RESUMEN
OBJECTIVE: Ethmoidal dural arteriovenous fistulas (DAVFs) are often associated with cortical venous drainage (CVD) and a higher incidence of hemorrhage compared with DAVFs in other locations. They may be treated with open surgical disconnection or with endovascular treatment (EVT). In this systematic review and meta-analysis, the authors compare the outcomes of ethmoidal DAVFs treated with open microsurgery versus EVT and report four additional cases of ethmoidal DAVFs treated with open microsurgery in their institution. METHODS: A literature search of the PubMed and Scopus databases was conducted between December 2021 and May 2022 to identify relevant articles published between 1990 and 2021 using the PRISMA guidelines. References were reviewed and screened by two authors independently, and disagreements were resolved through consensus. Exclusion criteria included non-English-language studies, those with an incorrect study design, those reporting DAVFs in a nonethmoidal location, and studies whose outcomes were not stratified based on DAVF location. Inclusion criteria were any studies reporting on ethmoidal DAVFs treated by either microsurgery or EVT. A risk of bias assessment was performed using the Newcastle-Ottawa Scale. The authors performed a pooled proportional meta-analysis to compare patient outcomes. RESULTS: Twenty studies were included for analysis. Of 224 patients, 142 were treated with surgery, while 103 were treated with EVT. Seventy percent (148/210) of the patients were symptomatic at presentation, with hemorrhage being the most common presentation (48%). CVD was present in 98% of patients and venous ectasia in 61%. The rates of complete DAVF obliteration with surgery and EVT were 89% and 70%, respectively (95% CI -30% to -10%, p < 0.03). Twenty percent (21/103) of endovascularly treated fistulas required subsequent surgery. Procedure-related complications occurred in 10% of the surgical cases, compared with 13% of the EVT cases. The authors' case series included 4 patients with ethmoidal DAVFs treated surgically with complete obliteration, without any postoperative complications. CONCLUSIONS: The complete obliteration rates of ethmoidal DAVF appear to be higher and more definitive with microsurgical intervention than with EVT. While complication rates between the two procedures seem similar, patients treated with EVT may require further interventions for definitive treatment. The limitations of this study include its retrospective nature, the quality of studies included, and the continued evolving technologies of EVT. Future studies should focus on the association between venous drainage pattern and the proclivity toward venous ectasia or rate of hemorrhage at presentation.
Asunto(s)
Malformaciones Vasculares del Sistema Nervioso Central , Embolización Terapéutica , Humanos , Malformaciones Vasculares del Sistema Nervioso Central/diagnóstico por imagen , Malformaciones Vasculares del Sistema Nervioso Central/cirugía , Malformaciones Vasculares del Sistema Nervioso Central/complicaciones , Dilatación Patológica/complicaciones , Dilatación Patológica/terapia , Embolización Terapéutica/métodos , Hemorragia , Resultado del Tratamiento , MicrocirugiaRESUMEN
Secondary intra- and extrahepatic bile duct dilatation is a very common condition that can be caused by several diseases. However, it has been rarely discussed in the specialized literature. Moreover, no distinct etiology can be determined in some cases, which hampers the diagnosis and treatment. Here, we discuss the etiological classification and treatment strategies of secondary intra- and extrahepatic bile duct dilatation based on an extensive literature review, as well as our experimental research and clinical experience. The etiology of secondary intra- and extrahepatic bile duct dilatation can be classified in different ways. From a clinicopathological perspective, it can be classified into obstruction-, lesion-, and compression-induced dilatation. Treatment varies depending on the cause. For example, endoscopic dilation or stenting is used for biliary strictures, laparoscopic choledochectomy for stone removal, and resection for cholangiocarcinoma.
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Conductos Biliares Extrahepáticos/patología , Conductos Biliares Intrahepáticos/patología , Dilatación Patológica/patología , Bilirrubina/sangre , Colestasis/patología , Dilatación Patológica/terapia , Humanos , Ictericia/patologíaRESUMEN
Mitral regurgitation (MR) is a known complication of transcatheter aortic valve replacement (TAVR). We report a case of a 90-year-old man with severe symptomatic aortic stenosis who underwent elective TAVR. The procedure was complicated by severe functional MR from left ventricular stunning and dilatation caused by hypotension throughout the procedure. An Impella CP (Abiomed, Inc, Danvers, MA) was inserted to unload the left ventricle and decrease its size with subsequent improvement in MR severity, which was sustained after Impella CP removal. In conclusion, we present the first case of successful management of post-TAVR severe functional MR with an Impella CP.
Asunto(s)
Estenosis de la Válvula Aórtica/cirugía , Válvula Aórtica , Circulación Asistida , Ventrículos Cardíacos , Corazón Auxiliar , Insuficiencia de la Válvula Mitral , Complicaciones Posoperatorias , Reemplazo de la Válvula Aórtica Transcatéter , Anciano de 80 o más Años , Válvula Aórtica/diagnóstico por imagen , Válvula Aórtica/patología , Válvula Aórtica/cirugía , Circulación Asistida/instrumentación , Circulación Asistida/métodos , Dilatación Patológica/diagnóstico , Dilatación Patológica/etiología , Dilatación Patológica/terapia , Ecocardiografía Transesofágica/métodos , Ventrículos Cardíacos/patología , Ventrículos Cardíacos/fisiopatología , Humanos , Masculino , Insuficiencia de la Válvula Mitral/diagnóstico , Insuficiencia de la Válvula Mitral/etiología , Insuficiencia de la Válvula Mitral/fisiopatología , Insuficiencia de la Válvula Mitral/terapia , Complicaciones Posoperatorias/diagnóstico , Complicaciones Posoperatorias/etiología , Complicaciones Posoperatorias/fisiopatología , Complicaciones Posoperatorias/terapia , Índice de Severidad de la Enfermedad , Cirugía Asistida por Computador/métodos , Reemplazo de la Válvula Aórtica Transcatéter/efectos adversos , Reemplazo de la Válvula Aórtica Transcatéter/métodos , Resultado del TratamientoRESUMEN
HIV is known to increase the risk of both ischemic and hemorrhagic strokes. There are many postulated mechanisms for this elevated risk including an HIV-induced vasculopathy and/or coagulopathy, opportunistic infections, and cardioembolic etiologies, among others. Regarding vasculopathy, prior reports have described the various changes to the arterial vasculature that can occur in the setting of HIV, yet the appropriate workup and management of this condition remains poorly defined. Here we describe two cases of patients with HIV presenting with large vessel intracranial occlusions in the setting of ectatic extracranial vasculature accompanied by intraluminal thrombus formation. One patient underwent thrombectomy, while the other improved after receiving IV-tPA. Inferring on these cases and the existing literature, a standardized workup and treatment algorithm is proposed, emphasizing the key management decisions that should be considered on a case-by-case basis.
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Infarto Cerebral/terapia , Dilatación Patológica/terapia , Infecciones por VIH/terapia , Trombectomía/métodos , Trombosis/terapia , Activador de Tejido Plasminógeno/uso terapéutico , Algoritmos , Infarto Cerebral/diagnóstico por imagen , Infarto Cerebral/patología , Infarto Cerebral/virología , Toma de Decisiones Clínicas/métodos , Dilatación Patológica/diagnóstico por imagen , Dilatación Patológica/patología , Dilatación Patológica/virología , Femenino , Fibrinolíticos/uso terapéutico , VIH/patogenicidad , Infecciones por VIH/diagnóstico por imagen , Infecciones por VIH/patología , Infecciones por VIH/virología , Humanos , Masculino , Persona de Mediana Edad , Trastornos Relacionados con Sustancias/diagnóstico por imagen , Trastornos Relacionados con Sustancias/patología , Trastornos Relacionados con Sustancias/virología , Trombosis/diagnóstico por imagen , Trombosis/patología , Trombosis/virologíaRESUMEN
PURPOSE: To compare accelerated corneal crosslinking (CXL) alone, CXL with simultaneous intrastromal corneal ring segments (CXL-ICRS), and CXL with simultaneous topography-guided photorefractive keratectomy (CXL-TG-PRK) in progressive keratoconus, pellucid marginal degeneration (PMD), or laser in situ keratomileusis (LASIK)-induced ectasia. SETTING: The Kensington Eye Institute and Bochner Eye Institute, Toronto, Canada. DESIGN: Prospective nonrandomized interventional study. METHODS: Visual and topographical outcomes using a comparative analysis adjusting for preoperative maximum keratometry (Kmax) were evaluated 1 year postoperatively. RESULTS: Four hundred fifty-two eyes from 375 patients with progressive keratoconus, PMD, or LASIK-induced ectasia that underwent accelerated (9 mW/cm, 10 minutes) CXL alone (n = 204), CXL-ICRS (n = 126), or CXL-TG-PRK (n = 122) were included. Change in logarithm of the minimum angle of resolution uncorrected distance visual acuity was significant with CXL-ICRS (-0.31; 95% CI, -0.38 to -0.24) and CXL-TG-PRK (-0.16; 95% CI, -0.24 to -0.09), but not with CXL alone. No significant differences in change were found between the 3 groups. Change in corrected distance visual acuity (CDVA) was significant in all 3 groups: -0.12 (95% CI, -0.15 to -0.10) with CXL alone, -0.23 (95% CI, -0.27 to -0.20) with CXL-ICRS, and -0.17 (95% CI, -0.21 to -0.13) with CXL-TG-PRK. Improvement in CDVA was greater with CXL-ICRS than with CXL alone (-0.08 ± 0.02; P < .0001) and CXL-TG-PRK (-0.05 ± 0.02; P = .005). Change in Kmax was significant with CXL-ICRS [-3.21 diopters (D); 95% CI, -3.98 to -2.45] and CXL-TG-PRK (-3.69 D; 95% CI, -4.49 to -2.90), but not with CXL alone (-0.05 D; 95% CI, -0.66 to 0.55). CONCLUSIONS: CXL alone might be best for keratoconic patients who meet the inclusion criteria. CXL-ICRS might be more effective for eyes with more irregular astigmatism and worse CDVA and CXL-TG-PRK for eyes requiring improvements in irregular astigmatism but still have good CDVA.
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Reactivos de Enlaces Cruzados , Queratocono/terapia , Láseres de Excímeros/uso terapéutico , Queratectomía Fotorrefractiva/métodos , Fármacos Fotosensibilizantes/uso terapéutico , Prótesis e Implantes , Adulto , Colágeno/metabolismo , Sustancia Propia/metabolismo , Sustancia Propia/cirugía , Topografía de la Córnea , Dilatación Patológica/terapia , Femenino , Humanos , Queratocono/tratamiento farmacológico , Queratocono/fisiopatología , Queratocono/cirugía , Masculino , Pronóstico , Estudios Prospectivos , Implantación de Prótesis , Refracción Ocular/fisiología , Riboflavina/uso terapéutico , Cirugía Asistida por Computador , Encuestas y Cuestionarios , Rayos Ultravioleta , Agudeza Visual/fisiología , Adulto JovenRESUMEN
BACKGROUND: The natural history and management of dural ectasia in Neurofibromatosis 1 (NF1) is still largely unknown. Dural ectasias are one of the common clinical manifestations of NF1; however, the treatment options for dural ectasias remain unstudied. OBJECTIVE: To investigate the natural history, diagnosis, management, and outcome of the largest case series of patients with NF1-associated dural ectasia to date. METHODS: Records from our NF1 clinic were reviewed to identify NF1 patients with computed tomography or magnetic resonance imaging evidence of dural ectasia(s) to determine their clinical course. Demographics, symptoms, radiographic and histopathologic findings, treatment, and clinical course were assessed. RESULTS: Thirty-four of 37 patients were managed without surgery. Of the 18 initially asymptomatic patients, 5 (27.8%) progressed to symptoms attributable to a dural ectasia (onset of 2.7% per patient-year). Three patients required surgical intervention because of extraspinal mass effect. All 3 initially improved but had symptom recurrence within 2 yr. Reoperation involved shunt placement for cerebrospinal fluid (CSF) diversion. On imaging review, 26 (76.5%) of the nonsurgical patients harbored an associated nearby plexiform neurofibroma. Pathology of one surgical case revealed dural infiltration by diffuse neurofibroma. CONCLUSION: Using the largest NF1-associated dural ectasia group to date, we report the first symptom-onset rate for nonsurgical patients. In the few cases requiring surgery for decompression, primary resection, and patching of ectasias failed, subsequently requiring CSF shunting. We demonstrate imaging evidence of nearby plexiform neurofibroma in a majority of cases, which, when combined with histopathology, provides a novel explanation for the formation of dural ectasias.
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Duramadre/patología , Neurofibromatosis 1/complicaciones , Enfermedades de la Médula Espinal/etiología , Enfermedades de la Médula Espinal/terapia , Adolescente , Adulto , Anciano , Niño , Preescolar , Tratamiento Conservador/métodos , Descompresión Quirúrgica/métodos , Dilatación Patológica/etiología , Dilatación Patológica/terapia , Femenino , Humanos , Lactante , Masculino , Persona de Mediana Edad , Adulto JovenRESUMEN
PURPOSE: To assess the clinical efficacy of sequential intrastromal corneal ring segment (ICRS) implantation and corneal crosslinking (CXL) in corneal ectasia. METHODS: This retrospective case series included eight eyes in which both ICRS implantation and CXL had been performed. CXL was performed within 1 month after ICRS implantation. The clinical outcomes (visual acuity, refractive errors, keratometry, and topographic indices) of these patients were compared with those of patients who had undergone only ICRS implantation (eight eyes) or CXL (20 eyes). RESULTS: Greater improvement in uncorrected visual acuity was observed in the ICRS + CXL group than in the ICRS or CXL alone groups at both 6 (p = 0.008) and 12 months (p = 0.028). Refractive errors of sphere and spherical equivalent were significantly reduced in both the ICRS (p = 0.002 at 6 months, p = 0.004 at 12 months) and ICRS + CXL groups (p < 0.001 at both 6 and 12 months). Keratometric values including the maximum, minimum, and average were significantly reduced in all 3 groups at postoperative 6 and 12 months; however, the greatest reductions were observed in the ICRS + CXL group (all p < 0.001). CONCLUSIONS: ICRS implantation followed by CXL within 1 month seems to be effective, and may be superior to ICRS or CXL alone in improving visual acuity and reducing refractive errors and keratometric values.
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Colágeno/metabolismo , Sustancia Propia/cirugía , Reactivos de Enlaces Cruzados , Queratocono/terapia , Fármacos Fotosensibilizantes/uso terapéutico , Prótesis e Implantes , Implantación de Prótesis , Adulto , Terapia Combinada , Paquimetría Corneal , Sustancia Propia/metabolismo , Topografía de la Córnea , Dilatación Patológica/terapia , Femenino , Humanos , Queratocono/tratamiento farmacológico , Queratocono/metabolismo , Queratocono/cirugía , Masculino , Refracción Ocular/fisiología , Errores de Refracción/fisiopatología , Estudios Retrospectivos , Riboflavina/uso terapéutico , Tomografía de Coherencia Óptica , Rayos Ultravioleta , Agudeza Visual/fisiología , Adulto JovenRESUMEN
Abstract A 26-year-old man, single, business student, reveals a ectasic cornea during corneal topography exam. Among some procedures, the patient chose Orthokeratology to do a corneal reshape and got successfully a good visual acuity, going against the most authors guidance.
Resumo Estudante de 26 anos, masculino, estudante de economia, apresentou ao exame topográfico de córneas, ectasia corneal. Dentre todos os procedimentos apresentados, optou pela ortoceratologia para o remodelamento corneal, e obteve sucesso com melhora da acuidade visual, indo contra a orientação da maioria dos autores.
Asunto(s)
Humanos , Masculino , Adulto , Córnea/patología , Dilatación Patológica/terapia , Procedimientos de Ortoqueratología , Agudeza Visual , Topografía de la Córnea , Dilatación Patológica/diagnóstico , Queratocono/diagnósticoRESUMEN
A 21-year-old female patient with repaired tetralogy of Fallot and aortic valvular reconstruction with aneurysmal aortic root and severe aortic regurgitation underwent aortic root replacement. Intrinsic aortopathy in tetralogy of Fallot and its surgical importance are highlighted.
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Aneurisma de la Aorta Torácica/cirugía , Insuficiencia de la Válvula Aórtica/cirugía , Válvula Aórtica/cirugía , Complicaciones Posoperatorias/cirugía , Tetralogía de Fallot/cirugía , Aorta/fisiopatología , Aorta/cirugía , Puente Cardiopulmonar , Dilatación Patológica/terapia , Femenino , Humanos , Procedimientos de Cirugía Plástica , Reoperación , Tetralogía de Fallot/complicaciones , Adulto JovenRESUMEN
BACKGROUND: Some patients complain that eating lettuce, gives them gas and abdominal distention. Our aim was to determine to what extent the patients' assertion is sustained by evidence. METHODS: An in vitro study measured the amount of gas produced during the process of fermentation by a preparation of human colonic microbiota (n = 3) of predigested lettuce, as compared to beans, a high gas-releasing substrate, to meat, a low gas-releasing substrate, and to a nutrient-free negative control. A clinical study in patients complaining of abdominal distention after eating lettuce (n = 12) measured the amount of intestinal gas and the morphometric configuration of the abdominal cavity in abdominal CT scans during an episode of lettuce-induced distension as compared to basal conditions. KEY RESULTS: Gas production by microbiota fermentation of lettuce in vitro was similar to that of meat (P = .44), lower than that of beans (by 78 ± 15%; P < .001) and higher than with the nutrient-free control (by 25 ± 19%; P = .05). Patients complaining of abdominal distension after eating lettuce exhibited an increase in girth (35 ± 3 mm larger than basal; P < .001) without significant increase in colonic gas content (39 ± 4 mL increase; P = .071); abdominal distension was related to a descent of the diaphragm (by 7 ± 3 mm; P = .027) with redistribution of normal abdominal contents. CONCLUSION AND INFERENCES: Lettuce is a low gas-releasing substrate for microbiota fermentation and lettuce-induced abdominal distension is produced by an uncoordinated activity of the abdominal walls. Correction of the somatic response might be more effective than the current dietary restriction strategy.
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Cavidad Abdominal/diagnóstico por imagen , Dilatación Patológica/etiología , Gases/metabolismo , Microbioma Gastrointestinal/fisiología , Lactuca/efectos adversos , Cavidad Abdominal/patología , Pared Abdominal/diagnóstico por imagen , Pared Abdominal/fisiopatología , Adulto , Animales , Antropometría , Biorretroalimentación Psicológica , Bovinos , Diagnóstico Diferencial , Diafragma/diagnóstico por imagen , Diafragma/fisiopatología , Digestión , Dilatación Patológica/diagnóstico por imagen , Dilatación Patológica/terapia , Electromiografía , Heces/microbiología , Femenino , Fermentación , Flatulencia/diagnóstico , Humanos , Técnicas In Vitro , Carne , Persona de Mediana Edad , Contracción Muscular , Phaseolus , Solución Salina , Tomografía Computarizada por Rayos X , Adulto JovenAsunto(s)
Adenocarcinoma/diagnóstico por imagen , Conductos Biliares/diagnóstico por imagen , Conductos Biliares/patología , Conductos Pancreáticos/diagnóstico por imagen , Conductos Pancreáticos/patología , Neoplasias Intraductales Pancreáticas/diagnóstico por imagen , Neoplasias Pancreáticas/diagnóstico por imagen , Adenocarcinoma/complicaciones , Adenocarcinoma/patología , Anciano , Colangiopancreatografia Retrógrada Endoscópica , Pancreatocolangiografía por Resonancia Magnética , Dilatación Patológica/diagnóstico por imagen , Dilatación Patológica/etiología , Dilatación Patológica/terapia , Biopsia por Aspiración con Aguja Fina Guiada por Ultrasonido Endoscópico , Femenino , Humanos , Neoplasias Intraductales Pancreáticas/patología , Neoplasias Pancreáticas/complicaciones , Neoplasias Pancreáticas/patología , Stents Metálicos Autoexpandibles , Tomografía Computarizada por Rayos XRESUMEN
PURPOSE: To report an unusual case of bilateral crystalline keratopathy presenting several years after a laser in situ keratomileusis (LASIK) procedure. METHODS: Case report and review of the literature. RESULTS: A healthy 42-year-old woman with post-LASIK ectasia, treated with long-term corneoscleral contact lenses, developed new-onset crystalline keratopathy in both eyes. Anterior segment optical coherence tomography demonstrated bilaterally symmetric paracentral rings of hyperreflectivity, involving the LASIK corneal flaps. There was good clearance of the corneoscleral contact lenses with no corneal-lens touch in all quadrants. There was no evidence of infectious or systemic etiologies. Genetic testing for the UBIAD1 gene for Schnyder corneal dystrophy was negative. Continued clinical observations have exhibited progressive corneal crystalline deposition, yet the patient has remained visually asymptomatic. CONCLUSIONS: This is the first known reported case of significantly delayed progressive noninfectious crystalline keratopathy in post-LASIK ectasia. The pathophysiology of this condition remains elusive to date and highlights the challenges of noninvasive diagnostic techniques and yet the utility of molecular genetic analysis in elucidating the etiology of this unique clinical presentation.
Asunto(s)
Lentes de Contacto/efectos adversos , Enfermedades de la Córnea/etiología , Dilatación Patológica/terapia , Queratomileusis por Láser In Situ/efectos adversos , Adulto , Femenino , HumanosRESUMEN
PURPOSE: To analyze the relationship between corneal sagittal height and asymmetry parameters derived from Placido-videokeratoscopy with the parameters of fitted scleral lenses (ScCLs). METHODS: Corneal topographies were measured with MedmontE300 in a total of 126 eyes with irregular and regular corneas before ScCL fitting were analyzed. Measurements of sagittal height (OC-SAG) at steep and flat corneal meridians were obtained for 10 mm and 12 mm chords. Estimated Height (EHChord) parameters were taken for a chord equal to the diameter of the lens that each subject was wearing at different semi-meridians. Corneal asymmetry (difference in OC-SAG between steep and flat corneal meridians) was also assessed. These outcomes were correlated to ScCL parameters that subjects were wearing after 1 month. RESULTS: The mean ScCL-SAG was 4696 ± 240 µm, and the mean OC-SAG ranged from 1891 µm (10 mm), 2914 µm (12 mm), and between 4162 µm and 4251 µm for EH0-180º and EH30-210º. Stronger correlations (p < 0.001) between OC-SAG and ScCL-SAG were determined for EH0-180º (r = 0.595) and EH30-210º (r = 0.618). The mean differences between OC-SAG and ScCL-SAG were between 447 ± 290 µm (EH0-180º) and 389 ± 360 µm (EH30-210º). There was no relationship between corneal asymmetry and the need to fit a ScCL with toric haptic design in irregular corneas. Orientation of flat corneal and scleral meridians were similar only in corneas with high regular astigmatism. CONCLUSIONS: EHChord attributes were the parameters that best correlated with the ScCL-SAG. The corneal asymmetry was shown to be a poor predictor for the need to fit a ScCL with toricity at landing zone in irregular corneas, but could have some predictive power in regular corneas.
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Lentes de Contacto Hidrofílicos , Topografía de la Córnea/métodos , Queratocono/terapia , Ajuste de Prótesis/métodos , Errores de Refracción/terapia , Esclerótica , Adolescente , Adulto , Anciano , Dilatación Patológica/terapia , Femenino , Humanos , Masculino , Persona de Mediana Edad , Estudios Retrospectivos , Adulto JovenRESUMEN
BACKGROUND: To report a first case of lenticule addition and corneal cross-linking for post-LASIK ectasia with associated corneal thinning. CASE PRESENTATION: Lenticule addition followed by corneal cross-linking was performed on the left eye of a patient with post-LASIK ectasia. Postoperatively, the corneal power and elevation were stable with a remarkable improvement in corneal thickness, and the lenticule had merged with the adjacent corneal stroma at 30 months follow-up. The patient's corrected distance visual acuity gained two lines. CONCLUSIONS: This case provides a potential treatment option for patients with keratectasia and keratoconus in association with thin corneal thickness (less than 400 µm) and may provide the benefit of delaying or avoiding the need for keratoplasty, which has its own associated complications and is limited by the availability of donor corneas.
Asunto(s)
Sustancia Propia/cirugía , Reactivos de Enlaces Cruzados , Queratocono/terapia , Queratomileusis por Láser In Situ , Láseres de Excímeros , Fotoquimioterapia/métodos , Complicaciones Posoperatorias , Adulto , Colágeno/metabolismo , Terapia Combinada , Sustancia Propia/metabolismo , Topografía de la Córnea , Dilatación Patológica/etiología , Dilatación Patológica/terapia , Humanos , Queratocono/etiología , Queratocono/metabolismo , Queratocono/fisiopatología , Masculino , Microscopía Confocal , Fármacos Fotosensibilizantes/uso terapéutico , Riboflavina/uso terapéutico , Tomografía de Coherencia Óptica , Rayos Ultravioleta , Agudeza Visual/fisiologíaRESUMEN
The surgical technique of olfactory cleft dilatation consists in transmucosal lateral fracture-dislocation of the lateral wall of each olfactory cleft (i.e., of the turbinate wall of the ethmoid, composed, from anterior to posterior, of the middle, superior and supreme turbinates), in order to get access to the recess hosting the human olfactory mucosa and to the roof of the olfactory cleft (i.e., cribriform plate), with minimal trauma to the mucosa. Olfactory cleft dilatation is indicated for dysosmia secondary to constitutional stenosis of the olfactory clefts due to abnormal development of the ethmoid. Constitutional stenosis of the olfactory clefts should be differentiated from inflammatory obstruction and other diseases of the olfactory clefts, and especially from respiratory epithelial adenomatoid hamartoma, which enlarges the olfactory clefts and must be treated by resection. The technique of olfactory cleft dilatation is illustrated by three surgical cases. There was clear improvement in dysosmia in all three cases, without any complications. The place of constitutional olfactory cleft stenosis needs still to be defined in both diagnosis and treatment of dysosmia.
Asunto(s)
Constricción Patológica/terapia , Dilatación Patológica/terapia , Hueso Etmoides/patología , Adolescente , Adulto , Constricción Patológica/diagnóstico por imagen , Dilatación Patológica/diagnóstico por imagen , Endoscopía , Hueso Etmoides/cirugía , Femenino , Glucocorticoides/uso terapéutico , Humanos , Obstrucción Nasal/etiología , Obstrucción Nasal/terapia , Tabique Nasal/patología , Tabique Nasal/cirugía , Trastornos del Olfato/etiología , Trastornos del Olfato/terapia , Tomografía Computarizada por Rayos X , Cornetes Nasales/patología , Cornetes Nasales/cirugía , Adulto JovenRESUMEN
BACKGROUND: Prevalence and prognostic significance of pulmonary artery (PA) dilatation in congenital heart disease (CHD) have never been studied systematically. METHODS: Chest X-rays of 1192 consecutive adults with CHD were reviewed. Major diameter of the PA was determined by imaging techniques in those with PA dilatation. A value >29â¯mm was considered abnormal. Data on anatomy, hemodynamics, residual lesions and outcomes were retrospectively collected. RESULTS: Overall prevalence of PA dilatation was 18%. A minority of patients (5.5%) reached 40â¯mm (aneurysm; PAA) and 1.8% exceeded 50â¯mm. The most common PAA underlying malformations were pulmonary stenosis (21%), and shunts (55%). Significantly larger diameters were observed in hypertensive shunts (40â¯mm; IQR 36.7-45â¯mm vs. 34â¯mm; IQR 32-36â¯mm) (pâ¯<â¯0.0001). However, the largest diameters were found in cono-truncal anomalies. There was no significant correlation between PA dimensions and systolic pulmonary pressure (râ¯=â¯-0.196), trans-pulmonary gradient (râ¯=â¯-0.203), pulmonary regurgitation (PR) (râ¯=â¯0.071) or magnitude of shunt (râ¯=â¯0.137) (pâ¯>â¯0.05 for all). Over follow-up, 1 sudden death (SD) occurred in one Eisenmenger patient. Complications included coronary (3), recurrent laryngeal nerve (1) and airway (1) compressions, progressive PR (1), and PA thrombosis (1). Coronary compression and SD were strongly associated (univariate analysis) with pulmonary hypertension (120 vs. 55â¯mmâ¯Hg; pâ¯=â¯0.002) but not with extreme PA dilatation (range: 40-65â¯mm). CONCLUSIONS: PA dilatation in CHD is common but only a small percentage of patients have PAA. Clinical impact on outcomes is low. Complications occurred almost exclusively in patients with pulmonary hypertension whereas PA diameter alone was not associated with adverse outcomes.
Asunto(s)
Aneurisma/diagnóstico por imagen , Aneurisma/epidemiología , Cardiopatías Congénitas/diagnóstico por imagen , Cardiopatías Congénitas/epidemiología , Arteria Pulmonar/diagnóstico por imagen , Adulto , Anciano , Aneurisma/terapia , Estudios de Cohortes , Dilatación Patológica/diagnóstico por imagen , Dilatación Patológica/epidemiología , Dilatación Patológica/terapia , Femenino , Estudios de Seguimiento , Cardiopatías Congénitas/terapia , Humanos , Masculino , Persona de Mediana Edad , Prevalencia , PronósticoRESUMEN
The intent of the Operational K9 (OpK9) ongoing series is to provide the Special Operations Medical Association community with clinical concepts and scientific information on preventive and prehospital emergency care relevant to the OpK9. Often the only medical support immediately available for an injured or ill OpK9 in the field is their handler or the human Special Operations Combat Medic or civilian tactical medic attached to the team (e.g., Pararescueman, 18D, SWAT medic). The information is applicable to personnel operating within the US Special Operations Command as well as civilian Tactical Emergency Medical Services communities that may have the responsibility of supporting an OpK9.
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Tratamiento de Urgencia , Vólvulo Gástrico/terapia , Vólvulo Gástrico/veterinaria , Animales , Dilatación Patológica/diagnóstico , Dilatación Patológica/terapia , Dilatación Patológica/veterinaria , Perros , Masculino , Estómago/patología , Vólvulo Gástrico/diagnóstico , Estados Unidos , Servicio Veterinario MilitarRESUMEN
A 79-year-old male with diabetes mellitus and old cerebral infarction was admitted to hospital due to fever and palpitation. Diagnosis of purulent pericarditis was established by pericardial effusion examination. The patient's general condition improved temporarily after drainage of the pericardial effusion. However, computed tomography demonstrated a saccular aneurysm arising from RCA have rapidly grown even larger, up to 63 × 51 mm on 7th hospital day. This indicated that the risk of rupture of the aneurysm was high. Percutaneous coronary intervention was applied to prevent rupture of the aneurysm. Several polytetrafluoroethylene (PTFE)-covered stents were required to cover the extended aneurysm lesion. A long drug-eluting stent (DES), which was initially implanted through the aneurysm, was itself implanted with 3 PTFE-covered stents located inside the DES. This procedure provided protection against endoleak of the aneurysm. To our knowledge, the present case shows for the first time that PTFE-covered stents located within DES are useful in treatment of a giant coronary aneurysm.
Asunto(s)
Aneurisma Coronario/diagnóstico por imagen , Aneurisma Coronario/terapia , Vasos Coronarios/diagnóstico por imagen , Dilatación Patológica/terapia , Stents , Anciano , Materiales Biocompatibles , Implantación de Prótesis Vascular , Aneurisma Coronario/microbiología , Vasos Coronarios/efectos de los fármacos , Dilatación Patológica/diagnóstico por imagen , Stents Liberadores de Fármacos , Endofuga/etiología , Endofuga/prevención & control , Humanos , Masculino , Intervención Coronaria Percutánea , Derrame Pericárdico/diagnóstico por imagen , Derrame Pericárdico/microbiología , Derrame Pericárdico/terapia , Pericarditis/complicaciones , Pericarditis/diagnóstico por imagen , Pericarditis/microbiología , Politetrafluoroetileno , Valor Predictivo de las Pruebas , Infecciones Estafilocócicas/complicaciones , Infecciones Estafilocócicas/microbiología , Staphylococcus aureus/aislamiento & purificación , SupuraciónRESUMEN
OBJECTIVE: To compare neurodevelopmental outcomes of preterm infants with and without intervention for posthemorrhagic ventricular dilatation (PHVD) managed with an "early approach" (EA), based on ventricular measurements exceeding normal (ventricular index [VI] <+2 SD/anterior horn width <6 mm) with initial temporizing procedures, followed, if needed, by permanent shunt placement, and a "late approach" (LA), based on signs of increased intracranial pressure with mostly immediate permanent intervention. METHODS: Observational cohort study of 127 preterm infants (gestation <30 weeks) with PHVD managed with EA (n = 78) or LA (n = 49). Ventricular size was measured on cranial ultrasound. Outcome was assessed at 18-24 months. RESULTS: Forty-nine of 78 (63%) EA and 24 of 49 (49%) LA infants received intervention. LA infants were slightly younger at birth, but did not differ from EA infants for other clinical measures. Initial intervention in the EA group occurred at younger age (29.4/33.1 week postmenstrual age; p < 0.001) with smaller ventricles (VI 2.4/14 mm >+2 SD; p < 0.01), and consisted predominantly of lumbar punctures or reservoir taps. Maximum VI in infants with/without intervention was similar in EA (3/1.5 mm >+2 SD; p = 0.3) but differed in the LA group (14/2.1 mm >+2 SD; p < 0.001). Shunt rate (20/92%; p < 0.001) and complications were lower in EA than LA group. Most EA infants had normal outcomes (>-1 SD), despite intervention. LA infants with intervention had poorer outcomes than those without (p < 0.003), with scores <-2 SD in 81%. CONCLUSION: In preterm infants with PHVD, those with early intervention, even when eventually requiring a shunt, had outcomes indistinguishable from those without intervention, all being within the normal range. In contrast, in infants managed with LA, need for intervention predicted worse outcomes. Benefits of EA appear to outweigh potential risks. CLASSIFICATION OF EVIDENCE: This study provides Class III evidence that for preterm infants with PHVD, an EA to management results in better neurodevelopmental outcomes than a LA.