Mammary fibromatosis in a female dog: case report.

Fibromatosis, or desmoid tumour, is characterized by excessive and infiltrative proliferation of connective tissue originating from aponeurotic muscle structures. Mammary fibromatosis is rare in humans and animals and its precise aetiology is unknown. A 10-year-old mixed-breed female dog developed a mass in the right cranial thoracic mammary gland (M1) and underwent lumpectomy. The mass was firm, with an irregular surface and distinct limits. Microscopically, it was a neoplastic proliferation of fusiform cells with low atypia, interspersed with abundant dense collagenous tissue, confirmed by histochemical staining with Gomori's trichrome and Masson's trichrome and immunopositivity for vimentin and smooth muscle actin, confirming mammary fibromatosis. Mammary fibromatosis in dogs needs further studies to elucidate its clinical, epidemiological and aetiopathogenic aspects.

Lesions of the oral cavity of dogs: 720 cases / Lesões da cavidade oral de cães: 720 casos

Seven hundred twenty cases of oral cavity lesions in dogs were diagnosed from 2015 to 2020 in Distrito Federal, Brazil. Four hundred thirty-two (60%) lesions were neoplastic, and 288 (40%) were non-neoplastic. Of the neoplasms, 229 (53%) were considered malignant and 203 (47%) benign, affecting mainly males, of 43 different breeds, with an average age of 9.4 years, mainly the gum and lip. Melanoma was the most (96/432, 22.2%) commonly diagnosed neoplasm, followed by peripheral odontogenic fibroma (68/432, 15.7%), papilloma (63/432, 14.5%) and squamous cell carcinoma (SCC) (56/432, 12.9%). Non-neoplastic lesions also affected males predominantly, from 41 different breeds, with an average age of 8.9 years, mainly in the gums, lip, and tongue. These lesions were diagnosed as inflammatory (230/288, 79.8%), hyperplastic (47/288, 16.3%) and other lesions (11/288, 3.8%).

Foram estudados 720 casos de lesões na cavidade oral em cães diagnosticados entre 2015 e 2020, no Distrito Federal. Dessas alterações, 432 (60%) foram neoplásicas e 288 (40%) não neoplásicas. Dentre os neoplasmas, 229 (53%) foram consideradas malignos e 203 (47%) benignos, acometendo principalmente machos, de 43 raças diferentes, com idade média 9,4 anos, afetando principalmente gengiva e lábio. Melanoma foi o neoplasma mais comumente diagnosticado (96/432; 22,2%), seguido do fibroma odontogênico periférico (68/432; 15,7%), papiloma (63/432; 14,5%) e carcinoma de células escamosas (56/432; 12,9%). As lesões não neoplásicas também acometeram predominantemente machos, de 41 raças diferentes, com idade média 8,9 anos, afetando principalmente gengiva, lábio e língua. Essas lesões foram diagnosticadas como inflamatórias (230/288; 79,8%), hiperplásicas (47/288; 16,3%) e como outras alterações (11/288; 3,8%).

Fibroma cutâneo atípico em uma vaca / Atypical cutaneous fibroma in a cow

Background: Cutaneous fibroma is a benign neoplasm affecting the fibroblasts and collagen matrix that develops in the dermis or subcutaneous tissue. This neoplasm is uncommon in cattle, and few reports have described the treatment and resolution of this neoplasm. Despite its benign character, a veterinarian should consider cutaneous fibroma in the differential diagnosis of skin tumors. This report aims to describe a rare case of large fibroma in the scapular region in a cow, with emphasis on the clinical-surgical and anatomopathological aspects of the condition. Case: A 3-year-old Girolando 3/4 cow was attended to at a rural property in Lagamar-MG, Brazil. According to the owner, the animal presented with a small mass in the right scapular region that grew progressively over 1 year and 6 months. Clinical examination revealed an exuberant and painless increase in volume on palpation in the proximal region of the right thoracic limb, which, in its vertical axis, extended from the proximal end of the scapula to near the olecranon tuberosity, and, in its horizontal axis, extended from the 6th intercostal space to the scapulohumeral joint, reaching the dimensions 66 cm and 62 cm, respectively. It presented with multiple nodules that were firm in consistency with extensive areas of ulceration. Neoplasia was suspected, and surgical excision was decided upon. The cow was sedated and restrained in the left lateral decubitus position. Trichotomy and antisepsis of the operative field were performed followed by an infiltrative anesthetic block around the tumor. The tumor was excised maintaining a safety margin of 1 cm. Dermorrhaphy was not possible, and healing by secondary intention was awaited. In the postoperative period, antibiotic therapy with benzathine penicillin, analgesia with meloxicamand dipyrone and daily dressing of the wound were performed. There were no postoperative complications and complete healing occurred approximately 100 days after surgery. One year after the surgical procedure, the owner reported that the cow did not present with recurrence of the neoplasm. The resected tumor weighed 11.2 kg, and, when cut, presented with solid conformation and whitish coloration. Tumor fragments were harvested, fixed in 10% formalin, and sent for histopathological examination, which revealed neoproliferation of remarkable cellular density composed of dense, well vascularized fibrocollagenous connective tissue arranged in multidirectional bundles and undulating pattern. Mild cellular pleomorphism was identified, and no mitosis figures were observed. Alcian blue staining was negative for mucopolysaccharides, differing from Masson's trichrome staining, which widely stained the fibrocollagenous tissue blue. In view of these findings, the diagnosis of cutaneous fibroma was confirmed. Discussion: Cutaneous fibromas are benign neoplasms of fibrous tissue, and they are uncommon in cattle and may be associated with bovine papillomavirus and/or trauma. Although the origin of cutaneous fibroma is not clear, the present report stands out due to the large size of the tumor mass. The complete healing of the surgical wound, the absence of recurrence one year after surgery and the return of the animal to dairy production demonstrate that the surgical treatment was adequate. The macro- and microscopic characteristics of the cutaneous fibroma in this case corroborate with other cases reported in the literature. Large cutaneous fibroma is uncommon in bovines, and may hinder surgical excision and prolong healing time, as well as the complete recovery of the animal. Moreover, the differential diagnosis with other neoplasms of fibroblastic origin is relevant, especially for those with malignant biological behavior, such as fibrosarcoma and myxosarcoma.

Odontogenic tumor, cholangioarcinoma and gastric fibroma in a dog case report

Odontogenic tumors producing amyloid are rare neoplasms. Cholangiocarcinomas and fibromas are also referred to as infrequent. The objective of this study was to report the case of a dog, 17 years old, a poodle, who was treated at the Veterinary Hospital of the Federal University of Uberlândia. At necropsy, the animal presented only nodule located in the oral cavity, in the same way, only nodule in the hepatic parenchyma and in addition, multiple masses in the stomach. Microscopically, the histological features were compatible with odontogenic tumor producing amyloid, cholangiocarcinoma and fibroma, respectively. Reports of simultaneous occurrence of distinct tumors are scarce in the literature.(AU)

Os tumores odontogênicos produtores de amiloide são neoplasias raras. Os colangiocarcinomas e fibromas também são referidos como infrequentes. Objetivou-se relatar o caso de um cão, 17 anos, poodle, que foi atendido no Hospital Veterinário da Universidade Federal de Uberlândia. À necropsia, o animal apresentou único nódulo localizado na cavidade oral, da mesma forma, único nódulo no parênquima hepático e ademais, múltiplas massas no estômago. Microscopicamente, as características histológicas foram compatíveis com tumor odontogênico produtor de amiloide, colangiocarcinoma e fibroma, respectivamente. Relatos de ocorrência simultânea de tumores distintos são escassos na literatura.(AU)

Odontogenic tumor, cholangioarcinoma and gastric fibroma in a dog – case report

Odontogenic tumors producing amyloid are rare neoplasms. Cholangiocarcinomas and fibromas are also referred to as infrequent. The objective of this study was to report the case of a dog, 17 years old, a poodle, who was treated at the Veterinary Hospital of the Federal University of Uberlândia. At necropsy, the animal presented only nodule located in the oral cavity, in the same way, only nodule in the hepatic parenchyma and in addition, multiple masses in the stomach. Microscopically, the histological features were compatible with odontogenic tumor producing amyloid, cholangiocarcinoma and fibroma, respectively. Reports of simultaneous occurrence of distinct tumors are scarce in the literature.

Os tumores odontogênicos produtores de amiloide são neoplasias raras. Os colangiocarcinomas e fibromas também são referidos como infrequentes. Objetivou-se relatar o caso de um cão, 17 anos, poodle, que foi atendido no Hospital Veterinário da Universidade Federal de Uberlândia. À necropsia, o animal apresentou único nódulo localizado na cavidade oral, da mesma forma, único nódulo no parênquima hepático e ademais, múltiplas massas no estômago. Microscopicamente, as características histológicas foram compatíveis com tumor odontogênico produtor de amiloide, colangiocarcinoma e fibroma, respectivamente. Relatos de ocorrência simultânea de tumores distintos são escassos na literatura.

Fibroma vaginal en perra (Canis familiaris) - reporte de caso / Vaginal fibroma in bitch (Canis familiaris) - case report / Fibroma vaginal em cadela (Canis familiaris) - relato de caso

Después de las neoplasias de las glándulas mamarias en las perras, los tumores de vulva y de la vagina son los más comúnmente observados en la rutina de cáncer, lo que representa aproximadamente el 2,4 al 3% de los tumores caninos. En este trabajo se describe un caso de fibroma vaginal en una perra mestiza, doce años de edad. El animal pertenecía a un refugio de animales y mostró un fuerte aumento de volumen en la zona vaginal. Los resultados del examen clínico y de laboratorio permitieron la realización de la extirpación quirúrgica exitosa y diagnóstico histopatológico de fibroma, con excelente recuperación y supervivencia. Aunque el informe de la literatura que los fibromas vaginales y vulvares son poco comunes en los perros, es evidente la necesidad de llevar a cabo un diagnóstico específico en la presencia de masas tumorales en esta región.(AU)

After the mammary gland neoplasms in bitches, tumors of vulva and vagina are the most commonly observed in cancer routine, representing approximately 2.4 to 3% of canine tumors. This paper describes a case of vaginal fibroma in a mongrel dog, twelve years old. The patient belonged to an animal shelter and exhibits a volume increase in the vaginal region. The results of clinical examination and laboratory allowed the realization of successful surgical excision and histopathological diagnosis of fibroma, with excellent recovery and survival. Although the literature report that vaginal and vulvar fibroids are uncommon in dogs, it is clear the need to carry out specific diagnosis in the presence of tumor masses in this region.(AU)

Depois das neoplasias de glândula mamária em cadelas, os tumores de vulva e vagina são os mais comumente observados na rotina oncológica, correspondendo aproximadamente 2,4 a 3% das neoplasias caninas. O presente trabalho descreve um caso de fibroma vaginal em uma cadela sem raça definida, de doze anos de idade. O animal pertencia a um abrigo de animais e exibia um aumento acentuado de volume na região vaginal. Os resultados do exame clínico e laboratorial permitiram a realização de extirpação cirúrgica com sucesso e diagnóstico histopatológico de fibroma, com ótima recuperação e sobrevida da paciente. Apesar da literatura relatar que fibromas vaginais e vulvares são incomuns em cadelas, fica claro a necessidade da realização de diagnósticos específicos na presença de massas tumorais nesta região.(AU)

Fibroma vaginal en perra (Canis familiaris) - reporte de caso / Vaginal fibroma in bitch (Canis familiaris) - case report / Fibroma vaginal em cadela (Canis familiaris) - relato de caso

Después de las neoplasias de las glándulas mamarias en las perras, los tumores de vulva y de la vagina son los más comúnmente observados en la rutina de cáncer, lo que representa aproximadamente el 2,4 al 3% de los tumores caninos. En este trabajo se describe un caso de fibroma vaginal en una perra mestiza, doce años de edad. El animal pertenecía a un refugio de animales y mostró un fuerte aumento de volumen en la zona vaginal. Los resultados del examen clínico y de laboratorio permitieron la realización de la extirpación quirúrgica exitosa y diagnóstico histopatológico de fibroma, con excelente recuperación y supervivencia. Aunque el informe de la literatura que los fibromas vaginales y vulvares son poco comunes en los perros, es evidente la necesidad de llevar a cabo un diagnóstico específico en la presencia de masas tumorales en esta región.

After the mammary gland neoplasms in bitches, tumors of vulva and vagina are the most commonly observed in cancer routine, representing approximately 2.4 to 3% of canine tumors. This paper describes a case of vaginal fibroma in a mongrel dog, twelve years old. The patient belonged to an animal shelter and exhibits a volume increase in the vaginal region. The results of clinical examination and laboratory allowed the realization of successful surgical excision and histopathological diagnosis of fibroma, with excellent recovery and survival. Although the literature report that vaginal and vulvar fibroids are uncommon in dogs, it is clear the need to carry out specific diagnosis in the presence of tumor masses in this region.

Depois das neoplasias de glândula mamária em cadelas, os tumores de vulva e vagina são os mais comumente observados na rotina oncológica, correspondendo aproximadamente 2,4 a 3% das neoplasias caninas. O presente trabalho descreve um caso de fibroma vaginal em uma cadela sem raça definida, de doze anos de idade. O animal pertencia a um abrigo de animais e exibia um aumento acentuado de volume na região vaginal. Os resultados do exame clínico e laboratorial permitiram a realização de extirpação cirúrgica com sucesso e diagnóstico histopatológico de fibroma, com ótima recuperação e sobrevida da paciente. Apesar da literatura relatar que fibromas vaginais e vulvares são incomuns em cadelas, fica claro a necessidade da realização de diagnósticos específicos na presença de massas tumorais nesta região.

Challenges in Evaluating the Severity of Fibropapillomatosis: A Proposal for Objective Index and Score System for Green Sea Turtles (Chelonia mydas) in Brazil.

Fibropapillomatosis (FP) is a neoplastic disease that affects marine turtles worldwide, especially green sea turtles (Chelonia mydas). FP tumors can develop on the body surface of marine turtles and also internally in the oral cavity and viscera. Depending on their quantity, size and anatomical distribution, these tumors can interfere with hydrodynamics and the ability to feed, hence scoring systems have been proposed in an attempt to quantify the clinical manifestation of FP. In order to establish a new scoring system adapted to geographic regions, we examined 214 juvenile green sea turtles with FP caught or rescued at Brazilian feeding areas, counted their 7466 tumors and classified them in relation to their size and anatomical distribution. The patterns in quantity, size and distribution of tumors revealed interesting aspects in the clinical manifestation of FP in specimens studied in Brazil, and that FP scoring systems developed for other areas might not perform adequately when applied to sea turtles on the Southwest Atlantic Ocean. We therefore propose a novel method to evaluate the clinical manifestation of FP: fibropapillomatosis index (FPI) that provides the Southwest Atlantic fibropapillomatosis score (FPSSWA). In combination, these indexing and scoring systems allow for a more objective, rapid and detailed evaluation of the severity of FP in green sea turtles. While primarily designed for the clinical manifestation of FP currently witnessed in our dataset, this index and the score system can be adapted for other areas and compare the characteristics of the disease across regions. In conclusion, scoring systems to classify the severity of FP can assist our understanding on the environmental factors that modulate its development and its impacts on the individual and population health of green sea turtles.

Aspectos clínicos e imaginológicos de fibroma vaginal em cadela - relato de caso / Clinical and imaging diagnosis of vaginal fibroma in a bitch - case report / Aspectos clínicos e imagenológicos de un fibroma vaginal en perra - relato de caso

Tumores vaginais e vulvares são os tumores mais comuns do trato genital de cadelas. Descreve-se o caso de uma cadela da raça chow chow, com onze anos, não castrada, com histórico de iscúria, estrangúria e tenesmo fecal. Exames ultrassonográfico e tomográfico permitiram a caracterização de massa em cavidade pélvica projetando-se para a região abdominal caudal e promovendo deslocamento cranial da bexiga, obstrução uretral e obstrução parcial de cólon descendente. Após biópsia percutânea guiada por ultrassom e análise histopatológica, foi possível estabelecer o diagnóstico de fibroma vaginal. Ressalta-se nesse caso a importância dos exames de diagnóstico por imagem para o estabelecimento do diagnóstico e a caracterização de alterações secundárias decorrentes do crescimento tumoral. Além disso, o exame tomográfico forneceu informações importantes para o planejamento cirúrgico do paciente.(AU)

Vaginal and vulvar neoplasms are the most common tumors in the reproductive tract of bitches. This article describes the case of an eleven-year old non-spayed chow chow bitch with clinical signals of ischuria, stranguria, and fecal tenesmus. Ultrasonographic and tomographic exams showed a mass within the pelvic cavity that projected to the caudal abdominal region and displaced the bladder cranially, with partial obstruction of the urethra and descending colon. Vaginal fibroma was diagnosed after ultrasonography-guided biopsy and histological analysis of tissue mass. This case report shows the importance of imaging exams for clinical diagnoses and characterization of secondary changes due to tumor growth. Further, the tomographic exam provided relevant data for surgical planning.(AU)

Los neoplasmas vaginales y de vulva son las tumores más comunes del tracto genital de las perras. Se relata el caso de una perra Chow Chow de 11 años, no castrada, con histórico de retención urinaria, estrangúria y tenesmo fecal. Los exámenes ecográficos y tomográficos permitieron la caracterización de una masa en la cavidad pélvica que se proyectaba hacia la región abdominal caudal, provocando el desplazamiento craneal de la vejiga, obstrucción uretral y obstrucción parcial del colon descendiente. Después de realizada una biopsia percutánea guiada por ecografía y su examen histopatológico, fue posible establecer el diagnóstico de fibroma vaginal. Se destaca en el presente caso, la importancia de las exámenes de diagnóstico por imagen para poder establecer el diagnóstico y la caracterización de las alteraciones secundarias producidas como consecuencia del crecimiento tumoral. Además, el examen tomográfico proporcionó informaciones importantes para la planificación de la cirugía del paciente.(AU)

Aspectos clínicos e imaginológicos de fibroma vaginal em cadela - relato de caso / Clinical and imaging diagnosis of vaginal fibroma in a bitch - case report / Aspectos clínicos e imagenológicos de un fibroma vaginal en perra - relato de caso

Tumores vaginais e vulvares são os tumores mais comuns do trato genital de cadelas. Descreve-se o caso de uma cadela da raça chow chow, com onze anos, não castrada, com histórico de iscúria, estrangúria e tenesmo fecal. Exames ultrassonográfico e tomográfico permitiram a caracterização de massa em cavidade pélvica projetando-se para a região abdominal caudal e promovendo deslocamento cranial da bexiga, obstrução uretral e obstrução parcial de cólon descendente. Após biópsia percutânea guiada por ultrassom e análise histopatológica, foi possível estabelecer o diagnóstico de fibroma vaginal. Ressalta-se nesse caso a importância dos exames de diagnóstico por imagem para o estabelecimento do diagnóstico e a caracterização de alterações secundárias decorrentes do crescimento tumoral. Além disso, o exame tomográfico forneceu informações importantes para o planejamento cirúrgico do paciente.

Vaginal and vulvar neoplasms are the most common tumors in the reproductive tract of bitches. This article describes the case of an eleven-year old non-spayed chow chow bitch with clinical signals of ischuria, stranguria, and fecal tenesmus. Ultrasonographic and tomographic exams showed a mass within the pelvic cavity that projected to the caudal abdominal region and displaced the bladder cranially, with partial obstruction of the urethra and descending colon. Vaginal fibroma was diagnosed after ultrasonography-guided biopsy and histological analysis of tissue mass. This case report shows the importance of imaging exams for clinical diagnoses and characterization of secondary changes due to tumor growth. Further, the tomographic exam provided relevant data for surgical planning.

Los neoplasmas vaginales y de vulva son las tumores más comunes del tracto genital de las perras. Se relata el caso de una perra Chow Chow de 11 años, no castrada, con histórico de retención urinaria, estrangúria y tenesmo fecal. Los exámenes ecográficos y tomográficos permitieron la caracterización de una masa en la cavidad pélvica que se proyectaba hacia la región abdominal caudal, provocando el desplazamiento craneal de la vejiga, obstrucción uretral y obstrucción parcial del colon descendiente. Después de realizada una biopsia percutánea guiada por ecografía y su examen histopatológico, fue posible establecer el diagnóstico de fibroma vaginal. Se destaca en el presente caso, la importancia de las exámenes de diagnóstico por imagen para poder establecer el diagnóstico y la caracterización de las alteraciones secundarias producidas como consecuencia del crecimiento tumoral. Además, el examen tomográfico proporcionó informaciones importantes para la planificación de la cirugía del paciente.

Pólipo fibroepitelial em um iguana (Iguana iguana Linnaeus, 1758)mantido em cativeiro domiciliar - relato de caso / Fibroepithelial polyp in a captive Green Iguana (Iguana iguana Linnaeus, 1758) - case report

O diagnóstico de neoplasias e subsequente tratamento bem sucedido vêm aumentando na clínicade répteis, em função de melhores condições de vida em cativeiro associadas a maiores conhecimentostécnicos em manejo e medicina. Um iguana (Iguana iguana Linnaeus, 1758) adulto do sexomasculino foi atendido em função da presença de uma proliferação tecidual cutânea na regiãorostral. Suspeitou-se do processo ter sido desencadeado por fricção da área afetada contra a paredede vidro do recinto, e a lesão foi removida cirurgicamente. O exame histopatológico possibilitou odiagnóstico de pólipo fibroepitelial, neoplasia de natureza benigna, e o paciente recuperou-se semintercorrências.(AU)

Diagnosis of neoplasia and subsequent successful treatment are increasing in reptile practice, due tobetter living conditions in captivity associated with greater expertise in management and medicine.There was examined a male adult iguana (Iguana iguana Linnaeus, 1758) presenting a cutaneous proliferationin the rostral area. The process was suspected to have been triggered by rubbing the affectedarea against the glass wall of the enclosure, and the lesion was surgically removed. Histopathologicalexamination allowed the diagnosis of a benign neoplasm, the fibroepithelial polyp, and the patientrecovered uneventfully.(AU)

Pólipo fibroepitelial em um iguana (Iguana iguana Linnaeus, 1758)mantido em cativeiro domiciliar - relato de caso / Fibroepithelial polyp in a captive Green Iguana (Iguana iguana Linnaeus, 1758) - case report

O diagnóstico de neoplasias e subsequente tratamento bem sucedido vêm aumentando na clínicade répteis, em função de melhores condições de vida em cativeiro associadas a maiores conhecimentostécnicos em manejo e medicina. Um iguana (Iguana iguana Linnaeus, 1758) adulto do sexomasculino foi atendido em função da presença de uma proliferação tecidual cutânea na regiãorostral. Suspeitou-se do processo ter sido desencadeado por fricção da área afetada contra a paredede vidro do recinto, e a lesão foi removida cirurgicamente. O exame histopatológico possibilitou odiagnóstico de pólipo fibroepitelial, neoplasia de natureza benigna, e o paciente recuperou-se semintercorrências.

Diagnosis of neoplasia and subsequent successful treatment are increasing in reptile practice, due tobetter living conditions in captivity associated with greater expertise in management and medicine.There was examined a male adult iguana (Iguana iguana Linnaeus, 1758) presenting a cutaneous proliferationin the rostral area. The process was suspected to have been triggered by rubbing the affectedarea against the glass wall of the enclosure, and the lesion was surgically removed. Histopathologicalexamination allowed the diagnosis of a benign neoplasm, the fibroepithelial polyp, and the patientrecovered uneventfully.

Evidence of regression of fibropapillomas in juvenile green turtles Chelonia mydas caught in Niterói, southeast Brazil.

Fibropapillomatosis is a disease characterized by cutaneous tumors affecting all marine turtle species, but mostly Chelonia mydas. The disease was first reported in 1938, and since then, the number of sightings has been increasing over the years. This disease can cause many complications in the affected animal and can lead to death, and is thus included in the many threats to marine turtle populations. It is still not known for certain what causes this disease, although many studies indicate a herpesvirus as the main etiologic agent. The incidence of fibropapillomatosis is rarely reported in adults, leading to speculations that there may be a cure for the disease or that the animals die before reaching adulthood. In this paper, 2 cases of fibropapillomatosis regression are reported from juvenile C. mydas caught between July 2008 and July 2010 in the coastal zone of Itaipu, Niterói, Rio de Janeiro, Brazil. These individuals were identified photographically upon recapture. One individual had a total regression (disappearance) of external papilloma within 164 d between first capture and recapture, and the other individual had a partial regression (decrease in size) observed within 13 to 188 d of recapture. The mechanism that triggers the regression is still unknown but is likely to be an immune system response or removal of the tumor promoter. There are few reported cases of regression in the world, and constant monitoring through mark-recapture is necessary to assess whether the marine turtles affected by this disease have real chances of survival.

Cutaneous fibroma in a captive common snapping turtle (Chelydra serpentina).

An adult female common snapping turtle (Chelydra serpentina) had a mass on the plantar surface of the right forelimb that was removed surgically. Microscopical examination revealed many spindle cells with mild anisocytosis and anisokaryosis and a surrounding collagenous stroma. There were no mitoses. Immunohistochemistry showed that the spindle cells expressed vimentin, but not desmin. A diagnosis of cutaneous fibroma was made. Tumours are reported uncommonly in chelonian species. Cutaneous fibroma has been diagnosed in an alligator snapping turtle (Macrochelys temminckii), but not previously in a common snapping turtle.

Fibromatous Epulis in a Captive Lion (Panthera leo)

An epulis in the oral cavity of an aged captive lion in Brasilia, Brazil, is reported. Oral inspection of the animal revealed a pale blunt and irregular multilobulated mass involving the upper left caninum tooth. Microscopic features of the mass included a fibrous stroma (mesenchyme) interspaced with a few blood vessels, suggesting a periodontal ligament origin. The dense collagen fiber background had a moderate cellularity composed of regularly orientated fibroblasts and it surrounded foci of osteoid or mineralized material. Mild overlying gingival epithelial hyperplasia with some irregular cellular cords was also observed. Based on the location of the lesion as well as the gross and microscopic features, the lesion was classified as fibromatous epulis and is believed to be the first report in this species.(AU)

Relationship between fibropapillomatosis and environmental quality: a case study with Chelonia mydas off Brazil.

We documented the presence of fibropapillomatosis (FP), a debilitating tumor-forming disease, in marine turtles in Espirito Santo Bay (Brazil) from March 2007 to April 2008, and assessed the value of a specific environmental index for predicting the prevalence of FP. Turtles were captured monthly with entanglement nets and scored for presence and severity of FP. For the assessment of habitat quality, we used the ecological evaluation index (EEI) based on benthic macrophytes. The FP-free control area was classified as good quality (EEI = 8) and the study area, with high FP prevalence, was classified as bad quality (EEI= 2). Prevalence of FP in the study area was 58.3% with an average of 40 tumors per individual, and prevalence varied positively with curved carapace length (CCL). No FP was seen in the control area. The number of turtles heavily afflicted (tumor score category 3) was 10 times larger than those lightly affected (tumor score category 1). Most tumors were found on or near the front and rear flippers; no oral tumors or internal tumors were found. At recapture, 41% of formerly tumor-free turtles revealed FP, often increasing in severity with time, and very few turtles showed signs of disease regression. From the results of this study we concluded that FP is particularly severe in Espírito Santo Bay. Future studies should focus on evaluating how widespread FP is in Brazil, whether prevalence is increasing or decreasing, and elucidating the pathology and pathogenesis of FP in sea turtles in Brazil.

Hematological profile of Chelonia mydas (Testudines, Cheloniidae) according to the severity of fibropapillomatosis or its absence / Perfil hematológico de Chelonia mydas (Testudines, Cheloniidae) de acordo com o grau de acometimento pela fibropapilomatose e sua ausência

The green turtle Chelonia mydas feeds and nests in the Brazilian coastal area and is considered an endangered species by the World Conservation Union (IUCN 2009) and threatened by the Red List of Brazilian Fauna (Ministério do Meio Ambiente 2009). Fibropapillomatosis is a disease characterized by benign skin tumors (fibropapillomas), and it is one of the main threats to the survival of this species. Studies suggest the involvement of viruses as infectious agents associated with environmental and genetic factors. Blood samples were collected from 45 turtles captured in the coastal area of the state of Sao Paulo, Brazil. From these, 27 were affected by fibropapillomas and 18 were tumor free. Biometrical data on the turtles, size, location and quantity of tumors were recorded. The area occupied by fibropapillomas per animal was calculated and four groups were determined according to severity of the disease or its absence. The objective of the study was to compare hemogram results of the sea turtles classified in these four groups. The lowest hematocrit value was observed in severely affected animals. In the hemoglobin assay, the highest value was observed in the group of tumor free turtles and the lowest, in animals severely affected. Lymphocyte counts and curved carapace length were on the verge of statistical significance.

Chelonia mydas, denominada tartaruga verde, é uma tartaruga marinha que frequenta o litoral brasileiro para alimentação e nidificação e é considerada em perigo de extinção pela IUCN (World Conservation Union, 2009) e ameaçada pela Lista Vermelha da Fauna Brasileira (Ministério do Meio Ambiente, 2009). A fibropapilomatose, doença caracterizada por tumores cutâneos benignos (fibropapilomas), é uma das mais importantes ameaças à sobrevivência dessa espécie. Pesquisas sugerem o envolvimento de agentes infecciosos virais em associação com fatores ambientais e genéticos. Foram colhidas amostras sanguíneas de 45 tartarugas provenientes do litoral do estado de São Paulo, Brasil, sendo 18 sem fibropapilomas e 27 acometidas. Dados de biometria das tartarugas, quantidade, localização e tamanho dos tumores foram anotados. Foi realizado o cálculo da área de fibropapilomas por animal e foram estipulados 4 grupos de acordo com o grau de acometimento e sua ausência. O objetivo foi realizar uma comparação entre os hemogramas das tartarugas marinhas classificadas nos 4 grupos. Animais de grau grave apresentaram o menor valor para hematócrito. Para dosagem de hemoglobina, observou-se que o maior valor foi para o grupo de tartarugas sem fibropapilomas e o menor para o de grau grave. Os valores de linfócitos e comprimento curvilíneo da carapaça beiraram a significância estatística.

Hematological profile of Chelonia mydas (Testudines, Cheloniidae) according to the severity of fibropapillomatosis or its absence / Perfil hematológico de Chelonia mydas (Testudines, Cheloniidae) de acordo com o grau de acometimento pela fibropapilomatose e sua ausência

The green turtle Chelonia mydas feeds and nests in the Brazilian coastal area and is considered an endangered species by the World Conservation Union (IUCN 2009) and threatened by the Red List of Brazilian Fauna (Ministério do Meio Ambiente 2009). Fibropapillomatosis is a disease characterized by benign skin tumors (fibropapillomas), and it is one of the main threats to the survival of this species. Studies suggest the involvement of viruses as infectious agents associated with environmental and genetic factors. Blood samples were collected from 45 turtles captured in the coastal area of the state of Sao Paulo, Brazil. From these, 27 were affected by fibropapillomas and 18 were tumor free. Biometrical data on the turtles, size, location and quantity of tumors were recorded. The area occupied by fibropapillomas per animal was calculated and four groups were determined according to severity of the disease or its absence. The objective of the study was to compare hemogram results of the sea turtles classified in these four groups. The lowest hematocrit value was observed in severely affected animals. In the hemoglobin assay, the highest value was observed in the group of tumor free turtles and the lowest, in animals severely affected. Lymphocyte counts and curved carapace length were on the verge of statistical significance.(AU)

Chelonia mydas, denominada tartaruga verde, é uma tartaruga marinha que frequenta o litoral brasileiro para alimentação e nidificação e é considerada em perigo de extinção pela IUCN (World Conservation Union, 2009) e ameaçada pela Lista Vermelha da Fauna Brasileira (Ministério do Meio Ambiente, 2009). A fibropapilomatose, doença caracterizada por tumores cutâneos benignos (fibropapilomas), é uma das mais importantes ameaças à sobrevivência dessa espécie. Pesquisas sugerem o envolvimento de agentes infecciosos virais em associação com fatores ambientais e genéticos. Foram colhidas amostras sanguíneas de 45 tartarugas provenientes do litoral do estado de São Paulo, Brasil, sendo 18 sem fibropapilomas e 27 acometidas. Dados de biometria das tartarugas, quantidade, localização e tamanho dos tumores foram anotados. Foi realizado o cálculo da área de fibropapilomas por animal e foram estipulados 4 grupos de acordo com o grau de acometimento e sua ausência. O objetivo foi realizar uma comparação entre os hemogramas das tartarugas marinhas classificadas nos 4 grupos. Animais de grau grave apresentaram o menor valor para hematócrito. Para dosagem de hemoglobina, observou-se que o maior valor foi para o grupo de tartarugas sem fibropapilomas e o menor para o de grau grave. Os valores de linfócitos e comprimento curvilíneo da carapaça beiraram a significância estatística.(AU)

Fibrossarcoma de aplicação em felinos: relato de três casos / Application fibrossarcoma in cats: three cases report

O fibrossarcoma é um tumor mesenquimal originado dos fibroblastos localizando-se principalmente na pele, tecido subcutâneo ou na cavidade oral. Essa é a variação histológica de ocorrência mais comum entre os sarcomas vacinais, atualmente designados como sarcomas de aplicação, visto que essas neoplasias também vem sendo associadas à aplicação de outros fármacos injetáveis e não apenas vacinas. O presente estudo objetiva descrever três casos de fibrossarcoma de aplicação em felinos atendidos no Hospital de Clínicas Veterinárias da Universidade Federal do Rio do Rio Grande do Sul. Foram atendidos, no período compreendido entre 2005 e 2006, três felinos sem raça definida, de ambos os sexos e idade variando entre 3 a 11 anos, cadastrados, apresentado massa tumoral de tamanho e localização variáveis. Todos os casos foram confirmados através da histopatologia. Em todos pacientes os padrões hematológicos e bioquímicos (funções renal e hepática) encontravam-se dentro dos padrões de normalidade para a espécie. Com a observação e acompanhamento dos casos puderam-se observar de forma particular as diversas características individuais apresentadas, como etiologia, patogenia, comportamento tumoral, alternativas de terapia clínica e cirúrgica e tempo de sobrevida. Este trabalho contribui com as publicações na área, enriquecendo a ainda incipiente literatura específica(AU)

Fibrossarcoma is a mesenquimal tumor originated of the fibroblast and situated in the skin, subcutaneous tissue or in the oral cavitie. Fibrassarcoma is the most common histological type, although cases of histiocytomas, osteossarcomas, chondrossarcomas and rabdomyossarcoma have been reported. The present study describes three cases of application fibrossarcoma in cats, admited in the Veterinarian Clinical Hospital of Rio Grande do Sul. With the accompaniment of the cases it could be observed of particular and characteristics, as etiology, tumoral behavior, alternatives of clinical and surgical therapy and survivor time of pacients. This study contributes with publications already existing in the area, enriching incipient specific literature(AU)

Fibrossarcoma de aplicação em felinos: relato de três casos / Application fibrossarcoma in cats: three cases report

O fibrossarcoma é um tumor mesenquimal originado dos fibroblastos localizando-se principalmente na pele, tecido subcutâneo ou na cavidade oral. Essa é a variação histológica de ocorrência mais comum entre os sarcomas vacinais, atualmente designados como sarcomas de aplicação, visto que essas neoplasias também vem sendo associadas à aplicação de outros fármacos injetáveis e não apenas vacinas. O presente estudo objetiva descrever três casos de fibrossarcoma de aplicação em felinos atendidos no Hospital de Clínicas Veterinárias da Universidade Federal do Rio do Rio Grande do Sul. Foram atendidos, no período compreendido entre 2005 e 2006, três felinos sem raça definida, de ambos os sexos e idade variando entre 3 a 11 anos, cadastrados, apresentado massa tumoral de tamanho e localização variáveis. Todos os casos foram confirmados através da histopatologia. Em todos pacientes os padrões hematológicos e bioquímicos (funções renal e hepática) encontravam-se dentro dos padrões de normalidade para a espécie. Com a observação e acompanhamento dos casos puderam-se observar de forma particular as diversas características individuais apresentadas, como etiologia, patogenia, comportamento tumoral, alternativas de terapia clínica e cirúrgica e tempo de sobrevida. Este trabalho contribui com as publicações na área, enriquecendo a ainda incipiente literatura específica

Fibrossarcoma is a mesenquimal tumor originated of the fibroblast and situated in the skin, subcutaneous tissue or in the oral cavitie. Fibrassarcoma is the most common histological type, although cases of histiocytomas, osteossarcomas, chondrossarcomas and rabdomyossarcoma have been reported. The present study describes three cases of application fibrossarcoma in cats, admited in the Veterinarian Clinical Hospital of Rio Grande do Sul. With the accompaniment of the cases it could be observed of particular and characteristics, as etiology, tumoral behavior, alternatives of clinical and surgical therapy and survivor time of pacients. This study contributes with publications already existing in the area, enriching incipient specific literature