RESUMEN
BACKGROUND AND AIMS: We aimed to characterize the epidemiologic and comorbidities profiles of patients with chronic Hepatitis D (CHD) followed in clinical practice in Italy and explored their interferon (IFN) eligibility. METHODS: This was a cross-sectional study of the PITER cohort consisting of consecutive HBsAg-positive patients from 59 centers over the period 2019-2023. Multivariable analysis was performed by logistic regression model. RESULTS: Of 5492 HBsAg-positive enrolled patients, 4152 (75.6%) were screened for HDV, 422 (10.2%) were anti-HDV positive. Compared with HBsAg mono-infected, anti-HDV positive patients were more often younger, non-Italians, with a history of drug use, had elevated alanine transaminase (ALT), cirrhosis, or hepatocellular carcinoma (HCC). Compared with Italians, anti-HDV positive non-Italians were younger (42.2% age ≤ 40 years vs. 2.1%; P < 0.001), more often females (males 43.0% vs. 68.6%; P < 0.001) with less frequent cirrhosis and HCC. HDV-RNA was detected in 63.2% of anti-HDV-positive patients, who were more likely to have elevated ALT, cirrhosis, and HCC. Extrahepatic comorbidities were present in 47.4% of anti-HDV positive patients and could affect the eligibility of IFN-containing therapies in at least 53.0% of patients in care. CONCLUSIONS: CHD affects young, foreign-born patients and older Italians, of whom two-thirds had cirrhosis or HCC. Comorbidities were frequent in both Italians and non-Italians and impacted eligibility for IFN.
Asunto(s)
Hepatitis D Crónica , Virus de la Hepatitis Delta , Humanos , Femenino , Masculino , Italia/epidemiología , Hepatitis D Crónica/epidemiología , Adulto , Persona de Mediana Edad , Estudios Transversales , Virus de la Hepatitis Delta/inmunología , Virus de la Hepatitis Delta/genética , Estudios de Cohortes , Cirrosis Hepática/epidemiología , Cirrosis Hepática/virología , Carcinoma Hepatocelular/epidemiología , Carcinoma Hepatocelular/virología , Comorbilidad , Anciano , Antígenos de Superficie de la Hepatitis B/sangre , Neoplasias Hepáticas/epidemiología , Neoplasias Hepáticas/virología , Interferones/uso terapéutico , Antivirales/uso terapéuticoRESUMEN
Las complicaciones hepáticas constituyen actualmente una de las principales causas de consulta médica, hospitalización y muerte en los pacientes infectados por el virus de la inmunodeficiencia humana(VIH).A ello contribuyen en gran medida las hepatitis víricas, que son particularmente frecuentes en esta población (..) (AU)
Hepatic complications currently represent one of the leading reasons for medical consultations, hospitalisation, and death in the HIV-infected population. This is (..) (AU)