Asunto(s)
Cardiopatías Congénitas/epidemiología , Progenie de Nacimiento Múltiple/estadística & datos numéricos , Gemelos Siameses , Aorta Torácica/anomalías , Ventrículo Derecho con Doble Salida/epidemiología , Defectos de los Tabiques Cardíacos/epidemiología , Humanos , Síndrome del Corazón Izquierdo Hipoplásico/epidemiología , Recién Nacido , Prevalencia , Atresia Pulmonar/epidemiología , Estudios Retrospectivos , Síndrome de Cimitarra/epidemiología , Tetralogía de Fallot/epidemiología , Transposición de los Grandes Vasos/epidemiología , Atresia Tricúspide/epidemiología , Tronco Arterial Persistente/epidemiología , Estados UnidosRESUMEN
The objective of the study was to evaluate the rate of major congenital anomalies after first trimester exposure to ondansetron for nausea and vomiting of pregnancy (NVP). The design is a prospective, comparative, observational cohort study, performed at the Israeli Teratology Information Service between 2010 and 2014. Follow-up was obtained for 195 ondansetron-exposed, 110 metoclopramide-exposed, and 778 pregnancies with non-teratogenic exposure (NTE). The overall rate of major anomalies did not significantly differ between the groups [4/200 = 2.0 % (ondansetron), 1/109 = 0.9 % (metoclopramide), and 13/731 = 1.8 % (NTE)]. All the anomalies in both the ondansetron and metoclopramide groups, and 6/13 anomalies in the NTE group, were cardiac septal defects most of which spontaneously resolved. Both ondansetron (adjHR = 0.29, 95 % CI 0.10-0.80) and metoclopramide (adjHR = 0.27, 95 % CI 0.08-0.86) were associated with lower miscarriage rate compared to NTE. Based on the present study, ondansetron during pregnancy is not associated with an increased risk for overall major anomalies, nor for clinically important cardiac defects. It may be a reasonable alternative for women with severe NVP who do not respond to first line medications.
Asunto(s)
Anomalías Inducidas por Medicamentos/epidemiología , Antieméticos/toxicidad , Metoclopramida/toxicidad , Ondansetrón/toxicidad , Adolescente , Adulto , Niño , Preescolar , Femenino , Defectos de los Tabiques Cardíacos/epidemiología , Humanos , Masculino , Intercambio Materno-Fetal , Náusea/tratamiento farmacológico , Embarazo , Resultado del Embarazo , Estudios Prospectivos , Vómitos/tratamiento farmacológico , Adulto JovenRESUMEN
Pulmonary atresia with ventricular septal defect (PA/VSD) is a complex cyanotic congenital heart disease with a wide-range of presentations and treatment strategies, depending on the source of pulmonary circulation, anatomy of pulmonary arteries (PAs), and major aortopulmonary collateral arteries (MAPCAs). Data about the outcomes in developing countries is scarce. We therefore conducted a retrospective study to assess survival rates and mortality risks of 90 children with PA/VSD at Siriraj Hospital, Thailand during 2005-2016. Patients with single ventricle were excluded. Survival and mortality risks were analyzed at the end of 2018. The median age of diagnosis was 0.5 (0-13.8) years. The patients' PAs were categorized into four groups: 1) PA/VSD with confluent PAs (n = 40), 2) PA/VSD with confluent PAs and MAPCAs (n = 21), 3) PA/VSD with non-confluent PAs and MAPCAs (n = 12), and 4) PA/VSD with small native PAs and MAPCAs (n = 17). Of the 88 patients who underwent operations, 32 patients had complete repair at 8.4 ± 4.6 years old. During the follow-up [median time of 5.7 years (7 days-13.6 years)], 17 patients (18.9%) died. The survival rates at 1, 5, and 10 years of age were 95%, 83.7%, and 79.6%, respectively. Significant mortality risks were the presence of associated anomalies and non-confluent PAs.
Asunto(s)
Defectos del Tabique Interventricular/cirugía , Defectos de los Tabiques Cardíacos/epidemiología , Defectos de los Tabiques Cardíacos/mortalidad , Atresia Pulmonar/epidemiología , Atresia Pulmonar/mortalidad , Adolescente , Aorta Torácica/cirugía , Niño , Preescolar , Estudios de Cohortes , Femenino , Cardiopatías Congénitas/fisiopatología , Humanos , Lactante , Recién Nacido , Masculino , Arteria Pulmonar/fisiopatología , Circulación Pulmonar/fisiología , Estudios Retrospectivos , Tailandia/epidemiologíaRESUMEN
OBJECTIVES: To assess features and outcome in fetuses with pulmonary atresia with ventricular septal defect (PA-VSD). METHODS: Fetuses with PA-VSD were prospectively enrolled and grouped on the basis of the pulmonary blood supply, including type A (only arterial duct [DA]), type B (both DA and major aortopulmonary collateral arteries [MAPCAs] present), and type C (MAPCAs only). The echocardiography features, associated chromosomal/genetic malformations, and postnatal outcome were compared among the three groups. RESULTS: Fifty-five fetuses with PA-VSD were enrolled. The presence of confluent PAs varied, with the highest displaying rate in type A and lowest rate in type C (100% vs 41.1%). The intrapericardial pulmonary arteries in all groups were hypoplastic but smaller in types B and C than in type A (P < .05). Deletion of 22q11.2 and right aortic arch were more frequently observed in types B and C than in type A. At the end of the study, overall survival rates in type C were lower than those in type A (22.1% vs 77.3%). CONCLUSION: There are great differences in the size of pulmonary arteries, associated genetic malformations, and perinatal outcomes among fetuses with PA-VSD. These results could be used for family counseling and surgical planning.
Asunto(s)
Defectos de los Tabiques Cardíacos , Resultado del Embarazo , Atresia Pulmonar , Circulación Pulmonar/fisiología , Adulto , Ecocardiografía/métodos , Femenino , Estudios de Seguimiento , Defectos de los Tabiques Cardíacos/clasificación , Defectos de los Tabiques Cardíacos/diagnóstico , Defectos de los Tabiques Cardíacos/epidemiología , Defectos de los Tabiques Cardíacos/fisiopatología , Humanos , Recién Nacido , Masculino , Embarazo , Resultado del Embarazo/epidemiología , Pronóstico , Estudios Prospectivos , Arteria Pulmonar/anomalías , Arteria Pulmonar/diagnóstico por imagen , Arteria Pulmonar/fisiopatología , Atresia Pulmonar/clasificación , Atresia Pulmonar/diagnóstico , Atresia Pulmonar/epidemiología , Atresia Pulmonar/fisiopatología , Ultrasonografía Prenatal/métodos , Adulto JovenRESUMEN
Atrioventricular septal defects (AVSDs) have been identified as intriguingly infrequent among Hispanics with Down syndrome (DS) born in the United States. The aim of this study was to evaluate the effect of possible maternal risk factors in the presence of congenital heart defects (CHDs) in Mexican infants with DS. A total of 231 live birth infants born with DS during 2009-2018 at the "Dr. Juan I. Menchaca" Civil Hospital of Guadalajara (Guadalajara, Mexico) were ascertained in a case-control study. Patients with DS with any major CHD were included as cases and those without major CHD as controls. Potential risk factors were analyzed using logistic regression. Of eligible infants with DS, 100 (43.3%) had ≥1 major CHDs (cases) and were compared with a control group of 131 infants (56.7%) with DS without CHDs. Prevalent CHDs were ostium secundum atrial septal defects (ASDs) (46.9%), ventricular septal defects (27.3%), and AVSDs (14%). Lack of folic acid supplementation before pregnancy had a significant risk for CHDs in infants with DS (adjusted odds ratio [aORs] = 2.9 (95% confidence interval [95% CI]: 1.0-8.6) and in the analysis by subtype of CHDs, also, for the occurrence of ASDs (aOR = 11.5, 95% CI: 1.4-94.4). Almost half of the infants with DS in our sample had CHDs, being ASD the commonest subtype and AVSD the rarest. Our ethnic background alone or in concomitance with observed nutritional disadvantages seems to contribute differences in CHD subtype rates in our DS patients.
Asunto(s)
Síndrome de Down/epidemiología , Cardiopatías Congénitas/epidemiología , Defectos del Tabique Interatrial/epidemiología , Defectos de los Tabiques Cardíacos/epidemiología , Adulto , Síndrome de Down/complicaciones , Síndrome de Down/fisiopatología , Femenino , Cardiopatías Congénitas/complicaciones , Cardiopatías Congénitas/fisiopatología , Defectos de los Tabiques Cardíacos/complicaciones , Defectos de los Tabiques Cardíacos/fisiopatología , Defectos del Tabique Interatrial/complicaciones , Defectos del Tabique Interatrial/fisiopatología , Humanos , Lactante , Masculino , Edad Materna , México/epidemiología , Edad Paterna , Embarazo , Factores de Riesgo , Estados Unidos/epidemiologíaRESUMEN
OBJECTIVE: To compare the frequency of asymmetric septal hypertrophy in appropriate for gestational age infants born to diabetic mothers with those born to non-diabetic mothers. METHODS: We compared 38 full term infants born to diabetic mothers with 85 full term infants of non-diabetic mothers. 2-D echocardiography was obtained in the first 24 hours after birth. RESULTS: Asymmetric septal hypertrophy was only present in infants born to diabetic mothers (50% vs. 0%; P<0.001). Intraventricular septum thickness and intraventricular septum/posterior wall of the left ventricle ratio was also significantly higher in the first group (P<0.001). We found no correlation between mother´s glycated hemoglobin levels and intraventricular septum thickness in newborns. CONCLUSION: Asymmetric septal hypertrophy is a common finding in infants born to diabetic mothers, even if they are appropriate for gestational age.
Asunto(s)
Edad Gestacional , Defectos de los Tabiques Cardíacos , Embarazo en Diabéticas/epidemiología , Diabetes Mellitus/epidemiología , Ecocardiografía , Femenino , Hemoglobina Glucada/análisis , Defectos de los Tabiques Cardíacos/diagnóstico por imagen , Defectos de los Tabiques Cardíacos/epidemiología , Defectos de los Tabiques Cardíacos/patología , Humanos , Hipertrofia , Recién Nacido , Masculino , Madres/estadística & datos numéricos , EmbarazoRESUMEN
BACKGROUND: While topical azoles are the first-line treatment for fungal infections, oral fluconazole is frequently used during pregnancy. We aimed to assess the effect of exposure to low and high doses of fluconazole during pregnancy on the occurrence of spontaneous abortions, major congenital malformations and stillbirths. METHODS: Within the Quebec Pregnancy Cohort (1998-2015), we identified women exposed to low- (≤ 150 mg) and high-dose (> 150 mg) fluconazole, and women who were not exposed. For each case of spontaneous abortion or stillbirth, up to 5 controls were randomly selected using an incidence density sampling method matched on gestational age at diagnosis of spontaneous abortion or stillbirth (index date) and the year of the last menstrual period. For cases of major congenital malformation, we considered all liveborn babies as controls. Generalized estimation equation models were used to analyze the 3 main outcomes separately. RESULTS: Within a cohort of 441 949 pregnancies, 320 868 pregnancies were included in the analyses of spontaneous abortions, 226 599 of major congenital malformations and 7832 of stillbirths. Most (69.5%) women exposed to fluconazole in pregnancy received the common single therapeutic dose of 150 mg (low dose); the remainder received a dose of > 150 mg (high dose). Use of oral fluconazole during early pregnancy was associated with an increased risk of spontaneous abortion compared with no exposure (adjusted odds ratio [OR] for 345 cases exposed to low-dose treatment 2.23, 95% confidence interval [CI] 1.96-2.54; adjusted OR for 249 cases exposed to high-dose treatment 3.20, 95% CI 2.73-3.75). Exposure to fluconazole during the first trimester did not increase the risk of overall major congenital malformations; however, exposure to a high dose during the first trimester was associated with an increased risk of cardiac septal closure anomalies (adjusted OR 1.81, 95% CI 1.04-3.14; 13 exposed cases) compared with no exposure. No association was found between exposure to fluconazole during pregnancy and the risk of stillbirth. INTERPRETATION: Any maternal exposure to fluconazole during pregnancy may increase risk of spontaneous abortion and doses higher than 150 mg during the first trimester may increase risk of cardiac septal closure anomalies.
Asunto(s)
Aborto Espontáneo/inducido químicamente , Antifúngicos/efectos adversos , Fluconazol/efectos adversos , Defectos de los Tabiques Cardíacos/inducido químicamente , Exposición Materna/efectos adversos , Mortinato/epidemiología , Aborto Espontáneo/epidemiología , Administración Oral , Adolescente , Adulto , Antifúngicos/administración & dosificación , Candidiasis Vulvovaginal/tratamiento farmacológico , Estudios de Casos y Controles , Estudios de Cohortes , Femenino , Fluconazol/administración & dosificación , Edad Gestacional , Defectos de los Tabiques Cardíacos/epidemiología , Humanos , Modelos Logísticos , Análisis Multivariante , Embarazo , Complicaciones Infecciosas del Embarazo/tratamiento farmacológico , Primer Trimestre del Embarazo , Quebec/epidemiología , Adulto JovenRESUMEN
OBJECTIVE: To determine the associations between transthoracic echocardiogram (TTE) cardiac structure/function measures and cardioembolic stroke (CES) and new-onset atrial fibrillation (AF) in patients without known AF. METHODS: Inpatients at a single institution (2013-2015) with imaging-confirmed ischemic stroke, no AF, and TTE within the 1st week were included. TTE structure/function variables were abstracted. Stroke subtype (CES vs other) was defined according to Trial of Org 10172 in Acute Stroke Treatment, blinded to TTE results. New AF was defined as any duration of AF on ECG, telemetry, or event monitor. Separate multivariable logistic regression models defined associations between CES or new-onset AF and TTE measures, adjusting for demographic and vascular risk factors. RESULTS: Of 322 participants (mean age 60 years), 55% were male and 56% African American. In adjusted models (odds ratio, 95% confidence interval), odds of CES increased per 0.1 cm increase in left atrial (LA) systolic diameter (1.06, 1.02-1.11), 1 cm/s in mitral E point velocity (1.03, 1.02-1.05), with presence of mitral valve dysfunction (3.78, 1.42-10.02), and with wall motion abnormality (2.00, 1.13-3.55). As ejection fraction increased (per 10%), odds of CES decreased (0.65, 0.53-0.79). New-onset AF was also associated with increasing LA systolic diameter (1.13, 1.04-1.22). CONCLUSIONS: Cardiac structural changes independent of AF and detectable on TTE may be on the CES causal pathway. Confirming these results could have implications for future use of TTE and decisions about antithrombotic vs anticoagulant treatment.
Asunto(s)
Fibrilación Atrial/epidemiología , Corazón/diagnóstico por imagen , Embolia Intracraneal/epidemiología , Accidente Cerebrovascular/epidemiología , Anciano , Válvula Aórtica/diagnóstico por imagen , Válvula Aórtica/fisiopatología , Ecocardiografía , Femenino , Defectos de los Tabiques Cardíacos/diagnóstico por imagen , Defectos de los Tabiques Cardíacos/epidemiología , Humanos , Masculino , Persona de Mediana Edad , Válvula Mitral/diagnóstico por imagen , Válvula Mitral/fisiopatología , Tamaño de los Órganos , Factores de Riesgo , Volumen Sistólico , Tabique Interventricular/diagnóstico por imagen , Tabique Interventricular/patologíaRESUMEN
Congenital heart defects (CHD) are the most common congenital malformation reported in the literature, with a global incidence of eight per every 1,000 live births. In the United States approximately 40,000 infants are born each year with a CHD. Of the infants diagnosed with a CHD, one in every four heart defects are life threatening in origin. Early identification and treatment of congenital heart lesions, beginning with a comprehensive physical assessment after birth, are critical. For infants delivered at community-based hospitals, the importance of the physical assessment, timing of diagnostic strategies, anticipatory planning, and interprofessional collaboration among referring and accepting centers cannot be understated. This article presents a rare case of an infant with atrioventricular canal complicated by dextrocardia. Embryology, pathophysiology, epidemiology, symptomology, cardiac assessment, diagnostics, treatment, and nursing strategies for facilitating transfer of care from community-based hospitals to tertiary medical centers are discussed.
Asunto(s)
Dextrocardia/fisiopatología , Dextrocardia/cirugía , Cardiopatías Congénitas/fisiopatología , Cardiopatías Congénitas/cirugía , Defectos de los Tabiques Cardíacos/fisiopatología , Defectos de los Tabiques Cardíacos/cirugía , Adulto , Dextrocardia/diagnóstico , Dextrocardia/epidemiología , Cardiopatías Congénitas/diagnóstico , Defectos de los Tabiques Cardíacos/diagnóstico , Defectos de los Tabiques Cardíacos/epidemiología , Humanos , Incidencia , Recién Nacido , Masculino , Resultado del Tratamiento , Estados Unidos/epidemiologíaRESUMEN
Reports on pulmonary hypertension (PH) in the aging congenital heart disease (CHD) population are few and focused on arterial PH and patients with systemic-to-pulmonary shunts. Our objective was to estimate incidence and mortality of adult-onset PH in the CHD population. Using Danish nationwide registries, we identified all patients diagnosed with CHD from 1963 to 1974 and 1977 to 2012. Patients were matched 1:10 by birth year and gender with general population subjects. Between 1977 and 2013 adults >18 years of age were followed up until PH diagnosis, death, or emigration, whichever came first, using data from the Danish National Registry of Patients. We computed cumulative incidences of PH. Using Cox regression, we compared the mortality rate between CHD subjects with and without PH matched by gender and birth year. We identified 14,860 patients with CHD. At 70 years of age, their overall cumulative incidence of PH was 7.2% (8.3% in those with systemic-to-pulmonary shunts and 5.3% in those without) compared with 0.4% in the general population. The 1-, 5-, and 10-year mortality for adults with CHD and PH was 24%, 44%, and 52%, respectively. This represented a 4-fold (95% confidence interval 3.3 to 5.6) increase in mortality compared with adults with CHD without PH after adjusting for gender, birth year, CHD severity, and presence of extracardiac defects. In conclusion the incidence of PH was substantially increased in adults with CHD relative to the general population. Of note, the increased incidence was not limited to those with a history of systemic-to-pulmonary shunts. PH was associated with increased mortality.
Asunto(s)
Cardiopatías Congénitas/epidemiología , Hipertensión Pulmonar/epidemiología , Mortalidad , Adolescente , Adulto , Anciano , Defecto del Tabique Aortopulmonar/epidemiología , Estudios de Casos y Controles , Dinamarca/epidemiología , Ventrículo Derecho con Doble Salida/epidemiología , Conducto Arterioso Permeable/epidemiología , Femenino , Estudios de Seguimiento , Cardiopatías Congénitas/mortalidad , Defectos de los Tabiques Cardíacos/epidemiología , Defectos del Tabique Interatrial/epidemiología , Defectos del Tabique Interventricular/epidemiología , Humanos , Hipertensión Pulmonar/mortalidad , Incidencia , Masculino , Persona de Mediana Edad , Modelos de Riesgos Proporcionales , Sistema de Registros , Tetralogía de Fallot/epidemiología , Adulto JovenRESUMEN
CONTEXT: Several studies have investigated the association between heavy metal exposure and congenital heart defects (CHDs). However, there are limited data regarding the relationship between barium exposure and the occurrence of CHDs. The objective of this study was to analyze the association between barium exposure in mothers and the risk of CHD in offspring. MATERIALS AND METHODS: We developed a case-control study with 399 cases and 490 controls with normal live births in China. The concentrations of barium in hair of pregnant woman and fetal placenta were measured. We used a logistic regression analysis to explore the association between barium exposure and the risk of CHD. RESULTS: Logistic regression analysis indicated that the median concentration of barium in maternal hair in the CHD group was 4.180 ng/mg (adjusted odds ratio [aOR], 1.230; 95% confidence interval [CI], 1.146-1.321; p < .001), which was significantly higher than that in the control group (2.740 ng/mg). Furthermore, the median concentration of barium in fetal placental tissue in the CHD group was 0.617 ng/mg, while that in the control group was 0.447 ng/mg (aOR, 1.392; 95% CI, 1.074-1.659; p = .003). Significant differences in the concentration of barium in hair were also found between the different CHD subtypes and the controls. These differences were found in cases with septal defects (p < .001), conotruncal defects (p < .001), right ventricular outflow track obstruction (p < .001), left ventricular outflow track obstruction (p < .001), and anomalous pulmonary venous return (p = .010). Significantly different barium concentrations in fetal tissue were only found in cases with septal defects (p = .010). CONCLUSIONS: Maternal barium exposure was dose-dependently related to the risk of CHD in the offspring. Our findings suggest that the occurrence of some subtypes of CHD is associated with barium exposure.
Asunto(s)
Bario/envenenamiento , Cardiopatías Congénitas/inducido químicamente , Cardiopatías Congénitas/epidemiología , Adulto , Bario/análisis , Estudios de Casos y Controles , China/epidemiología , Relación Dosis-Respuesta a Droga , Femenino , Cabello/química , Defectos de los Tabiques Cardíacos/inducido químicamente , Defectos de los Tabiques Cardíacos/epidemiología , Humanos , Recién Nacido , Exposición Materna , Placenta/química , Embarazo , Diagnóstico Prenatal , Efectos Tardíos de la Exposición Prenatal , Factores de Riesgo , Adulto JovenRESUMEN
BACKGROUND: Familial recurrence of Hirschsprung disease (HSCR) is well documented, and risk estimates for relatives have been reported from various populations. We describe the familial clustering of HSCR cases using well-established unbiased familial aggregation techniques within the context of a population genealogy. METHODS: Patients included 264 HSCR cases identified using ICD-9 diagnosis coding from the two largest healthcare providers in Utah who also had linked genealogy data. The GIF statistic was used to identify excess familial clustering by comparing average relatedness of cases to matched controls. In addition, relative risks (RRs) of HSCR in relatives of cases were estimated using age-, sex- and birthplace-matched disease rates, and for several diseases frequently associated with HSCR (Down syndrome, multiple endocrine neoplasia IIa, central hypoventilation syndrome, Bardet-Biedl syndrome, ventricular and atrial septal defect). RESULTS: Significant excess relatedness was observed for all HSCRs (p<1e-3). Significant RRs for HSCR were observed for first-, second-, and fourth-degree relatives of cases (RR=12.0, 10.0, and 4.6, respectively). Significant elevated risks of Down syndrome, Bardet-Biedl syndrome, and atrial and ventricular septal defects were observed for HSCR cases. CONCLUSION: This population-based survey of HSCR provides confirmation of a genetic contribution to HSCR disease and presents unbiased risk estimates that may have clinical value in predicting recurrence. LEVEL OF EVIDENCE RATING: Prognosis study, level II.
Asunto(s)
Predisposición Genética a la Enfermedad , Enfermedad de Hirschsprung/genética , Síndrome de Bardet-Biedl/epidemiología , Síndrome de Bardet-Biedl/genética , Consanguinidad , Síndrome de Down/epidemiología , Síndrome de Down/genética , Femenino , Genealogía y Heráldica , Defectos de los Tabiques Cardíacos/epidemiología , Defectos de los Tabiques Cardíacos/genética , Enfermedad de Hirschsprung/diagnóstico , Enfermedad de Hirschsprung/epidemiología , Humanos , Clasificación Internacional de Enfermedades , Masculino , Linaje , Riesgo , Utah/epidemiologíaRESUMEN
BACKGROUND: Atrioventricular septal defect (AVSD) has an incidence of 4-5.3 per 10.000 live births and is associated with Down syndrome (DS). Data on arrhythmias and sudden cardiac death (SCD) after AVSD correction is scarce. AIM: To analyse the incidence of post-operative arrhythmias and SCD after AVSD correction and explore risk factors. METHODS: This is a retrospective multicenter study including patients after biventricular AVSD correction. Univariate and multivariate analyses were performed to explore risk factors. RESULTS: A total of 415 patients were included with a mean follow-up duration of 9years (range; <30days-47years). Early post-operative SVTs were documented in 33 patients (8%) and late post-operative SVTs in 15 patients (3.6%). Non-syndromic AVSD (p=0.022, HR=2.64; 95% CI=1.15-6.04) and cAVSD (p=0.005, HR=3.7; 95% CI=1.39-7.51) were independent risk factors for early post-operative SVTs and significant more late post-operative SVTs occurred in non-syndromic patients (p=0.016, HR=6.38; 95% CI=1.42-28.71) and in pAVSD (p=0.045, HR=3.703; 95% CI=1.03-13.32). Fifteen patients (3.6%) received a pacemaker. Non-syndromic AVSD (p=0.008, HR=15.82; 95% CI=2.04-122.47), pAVSD (p=0.017, HR=6.26; 95% CI=1.39-28.28) and re-operation (p=0.007, HR=4.911; 95% CI=1.54-15.64) were independent risk factors for postoperative pacemaker implantation. Late life-threatening ventricular arrhythmias and SCD occurred in 0.5% and 1.7% respectively. CONCLUSION: There is good long-term survival after AVSD correction and incidence of SCD is low. Non-syndromic AVSD and cAVSD are independent risk factors for early post-operative SVTs. Non-syndromic AVSD patients have significant more early 3rd degree AVB and late post-operative SVTs. Non-syndromic patients with partial AVSD who have undergone reoperation have a significant higher risk of pacemaker implantation.
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Arritmias Cardíacas/epidemiología , Muerte Súbita Cardíaca/epidemiología , Defectos de los Tabiques Cardíacos/epidemiología , Defectos de los Tabiques Cardíacos/cirugía , Complicaciones Posoperatorias/epidemiología , Adolescente , Adulto , Arritmias Cardíacas/diagnóstico , Niño , Preescolar , Bases de Datos Factuales/tendencias , Femenino , Estudios de Seguimiento , Defectos de los Tabiques Cardíacos/diagnóstico , Humanos , Incidencia , Masculino , Persona de Mediana Edad , Complicaciones Posoperatorias/diagnóstico , Estudios Retrospectivos , Factores de Riesgo , Factores de Tiempo , Adulto JovenRESUMEN
BACKGROUND: The pattern and risk factors for congenital heart diseases (CHD) in children with Down syndrome (DS) vary over time. OBJECTIVES: To update knowledge of the prevalence, types, trends and associated factors for CHD in children with DS in the Egyptian Delta. DESIGN: A retrospective hospital record-based descriptive study. SETTING: A tertiary care center in Mansoura, Egypt during a period of 14 years from 2003 up to 2016. PATIENTS AND METHODS: We studied children with genetically proven DS. Relevant sociodemographic factors, medical history, clinical examination, karyotype and echocardiographic data were statistically analyzed. MAIN OUTCOME MEASURES: Prevalence, types and risk factors of CHD in DS. RESULTS: The prevalence of overall, isolated and multiple CHD in 1720 children with DS were 36.9%, 29% and 8%, respectively. Isolated defects accounted for 78.4% of all CHD. Ventricular septal defect, atrioventricular septal defect and atrial septal defect were the most frequent isolated defects. There was a downward trend in the prevalence of overall CHD (from 56.2% to 25.0%) and isolated CHD (from 56.2% to 19.8%). The logistic regression model predicted 65.7% of CHD and revealed that passive maternal smoking, lack of folic acid/multivitamin supplementation and parental consanguinity were the independent predictors of CHD in children with DS with adjusted odds ratios of 1.9, 1.8 and 1.9, respectively. CONCLUSION: More than one-third of children with DS have CHD with ventricular septal defect, which is the most common. Avoidance of passive maternal smoking and consanguineous marriage together with maternal folic acid supplementation could contribute to further reduction of CHD in children with DS. LIMITATIONS: Single-center study and retrospective.
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Síndrome de Down/complicaciones , Cardiopatías Congénitas/epidemiología , Defectos del Tabique Interventricular/epidemiología , Adolescente , Niño , Preescolar , Consanguinidad , Egipto/epidemiología , Ácido Fólico/administración & dosificación , Cardiopatías Congénitas/etiología , Cardiopatías Congénitas/fisiopatología , Defectos de los Tabiques Cardíacos/epidemiología , Defectos de los Tabiques Cardíacos/etiología , Defectos del Tabique Interatrial/epidemiología , Defectos del Tabique Interatrial/etiología , Defectos del Tabique Interventricular/etiología , Humanos , Lactante , Modelos Logísticos , Prevalencia , Estudios Retrospectivos , Factores de Riesgo , Fumar/efectos adversosRESUMEN
INTRODUCTION: This is the second report based on a survey of Divers Alert Network Asia-Pacific (DAN AP) members who dive with cardiovascular and respiratory conditions and diabetes. It examines the medical management of the divers' conditions, any diving modifications used to mitigate the risk and outcomes. METHODOLOGY: An online cross-sectional survey was sent to 833 divers who had declared a targeted medical condition when applying for DAN AP membership between July 2009 and August 2013. RESULTS: Two-hundred-and-sixty-eight respondents (32%) provided sufficient information on their conditions to be included in the analyses. These included ischaemic heart disease (31), arrhythmias (20), cardiac septal defects (31), other cardiac conditions (10), hypertension (127), diabetes (25), asthma (40) and pneumothorax (5). Forty-nine per cent had sought specialist diving medical advice about their condition and 23% reported modifying their diving practices to mitigate their risk. The cohort had completed 183,069 career dives, 57,822 of these since being diagnosed with their medical condition. There were 27 individuals who reported having decompression illness (25 of whom were subsequently diagnosed with a persistent foramen ovale), and two individuals who experienced an arrhythmia during diving. CONCLUSIONS: Some DAN AP members are diving with medical conditions which could potentially impact the safety of their diving. A minority modified their diving practices to mitigate the risk of their condition and approximately half sought specialist diving medical advice. The incidence of diving-related problems precipitated by known and managed pre-existing health conditions seems low but further studies of larger cohorts and incorporating fatality data would be necessary to confirm this. These results are limited by the 32% response rate and potential for bias towards selection of those most careful with their health.
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Asma/epidemiología , Diabetes Mellitus/epidemiología , Buceo/estadística & datos numéricos , Cardiopatías/epidemiología , Hipertensión/epidemiología , Neumotórax/epidemiología , Arritmias Cardíacas/epidemiología , Enfermedad de Descompresión/epidemiología , Femenino , Defectos de los Tabiques Cardíacos/epidemiología , Humanos , Masculino , Persona de Mediana Edad , Isquemia Miocárdica/epidemiología , Medicamentos bajo Prescripción/uso terapéutico , Distribución por Sexo , Encuestas y CuestionariosRESUMEN
OBJECTIVES: Management strategy for unbalanced complete atrioventricular septal defects (CASVSDs) includes single-ventricle (SV) palliation and primary or staged biventricular (BiV) repair. More recently, BiV conversion (BiVC) from SV palliation and staged BiV recruitment (BiVR) have also been advocated. This study assesses mid-term outcomes in patients with unbalanced CASVSDs according to management strategy. METHODS: Consecutive patients with unbalanced CASVSDs who underwent surgery at a tertiary care centre from January 2000 to February 2016 with institutional review board approval. The index surgery was defined as the first palliation procedure for the SV group, a BiV repair for the BiV repair group and conversion or the first procedure for recruitment for the BiVC/BiVR group. Kaplan-Meier and Cox regression were used for time-to-event analysis of death/transplant and unplanned reinterventions that occurred after the index surgery. RESULTS: There were 212 patients: 82 (38.7%) had SV palliation, 67 (31.6%) had BiV repair and 63 (29.7%) had BiVC/BiVR, respectively; 50 patients had undergone a successful BiVC. There were 93 (43.9%) boys; 51 (24%) patients had Down syndrome; and 101 (48%) patients had heterotaxy. In the entire cohort, there were 40 (18.9%) deaths, 110 (51.9%) reinterventions, 82 (38.7%) surgical reinterventions and 70 (33%) catheter reinterventions, with some patients having more than 1 reintervention. Median length of follow-up was 35 (range 1-192) months. The BiVC/BiVR group had a transplant-free survival benefit similar to that of the primary BiV repair group compared with the SV group. The BiV repair group needed fewer catheter-based reinterventions compared with the SV and BiVC/BiVR groups. CONCLUSIONS: BiVC or BiVR from an SV pathway can be achieved with low rates of mortality and morbidity in patients with unbalanced CASVSDs.
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Procedimientos Quirúrgicos Cardíacos/métodos , Defectos de los Tabiques Cardíacos/cirugía , Ventrículos Cardíacos/cirugía , Cuidados Paliativos/métodos , Niño , Preescolar , Ecocardiografía , Femenino , Estudios de Seguimiento , Defectos de los Tabiques Cardíacos/diagnóstico , Defectos de los Tabiques Cardíacos/epidemiología , Ventrículos Cardíacos/diagnóstico por imagen , Humanos , Lactante , Recién Nacido , Masculino , Massachusetts/epidemiología , Morbilidad/tendencias , Estudios Retrospectivos , Factores de Tiempo , Resultado del TratamientoRESUMEN
AIMS: To investigate the safety of fluoxetine use during pregnancy, and to better understand the relationship between maternal fluoxetine use during the first trimester and congenital malformations in infants. METHODS: PubMed and Web of Science databases were systematically searched from inception to 21 March 2016. Additional studies were identified in a manual search of the reference lists. Two reviewers independently extracted data. A third reviewer checked the data. Estimates were pooled using a random-effects model to calculate the summarized relative ratios (RR) and 95% confidence intervals (CI). RESULTS: Among 1918 initially identified articles, 16 cohort studies were included. The offspring of pregnant women exposed to fluoxetine during the first trimester had a statistically increased risk of major malformations (RR = 1.18, 95% CI = 1.08-1.29), cardiovascular malformations (RR = 1.36, 95% CI = 1.17-1.59), septal defects (RR = 1.38, 95% CI = 1.19-1.61), and non-septal defects (RR = 1.39, 95% CI = 1.12-1.73) with low heterogeneity in infants. There were no significant observations of other system-specific malformations in the nervous system, eye, urogenital system, digestive system, respiratory system, or musculoskeletal system, respectively. There was no indication of publication bias. CONCLUSIONS: The results of this meta-analysis indicate maternal fluoxetine use is associated with a slightly increased risk of cardiovascular malformations in infants. Health care providers and pregnant women must weigh the risk-benefit potential of these drugs when making decisions about whether to treat with fluoxetine during pregnancy.
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Anomalías Inducidas por Medicamentos/epidemiología , Antidepresivos de Segunda Generación/efectos adversos , Depresión/tratamiento farmacológico , Fluoxetina/efectos adversos , Defectos de los Tabiques Cardíacos/epidemiología , Complicaciones del Embarazo/tratamiento farmacológico , Anomalías Inducidas por Medicamentos/etiología , Femenino , Defectos de los Tabiques Cardíacos/inducido químicamente , Humanos , Incidencia , Lactante , Embarazo , Primer Trimestre del Embarazo , Sesgo de PublicaciónRESUMEN
OBJECTIVES: To determine the risk of atrioventricular valve failure (valve intervention or moderate or greater regurgitation) during the lifetime of patients with single ventricle physiology and common atrioventricular valve. METHODS: Patients' data were extracted from an existing bi-national, population based registry. A retrospective review of their medical records was undertaken to determine the incidence of atrioventricular valve repair/replacement or moderate or greater regurgitation. RESULTS: From a registry of 1468 Fontan survivors, 136 patients with common atrioventricular valve were identified. Complete echocardiographic follow-up was available for 114 patients. Median length of follow-up was 10.2 years (interquartile range 5-15 years). Twenty-five year survival and freedom from Fontan failure were 94% [95% confidence interval (CI), 88-100%] and 74% (95% CI, 64-87%), respectively. Twenty-eight patients underwent 24 initial repairs and 4 replacements. The 24 patients undergoing repair subsequently needed 6 re-repairs, 2 replacements and 8 had moderate or greater regurgitation at last follow-up. Four-year freedom from atrioventricular valve repair failure was 50% (95% CI, 34-75%). An additional 30 patients developed moderate or greater atrioventricular valve regurgitation (6 New York Heart Association ≥3, 10 Fontan failures, 0 deaths). Cumulative incidence of the composite endpoint of atrioventricular valve failure at 28 years was 62% (95% CI, 49-74%). CONCLUSIONS: Patients with single ventricle physiology and common atrioventricular valve experience a continuous decline in valve function. The majority of patients experience valve failure in the first 30 years of life.
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Procedimiento de Fontan , Defectos de los Tabiques Cardíacos , Ventrículos Cardíacos , Niño , Preescolar , Femenino , Procedimiento de Fontan/efectos adversos , Procedimiento de Fontan/mortalidad , Procedimiento de Fontan/estadística & datos numéricos , Defectos de los Tabiques Cardíacos/epidemiología , Defectos de los Tabiques Cardíacos/mortalidad , Defectos de los Tabiques Cardíacos/cirugía , Enfermedades de las Válvulas Cardíacas/mortalidad , Ventrículos Cardíacos/fisiopatología , Ventrículos Cardíacos/cirugía , Humanos , Estimación de Kaplan-Meier , Masculino , Cuidados Paliativos/estadística & datos numéricos , Estudios RetrospectivosRESUMEN
OBJECTIVE: Atrioventricular septal defect is associated with a high risk of a chromosomal abnormality, particularly trisomy 21. The aim of this study is to assess the rate of trisomy 21 in fetuses diagnosed with an atrioventricular septal defect and to examine the influence of prior screening on the rate of trisomy 21. METHODS: Electronic ultrasound database was searched to identify fetuses diagnoses with an atrioventricular septal defect from 2002 to 2014. Rate of trisomy 21 and other aneuploidies was calculated among fetuses with normal situs. The prevalence of trisomy 21 and other aneuploidies was assessed in women with low and high first trimester risk for trisomy 21, using a cut-off value of 1:150 and 1:250. RESULTS: A total 110 fetuses with a diagnosis of atrioventricular septal defect were identified. Among the 98 fetuses with normal situs, the prevalence of trisomy 21 was 46% (95% CI: 36-56%). Using a 1:150 threshold, the rate of trisomy 21 within the low-risk group was 41% (95% CI: 27-57%) while in the high-risk group it was 70% (95% CI: 52-83%), significantly higher than in the low risk group (p=0.028). Similar results were obtained when the 1:250 threshold was applied (66% versus 41%, p=0.055). CONCLUSIONS: The rate of trisomy 21 among fetuses identified with an atrioventricular septal defect in the second trimester is high even in those that undergo first trimester combined screening. Some fetuses with a high-risk screening result show a normal karyotype. Therefore, an offer of an invasive procedure to check fetal karyotyping is indicated. Knowledge of these rates may be helpful for parents in the decision making process.