Bartonella vinsonii subsp. berkhoffii and Bartonella henselae as potential causes of proliferative vascular diseases in animals.

Bartonella species are highly fastidious, vector borne, zoonotic bacteria that cause persistent intraerythrocytic bacteremia and endotheliotropic infection in reservoir and incidental hosts. Based upon prior in vitro research, three Bartonella sp., B. bacilliformis, B. henselae, and B. quintana can induce proliferation of endothelial cells, and each species has been associated with in vivo formation of vasoproliferative tumors in human patients. In this study, we report the molecular detection of B. vinsonii subsp. berkhoffii, B. henselae, B. koehlerae, or DNA of two of these Bartonella species simultaneously in vasoproliferative hemangiopericytomas from a dog, a horse, and a red wolf and in systemic reactive angioendotheliomatosis lesions from cats and a steer. In addition, we provide documentation that B. vinsonii subsp. berkhoffii infections induce activation of hypoxia inducible factor-1 and production of vascular endothelial growth factor, thereby providing mechanistic evidence as to how these bacteria could contribute to the development of vasoproliferative lesions. Based upon these results, we suggest that a fourth species, B. vinsonii subsp. berkhoffii, should be added to the list of bartonellae that can induce vasoproliferative lesions and that infection with one or more Bartonella sp. may contribute to the pathogenesis of systemic reactive angioendotheliomatosis and hemangiopericytomas in animals.

Tumor parafaríngeo. A propósito de un caso de sarcoma sinovial cervical / Parapharyngeal tumor. About a case of cervical synovial sarcoma

Presentamos un caso de sarcoma sinovial en un joven de 27 años cuyo tumor asentaba a nivel cervical derecho, caso raro por su frecuencia, pues solo existen publicados unos 80 casos. El paciente debutó con sensación de masa a nivel cervical derecho. Su diagnóstico fue realizado mediante biopsia y técnicas e immunohistoquímica. El tratamiento que se le practicó fue cirugía tumoral radical seguida de radioterapia. En el momento actual, dos años después, el paciente se encuentra en perfecto estado (AU)

[Deep mycosis and lung tumor induced by dark-pigmented micromycetes]. / Glybokyi mykoz ta rak legen', sprychyneni temnopigmentovanymy miromitsetamy.

The authors carried out an experiment on mice infected with dark-pigmented micromicetes Aspergillus clavitus and Exophiala dermatitidis, preplanted from lung operational material of patients with chronic non-specific lung disease and destructive tuberculosis. The infection was produced by the peroral method in the first group of animals and by the intranasal method in the second group. By day 30 the test animals developed mycotic sepsis, fifty percent of the animals had malignant lung growths (adenocarcinoma, squamous cell carcinoma and angiopericytoma). Established in the experiment was toxicity and cancerogenity of dark-pigmented micromicetes Aspergillus clavitus and Exophiala dermatitidis. A model of mycotic sepsis and micromicete-induced lung cancer has been created.

[Ultrastructure of experimental virus-induced hemangiopericytomas]. / Ul'trastruktura éksperimental'nykh virusindutsirovannykh gemangioperitsitom

Electron-microscopy studies of malignant low-differentiated hemangiopericytomas, induced by adenovirus of monkeys SA7(C8) and bovine adenovirus type 3 were, carried out. At earlier stages of the development of these tumours in tumourous cells located around capillaries there were observed the ultrastructural characteristics typical of pericytes and cells of human hemangiopericytis: the presence of the basal layer and fibrills as thick as 40 A. As differentiation proceeded, tumorous cells acquired an elongated form, and in some of them there appeared myofilaments typical of smooth-muscle cells, with local thickenings, as well as multitude of pinicytic vacules along the plasmatic membranes of cells. The foregoing confirms the assumption of hemangiopericytomas as a prestage of leio-(angioleio-) myosarcomas. Moreover, the tumour cells revealed the presence of cilia, fibrills as thick as 100A, 75A, annulate lamelae, and myelin-like formations.