de la Enfermedad , Sustancia Blanca/diagnóstico por imagen , Enfermedad de Alzheimer/psicología , Estudios de Casos y Controles , Disfunción Cognitiva/psicología , HumanosRESUMEN
Wide-spread visualization methods which are computed tomography (CT) and magnetic resonance imaging (MRI) are not sensitive to mild traumatic brain injury (mTBI). However, mTBI may cause changes of cerebral microstructure that could be found using diffusion-tensor imaging. The aim of this study is to reveal the impact of acute mTBI (no more than 3 days after trauma) on diffusion parameters in corpus callosum, corticospinal tract, and thalamus in children (aged 14-18). Fractional anisotropy (FA) and apparent diffusion coefficient (ADC) were analyzed. Significant increase in FA and decrease in ADC were observed in thalamus. The trend to an increase in FA is observed in corpus callosum.
Asunto(s)
Conmoción Encefálica/diagnóstico por imagen , Cuerpo Calloso/diagnóstico por imagen , Imagen de Difusión Tensora/tendencias , Tálamo/diagnóstico por imagen , Agua , Adolescente , Anisotropía , Conmoción Encefálica/metabolismo , Niño , Cuerpo Calloso/metabolismo , Difusión , Imagen de Difusión Tensora/métodos , Femenino , Humanos , Masculino , Tálamo/metabolismo , Agua/metabolismoRESUMEN
It is well established that the posterior region of the corpus callosum, known as the splenium, is relatively preserved during the course of normal ageing. However, the effect of age on its distinct interhemispheric tract bundles that project to bilateral occipital, parietal and temporal areas of the cortex, is largely unknown. In the present study, diffusion tensor imaging was used to directly examine the integrity of these distinct segregations and their diffusion metrics were compared between groups of young adults (n = 20, mean age = 30.75) and older adults (n = 19, mean age = 80.21). Results revealed that while occipital tracts were preserved in older adults, parietal and temporal segments were particularly impaired. These findings are the first to indicate the existence of selective alterations in the posterior region of the corpus callosum in older age.
Asunto(s)
Envejecimiento/patología , Cuerpo Calloso/diagnóstico por imagen , Imagen de Difusión Tensora/tendencias , Sustancia Blanca/diagnóstico por imagen , Adulto , Anciano , Anciano de 80 o más Años , Cuerpo Calloso/patología , Estudios Transversales , Femenino , Humanos , Masculino , Sustancia Blanca/patología , Adulto JovenRESUMEN
Structural and functional differences between the brains of female and male adults have been well documented. However, potential sex differences in the patterns of rich-club organization and the coupling between their structural connectivity (SC) and functional connectivity (FC) remain to be determined. In this study, functional magnetic resonance imaging and diffusion tensor imaging techniques were combined to examine sex differences in rich-club organization. Females had a stronger SC-FC coupling than males. Moreover, stronger SC-FC coupling in the females was primarily located in feeder connections and non-rich-club nodes of the left inferior frontal gyrus and inferior parietal lobe and the right superior frontal gyrus and superior parietal gyrus, whereas higher coupling strength in males was primarily located in rich-club connections and rich-club node of the right insula, and non-rich-club nodes of the left hippocampus and the right parahippocampal gyrus. Sex-specific patterns in correlations were also shown between SC-FC coupling and cognitive function, including working memory and reasoning ability. The topological changes in rich-club organization provide novel insight into sex-specific effects on white matter connections that underlie a potential network mechanism of sex-based differences in cognitive function.
Asunto(s)
Encéfalo/anatomía & histología , Encéfalo/diagnóstico por imagen , Red Nerviosa/anatomía & histología , Red Nerviosa/diagnóstico por imagen , Caracteres Sexuales , Adulto , Encéfalo/fisiología , Bases de Datos Factuales/tendencias , Imagen de Difusión Tensora/tendencias , Femenino , Humanos , Masculino , Red Nerviosa/fisiología , Adulto JovenRESUMEN
The relationship between cognitive performance, macro and microstructural brain anatomy and accelerated aging as measured by a highly accurate epigenetic biomarker of aging known as the epigenetic clock in healthy adolescents has not been studied. Healthy adolescents enrolled in the Cape Town Adolescent Antiretroviral Cohort Study were studied cross sectionally. The Illumina Infinium Methylation EPIC array was used to generate DNA methylation data from the blood samples of 44 adolescents aged 9 to 12 years old. The epigenetic clock software and method was used to estimate two measures, epigenetic age acceleration residual (AAR) and extrinsic epigenetic age acceleration (EEAA). Each participant underwent neurocognitive testing, T1 structural magnetic resonance imaging (MRI), and diffusion tensor imaging (DTI). Correlation tests were run between the two epigenetic aging measures and 10 cognitive functioning domains, to assess for differences in cognitive performance as epigenetic aging increases. In order to investigate the associations of epigenetic age acceleration on brain structure, we developed stepwise multiple regression models in R (version 3.4.3, 2017) including grey and white matter volumes, cortical thickness, and cortical surface area, as well as DTI measures of white matter microstructural integrity. In addition to negatively affecting two cognitive domains, visual memory (p = .026) and visual spatial acuity (p = .02), epigenetic age acceleration was associated with alterations of brain volumes, cortical thickness, cortical surface areas and abnormalities in neuronal microstructure in a range of regions. Stress was a significant predictor (p = .029) of AAR. Understanding the drivers of epigenetic age acceleration in adolescents could lead to valuable insights into the development of neurocognitive impairment in adolescents.
Asunto(s)
Desarrollo del Adolescente/fisiología , Envejecimiento/metabolismo , Encéfalo/crecimiento & desarrollo , Encéfalo/metabolismo , Epigénesis Genética/fisiología , Pobreza/tendencias , Adolescente , Envejecimiento/genética , Envejecimiento/psicología , Encéfalo/diagnóstico por imagen , Niño , Estudios de Cohortes , Estudios Transversales , Imagen de Difusión Tensora/tendencias , Femenino , Humanos , Estudios Longitudinales , Masculino , Pruebas de Estado Mental y Demencia , Pobreza/psicologíaRESUMEN
Background and Purpose- Widespread reductions in white matter integrity are associated with cognitive dysfunction in sickle cell anemia. Silent cerebral infarction (SCI), vasculopathy (VSC), and low hemoglobin concentration (Hb) are implicated; we aimed to determine independent contributions to microstructural white matter injury and whether white matter integrity differs across arterial territories. Methods- Sixty two children with sickle cell anemia aged 6 to 19 years were prospectively studied at Muhimbili National Hospital, Tanzania. SCI± and VSC± were identified on magnetic resonance imaging (MRI)/magnetic resonance angiography (MRA) scans by 2 neuroradiologists. Tract-based spatial statistics tested for voxel-wise differences in diffusion tensor imaging metrics (ie, fractional anisotropy, mean diffusivity, radial diffusivity, and axial diffusivity) between SCI± and VSC± groups, with correlations between diffusion tensor imaging metrics and Hb. In tract-based spatial statistics analyses, potentially mediating factors (ie, age, sex, as well as Hb, SCI, and/or vasculopathy) were covariates. Differences in mean diffusion tensor imaging metrics across regions of interest in arterial territories were explored. Results- Compared with SCI- patients (n=45), SCI+ patients (n=17) exhibited increased radial diffusivity in multiple regions; negative relationships were observed between mean diffusivity, axial diffusivity, and Hb (P<0.005). Compared with VSC- patients (n=49), mild (n=6) or moderate (n=7) VSC+ patients exhibited reduced fractional anisotropy in widespread regions (P<0.05) including the anterior longitudinal fasciculi, corpus callosum, internal capsule, corona radiata, and corticospinal tracts. Overall, the posterior cerebral arterial territory had higher mean mean diffusivity and mean radial diffusivity than the anterior and middle cerebral arterial territories, although no patient had vasculopathy in this area. There was an interaction between territory and vasculopathy. Conclusions- SCI, vasculopathy, and Hb are independent risk factors, and thus treatment targets, for diffuse white matter injury in patients with sickle cell anemia. Exacerbation of hemodynamic stress may play a role.
Asunto(s)
Anemia de Células Falciformes/diagnóstico por imagen , Anemia de Células Falciformes/epidemiología , Encéfalo/diagnóstico por imagen , Imagen de Difusión Tensora/tendencias , Angiografía por Resonancia Magnética/tendencias , Sustancia Blanca/diagnóstico por imagen , Adolescente , Niño , Femenino , Humanos , Masculino , Estudios Prospectivos , Tanzanía/epidemiología , Adulto JovenRESUMEN
The ability of diffusion tensor MRI to detect the preferential diffusion of water in cerebral white matter tracts enables neurosurgeons to noninvasively visualize the relationship of lesions to functional neural pathways. Although viewed as a research tool in its infancy, diffusion tractography has evolved into a neurosurgical tool with applications in glioma surgery that are enhanced by evolutions in crossing fiber visualization, edema correction, and automated tract identification. In this paper the current literature supporting the use of tractography in brain tumor surgery is summarized, highlighting important clinical studies on the application of diffusion tensor imaging (DTI) for preoperative planning of glioma resection, and risk assessment to analyze postoperative outcomes. The key methods of tractography in current practice and crucial white matter fiber bundles are summarized. After a review of the physical basis of DTI and post-DTI tractography, the authors discuss the methodologies with which to adapt DT image processing for surgical planning, as well as the potential of connectomic imaging to facilitate a network approach to oncofunctional optimization in glioma surgery.
Asunto(s)
Neoplasias Encefálicas/diagnóstico por imagen , Conectoma/métodos , Imagen de Difusión Tensora/métodos , Glioma/diagnóstico por imagen , Red Nerviosa/diagnóstico por imagen , Procedimientos Neuroquirúrgicos/métodos , Neoplasias Encefálicas/cirugía , Conectoma/tendencias , Imagen de Difusión Tensora/tendencias , Glioma/cirugía , Humanos , Red Nerviosa/cirugía , Procedimientos Neuroquirúrgicos/tendencias , Resultado del TratamientoRESUMEN
Delayed recovery from concussion can dramatically affect a child's social, emotional, and educational development, yet little is known about what causes some children to recover faster than others. The contribution of white matter disruption in children with delayed recovery has been hypothesized, but findings are limited by methodological issues such as: small heterogeneous samples, bias toward children with delayed recovery, and inconsistencies in timing of brain imaging, both within and between studies. The aim of the present study was to assess diffusion neuroimaging correlates of delayed recovery post-concussion in children. A prospective, longitudinal, observational cohort study was conducted at a statewide tertiary pediatric hospital. Forty-three children who presented to the emergency department (ED) with concussion (defined according to the Zurich/Berlin Consensus Statement on Concussion in Sport) underwent magnetic resonance imaging (MRI) at a 2 weeks post-injury and were classified as either normally recovering (n = 26) or delayed recovering (n = 17). Diffusion imaging comparison using voxelwise tract-based spatial statistics (TBSS) analysis found no difference between the groups in fractional anisotropy, axial diffusion, radial diffusion, or mean diffusivity metrics (p > 0.05 threshold-free cluster enhancement [TFCE] corrected). Post-hoc tract-based Bayesian analysis found evidence for the null in 11 unique white matter tracts (Bayes factor >3). These findings indicate that delayed recovery from post-concussive symptoms in children is unlikely to be caused by white matter microstructural damage.
Asunto(s)
Conmoción Encefálica/diagnóstico por imagen , Recuperación de la Función/fisiología , Sustancia Blanca/diagnóstico por imagen , Adolescente , Conmoción Encefálica/fisiopatología , Conmoción Encefálica/terapia , Niño , Preescolar , Estudios de Cohortes , Imagen de Difusión Tensora/tendencias , Femenino , Humanos , Estudios Longitudinales , Masculino , Estudios Prospectivos , Factores de TiempoRESUMEN
Comprehensive delineation of white matter (WM) microstructural maturation from birth to childhood is critical for understanding spatiotemporally differential circuit formation. Without a relatively large sample of datasets and coverage of critical developmental periods of both infancy and early childhood, differential maturational charts across WM tracts cannot be delineated. With diffusion tensor imaging (DTI) of 118 typically developing (TD) children aged 0-8 years and 31 children with autistic spectrum disorder (ASD) aged 2-7 years, the microstructure of every major WM tract and tract group was measured with DTI metrics to delineate differential WM maturation. The exponential model of microstructural maturation of all WM was identified. The WM developmental curves were separated into fast, intermediate, and slow phases in 0-8 years with distinctive time period of each phase across the tracts. Shorter periods of the fast and intermediate phases in certain tracts, such as the commissural tracts, indicated faster earlier development. With TD WM maturational curves as the reference, higher residual variance of WM microstructure was found in children with ASD. The presented comprehensive and differential charts of TD WM microstructural maturation of all major tracts and tract groups in 0-8 years provide reference standards for biomarker detection of neuropsychiatric disorders.
Asunto(s)
Trastorno del Espectro Autista/diagnóstico por imagen , Encéfalo/diagnóstico por imagen , Encéfalo/crecimiento & desarrollo , Imagen de Difusión Tensora/tendencias , Sustancia Blanca/diagnóstico por imagen , Sustancia Blanca/crecimiento & desarrollo , Niño , Preescolar , Femenino , Humanos , Lactante , Recién Nacido , MasculinoRESUMEN
This prospective longitudinal study compares the ability of conventional and diffusion tensor imaging (DTI) parameters made at the cervical spinal cord injury (CSCI) site to predict long-term neurological and functional outcomes. Twenty patients with CSCI, with follow-up at 6 or 12 months, and 15 control volunteers were included. Conventional magnetic resonance imaging (MRI) and DTI parameters were measured on admission and follow-up studies. Stepwise regression analysis was performed to find relevant parameters (normalized DTI values, conventional MRI measurements, hemorrhagic contusion [HC] or non-HC [NHC]) that correlated with three primary outcome measures: patient International Standards for Neurological Classification of Spinal Cord Injury total motor score (ISNCSCI-TMS), ability to walk, and expected recovery of upper limb motor scores (ER-ULMS) at 6 or 12 months. Univariate analysis showed HC (p < 0.0001 to 0.0098), lesion length on follow-up MRI (p < 0.0001 to 0.019), mean diffusivity (p = 0.01 to 0.045), and axial diffusivity (p = 0.004 to 0.023) predicted all three primary outcomes. Conspicuity of HC was significantly better on axial susceptibility-weighted imaging (SWI) compared with T2* images (p = 0.0009). A negative correlation existed between HC volumes on sagittal SWI images and follow-up ISNCSCI-TMS ( p = 0.02). The regression model identified NHC as the best predictor of the ability to walk (sensitivity = 88.9%; specificity = 100%; positive predictive value = 100%; negative predictive value = 91%; p < 0.0001) and lesion length on follow-up MRI as the best predictor of ER-ULMS (ß coefficient = 0.12, standard error [SE] = 0.07; R2 = 0.64; p = 0.0002). Finally, NHC (ß coefficient = 24.2, SE = 3.7; p < 0.0001) and lesion length on initial MRI (ß coefficient = 0.78, SE = 0.2; p = 0.002) were the best predictors of ISNCSCI-TMS (R2 = 0.83; p < 0.0001). Our study demonstrates HC and follow-up lesion length are potential neuroimaging biomarkers in predicting long-term neurological and functional outcome following blunt CSCI.
Asunto(s)
Médula Cervical/diagnóstico por imagen , Imagen de Difusión Tensora/tendencias , Recuperación de la Función/fisiología , Traumatismos de la Médula Espinal/diagnóstico por imagen , Caminata/fisiología , Caminata/tendencias , Adulto , Anciano , Médula Cervical/lesiones , Imagen de Difusión Tensora/métodos , Femenino , Estudios de Seguimiento , Humanos , Estudios Longitudinales , Imagen por Resonancia Magnética/métodos , Imagen por Resonancia Magnética/tendencias , Masculino , Persona de Mediana Edad , Valor Predictivo de las Pruebas , Estudios Prospectivos , Traumatismos de la Médula Espinal/fisiopatología , Factores de Tiempo , Adulto JovenRESUMEN
OBJECTIVES: We examined whether changes in diffusion tensor imaging (DTI) indices of the lumbosacral enlargement are similar to those at the cervical level, and correlate with clinical assessments in patients with cervical spondylotic myelopathy (CSM). PATIENTS AND METHODS: Patients with CSM and healthy volunteers (40-42/group) received DTI scans at both lumbosacral enlargement and cervical spinal cord. Modified Japanese Orthopedic Association (mJOA) score was also recorded for those with CSM. The apparent diffusion coefficient (ADC) and fractional anisotropy (FA) values of DTI in the two groups were compared. We also examined the correlation between DTI indices (ADC and FA) of the lumbosacral enlargement and those of the cervical spinal cord, and between DTI indices and mJOA in the CSM group. RESULTS: Compared with the values of healthy subjects, the ADC values of patients with CSM were significantly increased, and FA values were significantly decreased at both cervical spinal cord and lumbosacral enlargement. Changes in FA value of the cervical cord showed a positive correlation to those of the lumbosacral enlargement in the CSM group. Importantly, a linear correlation was detected between mJOA score and DTI indices (ADC and FA) of the cervical cord, as well as FA value of the lumbosacral enlargement in the CSM group. CONCLUSION: DTI indices, especially FA, of the lumbosacral enlargement correlate with clinical assessments of patients with CSM, and hence may be useful for evaluating the severity of cervical cord injury.
Asunto(s)
Médula Cervical/diagnóstico por imagen , Imagen de Difusión Tensora/métodos , Región Lumbosacra/diagnóstico por imagen , Espondilosis/diagnóstico por imagen , Adulto , Anciano , Imagen de Difusión Tensora/tendencias , Femenino , Humanos , Masculino , Persona de Mediana Edad , Proyectos Piloto , Enfermedades de la Médula Espinal/complicaciones , Enfermedades de la Médula Espinal/diagnóstico por imagen , Espondilosis/complicacionesRESUMEN
OBJECTIVE: To investigate the multifactorial processes underlying cognitive aging based on the hypothesis that multiple causal pathways and mechanisms (amyloid, vascular, and resilience) influence longitudinal cognitive decline in each individual through worsening brain health. METHODS: We identified 1,230 elderly subjects (aged ≥50 years) with an average of 4.9 years of clinical follow-up and with amyloid positron emission tomography, diffusion tensor imaging, and structural magnetic resonance imaging scans from the population-based Mayo Clinic Study of Aging. We examined imaging markers of amyloid and brain health (white matter microstructural integrity and cortical thinning), systemic vascular health preceding the imaging markers, and early to midlife intellectual enrichment to predict longitudinal cognitive trajectories. We used latent growth curve models for modeling longitudinal cognitive decline. RESULTS: All the pathways (amyloid, vascular, resilience) converged through their effects on cortical thinning and worsening cognition and together explained patterns in cognitive decline. Resilience and vascular pathways (aging process, sex differences, education/occupation, and systemic vascular health) had significant impact on white matter microstructural integrity. Education/occupation levels contributed to white matter integrity through systemic vascular health. Worsening white matter integrity contributed to significant cortical thinning and subsequently longitudinal cognitive decline. Baseline amyloidosis contributed to a significant proportion of cognitive decline that accelerated with longer follow-up times, and its primary impact was through cortical thinning. INTERPRETATION: We developed an integrated framework to help explain the dynamic and complex process of cognitive aging by considering key causal pathways. Such an approach is important for both better comprehension of cognitive aging processes and will aid in the development of successful intervention strategies. ANN NEUROL 2019;86:866-877.
Asunto(s)
Angiopatía Amiloide Cerebral/diagnóstico por imagen , Circulación Cerebrovascular/fisiología , Envejecimiento Cognitivo/fisiología , Disfunción Cognitiva/diagnóstico por imagen , Imagen de Difusión Tensora/tendencias , Tomografía de Emisión de Positrones/tendencias , Anciano , Anciano de 80 o más Años , Amiloide/metabolismo , Angiopatía Amiloide Cerebral/metabolismo , Envejecimiento Cognitivo/psicología , Disfunción Cognitiva/metabolismo , Disfunción Cognitiva/psicología , Femenino , Estudios de Seguimiento , Humanos , Imagen por Resonancia Magnética/tendencias , Masculino , Persona de Mediana Edad , Vías Nerviosas/diagnóstico por imagen , Vías Nerviosas/metabolismoRESUMEN
Major depressive disorder (MDD) often emerges during adolescence with detrimental effects on development as well as lifetime consequences. Identifying neurobiological markers that are associated with the onset or course of this disorder in childhood and adolescence is important for early recognition and intervention and, potentially, for the prevention of illness onset. In this systematic review, 68 longitudinal neuroimaging studies, from 34 unique samples, that examined the association of neuroimaging markers with onset or changes in paediatric depression published up to 1 February 2019 were examined. These studies employed different imaging modalities at baseline; structural magnetic resonance imaging (MRI), diffusion tensor imaging (DTI), functional MRI (fMRI) or electroencephalography (EEG). Most consistent evidence across studies was found for blunted reward-related (striatal) activity (fMRI and EEG) as a potential biological marker for both MDD onset and course. With regard to structural brain measures, the results were highly inconsistent, likely caused by insufficient power to detect complex mediating effects of genetic and environmental factors in small sample sizes. Overall, there were a limited number of samples, and confounding factors such as sex and pubertal development were often not considered, whereas these factors are likely to be relevant especially in this age range.
Asunto(s)
Encéfalo/diagnóstico por imagen , Depresión/diagnóstico por imagen , Trastornos del Neurodesarrollo/diagnóstico por imagen , Neuroimagen/métodos , Adolescente , Encéfalo/fisiopatología , Niño , Depresión/fisiopatología , Depresión/psicología , Imagen de Difusión Tensora/métodos , Imagen de Difusión Tensora/tendencias , Electroencefalografía/métodos , Electroencefalografía/tendencias , Femenino , Humanos , Estudios Longitudinales , Imagen por Resonancia Magnética/métodos , Imagen por Resonancia Magnética/tendencias , Masculino , Trastornos del Neurodesarrollo/fisiopatología , Trastornos del Neurodesarrollo/psicología , Neuroimagen/tendencias , RecompensaRESUMEN
OBJECTIVE: To investigate dopamine D2/D3 receptor availability following traumatic brain injury (TBI) and their relationship to the presence of DSM-IV Major Depressive Disorder (MDD) and patterns of axonal injury. METHODS: Twelve moderate-severe TBI patients and 26 controls were imaged using [11C]PHNO positron emission tomography (PET) and structural magnetic resonance imaging (MRI). TBI patients and a second group of 32 controls also underwent diffusion tensor imaging (DTI) and neuropsychological assessment. Patients included six with post-injury MDD (TBI-MDD) and six without (TBI-NON). Non-displaceable binding potential (BPND) [11C]PHNO values were used to index D2/D3 receptor availability, and were calculated using a reference region procedure. Differences in BPND were examined using voxelwise and region-of-interest analyses. White matter microstructure integrity, quantified by fractional anisotropy (FA), was assessed and correlated with BPND. RESULTS: Lower [11C]PHNO BPND was found in the caudate across all TBI patients when compared to controls. Lower [11C]PHNO BPND was observed in the caudate of TBI-MDD patients and increased [11C]PHNO BPND in the Amygdala of TBI-NON patients compared to controls. There were no significant differences in [11C]PHNO BPND between TBI-MDD and TBI-NON patients. Furthermore, DTI provided evidence of axonal injury following TBI. The uncinate fasciculus and cingulum had abnormally low FA, with the uncinate particularly affected in TBI-MDD patients. Caudate [11C]PHNO BPND correlated with FA within the nigro-caudate tract. CONCLUSIONS: [11C]PHNO BPND is abnormal following TBI, which indicates post-traumatic changes in D2/D3 receptors. Patterns of [11C]PHNO BPND seen in patients with and without MDD suggest that further research would be beneficial to determine whether the use of dopaminergic treatment might be effective in the treatment of post-traumatic depression.
Asunto(s)
Lesiones Traumáticas del Encéfalo/diagnóstico por imagen , Lesiones Traumáticas del Encéfalo/metabolismo , Trastorno Depresivo Mayor/diagnóstico por imagen , Trastorno Depresivo Mayor/metabolismo , Receptores de Dopamina D2/metabolismo , Receptores de Dopamina D3/metabolismo , Adulto , Encéfalo/diagnóstico por imagen , Encéfalo/metabolismo , Lesiones Traumáticas del Encéfalo/complicaciones , Trastorno Depresivo Mayor/etiología , Imagen de Difusión Tensora/tendencias , Femenino , Humanos , Masculino , Persona de Mediana Edad , Tomografía de Emisión de Positrones/tendencias , Unión Proteica/fisiología , Adulto JovenRESUMEN
In a nationwide randomized controlled trial, white matter microstructure was assessed before and immediately after Cogmed Working-Memory Training (CWMT) in school-age neonatal critical illness survivors. Eligible participants were survivors (8-12 years) with an IQâ¯≥â¯80 and a z-score of ≤ -1.5 on (working)memory test at first assessment. Diffusion Tensor Imaging was used to assess white matter microstructure. Associations between any training-induced changes and improved neuropsychological outcome immediately and one year post-CWMT were evaluated as well. The trial was conducted between October 2014-June 2017 at Erasmus MC-Sophia, Rotterdam, Netherlands. Researchers involved were blinded to group allocation. Participants were randomized to CWMT(nâ¯=â¯14) or no-intervention(nâ¯=â¯20). All children completed the CWMT. Global fractional anisotropy(FA) increased significantly post-CWMT compared to no-intervention(estimated-coefficientâ¯=â¯.007, pâ¯=â¯.015). Increased FA(estimated coefficientâ¯=â¯.009, pâ¯=â¯.033) and decreased mean diffusivity(estimated-coefficientâ¯=â¯-.010, pâ¯=â¯.018) were found in the left superior longitudinal fasciculus(SFL) post-CWMT compared no-intervention. Children after CWMT who improved with >1SD on verbal working-memory had significantly higher FA in the left SLF post-CWMT(nâ¯=â¯6; improvementâ¯=â¯.408⯱â¯.01) than children without this improvement post-CWMT(nâ¯=â¯6; no-improvementâ¯=â¯.384⯱â¯.02), F(1,12)â¯=â¯6.22, pâ¯=â¯.041, ηp2â¯=â¯.47. No other structure-function relationships were found post-CWMT. Our findings demonstrate that white matter microstructure and associated cognitive outcomes are malleable by CWMT in survivors of neonatal critical illness.
Asunto(s)
Enfermedad Crítica/terapia , Aprendizaje/fisiología , Plasticidad Neuronal/fisiología , Sobrevivientes , Sustancia Blanca/diagnóstico por imagen , Sustancia Blanca/fisiología , Adolescente , Anisotropía , Niño , Imagen de Difusión Tensora/métodos , Imagen de Difusión Tensora/tendencias , Femenino , Humanos , Recién Nacido , Masculino , Memoria a Corto Plazo/fisiologíaRESUMEN
Recently, the field of Alzheimer's disease (AD) research has adopted a new framework that places the progression of AD along a continuum consisting of a preclinical stage, followed by conversion to mild cognitive impairment, and ultimately dementia. Important neuropathological changes occur in the preclinical phase, necessitating the identification of metrics that can detect such early changes. While cerebrospinal fluid (CSF) measures of amyloid and tau are generally accepted as biomarkers of AD pathology, neuroimaging measures used to index white matter alterations throughout the brain remain less widely endorsed as candidate biomarkers. To explore the relationship between white matter alterations and AD pathology, we review the literature on multimodal studies that assessed both CSF markers and white matter indices, derived from diffusion tensor imaging (DTI) methods, across cohorts primarily in the early phases of AD. Our review indicates that abnormal CSF measures of Aß42 and tau are associated with widespread alterations in white matter microstructure throughout the brain. Furthermore, white matter variability is related to individual differences in behavior and can aid in tracking longitudinal changes in cognition. Our review advocates for the utilization of DTI metrics in investigations of early AD and suggests that the combined use of DTI and CSF markers may better explain individual differences in cognition and disease progression. However, further research is needed to resolve certain mixed findings.
Asunto(s)
Enfermedad de Alzheimer/líquido cefalorraquídeo , Enfermedad de Alzheimer/diagnóstico por imagen , Péptidos beta-Amiloides/líquido cefalorraquídeo , Encéfalo/diagnóstico por imagen , Imagen de Difusión Tensora/métodos , Fragmentos de Péptidos/líquido cefalorraquídeo , Sustancia Blanca/diagnóstico por imagen , Biomarcadores/líquido cefalorraquídeo , Encéfalo/metabolismo , Disfunción Cognitiva/líquido cefalorraquídeo , Disfunción Cognitiva/diagnóstico por imagen , Imagen de Difusión Tensora/tendencias , Diagnóstico Precoz , Humanos , Estudios Longitudinales , Sustancia Blanca/metabolismo , Proteínas tau/líquido cefalorraquídeoRESUMEN
BACKGROUND: Cognitive outcomes in preterm (PT) children have been associated with microstructural properties of white matter. PT children who experienced neonatal inflammatory conditions have poorer cognitive outcomes than those who did not. The goal of this study was to contrast white matter microstructure and cognitive outcomes after preterm birth in relation to the presence or absence of severe inflammatory conditions in the neonatal period. METHODS: PT children (nâ¯=â¯35), born at gestational age 22-32â¯weeks, were classified as either PT+ (nâ¯=â¯12) based on a neonatal history of inflammatory conditions, including bronchopulmonary dysplasia, necrotizing enterocolitis or culture positive sepsis, or PT- (nâ¯=â¯23) based on the absence of the three inflammatory conditions. Full term (FT) children (nâ¯=â¯43) served as controls. Participants underwent diffusion MRI and cognitive testing (intelligence, reading, and executive function) at age 6â¯years. The corpus callosum was segmented into 7 regions using deterministic tractography and based on the cortical projection zones of the callosal fibers. Mean fractional anisotropy (FA) and mean diffusivity (MD) were calculated for each segment. General linear models with planned contrasts assessed group differences in FA, MD and cognitive outcomes. Pearson correlations assessed associations of white matter metrics and cognitive outcome measures. RESULTS: FA was significantly lower and MD was significantly higher in PT+ compared to PT- or FT groups in multiple callosal segments, even after adjusting for gestational age. Executive function scores, but not intelligence or reading scores, were less favorable in PT+ than in PT- groups. Among the entire sample, occipital FA was significantly correlated with IQ (râ¯=â¯0.25, pâ¯<â¯0.05), reading (râ¯=â¯0.32, pâ¯<â¯0.01), and executive function (râ¯=â¯-0.28, pâ¯<â¯0.05) measures. Anterior frontal FA and superior parietal FA were significantly correlated with executive function (râ¯=â¯-0.25, râ¯=â¯0.23, respectively, pâ¯<â¯0.05). CONCLUSIONS: We observed differences in the white matter microstructure of the corpus callosum and in the cognitive skills of 6-year-old PT children based on their history of neonatal inflammation. Neonatal inflammation is one medical factor that may contribute to variation in long-term neurobiological and neuropsychological outcomes in PT samples.
Asunto(s)
Cognición , Cuerpo Calloso/diagnóstico por imagen , Recien Nacido Prematuro/crecimiento & desarrollo , Recien Nacido Prematuro/psicología , Pruebas de Estado Mental y Demencia , Sustancia Blanca/diagnóstico por imagen , Niño , Cognición/fisiología , Cuerpo Calloso/fisiología , Imagen de Difusión Tensora/métodos , Imagen de Difusión Tensora/tendencias , Función Ejecutiva/fisiología , Femenino , Humanos , Recién Nacido , Inflamación/diagnóstico por imagen , Inflamación/psicología , Estudios Longitudinales , Masculino , Sustancia Blanca/fisiologíaRESUMEN
Competitive sport participation, in contact and collision sports, exposes athletes to repetitive head impacts. Although these impacts do not always result in overt symptomology or a diagnosed "concussion," evidence indicates that cumulative repetitive impacts affect brain pathophysiology. The purpose of this study was to perform a systematic review of prospective, longitudinal trials evaluating repetitive head impact exposure on white matter (WM) microstructure in collision and contact sport athletes to inform clinical care and treatment strategies. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed to determine studies that met predetermined inclusion and exclusion criteria. Initially, 2498 abstracts were identified, and 20 studies were critically evaluated herein. The majority of studies demonstrated significant longitudinal changes in anisotropy and/or diffusivity metrics that were associated with the quantity and/or the magnitude of head impact exposure, highlighting the utility of diffusion tensor imaging (DTI) for measuring changes in WM microstructure. Our review also comments on study methodology and describes how age, sex, sport, and time between sport cessation and DTI measures contribute to divergent findings within the literature. Suggestions for future research are also provided to overcome previous study limitations and maximize our understanding of the role of repetitive head impact exposure on WM integrity and long-term neurological sequela.