RESUMEN
OBJECTIVE: To describe a naso-facial reconstruction technique following bilateral rostral maxillectomy and its functional and cosmetic outcomes. ANIMALS: Two dogs. STUDY DESIGN: Clinical case series. METHODS: Two dogs were presented with a right rostral maxillary mass. Preoperative biopsy and staging revealed a biologically high-grade and histologically low-grade fibrosarcoma (Hi-Lo FSA). A combined nasal planectomy and radical bilateral rostral maxillectomy was performed sparing the labial/buccal mucocutaneous flaps bilaterally. Surgery resulted in asymmetry of the width of the flaps; the narrower flap was rotated medially to reconstruct the lip and create an oral vestibule. The wider flap was rotated medially to cover the remaining dorsolateral opening of the nasal conchae. The flaps overlapped in a parallel manner, discretely concealing the nasal passages, and separating them from the oral cavity. Hemorrhage occurred in both dogs, with one dog requiring a blood transfusion postoperatively. RESULTS: Oral Hi-Lo FSA with tumor-free margins was confirmed in both dogs. Both dogs recovered uneventfully within 4 weeks. Owners reported being very satisfied with the functional (return to normal exercise/activities and uncompromised respiration) and cosmetic outcomes. Based on the owners' telephone follow up, no tumor recurrence was noted at 15 (Dog 1) and 6 (Dog 2) months postoperatively. CONCLUSION: The full-thickness bilateral labial/buccal rotational flaps were used successfully to reconstruct the rostral maxilla, external nose and facial defects involving the nasal cavity. The technique resulted in acceptable functional and cosmetic outcomes and can be considered for naso-facial reconstruction in selected cases.
Asunto(s)
Enfermedades de los Perros , Neoplasias Maxilares , Procedimientos de Cirugía Plástica , Perros , Animales , Nariz/cirugía , Neoplasias Maxilares/cirugía , Neoplasias Maxilares/veterinaria , Recurrencia Local de Neoplasia/cirugía , Recurrencia Local de Neoplasia/veterinaria , Colgajos Quirúrgicos/veterinaria , Procedimientos de Cirugía Plástica/veterinaria , Enfermedades de los Perros/cirugíaRESUMEN
A 10-year-old male captive tiger (Panthera tigris) developed right-sided facial asymmetry and enlargement. Computed tomography revealed a destructive mass of the right maxillary bone with right nasal cavity involvement. Histopathology indicated a spindle cell sarcoma. A single fraction of 22 Gy using stereotactic radiotherapy was prescribed. After treatment, the facial conformation returned to normal and the tiger resumed normal behavior. Diagnostics 4 months later indicated severe metastatic disease. Humane euthanasia and necropsy were performed. This is the first case utilizing stereotactic radiotherapy for the treatment of cancer in a tiger.
Asunto(s)
Neoplasias Óseas/veterinaria , Leiomiosarcoma/veterinaria , Neoplasias Maxilares/veterinaria , Radiocirugia/veterinaria , Tigres , Animales , Neoplasias Óseas/diagnóstico , Neoplasias Óseas/radioterapia , Leiomiosarcoma/diagnóstico por imagen , Leiomiosarcoma/radioterapia , Masculino , Neoplasias Maxilares/diagnóstico por imagen , Neoplasias Maxilares/radioterapia , Tomografía Computarizada por Rayos X/veterinaria , Resultado del TratamientoRESUMEN
Odontoameloblastomas (previously incorporated within ameloblastic odontomas) are matrix-producing odontogenic mixed tumors and are closely related in histologic appearance to the 2 other types of matrix-producing odontogenic mixed tumors: odontomas and ameloblastic fibro-odontomas. The presence or absence of intralesional, induced non-neoplastic tissue must be accounted for in the diagnosis. Herein we describe a naturally occurring odontoameloblastoma with extensive chondroid cementum deposition in a guinea pig ( Cavia porcellus). Microscopically, the mass featured palisading neoplastic odontogenic epithelium closely apposed to ribbons and rings of a pink dental matrix (dentinoid), alongside extensive sheets and aggregates of chondroid cementum. The final diagnosis was an odontoameloblastoma given the abundance of odontogenic epithelium in association with dentinoid but a paucity of pulp ectomesenchyme. Chondroid cementum is an expected anatomical feature of cavies, and its presence within the odontoameloblastoma was interpreted as a response of the ectomesenchyme of the dental follicle to the described neoplasm. Our case illustrates the inductive capabilities of odontoameloblastomas while highlighting species-specific anatomy that has resulted in a histologic appearance unique to cavies and provides imaging and histologic data to aid diagnosis of these challenging lesions.
Asunto(s)
Neoplasias Maxilares/veterinaria , Recurrencia Local de Neoplasia/veterinaria , Tumores Odontogénicos/veterinaria , Enfermedades de los Roedores/diagnóstico , Animales , Diagnóstico Diferencial , Resultado Fatal , Cobayas , Masculino , Neoplasias Maxilares/diagnóstico , Recurrencia Local de Neoplasia/diagnóstico , Tumores Odontogénicos/diagnóstico , Enfermedades de los Roedores/diagnóstico por imagen , Enfermedades de los Roedores/patología , Especificidad de la Especie , Tomografía Computarizada por Rayos X/veterinariaRESUMEN
CASE REPORT: A 6-week-old Thoroughbred filly was presented for evaluation of an expansile mass overlying the right nasal passage and causing respiratory stertor. On skull radiographs, there was a loculated, soft tissue-opaque mass identified dorsal to the right upper premolars and effacing the right nasal cavity. Computed tomography (CT) revealed a locally extensive mass with relatively benign characteristics located centrally on the tooth root apices of the deciduous second premolar (506). The mass extended axially into the right nasal cavity, occluding the meatuses and causing displacement of the nasal septum to the left. CLINICAL OUTCOME & SIGNIFICANCE: Surgical excision was not deemed feasible with an athletic future in mind and the owners elected to euthanase the filly. Histopathologically, the mass was consistent with unicystic ameloblastoma and was lined intermittently with palisading, columnar basal cells (ameloblast-like cells) overlying a zone containing stellate cells in loose stroma. To the authors' knowledge this is the first report of a CT scan of an equine ameloblastoma. Although histopathology was essential for definitive diagnosis, CT clearly defined the origin of the mass and identified its locally extensive, cystic nature, which enabled informed decisions to be made.
Asunto(s)
Ameloblastoma/veterinaria , Neoplasias Maxilares/veterinaria , Tomografía Computarizada por Rayos X/veterinaria , Ameloblastoma/diagnóstico , Animales , Femenino , Caballos , Neoplasias Maxilares/diagnósticoRESUMEN
A 13-year-old Icelandic crossbred horse was presented with headshaking and progressive impairment of chewing. A slowly growing mass was identified in the anterior maxilla. This was associated with lysis of the alveolar bone and the roots of the incisors and there were nodular proliferations affecting the nasal septum and conchae. There was no response to chemotherapy and so the horse was humanely destroyed. Based on morphological, immunohistochemical and ultrastructural findings the mass was classified as a malignant glomus tumour with multifocal vascular spaces and additional neuroendocrine differentiation. An oronasal glomus tumour with neuroendocrine differentiation has not been described previously in an animal.
Asunto(s)
Tumor Glómico/veterinaria , Enfermedades de los Caballos/patología , Neoplasias Maxilares/veterinaria , Animales , Biomarcadores de Tumor/análisis , Diferenciación Celular , Femenino , Caballos , InmunohistoquímicaAsunto(s)
Enfermedades de los Perros/diagnóstico por imagen , Neoplasias Maxilares/veterinaria , Rabdomiosarcoma Embrionario/veterinaria , Animales , Quimioradioterapia/veterinaria , Diagnóstico Diferencial , Enfermedades de los Perros/terapia , Perros , Metástasis Linfática , Masculino , Neoplasias Maxilares/diagnóstico por imagen , Neoplasias Maxilares/secundario , Neoplasias Maxilares/terapia , Tomografía Computarizada Multidetector/veterinaria , Cuidados Paliativos , Pronóstico , Rabdomiosarcoma Embrionario/diagnóstico por imagen , Rabdomiosarcoma Embrionario/secundario , Rabdomiosarcoma Embrionario/terapiaRESUMEN
Two immature male dogs were presented for the treatment of extensive maxillary compound odontomas. In both cases, clinical evaluation and diagnostic imaging revealed extensive lesions invading and displacing anatomical structures of the maxilla. Histopathology confirmed the diagnoses in both cases. One dog was treated with partial rostral maxillectomy, and the other dog was treated with enucleation of the cystic lining and removal of tooth-like structures through a lateral rhinotomy utilizing an intraoral approach. This report illustrates the growth potential of maxillary compound odontomas in 2 dogs and highlights their subclinical appearance and excellent prognosis despite their extensive nature.
Asunto(s)
Enfermedades de los Perros/diagnóstico , Enfermedades de los Perros/cirugía , Neoplasias Maxilares/veterinaria , Odontoma/veterinaria , Animales , Perros , Masculino , Maxilar , Neoplasias Maxilares/diagnóstico , Neoplasias Maxilares/cirugía , Odontoma/diagnóstico , Odontoma/cirugía , Diente Impactado , Resultado del TratamientoRESUMEN
Elodontoma was diagnosed in two pet guinea pigs, one involving a maxillary premolar tooth and the other affecting a mandibular incisor tooth. Diagnostic imaging, including radiographs, computed tomography, and oral endoscopy was performed in order to quantify dental disease. Diagnostic imaging was also used to guide treatment of acquired dental disease, which included intraoral restoration of normal occlusal plane and tooth extraction using an extraoral approach. These are the first histologically confirmed cases of elodontoma in guinea pigs.
Asunto(s)
Neoplasias Mandibulares/veterinaria , Neoplasias Maxilares/veterinaria , Odontoma/veterinaria , Enfermedades de los Roedores/diagnóstico , Animales , Incisivo/diagnóstico por imagen , Incisivo/patología , Masculino , Neoplasias Mandibulares/diagnóstico , Neoplasias Mandibulares/etiología , Neoplasias Mandibulares/terapia , Neoplasias Maxilares/diagnóstico , Neoplasias Maxilares/etiología , Neoplasias Maxilares/terapia , Odontoma/diagnóstico , Odontoma/etiología , Odontoma/terapia , Radiografía , Enfermedades de los Roedores/etiología , Enfermedades de los Roedores/terapia , Resultado del TratamientoAsunto(s)
Neoplasias Maxilares/veterinaria , Tumores Odontogénicos/veterinaria , Neoplasias Cutáneas/veterinaria , Tigres , Animales , Masculino , Neoplasias Maxilares/diagnóstico , Neoplasias Maxilares/patología , Tumores Odontogénicos/diagnóstico , Tumores Odontogénicos/patología , Neoplasias Cutáneas/diagnóstico , Neoplasias Cutáneas/patologíaRESUMEN
CASE DESCRIPTION: An approximately 5-year-old sexually intact male alpaca was evaluated because of a right-sided maxillary mass that had recurred after previous surgical debulking. CLINICAL FINDINGS: Clinical, radiographic, and CT examination revealed an approximately 1.5-cm-diameter soft tissue mass associated with expansile osteolysis of the maxillary alveolar bone, beginning at the level of the right maxillary third premolar tooth extending caudally to the level of the rostral roots of the second molar tooth. TREATMENT AND OUTCOME: Right partial maxillectomy was performed, and histologic examination revealed an incompletely excised fibrosarcoma with osseous metaplasia. External beam radiation therapy to the tumor bed was initiated 1 month after surgery. Computerized planning was performed, and a total radiation dose of 48 Gy was prescribed in eleven 4.4-Gy fractions. Follow-up CT evaluations 6 and 58 weeks after radiation therapy was completed revealed no evidence of tumor recurrence. No clinical evidence of tumor recurrence was detected through 110 weeks after radiation therapy. CLINICAL RELEVANCE: The oral fibrosarcoma in the alpaca described here was successfully treated with surgical excision and adjuvant radiation therapy, resulting in excellent quality of life of the treated animal.
Asunto(s)
Camélidos del Nuevo Mundo , Fibrosarcoma/veterinaria , Neoplasias Maxilares/veterinaria , Animales , Fibrosarcoma/diagnóstico , Fibrosarcoma/radioterapia , Masculino , Neoplasias Maxilares/diagnóstico , Neoplasias Maxilares/radioterapiaAsunto(s)
Enfermedades de los Perros/diagnóstico , Neoplasias Pulmonares/veterinaria , Metaplasia/veterinaria , Osteosarcoma/veterinaria , Animales , Enfermedades de los Perros/patología , Perros , Neoplasias Pulmonares/diagnóstico , Neoplasias Pulmonares/patología , Masculino , Neoplasias Maxilares/patología , Neoplasias Maxilares/veterinaria , Metaplasia/diagnóstico , Metaplasia/patología , Osteosarcoma/patología , Osteosarcoma/cirugíaRESUMEN
A 3.5-year-old, male, neutered dwarf rabbit was presented with a history of a fast-growing gingival mass at the maxilla. The neoplasm was surgically completely excised. Histopathologically, an expansively growing, multilobulated, partially cystic, peripheral, keratinizing ameloblastoma was diagnosed. The immunohistochemical phenotyping of the tumour cells resulted in cytoplasmic labelling with various pan-cytokeratin antibodies. The cytokeratins 5/6, 7, 10 and 14 were expressed variably. Cytokeratin 20 was not detected. Vimentin was expressed in the cytoplasm of mesenchymal cells of the tumour stroma. In addition, in the nuclei of approximately 10% of the tumour cells the protein of the tumour suppressor gene p53 was expressed while in approximately 5% the proliferation marker Ki67 was expressed. Odontogenic tumours should be considered as a differential diagnosis of oral masses in rabbits.
Asunto(s)
Ameloblastoma/veterinaria , Neoplasias Maxilares/veterinaria , Conejos , Ameloblastoma/diagnóstico , Ameloblastoma/patología , Ameloblastoma/cirugía , Animales , Inmunohistoquímica , Queratinas/metabolismo , Masculino , Neoplasias Maxilares/diagnóstico , Neoplasias Maxilares/patología , Neoplasias Maxilares/cirugíaRESUMEN
OBJECTIVE: To describe the biological behavior, clinical outcome, and prognostic factors of osteosarcoma of the maxilla, mandible, or calvarium in dogs. DESIGN: Retrospective case series. ANIMALS: 183 client-owned dogs with osteosarcoma of the maxilla, mandible, or calvarium. PROCEDURES: Medical records for dogs treated for osteosarcoma of the maxilla, mandible, or calvarium from 1986 through 2012 were reviewed. Dogs with a histopathologic diagnosis of osteosarcoma and treated for a primary tumor arising from these bones of the head were included. RESULTS: Mean age was 9.3 years, and body weight was 31.8 kg (70.0 lb). Most dogs (124/183 [67.8%]) were purebred, and the most common primary tumor site was the maxilla (80 [43.7%]). Treatments included palliative medical treatment only (11/183 [6.0%]), coarsely fractionated radiation therapy (RT; 12 [6.6%]), fractionated or stereotactic RT (18 [9.8%]), surgery (135 [73.8%]), and both surgery and fractionated RT (7 [3.8%]). Eighty-three (45.4%) dogs received adjuvant chemotherapy. Local recurrence or progression occurred in 80 of 156 (51.3%) dogs, and 60 of 156 (38.5%) dogs developed distant metastases. Median survival time for all dogs was 239 days. Dogs that underwent surgery had a median survival time of 329 days. Histologically tumor-free surgical margins were associated with significantly decreased hazards of progression or recurrence (hazard ratio [HR], 0.4) and death (HR, 0.5). Dogs with osteosarcoma of the calvarium had a significantly greater hazard of local recurrence or progression (HR, 2.0). CONCLUSIONS AND CLINICAL RELEVANCE: In this study, tumor excision in dogs with histologically tumor-free margins resulted in better local control and longer survival time than did other treatment types.
Asunto(s)
Enfermedades de los Perros/terapia , Neoplasias Mandibulares/veterinaria , Neoplasias Maxilares/veterinaria , Osteosarcoma/veterinaria , Neoplasias Craneales/veterinaria , Animales , Antineoplásicos/uso terapéutico , Perros , Neoplasias Mandibulares/terapia , Neoplasias Maxilares/terapia , Osteosarcoma/terapia , Radioterapia/veterinaria , Estudios Retrospectivos , Factores de Riesgo , Neoplasias Craneales/terapia , Resultado del TratamientoRESUMEN
Osteosarcoma in dogs is a heterogeneous disease entity with regard to its histologic, clinical and biologic behaviour. Differences in behaviour are associated with tumour location. Oral and maxillofacial osteosarcomas are typically reported as a component of the broader classifications of axial osteosarcoma or osteosarcoma of flat bones to differentiate them from appendicular osteosarcoma. Similar to human oral and maxillofacial osteosarcoma, in dogs, these also appear to have less aggressive behaviour than appendicular osteosarcoma. Ideally, local control is achieved with wide surgical resection that results in tumour-free margins. Failure of local control is the most common contributor to poor prognosis. Chemotherapy and radiation treatment are reported to have variable outcomes. The aim of this article is to review the literature on oral and maxillofacial osteosarcoma in dogs in comparison to appendicular and axial osteosarcoma. Similarities and differences between oral and maxillofacial osteosarcoma in humans are addressed.
Asunto(s)
Enfermedades de los Perros/patología , Huesos Faciales/patología , Neoplasias Maxilares/veterinaria , Neoplasias de la Boca/veterinaria , Osteosarcoma/veterinaria , Neoplasias Craneales/veterinaria , Animales , Enfermedades de los Perros/terapia , Perros , Humanos , Neoplasias Maxilares/patología , Neoplasias Maxilares/terapia , Neoplasias de la Boca/patología , Neoplasias de la Boca/terapia , Osteosarcoma/patología , Osteosarcoma/terapia , Pronóstico , Neoplasias Craneales/patología , Neoplasias Craneales/terapiaRESUMEN
Loss of the caudal maxilla and ventral orbit after tumor resections can have negative functional and esthetic influences on the eye involved. This article reports on a case of a caudal maxillary acanthomatous ameloblastoma involving the ventral orbit that was resected and stabilized with a masseter muscle flap. The masseter muscle flap was generated from the superficial belly of the masseter muscle in order to close a defect in the orbital rim, created by a caudal maxillectomy. None of the published complications such as enophthalmos, excessive lacrimation, globe deviation, or strabismus were noted, 8 months following the procedure. The only clinical sign present at the time of re-evaluation was mild lacrimation. The authors propose the use of a masseter muscle flap as a viable technique in stabilizing the ventral orbit after caudal maxillectomy and ventral orbitectomy, preventing the complications associated with this surgery.
Asunto(s)
Ameloblastoma/veterinaria , Enfermedades de los Perros/cirugía , Músculo Masetero , Neoplasias Maxilares/veterinaria , Neoplasias Orbitales/secundario , Colgajos Quirúrgicos/veterinaria , Ameloblastoma/secundario , Ameloblastoma/cirugía , Animales , Perros , Masculino , Maxilar/cirugía , Neoplasias Maxilares/patología , Neoplasias Maxilares/cirugía , Órbita/cirugía , Neoplasias Orbitales/cirugíaRESUMEN
Imaging of patients with oral cancer is required to determine tumor extension in order to assist in prognosis and surgical planning. Conventional screen-film radiography (SFR) used to be the most common method for oral assessment, but computed tomography (CT) has become more available and is being used for obtaining complementary information. CT examinations eliminate superimposition by acquiring cross-sectional images of the region of interest. The objective of this study was to determine the diagnostic value of SFR compared with CT examinations for evaluation of oral masses in dogs. Twenty-one dogs received head and thorax SFR, and pre- and post-contrast head CT. Bony changes were observed in 80.9% and 95.2% of the cases in SFR and CT studies, respectively. Invasion of adjacent structures (i.e. nasal cavity, frontal and sphenoidal sinuses, orbit, maxillary recess, nasopharynx) was observed in only 30% of cases with SFR while CT showed 90.4% involvement. CT is an important preoperative examination modality and is more effective in identifying bone changes and tumor invasion of adjacent structures compared with SFR.
Asunto(s)
Enfermedades de los Perros/diagnóstico por imagen , Neoplasias Maxilares/veterinaria , Tomografía Computarizada por Rayos X/veterinaria , Película para Rayos X/veterinaria , Animales , Carcinoma de Células Escamosas/diagnóstico por imagen , Carcinoma de Células Escamosas/veterinaria , Medios de Contraste , Perros , Femenino , Fibrosarcoma/diagnóstico por imagen , Fibrosarcoma/veterinaria , Seno Frontal/diagnóstico por imagen , Cabeza/diagnóstico por imagen , Masculino , Neoplasias Maxilares/diagnóstico por imagen , Melanoma/diagnóstico por imagen , Melanoma/veterinaria , Cavidad Nasal/diagnóstico por imagen , Neoplasias Nasofaríngeas/diagnóstico por imagen , Neoplasias Nasofaríngeas/veterinaria , Invasividad Neoplásica , Neoplasias Nasales/diagnóstico por imagen , Neoplasias Nasales/veterinaria , Neoplasias Orbitales/diagnóstico por imagen , Neoplasias Orbitales/veterinaria , Neoplasias de los Senos Paranasales/diagnóstico por imagen , Neoplasias de los Senos Paranasales/veterinaria , Estudios Prospectivos , Seno Esfenoidal/diagnóstico por imagenAsunto(s)
Enfermedades de los Perros/cirugía , Maxilar/cirugía , Neoplasias Maxilares/veterinaria , Animales , Arco Dental/cirugía , Perros , Neoplasias Maxilares/cirugía , Mucosa Bucal/cirugía , Osteotomía/instrumentación , Osteotomía/métodos , Osteotomía/veterinaria , Colgajos Quirúrgicos/veterinaria , Técnicas de Cierre de Heridas/veterinariaRESUMEN
Medical records of dogs diagnosed with oral papillary squamous cell carcinoma between December 2008 and April 2011 were reviewed. Information abstracted included signalment, tumor location, tumor size, computed tomographic (CT) features, evidence of metastatic disease based on cytologic examination of lymph node aspirates and thoracic radiography, treatment, surgical margins, histologic features, and treatment outcome. Dogs included in the study were all sexually altered, predominantly large breed dogs with a mean age of 3.9-years (range, 0.5 to 9.0-years). The most common location was the rostral maxilla. Invasion of underlying bone and lymphadenopathy were evident on CT imaging in most dogs. No evidence of metastasis was found on mandibular lymph node cytology and thoracic radiography. Histologic analysis revealed similar morphologic findings for all surgically resected tumors. Surgical excision with 1-2 cm margins was complete in all cases, with a mean tumor-free interval of 12.1-months.
Asunto(s)
Carcinoma de Células Escamosas/veterinaria , Enfermedades de los Perros/patología , Neoplasias de la Boca/veterinaria , Tomografía Computarizada por Rayos X/veterinaria , Animales , Antineoplásicos/uso terapéutico , Biopsia , Carcinoma de Células Escamosas/diagnóstico por imagen , Carcinoma de Células Escamosas/patología , Carcinoma de Células Escamosas/secundario , Supervivencia sin Enfermedad , Enfermedades de los Perros/diagnóstico por imagen , Perros , Femenino , Estudios de Seguimiento , Ganglios Linfáticos/patología , Enfermedades Linfáticas/veterinaria , Masculino , Mandíbula/cirugía , Neoplasias Mandibulares/veterinaria , Maxilar/cirugía , Neoplasias Maxilares/veterinaria , Neoplasias de la Boca/diagnóstico por imagen , Neoplasias de la Boca/patología , Invasividad Neoplásica , Radiografía Torácica/veterinaria , Estudios Retrospectivos , Resultado del TratamientoRESUMEN
A gingival maxillary squamous cell carcinoma was diagnosed in a 12-year-old male Yorkshire Terrier. After a complete diagnostic work-up, including a computed tomography scan, the tumour was staged as T3bN1aM0 and considered non-resectable at presentation. The combination of neoadjuvant megavoltage radiotherapy and neoadjuvant and adjuvant chemotherapy with carboplatin and doxorubicin decreased the size of the tumour, allowing for surgery. The dog was free from local disease for 421 days after which it was euthanased at the owners' request.
Asunto(s)
Carcinoma de Células Escamosas/veterinaria , Quimioradioterapia Adyuvante/veterinaria , Enfermedades de los Perros/terapia , Neoplasias Gingivales/veterinaria , Neoplasias Maxilares/veterinaria , Animales , Antineoplásicos/uso terapéutico , Carcinoma de Células Escamosas/cirugía , Carcinoma de Células Escamosas/terapia , Terapia Combinada/veterinaria , Enfermedades de los Perros/cirugía , Perros , Neoplasias Gingivales/cirugía , Neoplasias Gingivales/terapia , Masculino , Neoplasias Maxilares/cirugía , Neoplasias Maxilares/terapia , Resultado del TratamientoRESUMEN
Peripheral nerve sheath tumors in domestic cats are infrequently reported and are often locally invasive. An 11-year-old Domestic Shorthair cat was originally diagnosed with a right maxillary benign peripheral nerve sheath tumor at incisional biopsy. At necropsy, the neoplasm had features of malignancy including metastases to the regional lymph nodes and lung. Histologically, the neoplasm contained 2 distinct regions: spindle cells arranged in dense interwoven bundles with Antoni A areas and Verocay bodies and Antoni B regions with loosely arranged spindle cells separated by a mucinous matrix. Immunohistochemically, the neoplastic cells in the primary mass and right mandibular lymph node were strongly positive for vimentin, S-100, and glial fibrillar acidic protein. The neoplastic cells within the lung were strongly positive for vimentin and weakly positive for S-100 and glial fibrillar acidic protein.