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1.
Jt Dis Relat Surg ; 35(2): 377-385, 2024 Apr 26.
Article En | MEDLINE | ID: mdl-38727118

OBJECTIVES: This study aimed to review a 35-year experience with chondromyxoid fibroma at our institution. PATIENTS AND METHODS: The study retrospectively analyzed the records of 31 consecutive patients (17 males, 14 females; mean age: 30.5±15.7 years; range, 6 to 63 years) with chondromyxoid fibroma who were treated between January 1988 and December 2021. The clinical and radiological characteristics of lesions, tumor volume, and recurrence rates were assessed using the tumor archive of the hospital. RESULTS: The mean follow-up duration was 65.9±42.0 months. Pelvis, proximal tibia, and distal femur were the most common sites of localization. The initial surgical treatment was performed on 27 patients at our clinic, while four patients were referred to the clinic after recurrence. The overall recurrence rate was 16.1%. Intralesional curettage was applied to 21 (77.8%) out of 27 patients. The cavity created after curettage was filled with bone graft (autograft or allograft) in 15 (55.5%) cases. Bone cement was applied in four (14.8%) cases. Resection was applied to five (18.5%) patients. In two (7.4%) cases, intralesional curettage alone was performed. One of these two patients experienced recurrence, resulting in a recurrence rate of 50% in this patient group. No recurrence was observed in other treatment groups. CONCLUSION: Intralesional curettage and filling the defect with bone graft or cement were effective for local control in most cases. Curettage alone was associated with high recurrence rates.


Bone Neoplasms , Curettage , Fibroma , Neoplasm Recurrence, Local , Humans , Male , Female , Retrospective Studies , Adult , Adolescent , Middle Aged , Bone Neoplasms/surgery , Bone Neoplasms/pathology , Bone Neoplasms/diagnostic imaging , Young Adult , Child , Fibroma/surgery , Fibroma/pathology , Curettage/methods , Neoplasm Recurrence, Local/surgery , Neoplasm Recurrence, Local/pathology , Bone Transplantation/methods , Bone Cements/therapeutic use
2.
Swiss Dent J ; 134(1): 123-129, 2024 Apr 05.
Article De | MEDLINE | ID: mdl-38741423

A 35-year-old patient presented with a painless, broad-based exophytic lesion in the buccal interdental region between teeth 13 and 14. Despite oral hygiene efforts the lesion persisted for around one year. Radiology excluded bone involvement, and histopathology after excision confirmed a fibromatous epulis, which is characterized by collagen-rich connective tissue. There was no recurrence within one-year follow-up. Surgical removal proved to be efficient.


Gingival Neoplasms , Humans , Adult , Gingival Neoplasms/surgery , Gingival Neoplasms/pathology , Gingival Neoplasms/diagnosis , Fibroma/surgery , Fibroma/pathology , Fibroma/diagnosis , Male , Diagnosis, Differential , Female
3.
Praxis (Bern 1994) ; 113(3): 78-82, 2024 Mar.
Article De | MEDLINE | ID: mdl-38655734

INTRODUCTION: Ischaemic stroke results from a sudden interruption of cerebral blood flow, often caused by thrombosis, embolism or hypoperfusion. Rarely, cardiac tumours are the cause of an embolic event. We report on an 80-year-old woman with a cerebral stroke. Successful thrombectomy revealed a histopathologically confirmed papillary fibroelastoma as the embolic source. Although it was not detectable on initial echocardiography, the tumour was discovered by transesophageal echocardiography. This case emphasises the importance of considering primary cardiac tumours as potential sources of emboli in ischaemic stroke. Keywords.


Echocardiography, Transesophageal , Heart Neoplasms , Humans , Female , Aged, 80 and over , Heart Neoplasms/diagnostic imaging , Heart Neoplasms/surgery , Heart Neoplasms/pathology , Diagnosis, Differential , Thrombectomy , Ischemic Stroke/diagnostic imaging , Ischemic Stroke/etiology , Ischemic Stroke/surgery , Fibroma/surgery , Fibroma/diagnostic imaging , Fibroma/pathology
5.
Childs Nerv Syst ; 40(6): 1919-1924, 2024 Jun.
Article En | MEDLINE | ID: mdl-38459146

Pediatric fibromyxoid soft tissue tumors may be associated with gene fusions such as YHWAZ::PLAG1, with only three reported cases in the literature. We present the fourth case, a 13-year-old male with a pediatric fibromyxoid brachial plexus tumor with YWHAZ::PLAG1 gene fusion. This is also the first case to be reported in an adolescent, in the brachial plexus, and in the Philippines. The patient presented with a 10-year history of a slowly growing left supraclavicular mass and a 1-year history of intermittent dysesthesia in the left upper extremity. Neurologic examination was unremarkable. Imaging revealed a large left supraclavicular lesion with intrathoracic extension. Surgical excision was performed, and histopathology revealed a fibromyxoid tumor with YWHAZ::PLAG1 gene fusion. Although previous examples of this gene fusion pointed toward lipoblastoma as their primary pathology, our tumor does not completely fulfill the current diagnostic criteria for a lipoblastoma and may represent an intermediate form of the disease. Our case is unique not only because it is the first reported adolescent patient harboring such a lesion but also because of the relatively lengthy natural history exhibited by the tumor prior to its resection. This provided us with valuable information about its behavior, which suggests a more indolent growth pattern. This case also highlights the clinical importance of molecular testing of tumors, where recognition of disease entities can assist clinicians in deciding and advocating for the proper management.


Brachial Plexus , Humans , Male , Adolescent , Brachial Plexus/surgery , Gene Fusion/genetics , 14-3-3 Proteins/genetics , Fibroma/genetics , Fibroma/surgery , Peripheral Nervous System Neoplasms/genetics , Peripheral Nervous System Neoplasms/surgery , Peripheral Nervous System Neoplasms/pathology , DNA-Binding Proteins/genetics , Soft Tissue Neoplasms/genetics , Soft Tissue Neoplasms/surgery , Soft Tissue Neoplasms/pathology
6.
Kyobu Geka ; 77(3): 222-225, 2024 Mar.
Article Ja | MEDLINE | ID: mdl-38465496

We experienced a case of papillary fibroelastoma of aortic valve, which had been located for preoperative 12 years without any symptom. We could assess tumor growth rate of 0.17 mm/year. Because of recent reports of recurrence, close follow-up should be continued.


Cardiac Papillary Fibroelastoma , Fibroma , Heart Neoplasms , Humans , Aortic Valve/diagnostic imaging , Aortic Valve/surgery , Cardiac Papillary Fibroelastoma/pathology , Heart Neoplasms/diagnostic imaging , Heart Neoplasms/surgery , Fibroma/diagnostic imaging , Fibroma/surgery
7.
BMJ Case Rep ; 17(3)2024 Mar 07.
Article En | MEDLINE | ID: mdl-38453223

A patient without a diagnosis of diabetes mellitus presented to the hospital due to a fall and hypoglycaemia on admission. The patient was found to have recurrent nocturnal fasting hypoglycaemia. CT revealed a large lung mass consistent with a solitary pleural fibroma, a rare tumour associated with insulin-like growth factor 2 (IGF-2) production. This case is an important reminder that potential causes of hypoglycaemia should be considered in non-diabetic patients.


Fibroma , Hypoglycemia , Pleural Neoplasms , Solitary Fibrous Tumor, Pleural , Humans , Insulin-Like Growth Factor II/metabolism , Pleural Neoplasms/diagnosis , Solitary Fibrous Tumor, Pleural/complications , Solitary Fibrous Tumor, Pleural/diagnostic imaging , Solitary Fibrous Tumor, Pleural/surgery , Hypoglycemia/diagnosis , Fibroma/complications , Fibroma/diagnostic imaging , Fibroma/surgery
8.
J Pediatr Hematol Oncol ; 46(3): e251-e253, 2024 Apr 01.
Article En | MEDLINE | ID: mdl-38408159

The plexiform fibromyxoma is a rare mesenchymal tumor in adults that generally originates in the antrum of stomach, being its occurrence in pediatric patients exceptional. It was classified as a distinct entity by World Health Organization in 2010. No recurrences and metastases have been documented in many of the reported patients to date, being the surgical treatment curative. We report the case of a 3-month-old infant who presented to the emergency department with an episode of intestinal subocclusion requiring an emergent surgery. During the surgical intervention, a mass was identified in the jejunum, causing partial occlusion of its lumen. The surgical pathology report revealed an infiltrative tumor composed of spindle-shaped cells disposed in a stroma with a plexiform pattern alternating myxoid areas. These findings and the immunohistochemical characteristics of the neoplastic cells led to classify the tumor as a plexiform fibromyxoma. A description of the immunophenotype of this tumor is made and differential diagnosis with other gastrointestinal tumors is also discussed.


Fibroma , Soft Tissue Neoplasms , Stomach Neoplasms , Humans , Infant , Fibroma/surgery , Fibroma/diagnosis , Fibroma/pathology , Stomach Neoplasms/diagnosis
10.
J Cardiothorac Surg ; 19(1): 79, 2024 Feb 09.
Article En | MEDLINE | ID: mdl-38336753

BACKGROUND: Cardiac papillary fibroelastoma is a rare benign tumor, which is often mistaken for a vegetation. Predominantly asymptomatic, it can cause life-threatening complications. Although rare, mobile papillary fibroelastoma movement between affected valves may hamper valve closure and damage the valve, leading to valvular regurgitation. Endothelial damage increases the risk of developing infective endocarditis. We report a rare case of a highly mobile papillary fibroelastoma originating from the atrial septum touching the mitral valve, leading to mitral regurgitation and, eventually, infective endocarditis. CASE PRESENTATION: A 26-year-old woman with suspected infective endocarditis was referred to us from a previous hospital after having experienced intermittent fever for a month. Before the fever, she had been experiencing exertional dyspnea. In addition, she had undergone a cesarean section two weeks before this admission. A transthoracic echocardiogram showed a mobile mass originating from the atrial septum touching the mitral valve with severe mitral regurgitation. Computed tomography revealed an occluded right profunda femoris artery with an embolus. Infective endocarditis associated with a mobile vegetation with high embolic risk was diagnosed, and urgent surgery was performed. Following the surgery, examinations revealed papillary fibroelastoma originating from the atrial septum and infective endocarditis of the mitral valve. The histopathological examination confirmed that a mass initially thought to be a mobile vegetation was a papillary fibroelastoma. The postoperative course was uneventful except for pericarditis. There has been no recurrence of infective endocarditis or papillary fibroelastoma. CONCLUSIONS: The highly mobile papillary fibroelastoma was thought to have caused both chronic mitral regurgitation and infective endocarditis. Mobile papillary fibroelastomas can cause endothelial damage to nearby valves and predispose patients to infective endocarditis.


Atrial Septum , Cardiac Papillary Fibroelastoma , Endocarditis, Bacterial , Endocarditis , Fibroma , Heart Neoplasms , Mitral Valve Insufficiency , Pregnancy , Humans , Female , Adult , Mitral Valve/diagnostic imaging , Mitral Valve/surgery , Mitral Valve/pathology , Mitral Valve Insufficiency/surgery , Cardiac Papillary Fibroelastoma/complications , Atrial Septum/diagnostic imaging , Atrial Septum/surgery , Cesarean Section/adverse effects , Endocarditis, Bacterial/complications , Endocarditis, Bacterial/diagnosis , Endocarditis, Bacterial/surgery , Endocarditis/complications , Endocarditis/diagnosis , Endocarditis/surgery , Heart Neoplasms/complications , Heart Neoplasms/diagnosis , Heart Neoplasms/surgery , Fibroma/complications , Fibroma/surgery
13.
Br J Oral Maxillofac Surg ; 62(3): 247-251, 2024 Apr.
Article En | MEDLINE | ID: mdl-38311535

This study presents the behavioural findings of central odontogenic fibroma (COF) in a specific ethnic group, analysing treatment methods and demonstrating how involved teeth should be managed in detail. Clinical, radiographic, and histological findings were gathered for 29 patients who visited our clinic, with all patients' data carefully examined by radiologists and reviewed microscopically. The cohort comprised 29 patients, with 16 females and 13 males, having a mean (SD) age of 33.1 (16.0) years. Among them, 19 patients were affected in the maxilla, with 15 showing anterior preference, and palatal depression was observed in six patients. Tooth resorption was evident in 15 patients, while 10 patients showed tooth displacement. Within the cohort, 13 patients underwent tooth extraction and resection, while the remaining 16 did not have teeth extracted. Notably, there was no significant difference in recurrence observed between these two groups. This study represents the largest study to date of COF within a single ethnic group and institution. A subset of cases exhibited noteworthy features of COF. However, intriguingly, despite these characteristics, the preservation of contiguous teeth did not demonstrate a significant impact on recurrence rates.


Fibroma , Odontogenic Tumors , Humans , Female , Male , Odontogenic Tumors/surgery , Odontogenic Tumors/pathology , Adult , Middle Aged , Fibroma/surgery , Fibroma/pathology , Adolescent , Tooth Extraction , Republic of Korea , Young Adult , Maxillary Neoplasms/surgery , Maxillary Neoplasms/pathology , Child , Neoplasm Recurrence, Local
14.
Acta Cytol ; 68(1): 66-72, 2024.
Article En | MEDLINE | ID: mdl-38281480

INTRODUCTION: Chondromyxoid fibroma (CMF) is a rare, benign bone tumor that occurs predominantly in the second and third decades of life, more frequently in males. Overexpression of GRM1 as a consequence of tumor-specific gene rearrangement of GRM1 has recently been reported as a useful immunohistochemical marker for histopathological diagnosis of CMF. However, the usefulness of GRM1 staining of cytology specimens has not yet been evaluated. In this report, the cytological findings and GRM1 immunocytochemistry of two cases of CMF are described. CASE PRESENTATIONS: Case 1 was a 15-year-old girl with a rib tumor. Imaging findings suggested a benign neurogenic tumor such as schwannoma. The tumor had increased in size over a 2-year period and was resected. Case 2 was a 14-year-old boy with a metatarsal tumor involving his left first toe. Imaging findings were suspicious of a benign neoplastic lesion. Biopsy findings suggested a benign tumor, and the patient underwent tumor resection. Cytologically, in both cases the tumor cells were predominantly spindle-shaped or stellate, with a myxoid to chondromyxoid background matrix and multinucleated giant cells, and these matrices were metachromatic with Giemsa staining. Cellular atypia was more accentuated in case 2 than in case 1. Immunocytochemical staining for GRM1 was positive in both cases. CONCLUSION: Due to the overlap in cytological findings, it is often difficult to differentiate CMF from chondroblastoma and chondrosarcoma grade 2. Immunocytochemical staining for GRM1 may support the diagnosis of CMF, and the reuse of Papanicolaou-stained specimens is applicable. The present cases further demonstrated the difficulty of differentiating CMF from other mimicking tumors such as chondroblastoma and chondrosarcoma grade 2. In such instances, immunocytochemistry for GRM1 is applicable to the diagnostic process, the value of which is strengthened by reusing Papanicolaou-stained specimens.


Bone Neoplasms , Chondroblastoma , Chondrosarcoma , Fibroma , Adolescent , Female , Humans , Male , Bone Neoplasms/diagnosis , Bone Neoplasms/surgery , Bone Neoplasms/pathology , Chondroblastoma/diagnosis , Chondroblastoma/surgery , Chondroblastoma/metabolism , Chondrosarcoma/pathology , Cytology , Fibroma/diagnosis , Fibroma/surgery , Fibroma/pathology , Receptors, Metabotropic Glutamate/immunology , Receptors, Metabotropic Glutamate/metabolism
15.
Cardiol Young ; 34(4): 933-934, 2024 Apr.
Article En | MEDLINE | ID: mdl-38282536

Left ventricular tumour is a rare condition in children. The causes include vegetations, thrombus, and fibroma. 2-year-old asymptomatic female presented with an innocent heart murmur at 6 months of age. Subsequent follow-ups at 18 months of age showed left ventricular mass. Surgical pathology revealed "nodular fasciitis." This type of tumour has never been described in the heart before.


Fasciitis , Fibroma , Heart Neoplasms , Child , Humans , Female , Child, Preschool , Fasciitis/diagnosis , Fasciitis/surgery , Fasciitis/etiology , Heart Neoplasms/diagnosis , Heart Neoplasms/surgery , Heart Neoplasms/complications , Fibroma/diagnosis , Fibroma/surgery , Fibroma/complications , Heart Ventricles/pathology , Heart Murmurs
16.
Gan To Kagaku Ryoho ; 51(1): 87-89, 2024 Jan.
Article Ja | MEDLINE | ID: mdl-38247101

A 60s female, who had undergone single-incision laparoscopic ileocecal resection for ascending colon cancer with pathological diagnosis of T3N1bM0, Stage Ⅲb, followed by adjuvant therapy with 8 courses CAPOX 2 years ago, had enhanced- computed tomography(CT)for follow-up and a 15-mm nodule near anastomotic site was found. 18F-fluorodeoxyglucose (FDG)-positron emission tomography(PET)CT revealed abnormal accumulation of 18F-FDG only to the lesion and diagnosis of"anastomotic recurrence"was made. We planned and safely performed resection of the anastomotic site and the nodule. The pathological diagnosis was fibromatosis-like tumor without evidence of recurrence, and margin was negative. Postoperative course was smooth and she was discharged on postoperative day 9. When we diagnose local recurrence, we need to keep it in mind that fibromatosis is one of the differential diagnoses, although its incidence rate is low.


Colonic Neoplasms , Fibroma , Female , Humans , Colon, Ascending/surgery , Colonic Neoplasms/surgery , Fibroma/diagnostic imaging , Fibroma/surgery , Anastomosis, Surgical , Combined Modality Therapy
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