Does circular economy affect environmental performance? The mediating role of sustainable supply chain management: the case study in China.

Governments and professionals have recently tried to improve public environmental knowledge and laws in order to meet growing environmental concerns. As a result, most nations see corporate environmental initiatives like the circular economy and the green supply chain as important (GSCM) as the best ways to address environmental problems. As a result, this study tries to show how important GSCM and the circular economy are regarding the economy of China's relationship to environmental sustainability. This study uses the partial least square structural equation model (PLS-SEM) on data to obtain trustworthy results from 387 Chinese manufacturing companies. A favorable and statistically significant correlation between GSCM, environmental performance, and the circular economy was revealed using PLS-SEM analysis. To raise environmental standards, eco-friendly methods like buying and designing green items are widely regarded today. Imagine if manufacturing companies adopt green supply chain management, which would improve their economic performance and increase operational effectiveness. The secret to a successful corporation is having successful operations.

Can China's industrial policies enhance the green competitiveness of the manufacturing industry?

This study innovatively uses local government regulations related to manufacturing to quantitatively identify industrial policies. The degree of influence and functional mechanism of China's industrial policies on the green competitiveness of the manufacturing industry are empirically examined using the provincial and regional panel data. Additionally, the synergistic complementary effect between industrial policy power and market forces and the fiscal decentralization's role in influencing industrial policies are investigated. The results reveal that the promulgation and implementation of industrial policies have significantly promoted the green competitiveness of the manufacturing industry. Regarding functional mechanisms, environmental governance has played a positive role in promoting the green competitiveness of the manufacturing industry supported by industrial policies, resource allocation, and innovation incentives. Meanwhile, industrial policies on green competitiveness in manufacturing depend on marketization and fiscal decentralization in local governments. The above findings demonstrate that the local governments in China, a developing economy, can play the role of development-oriented governments. Based on conforming to market deepening and system optimization, they can formulate and implement industrial policies in a rational manner and achieve green development and upgrade the manufacturing industry.

Assessment of COVID-19 control strategies in a steel industry using a SWOT matrix.

According to the health regulations, industrial environments due to the gathering of people are considered as one of the highest-risk places during the COVID-19 pandemic. Thus, planning with regard to health concerns can decisively help in infection control and continuity of businesses during the pandemic. The aim of this study was to evaluate the COVID-19 control management measures in the Sepid-farab Kavir Steel Complex (SKS complex) located in Isfahan province (Iran) using strengths, weaknesses, opportunities, and threats (SWOT) matrix. After a literature review and field surveys, all weak, strong, threatening, and opportunity points were collected and were listed using the internal factor evaluation (IFE) and external factor evaluation (EFE) matrices and then were prioritized and weighted. Next, given the sum of scores of IFE and EFE, the SWOT matrix was constructed, the disease prevention and control strategies in the complex was determined, and finally, experts proposed corrective measures to improve the current situation. The results of the IFE matrix (IFE) analysis showed that in terms of corona control, there are more weaknesses than strengths within the company (the score of this matrix was 201.12). Also the score of 165 on the EFE matrix indicated that external threats were predominant, compared to external opportunities of company. SWOT analysis showed that despite some external problems and challenges, the existence of a favorable internal decision-making system had an important role in developing appropriate health strategies and implementing effective prevention measures in SKS complex against the COVID-19.

Needle Manufacturing, Quality Control, and Optimization for Patient Comfort.

INTRODUCTION: There is an increasing rise of cosmetic injectables. We sought to understand the manufacturing, quality control process, and needle selection of hypodermic needles for fillers. OBJECTIVE: To understand the process of manufacturing and quality control of hypodermic needles and the relevance to an aesthetic clinician. METHODS: We conducted a search of the internet and contacted medical device companies to understand the manufacturing process. We then collaborated with the Executive director of global pharmaceutical technology from Abbvie as well as the packaging and device engineer at Galderma and summarized our findings. Finally, we reviewed the literature and summarized existing recommendations on techniques to minimize pain related to injection. RESULTS: Hypodermic needles undergo an extensive manufacturing and regulatory process. Many considerations are taken into account in needle manufacturing as well as the selection process with commercially available hyaluronic acid filler products. Needle manufacturers are held to universal standards though the International Organization for Standardization (ISO). Filler companies perform their own testing to evaluate suitability of needles for their product including leakage force, penetration force, extrusion force, etc. Finally, parameters such as needle length, needle diameter, and wall thickness are considered for selection of needle/hub with individual filler viscosity. CONCLUSION: There is extensive consideration that goes into needle manufacturing, quality control, and optimization for hyaluronic acid filler. Understanding the technical process helps inform the clinician and guide patient care for maximum comfort. J Drugs Dermatol. 2021;20(1):44-48. doi:10.36849/JDD.5591.

Approach to Establishment of Control Strategy for Oral Solid Dosage Forms Using Continuous Manufacturing.

As a result of the research activities of the Japan Agency for Medical Research and Development (AMED), this document aims to show an approach to establishing control strategy for continuous manufacturing of oral solid dosage forms. The methods of drug development, technology transfer, process control, and quality control used in the current commercial batch manufacturing would be effective also in continuous manufacturing, while there are differences in the process development using continuous manufacturing and batch manufacturing. This document introduces an example of the way of thinking for establishing a control strategy for continuous manufacturing processes.

Developing synthetic biology for industrial biotechnology applications.

Since the beginning of the 21st Century, synthetic biology has established itself as an effective technological approach to design and engineer biological systems. Whilst research and investment continues to develop the understanding, control and engineering infrastructural platforms necessary to tackle ever more challenging systems - and to increase the precision, robustness, speed and affordability of existing solutions - hundreds of start-up companies, predominantly in the US and UK, are already translating learnings and potential applications into commercially viable tools, services and products. Start-ups and SMEs have been the predominant channel for synthetic biology commercialisation to date, facilitating rapid response to changing societal interests and market pull arising from increasing awareness of health and global sustainability issues. Private investment in start-ups across the US and UK is increasing rapidly and now totals over $12bn. Health-related biotechnology applications have dominated the commercialisation of products to date, but significant opportunities for the production of bio-derived materials and chemicals, including consumer products, are now being developed. Synthetic biology start-ups developing tools and services account for between 10% (in the UK) and ∼25% (in the US) of private investment activity. Around 20% of synthetic biology start-ups address industrial biotechnology targets, but currently, only attract ∼11% private investment. Adopting a more networked approach - linking specialists, infrastructure and ongoing research to de-risk the economic challenges of scale-up and supported by an effective long-term funding strategy - is set to transform the impact of synthetic biology and industrial biotechnology in the bioeconomy.

Aluminium utensils: Is it a concern?

Aluminium utensils are ubiquitous in Indian households and other developing countries. Concerns have recently been raised on the pathological effects of aluminium on the human body, due to its leaching from utensils with long-term use, which has been associated with certain clinical conditions such as anaemia, dementia and osteo-malacia. While some studies suggest that cooking in utensils or aluminium foils is safe, others suggest that it may lead to toxic levels of aluminium in the body. However, studies have shown that leaching of aluminium from cooking utensils depends on many factors such as pH, temperature and cooking medium. In healthy controls, 0.01 %-1 % of orally ingested aluminium is absorbed from the gastrointestinal tract and is eliminated by the kidney. Although the metal has a tendency to accumulate in tissues and may result in their dysfunction, the literature suggests that the apprehension is more apt in patients with chronic renal insufficiency. This article offers solutions to mitigate the risk of aluminium toxicity.

Assessing the effects of lean on occupational health and safety in the Ready-Made Garment industry.

BACKGROUND: Garment manufacturers have been adopting lean manufacturing in order to increase productivity and competitiveness. However, the effects of lean on occupational health and safety (OHS) of the workers are not clear. In the literature, there is an ongoing debate about whether lean and OHS are complementary or contradictory. OBJECTIVE: The goal of this study was to contribute to the knowledge base about the relationship between lean and OHS in garment manufacturing. METHODS: The study follows an action research methodology including an intervention aimed at improving productivity and OHS in six garment manufacturers in Bangladesh. Both quantitative and qualitative methods were used for investigating the effect of lean tools on productivity and subsequently on OHS. RESULTS: We observed instances of improvements of OHS related to the application of three lean tools (VSM, 5 S, Time and Motion Study) in the factories. Furthermore, our results do not indicate negative health effect on workers' short-term muscular pain, but rather show a statistically significant improvement of workers' health. CONCLUSIONS: The results suggest that it is possible to apply lean without adverse effects for workers, if OHS risks are taken into consideration. However, possible long-term effects on workers' health need to be further investigated.

[Medical devices industry: the problem of clinical evaluation reports]. / L'industrie des dispositifs médicaux : la problématique des rapports d'évaluation clinique.

In order to achieve regulatory compliance and acquire authorisation for sale in Europe, each medical device must be supported by a clinical evaluation report (CER) which documents the clinical evaluation process in its entirety. This is not a new requirement but highly publicised scandals caused by defective medical devices increased scrutiny of notified bodies (the organisations designated by the European Union to evaluate medical device compliance) meaning they are more liable and must strengthen their inspections of medical device manufacturers. Manufacturers are already under increased pressure due to the new EU Medical device regulation published in 2017. The scope of the new regulation requires many manufacturers to evaluate the documentation for their whole product portfolio. CERs are an important part of regulatory compliance and are also one of the biggest challenges for manufacturers who do not have sufficient resources and do not dedicate enough time to this task. This article examines the background of this requirement while offering medical device manufacturers advice for successful clinical evaluation reports.

Exploration of the adverse effects of shift work in a multicultural environment.

BACKGROUND: Given that shift work spreads across many different business sectors, studies of its adverse effects are very topical. Much research has been done on the negative impact of shift work, but many researchers have not focused on its impact in a multicultural environment. OBJECTIVE: The aim of this study was to map out how shift work is perceived by workers in two different shift regimes and two national groups. METHODS: The research was carried out on Czech manufacturing workers and Turkish airport ground personnel using a questionnaire. The impact of shift work was studied from physical, mental, social and health aspects with connection to family status and gender. For statistical evaluation, Pearson's chi-squared test of independence was used. The effect of shift work on workers' performance and scrap rate was analysed only on the sample of the manufacturing workers. RESULTS: Fifty-five Czech male workers, 49 Turkish male workers and 60 Turkish female workers participated in the survey. The dependence between sexes was confirmed for mental aspects and sleeping routines. The main difference between nationalities is in work attitude, social aspects and sleeping routines. According to the family status, the difference was confirmed in all areas except social aspects. The lowest values of productivity and the highest scrap rate were observed on night shifts and the maximum productivity and lowest scrap rates were observed on afternoon shifts. CONCLUSIONS: Some of the basic assumptions were confirmed which suggests that a multicultural environment has an influence on the perception of shift work by the nations and gende.

Institutional barriers and enablers to implementing and complying with internationally accepted quality standards in the local pharmaceutical industry of Pakistan: a qualitative study.

Complying with good manufacturing practices (GMP) and ensuring a quality system is integral to production and supply of quality medicines and achieving universal health coverage. This study focus on the local production of medicines in Pakistan, a lower middle-income country that has observed considerable growth in the number of pharmaceutical companies over the past two decades. Against this background, we investigated: (1) How is quality assurance (QA) and GMP compliance understood and acted upon by local pharmaceutical manufacturers?; (2) What are the institutional barriers and enablers for QA and GMP compliance in the local pharmaceutical sector from the perspective of key stakeholders?; and (3) What are the institutional barriers and enablers for strengthening local regulatory capacity to improve QA in the industry in the long term? We used a qualitative study design involving 22 interviews of the drug regulatory bodies (n = 9), academia (n = 3) and local manufacturers (n = 10), identifying key themes in data by thematic analysis. Document analysis was used to collect additional information and supplement the interview data. We identified that manufacturing facilities operated under different GMP standards and interpretations, pointing towards an absence of harmonization in quality standards across the industry. Views diverged about the status of GMP compliance, with interviewees from academia presenting a more critical view compared with regulators who promoted a more positive story. Among the barriers explaining why companies struggled with quality standards, the lack of a mindset promoting quality and safety among profit-oriented manufacturers was prominent. At the federal level, DRAP's establishment represented an institutional improvement aiming to promote QA through inspections and guidance. While some positive measures to promote quality have been observed, the need for DRAP to strengthen its technical and regulatory capacity, enhance its engagement in international collaboration and learning, and improve transparency and accountability were highlighted. Overall, since the challenges in Pakistan are shared with other low- and middle-income countries with local production, there is a need to commit to international collaborative mechanisms, such as those lead by WHO, on this issue.

Development of an automatic classifier for the prediction of hearing impairment from industrial noise exposure.

The ISO-1999 [(2013). International Organization for Standardization, Geneva, Switzerland] standard is the most commonly used approach for estimating noise-induced hearing trauma. However, its insensitivity to noise characteristics limits its practical application. In this study, an automatic classification method using the support vector machine (SVM) was developed to predict hearing impairment in workers exposed to both Gaussian (G) and non-Gaussian (non-G) industrial noises. A recently collected human database (N = 2,110) from industrial workers in China was used in the present study. A statistical metric, kurtosis, was used to characterize the industrial noise. In addition to using all the data as one group, the data were also broken down into the following four subgroups based on the level of kurtosis: G/quasi-G, low-kurtosis, middle-kurtosis, and high-kurtosis groups. The performance of the ISO-1999 and the SVM models was compared over these five groups. The results showed that: (1) The performance of the SVM model significantly outperformed the ISO-1999 model in all five groups. (2) The ISO-1999 model could not properly predict hearing impairment for the high-kurtosis group. Moreover, the ISO-1999 model is likely to underestimate hearing impairment caused by both G and non-G noise exposures. (3) The SVM model is a potential tool to predict hearing impairment caused by diverse noise exposures.

Parallelism between risk and perception of risk among caregivers during anesthesia delivery.

The paper examines the different perceptions of risk associated with anesthesia systems from the viewpoint of the product manufacturer and the caregiver. Only a little research has been done with regard to the impact of perception of risk on patient safety in anesthesia. The role of the manufacturer in mitigating the perception of risk will be central for the work. The risk will be examined as the probability of negative occurrences based on the Medical Device Reportable (MDR) events for 2016 and 2017 and it will be examined how the caregiver perceives and manages these risks when delivering anesthesia. Analysis of the manufacturer's public Medical Device Reportable events data will be performed in the US market and will represent the actual risk achieved; this review will provide a perspective on how the risk is perceived and managed by the caregiver when delivering anesthesia. The goals of the paper are to highlight how the role of the manufacturers can have an impact on the reduction of perception of risk, increasing patient safety, and showing how the perception of risk is usually magnified by the hospital personnel.

Monitoring an Analysis of Perturbations in Fusion Deposition Modelling (FDM) Processes for the Use of Biomaterials.

During an FDM production process, there are different external disturbances to the characteristics of the machine that can affect to the production process. These disturbances will cause the final result differs from the desired one. Moreover, these disturbances, such as temperature or chamber humidity, are extremely important in case of using biocompatible materials. The use of these kind of materials with not controlled environment, can cause them to modify or loss of their properties; what will make the product unusable. Apart from these external disturbances, the conditions of the machine to which the material is subjected must also be considered, such as temperature, vibrations or extrusion speed. The monitoring of all these data will allow to know the conditions to which the product was exposed during the process. In this way, it will be able to verify the validity of the final product. For these reasons, the purpose of this work is to monitor the conditions of production of structures with biocompatible materials by fused deposition modelling (FDM) technique. This monitoring will allow us to obtain a report that guarantee the technical and geometrical characteristics of the model and the biomaterial properties. The parameters chosen to be monitored are: Diameter of filament use, temperature in extrusion nozzle, ambient temperature in closed chamber, ambient humidity in closed chamber. The obtained results, after collected and analysing the data, present variations of up to 3% in the temperature of the nozzle of the extruder with respect to set temperature. In the case of the filament diameter the difference with respect to the value provided from the filament supplier is of 13,7%. In addition, the results show how the ambient humidity in closed chamber has changed by 2 percentage points and the ambient temperature in closed chamber has been increased 6,52 °C with respect to the set values.

Training for Workers and Safety Representatives on Manufactured Nanomaterials.

Although nanotechnologies are increasingly present in numerous sectors of the economy, training resources available to workers exposed to them are still rare. In the European Union (EU), some initiatives exist that inform workers about exposure and risks, but they lack two key dimensions: the involvement of workers themselves in designing and implementing training materials and the key role played by safety representatives in improving occupational health and safety in EU member states. Making workers actors of their own training, rather than recipients of it, and empowering them, so that they can collectively question unsafe situations and ask for changes in their working conditions, is how training can positively impact their health and safety. This article describes a training package (materials, infographics, interactive web applet) designed specifically to achieve this objective. Developed under the NanoDiode project, it focuses on six key themes: types of nanomaterials, uses at work, risks, presence in the workplace, exposure, and experience sharing.

Green Procurement Relationships Development under Carbon Emissions Regulations: A Bi-Level Programming Approach.

A multi-period Stackelberg game is adopted to study a green procurement relationship between manufacturers and suppliers in a supply chain. The manufacturers are considered as leaders, while the suppliers are modelled as followers in this Stackelberg game. Accordingly, a mixed binary linear bi-level programming model is developed to elaborate the game in consideration of carbon tax scheme. The upper level (the leader) aims at selecting a proper number of suitable suppliers to provide heterogeneous raw materials at the lowest operational cost. The objective of the lower level (the follower) is to find optimal purchasing quantities of raw materials. In addition, two lemmas are introduced to transform the mixed linear bi-level programming model into a single level linear programming model. The numerical example illustrates that: (1) the manufacturer prefers to adopt the multiple sourcing strategy due to the flexibility; (2) keeping stable supplies and large order volumes could effectively reduce carbon emissions for the suppliers and make the supply chain greener.

Production quality and human factors engineering: A systematic review and theoretical framework.

The purpose of this paper is to systematically examine available empirical evidence on the impact of human factors (HF) in the design and management of manufacturing operations on system quality performance. A systematic review was conducted to map the linkages between the human-system fit in the design of operations systems (OS) with production quality. A total of 73 empirical studies were identified linking HF to OS performance in manufacturing. Quality risk factors included HF aspects in product design, process design and workstation design of the manufacturing OS. Quality deficits were associated with undesirable human effects of workload like fatigue and injury-related risk factors. Forty-six percent of the studies reported on efforts to improve HF in the OS with effect sizes for quality improvements reaching up to 86%. The paper documents available quality risk factors in the design of OS. It also provides a conceptual framework explaining HF-Quality linkage.

Effect of 6-week lumbar stabilization exercise performed on stable versus unstable surfaces in automobile assembly workers with mechanical chronic low back pain.

BACKGROUND: Automobile assembly workers repeatedly place burdens on their lumbar regions, which can lead to mechanical chronic low back pain. OBJECTIVE: This study aimed to compare the effects of lumbar stabilization exercises performed on a stable or unstable surface on lumbar pain, muscle strength, stability, disability, and depression in patients with chronic low back pain. METHODS: Twenty-four patients were randomly allocated to a stable or unstable surface group (n = 12 each). Both groups performed each lumbar stabilization exercise for 30 minutes daily five times per week for 6 weeks. Lumbar pain, muscle strength, stability, disability, and depression were assessed before and after intervention. RESULTS: After 6 weeks of training, lumbar pain, stability, disability, and depression improved significantly, whereas muscle strength did not. All post-test values in the unstable surface group improved significantly more than those in the stable surface group. CONCLUSIONS: Our findings indicate the more favorable effects of an unstable exercise surface in patients with chronic low back pain. However, further studies are needed to confirm our findings.

Caring for musicians' ears: insights from audiologists and manufacturers reveal need for evidence-based guidelines.

OBJECTIVE: This study investigated clinical care delivered to musicians in Australia by audiologists and manufacturers of musicians' hearing protectors (MHP). DESIGN: Audiologists with experience treating musicians were invited to complete a survey on their service delivery. A second survey was administered to manufacturers of MHPs. STUDY SAMPLE: Four manufacturers of MHP and 31 audiologists completed the surveys. Post hoc analyses were performed comparing the responses of audiologists with more versus less clinical experience; and those with and without musical training. RESULTS: There was considerable variation in the audiological care provided to musicians. Only one-third of audiologists performed pure-tone audiometry prior to MHP fitting, and there was little consistency across the sample in relation to impression taking, preferred attenuation or selection of canal length. There was also significant variation in the manufacturers' approach to MHP, each of whom provided different recommendations regarding preferred impression techniques and material viscosity. CONCLUSIONS: The results of this study reveal lack of consistency across the hearing healthcare sector with respect to care of musicians' hearing, with potential to impact upon the satisfaction with, and usage of, MHP. There is need for evidence-based, best practice guidelines and training to support clinical audiologists in providing optimal care.