Metastatic cervical carcinoma of the jaw presenting as periapical disease.

AIM: To present a case report of a metastasis from cervical cancer to the maxilla, which was misdiagnosed as periapical disease and to caution clinicians that metastases could have a disguised clinical presentation that must be taken into account in the differential diagnosis of periapical disease in oncologic patients. SUMMARY: Although metastatic tumours of the jaws are uncommon, they may mimic benign inflammatory processes and reactive lesions. The ability of metastatic lesions to mimic periapical disease is discussed and a brief review of the literature is presented, emphasizing the importance of correct diagnosis to prevent delay in diagnosing cancer. Attention should therefore be given to the patient's medical history, especially of those with a previous history of cancer, and all dental practitioners should be aware of the possibility of metastases that may be confused with periapical disease. Finally, endodontists are well placed to recognize malignant and metastatic oral lesions during the initial clinical stages, given that their treatments are usually based on frequent dental appointments and long-term follow-ups.

Synchronous antiresorptive osteonecrosis of the jaws and breast cancer metastasis.

Antiresorptive osteonecrosis of the jaws (ARONJ) is a significant and poorly understood oral complication that may affect patients receiving antiresorptive agents, such as intravenous bisphosphonate therapy. There are scarce reports of the coexistence of ARONJ and metastasis at the same jaw site in the English-language literature. In the present case, a 60-year-old white woman was referred for the evaluation of a nonhealing extraction socket. The patient was undergoing treatment with intravenous zoledronic acid to metastatic breast cancer in bone, and her medical history and clinical characteristics led to the diagnosis of ARONJ. Nevertheless, histologic analysis showed a fragment of necrotic bone and bacterial colonies associated with malignant epithelial cells that were confirmed to be metastatic breast adenocarcinoma. This case showed that jaw metastasis can occur at the same time and site of ARONJ, making diagnosis and management challenging.

Gnathic bone metastasis: a retrospective study of 10 cases.

UNLABELLED: Oral cavity metastases are extremely rare, and comprise 1% of all mouth malignant neoplasms. AIM: To retrospectively analyze the incidence of maxillary metastases, and to trace its epidemiological behavior. MATERIAL AND METHODS: A retrospective study was done of the period between January 1980 and January 2000;the following indicators were reviewed: sex, age, site of the metastasis, site of the primary tumor, and the histological type of tumors in 10 patients. RESULTS: The prevalence was similar in males and females (05 cases - 50%); three cases presented in the 2nd and 4th decades of life (30-30%). About half of the cases of metastases occurred in the maxilla and half in the mandible. The thyroid and prostate glands were the most prevalent primary tumor sites for metastases (03 cases each); the adenocarcinoma histological type had the highest metastatic rate (50%). CONCLUSIONS: Metastasis of the jaws is very rare and may occur at any age in both the genders, where the prevalence is equal for each sex. The thyroid and prostate seem to be the most frequent sites of distance metastasis of the jaws; the adenocarcinoma is the most frequent histological type causing such metastases.

Metástases dos ossos gnáticos: estudo retrospectivo de 10 casos / Gnathic bone metastasis: a retrospective study of 10 cases

Metástases em cavidade oral são extremamente raras, representando 1 por cento de todas as neoplasias malignas orais. OBJETIVO: Analisar retrospectivamente a incidência de metástase nos maxilares, traçando seu perfil de comportamento epidemiológico. MATERIAL E MÉTODOS: Através de estudo retrospectivo, foram analisados o sexo, idade, localização topográfica da metástase, sítio do tumor primário e tipo histológico, no período de janeiro de 1980 a janeiro de 2000, de um total de 10 pacientes. RESULTADOS: Observou-se que 5 pacientes eram do sexo masculino (50 por cento), 3 casos ocorreram nas 2ª e 4ª décadas de vida (30 e 30 por cento). Concernente à localização topográfica da metástase, metade dos casos ocorreu na maxila e metade na mandíbula. A tireóide e próstata foram os sítios de tumor primário que mais metastizaram para os ossos gnáticos (3 casos cada) e o adenocarcinoma foi o tipo histológico de maior ocorrência de metástase (50 por cento). Conclusões: As metástases nos maxilares acometem igualmente faixa etária, sexo e localização topográfica. A tireóide e próstata parecem ser os sítios mais freqüentes de metástase à distância, e o adenocarcinoma o tipo histológico de maior incidência de metástase.

Oral cavity metastases are extremely rare, and comprise 1 percent of all mouth malignant neoplasms. AIM: to retrospectively analyze the incidence of maxillary metastases, and to trace its epidemiological behavior. MATERIAL AND METHODS: A retrospective study was done of the period between January 1980 and January 2000;the following indicators were reviewed: sex, age, site of the metastasis, site of the primary tumor, and the histological type of tumors in 10 patients. RESULTS: The prevalence was similar in males and females (05 cases - 50 percent); three cases presented in the 2nd and 4th decades of life (30 - 30 percent). About half of the cases of metastases occurred in the maxilla and half in the mandible. The thyroid and prostate glands were the most prevalent primary tumor sites for metastases (03 cases each); the adenocarcinoma histological type had the highest metastatic rate (50 percent). Conclusions: Metastasis of the jaws is very rare and may occur at any age in both the genders, where the prevalence is equal for each sex. The thyroid and prostate seem to be the most frequent sites of distance metastasis of the jaws; the adenocarcinoma is the most frequent histological type causing such metastases.

Retinoblastoma familiar predispondo ao surgimento de um segundo tumor primário näo ocular / Hereditary retinoblastoma associated with a second non-ocular primary tumor

Os autores relatam um caso de retinoblastoma familiar associado ao aparecimento de um segundo tumor primário näo ocular e discutem possíveis teorias genéticas que predisporiam a estas duas neoplasias