RESUMEN
OBJECTIVE: To evaluate the relationship between obesity and asthma. METHODS: This was a preliminary cross-sectional analysis involving 925 subjects with mild-to-moderate or severe asthma evaluated between 2013 and 2015. Obesity was defined on the basis of body mass index (BMI) and abdominal circumference. We collected clinical, laboratory, and anthropometric parameters, as well as pulmonary function test results and data regarding comorbidities. The subjects also completed asthma control and quality of life questionnaires. RESULTS: Obese individuals had a significantly higher number of neutrophils in peripheral blood than did nonobese individuals (p = 0.01). Among the obese individuals, 163 (61%) had positive skin-prick test results, as did 69% and 71% of the individuals classified as being overweight or normal weight, respectively. Obese individuals showed lower spirometric values than did nonobese individuals, and 32% of the obese individuals had uncontrolled asthma, a significantly higher proportion than that found in the other groups (p = 0.02). CONCLUSIONS: Obese individuals with asthma seem to present with poorer asthma control and lower pulmonary function values than do nonobese individuals. The proportion of subjects with nonatopic asthma was higher in the obese group. Our results suggest that obese individuals with asthma show a distinct inflammatory pattern and are more likely to present with difficult-to-control asthma than are nonobese individuals.
Asunto(s)
Asma/fisiopatología , Obesidad/fisiopatología , Adolescente , Adulto , Asma/sangre , Índice de Masa Corporal , Estudios Transversales , Eosinofilia/sangre , Eosinofilia/fisiopatología , Femenino , Volumen Espiratorio Forzado , Humanos , Masculino , Persona de Mediana Edad , Neutrófilos/fisiología , Obesidad/sangre , Calidad de Vida , Valores de Referencia , Índice de Severidad de la Enfermedad , Espirometría , Estadísticas no Paramétricas , Capacidad Vital , Adulto JovenRESUMEN
ABSTRACT Objective: To evaluate the relationship between obesity and asthma. Methods: This was a preliminary cross-sectional analysis involving 925 subjects with mild-to-moderate or severe asthma evaluated between 2013 and 2015. Obesity was defined on the basis of body mass index (BMI) and abdominal circumference. We collected clinical, laboratory, and anthropometric parameters, as well as pulmonary function test results and data regarding comorbidities. The subjects also completed asthma control and quality of life questionnaires. Results: Obese individuals had a significantly higher number of neutrophils in peripheral blood than did nonobese individuals (p = 0.01). Among the obese individuals, 163 (61%) had positive skin-prick test results, as did 69% and 71% of the individuals classified as being overweight or normal weight, respectively. Obese individuals showed lower spirometric values than did nonobese individuals, and 32% of the obese individuals had uncontrolled asthma, a significantly higher proportion than that found in the other groups (p = 0.02). Conclusions: Obese individuals with asthma seem to present with poorer asthma control and lower pulmonary function values than do nonobese individuals. The proportion of subjects with nonatopic asthma was higher in the obese group. Our results suggest that obese individuals with asthma show a distinct inflammatory pattern and are more likely to present with difficult-to-control asthma than are nonobese individuals.
RESUMO Objetivo: Avaliar a relação entre obesidade e asma. Métodos: Análise preliminar transversal de dados de um estudo de caso-controle com 925 pacientes com asma leve a moderada ou grave, avaliados entre 2013 e 2015. A classificação de obesidade levou em conta o índice de massa corpórea (IMC) e a circunferência abdominal. Foram coletados parâmetros clínicos, laboratoriais, medidas antropométricas e de função pulmonar, assim como resultados de questionários de controle da asma e de qualidade de vida e presença de comorbidades. Resultados: Os indivíduos obesos apresentaram um número significativamente maior de neutrófilos no sangue periférico que os não obesos (p = 0,01). Entre os obesos, 163 (55%) apresentaram positividade no teste alérgico, enquanto os grupos com sobrepeso e IMC normal apresentaram positividade em 62% e 67%, respectivamente. Os parâmetros espirométricos dos indivíduos obesos foram mais baixos que os dos não obesos, e 97 obesos (32%) apresentaram asma não controlada, uma proporção significativamente maior do que a observada nos demais grupos de estudo (p = 0,02). Conclusões: Indivíduos asmáticos e obesos têm pior controle da asma e valores mais baixos de parâmetros de função pulmonar que os não obesos. A proporção de pacientes sem atopia entre asmáticos obesos foi maior que entre os não obesos. Nossos resultados sugerem que indivíduos asmáticos obesos podem apresentar um padrão inflamatório diferente do habitual e doença de mais difícil controle quando comparados com indivíduos asmáticos não obesos.
Asunto(s)
Humanos , Masculino , Femenino , Adolescente , Adulto , Persona de Mediana Edad , Adulto Joven , Asma/fisiopatología , Obesidad/fisiopatología , Calidad de Vida , Valores de Referencia , Asma/sangre , Espirometría , Índice de Severidad de la Enfermedad , Índice de Masa Corporal , Capacidad Vital , Volumen Espiratorio Forzado , Estudios Transversales , Estadísticas no Paramétricas , Eosinofilia/fisiopatología , Eosinofilia/sangre , Neutrófilos/fisiología , Obesidad/sangreRESUMEN
La esofagitis eosinofílica (EE) es una enfermedad primaria del esófago, previamente confundida con el reflujo gastroesofágico (RGE), cuyo conocimiento se ha desarrollado principalmente en la última década. Se define como la presencia de síntomas de disfunción esofágica (principalmente disfagia e impactación alimentaria), asociados a por lo menos una biopsia esofágica con más de 15 eosinófilos por campo de mayor aumento (CMA), y la exclusión de RGE. Su prevalencia va en aumento y afecta principalmente a niños y hombres jóvenes de raza blanca con historia previa de atopía. La EE sería causada por una reacción alérgica a ciertos alimentos y/o aeroalérgenos mediada por citoquinas y con cambios genéticos involucrados. La presentación clínica varía con la edad siendo la disfagia el síntoma más frecuente en todos los grupos etarios. El diagnóstico es clínico, endoscópico y anatomopatológico. Se requiere de una endoscopía digestiva alta (EDA) para evaluar hallazgos característicos y tomar biopsias para el estudio histológico. Los tratamientos actuales incluyen medidas dietéticas basadas en la eliminación de la exposición de alérgenos alimentarios y uso de corticoesteroides tópicos. El objetivo de esta revisión es analizar el estado actual de la definición de EE, historia, epidemiología, fisiopatología, diagnóstico y principalmente ayudara mejorar su sospecha diagnóstica y manejo.
Eosinophilic esophagitis (EE) is a primary disease of the esophagus, previously mistaken with gastroesophageal reflux disease (GERD). Its knowledge has developed over the last decade. EE is defined as the presence ofesophageal dysfunction symptoms (mostly dysphagia and food impaction) associated to at least 1 esophageal biopsy with 15 or more eosinophils in 1 high-power field and absence of GERD. Its prevalence is rising, affecting principally white boys and young males with previous history of atopy. EE would be caused by an allergic reaction to certain food and aeroallergens mediated by citoquines with genetic changes involved. Clinical presentation varies with age being dysphagia the most common symptom in all age goups. The diagnosis is clinical, endoscopic and histopathologic. It requires an endoscopy to evaluate mucosal findings and to take the biopsies. Treatment includes elimination diets and topical steroids. The purpose of this review is to analyze the current state of the definition, history, epidemiology, fisiopathology and the diagnosis of EE, with an emphasis on improving its suspicion index and initial management.
Asunto(s)
Humanos , Eosinofilia/diagnóstico , Eosinofilia/fisiopatología , Eosinofilia/terapia , Esofagitis/diagnóstico , Esofagitis/fisiopatología , Esofagitis/terapia , Eosinofilia/epidemiología , Esofagitis/epidemiología , Pronóstico , Trastornos de Deglución/etiologíaRESUMEN
BACKGROUND/AIMS: Although eosinophils are considered to play an important role in the pathogenesis of various parasitic, allergic and autoimmune digestive diseases, their role in fulminant hepatic failure (FHF) is unknown. Our contribution was to identify and quantify eosinophils and cytokine levels [interleukin (IL)-6, IL-5 and macrophage inflammatory protein (MIP)-1alpha] in liver parenchyma and peripheral blood from FHF patients at pre- and post-transplantation steps. METHODS: Histochemical methods were used to identify/quantify eosinophils in liver samples. Liver and plasma cytokine levels were quantified using immunofluorescence methods. RESULTS: Fulminant hepatic failure patients showed a high number of intrahepatic eosinophils concomitant with an increased expression of IL-6, besides the IL-6-positive eosinophils associated with the lack of IL-5. Also, an increased number of eosinophils and soluble IL-6 and MIP-1alpha with a low expression of IL-5 in peripheral blood at the pretransplantation step was observed. CONCLUSIONS: The increased number of intrahepatic eosinophils, besides the high production of IL-6, may be involved in liver dysfunction. In addition, the low presence of IL-5 in liver and peripheral blood may represent a particular pattern of eosinophil behaviour in human liver failure, which may also involve MIP-1alpha. Further ex vivo studies are necessary to evaluate the specific role of eosinophils in FHF.
Asunto(s)
Eosinofilia/sangre , Eosinófilos/inmunología , Interleucina-5/sangre , Interleucina-6/sangre , Fallo Hepático Agudo/sangre , Adolescente , Adulto , Anciano , Biomarcadores/sangre , Movimiento Celular , Quimiocina CCL3/sangre , Preescolar , Eosinofilia/fisiopatología , Femenino , Hepatocitos/metabolismo , Humanos , Hígado/metabolismo , Fallo Hepático Agudo/fisiopatología , Fallo Hepático Agudo/cirugía , Trasplante de Hígado , Masculino , Persona de Mediana Edad , Adulto JovenRESUMEN
In noninfected rats, challenge with allergen following local IgE sensitization induced a pleurisy marked by intense protein exudation that plateaued from 30 min to 4 h after challenge, reducing thereafter. Infection of rats with Angiostrongylus costaricensis induced a 5-fold increase in blood eosinophil numbers by 25 days postinfection, whereas the numbers of eosinophils in the pleural cavity ranged from normal to a weak increase. In infected rats, identically sensitized, challenge with Ag induced a much shorter duration of pleural edema with complete resolution by 4 h, but no change in the early edema response. In parallel, infection increased the number of eosinophils recovered from the pleural cavity at 4 h, but not at 30 min, following allergen challenge. Pretreatment with IL-5 (100 IU/kg, i.v.) also increased eosinophil numbers in blood and, after allergen challenge, shortened the duration of the pleural edema and increased pleural eosinophil numbers. There were increases in the levels of both PGE2 and lipoxin A4 (LXA4) in pleural exudate. Selective cyclooxygenase (COX)-2 inhibitors, NS-398, meloxicam, and SC-236, did not alter pleural eosinophilia, but reversed the curtailment of the edema in either infected or IL-5-pretreated rats. Pretreatment of noninfected animals with the PGE analogue, misoprostol, or two stable LXA4 analogues did not alter the magnitude of pleural exudation response, but clearly shortened its duration. These results indicate that the early resolution of allergic pleural edema observed during A. costaricensis infection coincided with a selective local eosinophilia and seemed to be mediated by COX-2-derived PGE2 and LXA4.
Asunto(s)
Angiostrongylus/inmunología , Dinoprostona/fisiología , Edema/terapia , Eosinofilia/enzimología , Ácidos Hidroxieicosatetraenoicos/fisiología , Hipersensibilidad/terapia , Isoenzimas/metabolismo , Lipoxinas , Prostaglandina-Endoperóxido Sintasas/metabolismo , Infecciones por Strongylida/enzimología , Administración Oral , Animales , Antiinflamatorios no Esteroideos/metabolismo , Antiinflamatorios no Esteroideos/farmacología , Antígenos Helmínticos/administración & dosificación , Corticosterona/sangre , Ciclooxigenasa 2 , Inhibidores de la Ciclooxigenasa 2 , Inhibidores de la Ciclooxigenasa/administración & dosificación , Dinoprostona/metabolismo , Edema/enzimología , Edema/patología , Edema/fisiopatología , Eosinofilia/patología , Eosinofilia/fisiopatología , Exudados y Transudados/efectos de los fármacos , Exudados y Transudados/enzimología , Femenino , Ácidos Hidroxieicosatetraenoicos/metabolismo , Hipersensibilidad/enzimología , Hipersensibilidad/patología , Hipersensibilidad/fisiopatología , Inyecciones Intraperitoneales , Inyecciones Intravenosas , Interleucina-5/administración & dosificación , Isoenzimas/farmacología , Cinética , Leucotrieno C4/metabolismo , Masculino , Misoprostol/administración & dosificación , Derrame Pleural/enzimología , Derrame Pleural/metabolismo , Derrame Pleural/patología , Derrame Pleural/prevención & control , Pleuresia/enzimología , Pleuresia/patología , Pleuresia/fisiopatología , Prostaglandina-Endoperóxido Sintasas/farmacología , Ratas , Ratas Wistar , Infecciones por Strongylida/patología , Infecciones por Strongylida/fisiopatologíaAsunto(s)
Humanos , Masculino , Femenino , Recién Nacido , Lactante , Preescolar , Adolescente , Eosinófilos/fisiología , Eosinofilia/etiología , Eosinófilos/efectos de los fármacos , Eosinófilos/inmunología , Eosinofilia/diagnóstico , Eosinofilia/fisiopatología , Síndrome Hipereosinofílico/diagnóstico , Eosinofilia Pulmonar , Síndrome de Eosinofilia-Mialgia , Hiperplasia Angiolinfoide con Eosinofilia/etiología , Factores Quimiotácticos Eosinófilos , Mediadores de Inflamación , Programas de AutoevaluaciónAsunto(s)
Humanos , Masculino , Femenino , Recién Nacido , Lactante , Preescolar , Adolescente , Eosinófilos/fisiología , Eosinofilia/etiología , Hiperplasia Angiolinfoide con Eosinofilia/etiología , Factores Quimiotácticos Eosinófilos , Eosinófilos , Eosinófilos/inmunología , Síndrome de Eosinofilia-Mialgia , Eosinofilia/diagnóstico , Eosinofilia/fisiopatología , Mediadores de Inflamación , Eosinofilia Pulmonar , Programas de Autoevaluación , Síndrome Hipereosinofílico/diagnósticoRESUMEN
So far, the inhaled steroids are the most potent topical anti-inflammatories; however, they have disadvantages on their correct administration and possible side effects. The leukotrienes: LTC4, LTD4 and LTE4 are agents that are related with the asthma, because they promote the eosinophils proliferation, the destruction of the bronchial epithelium, bronchial constriction, sanguineous vasodilatation, stimulation of the mucous-producing glands with hypersecretion and decrease of the ciliary motility. The leukotrienes modifiers possess an effect antiinflammatory in the bronchial asthma, demonstrated in diverse clinical studies and they have a beneficial effect in the remodelling of the airways. They can also have clinical applications in the COPD, allergic rhinitis and in the chronic urticaria; however to make wider recommendations of their therapeutic indications more studies they will be made.
Asunto(s)
Antiasmáticos/uso terapéutico , Asma/tratamiento farmacológico , Antagonistas de Leucotrieno/uso terapéutico , Acetatos/farmacología , Acetatos/uso terapéutico , Administración Oral , Antiasmáticos/farmacología , Antiinflamatorios no Esteroideos/farmacología , Antiinflamatorios no Esteroideos/uso terapéutico , Broncoconstricción/efectos de los fármacos , Broncodilatadores/farmacología , Ciclopropanos , Eosinofilia/fisiopatología , Humanos , Hidroxiurea/análogos & derivados , Hidroxiurea/farmacología , Hidroxiurea/uso terapéutico , Indoles , Antagonistas de Leucotrieno/farmacología , Leucotrienos/fisiología , Fenilcarbamatos , Quinolinas/farmacología , Quinolinas/uso terapéutico , Sulfuros , Sulfonamidas , Compuestos de Tosilo/farmacología , Compuestos de Tosilo/uso terapéuticoRESUMEN
In this study, interleukin-5 (IL-5) transgenic mice with lifelong eosinophilia were assessed for resistance to primary infections with two tissue-invading nematodes, Nippostrongylus brasiliensis and Toxocara canis. Relative to nontransgenic littermates, three lines of IL-5 transgenic mice with varying degrees of eosinophilia all displayed enhanced resistance to N. brasiliensis. Although the timing of final worm expulsion was similar in transgenic and nontransgenic hosts, intestinal worms in transgenic mice were fewer in number throughout infection, failed to increase in size over the course of the infection, and were much less fecund. In contrast, T. canis larvae were recovered in similar numbers from tissues of transgenic mice with "low" or "high" eosinophilia and from nontransgenic mice. These results and other data suggest that eosinophils can contribute to host resistance to some parasite species. Parasite transit time through the host may correlate with relative sensitivity to eosinophils.
Asunto(s)
Interleucina-5/inmunología , Nippostrongylus/inmunología , Infecciones por Strongylida/inmunología , Toxocara canis/inmunología , Toxocariasis/inmunología , Animales , Eosinofilia/fisiopatología , Femenino , Inmunidad Innata/inmunología , Interleucina-5/genética , Intestino Delgado/parasitología , Intestino Delgado/patología , Masculino , Ratones , Ratones Endogámicos CBA , Ratones Transgénicos , Nippostrongylus/fisiología , Óvulo , Infecciones por Strongylida/parasitología , Infecciones por Strongylida/patología , Toxocara canis/fisiología , Toxocariasis/parasitología , Toxocariasis/patologíaRESUMEN
Se presenta un paciente de 27 años, sexo masculino, con una ulceración en borde lateral de la lengua, acompañada de dolor y prurito leves. El estudio histopatológico confirmó el diagnóstico de úlcera eosinofílica de la lengua. Se observó remisión total espontánea, siete días después de la biopsia. La úlcera eosinofílica de la lengua tiene un curso benigno autolimitante. Su comienzo rápido y el corto tiempo de curación son claves en el diagnóstico diferencial con el epitelioma espinocelular. Un reconocimiento temprano de esta entidad es importante, a efectos de evitar tratamientos potencialmente mutilantes innecesarios
Asunto(s)
Humanos , Masculino , Adulto , Lengua/patología , Úlceras Bucales/diagnóstico , Eosinofilia/fisiopatología , Úlceras Bucales/patologíaRESUMEN
Se presenta un paciente de 27 años, sexo masculino, con una ulceración en borde lateral de la lengua, acompañada de dolor y prurito leves. El estudio histopatológico confirmó el diagnóstico de úlcera eosinofílica de la lengua. Se observó remisión total espontánea, siete días después de la biopsia. La úlcera eosinofílica de la lengua tiene un curso benigno autolimitante. Su comienzo rápido y el corto tiempo de curación son claves en el diagnóstico diferencial con el epitelioma espinocelular. Un reconocimiento temprano de esta entidad es importante, a efectos de evitar tratamientos potencialmente mutilantes innecesarios (AU)
Asunto(s)
Humanos , Masculino , Adulto , Lengua/patología , Úlceras Bucales/diagnóstico , Eosinofilia/fisiopatología , Úlceras Bucales/patologíaRESUMEN
Allergen-induced bone marrow responses are observable in human allergic asthmatics, involving specific increases in eosinophil-basophil progenitors (Eo/B-CFU), measured either by hemopoietic assays or by flow cytometric analyses of CD34-positive, IL-3R alpha-positive, and/or IL-5-responsive cell populations. The results are consistent with the upregulation of an IL-5-sensitive population of progenitors in allergen-induced late phase asthmatic responses. Studies in vitro on the phenotype of developing eosinophils and basophils suggest that the early acquisition of IL-5R alpha, as well as the capacity to produce cytokines such as GM-CSF and IL-5, are features of the differentiation process. These observations are consistent with findings in animal models, indicating that allergen-induced increases in bone marrow progenitor formation depend on hemopoietic factor(s) released post-allergen. The possibility that there is constitutive marrow upregulation of eosinophilopoiesis in allergic airways disease is also an area for future investigation.
Asunto(s)
Asma/fisiopatología , Médula Ósea/fisiología , Eosinofilia/fisiopatología , Eosinófilos/fisiología , Alérgenos , Animales , Basófilos , Modelos Animales de Enfermedad , Hematopoyesis/inmunología , Humanos , Hipersensibilidad Inmediata , Interleucina-5RESUMEN
The inflammatory response in the upper airways secondary to viral or bacterial infection is frequent cause of medical attention and rhinosinusitis a common complication, changes in local and systemic immunity could facilitate the presence of sinusitis. Mediators derived from eosinophil could be also an important factor to develop nasal inflammation.
Asunto(s)
Rinitis/fisiopatología , Ribonucleasas , Sinusitis/fisiopatología , Proteínas Sanguíneas/análisis , Enfermedad Crónica , Proteínas en los Gránulos del Eosinófilo , Eosinofilia/fisiopatología , Humanos , Mucosa Nasal/inmunología , Senos Paranasales/fisiopatología , Infecciones del Sistema Respiratorio/complicaciones , Infecciones del Sistema Respiratorio/inmunología , Rinitis/etiología , Rinitis/inmunología , Rinitis Alérgica Perenne/inmunología , Rinitis Alérgica Perenne/fisiopatología , Sinusitis/etiología , Sinusitis/inmunologíaRESUMEN
Eosinophils are supposed to play a critical role in the pathology of several allergic diseases because after activation they can release toxic and proinflammatory agents. In this study we have investigated whether IgE-mediated rat pleurisy could be affected by an ongoing pleural eosinophilic inflammatory response. IgE-passively sensitized rats were challenged with an intrapleural (i.pl.) injection of allergen (dinitrophenylated bovine serum albumin, 1 microgram/cavity) and exudation assessed by measuring the amount of protein extravasated into the pleural cavity within 4 h. We have confirmed that lipopolysaccharide (LPS) stimulation (250 ng/cavity i.pl.) was followed by a marked pleural neutrophilia, apparent at 3 h, which was followed by an eosinophil accumulation noted within 48-72 h postchallenge. We have also confirmed that a boiled sample of LPS pleural washing (LPS-PW, 200 microliters i.pl.) caused selective eosinophilia in recipient rats. Pleural exudation remained unaltered when the allergenic challenge was performed 3 h after LPS in a condition of intense pleural fluid neutrophilia. In contrast, this was significantly reduced (P < .001) when the challenge occurred 72 h after LPS or 24 h after LPS-PW in selective pleural fluid eosinophilia. In another series of experiments repeated daily i.pl. injections of platelet-activating factor (PAF; 1 microgram/cavity) resulted in a progressive increase in eosinophil number recovered from the pleural cavity. The values were 1.2 +/- 0.2, 3.0 +/- 0.2, and 5.8 +/- 0.5 x 10(6) eosinophils/cavity (mean +/- SEM) after 0, 1, and 4 injections, respectively. Allergen challenge performed after 0, 1, or 4 PAF stimulations led to pleural protein levels of 88.6 +/- 5.7, 33.7 +/- 0.7, and 19.4 +/- 2.3 mg/cavity, respectively, indicating that the allergic pleurisy is inhibited in a manner dependent on the magnitude of eosinophil accumulation. Furthermore, the impairment of PAF-induced eosinophil accumulation by cetirizine (30 mg/kg i.p.) restored the exudatory response. Exudation triggered by compound 48/80 (25 micrograms/cavity), histamine (200 micrograms/cavity), or 5-hydroxytryptamine (100 micrograms/cavity) was not affected by four previous PAF daily injections. The findings indicate that allergen-induced exudation is selectively down-regulated in the eosinophil-enriched pleural space of rats, a suppression that increased with increasing eosinophil number and disappeared after chemical impairment of the eosinophilia.
Asunto(s)
Proteínas Sanguíneas/metabolismo , Eosinófilos/fisiología , Exudados y Transudados/citología , Inmunoglobulina E/fisiología , Derrame Pleural/patología , Animales , Dinitrofenoles , Eosinofilia/inducido químicamente , Eosinofilia/patología , Eosinofilia/fisiopatología , Eosinófilos/inmunología , Femenino , Histamina/toxicidad , Hipersensibilidad/inmunología , Hipersensibilidad/fisiopatología , Inmunoglobulina E/inmunología , Lipopolisacáridos/toxicidad , Masculino , Mastocitos/citología , Factor de Activación Plaquetaria/toxicidad , Ratas , Ratas Wistar , Serotonina/toxicidad , Albúmina Sérica Bovina , p-Metoxi-N-metilfenetilamina/toxicidadAsunto(s)
Eosinofilia/complicaciones , Gastroenteritis/complicaciones , Cromolin Sódico/uso terapéutico , Diagnóstico Diferencial , Dieta , Eosinofilia/etiología , Eosinofilia/fisiopatología , Eosinofilia/terapia , Estómago/patología , Gastroenteritis/etiología , Gastroenteritis/fisiopatología , Gastroenteritis/terapia , Intestino Delgado/patología , Signos y Síntomas , Esteroides/uso terapéuticoRESUMEN
El síndrome de hiper IgE (SHIE) es una rara entidad que se caracteriza por presentar infecciones cutáneas y respiratorias, sobre todo neumonías a estafilococo, con posterior formación de neumatoceles, disturbios en el metabolismo óseo y una IgE sumamente elevada. En el presente artículo se trata de actualizar el tema en sus aspectos fisiopatológicos, inmunológicos y nuevas conductas de tratamiento
Asunto(s)
Humanos , Eosinofilia/fisiopatología , Hipergammaglobulinemia/inmunología , Inmunoglobulina E/inmunología , Síndrome de Job/fisiopatología , Eccema/etiología , Eccema/inmunología , Eosinofilia/complicaciones , Eosinofilia/inmunología , Histamina/sangre , Interferón Tipo I/deficiencia , Interferón gamma/deficiencia , Interferón gamma/uso terapéutico , Osteogénesis Imperfecta/etiología , Osteoporosis/etiología , Síndrome de Job/inmunología , Síndrome de Job/terapia , Linfocitos T/inmunologíaRESUMEN
El síndrome de hiper IgE (SHIE) es una rara entidad que se caracteriza por presentar infecciones cutáneas y respiratorias, sobre todo neumonías a estafilococo, con posterior formación de neumatoceles, disturbios en el metabolismo óseo y una IgE sumamente elevada. En el presente artículo se trata de actualizar el tema en sus aspectos fisiopatológicos, inmunológicos y nuevas conductas de tratamiento