1.
J Allergy Clin Immunol
; 147(2): 749-753.e2, 2021 02.
Article
En
| MEDLINE
| ID: mdl-32853637
2.
Clin Lab Med
; 39(4): 579-590, 2019 12.
Article
En
| MEDLINE
| ID: mdl-31668271
The complement system is a critical component of both the innate and adaptive immune systems that augments the function of antibodies and phagocytes. Antigen-antibody immune complexes, lectin binding, and accelerated C3 tick-over can activate this well-coordinated and carefully regulated process. The importance of this system is highlighted by the disorders that arise when complement components or regulators are deficient or dysregulated. This article describes the pathways involved in complement activation and function, the regulation of these various pathways, and the interpretation of laboratory testing performed for the diagnosis of diseases of complement deficiency, exuberant complement activation, and complement dysregulation.
Complement System Proteins , Hereditary Complement Deficiency Diseases , Immunologic Tests , Complement C3-C5 Convertases/analysis , Complement C3-C5 Convertases/metabolism , Complement C3-C5 Convertases/physiology , Complement System Proteins/analysis , Complement System Proteins/metabolism , Complement System Proteins/physiology , Hereditary Complement Deficiency Diseases/blood , Hereditary Complement Deficiency Diseases/diagnosis , Humans , Models, Biological
3.
Clin Chem Lab Med
; 57(8): e179-e182, 2019 07 26.
Article
En
| MEDLINE
| ID: mdl-30721140
4.
Rheumatology (Oxford)
; 58(5): 918-919, 2019 05 01.
Article
En
| MEDLINE
| ID: mdl-30608615