RESUMEN
No puerpério, a mulher passa por intensas mudanças de ordem familiar e social, como também de adaptações psicológicas e biológicas, que são marcadas por alterações metabólicas e hormonais complexas, sendo a fase de maior risco para o desenvolvimento de algum transtorno mental. Objetivo:Realizar uma revisão da literatura paraidentificar a assistência à saúde nos transtornos mentais no período de puerpério. Metodologia:Estudo descritivo na modalidade revisão integrativa, realizado com artigos originais disponíveis nas línguas portuguesa, inglesa e espanhola, publicados nas bases de dados Scientific Electronic LibraryOnline (SCIELO) e Literatura Latino-Americana em Ciências da Saúde (LILACS), no período de 2015 a 2021 com os seguintes descritores: assistência de enfermagem, transtornos mentais e períodopós-parto. Resultados:Foram encontrados 58artigos, dos quais 17foram selecionados ao final do processo. 10 trabalhos evidenciaram fatores associados com transtorno mental, 4 trabalhos descreveram medidas de proteção e 3 abordaram ações assistenciais de saúde na intervenção dos transtornos mentais no puerpério. Conclusões:Após análise da literatura, observa-seque o baixo suporte social e familiar se mostraram como principais fatores de risco associados aos transtornos mentais para a puérpera. Já os fatores de proteção foram relacionados com aumento do apoio familiar e assistencial por meio dos serviços de saúde, bem como a importância da enfermagem na implementação de estratégias preventivas para os transtornos mentais no puerpério (AU).
In the puerperium, women undergoes intense changes of family and social order, as well as psychological and biological adaptations, which are marked by complex metabolic and hormonal alterations, being the phase of greatest risk for the development of somemental disorder. Objective: Conduct a review of the literature to identify health care in mental disorders in the postpartum period.Methodology:Descriptive study in the integrative review modality, carried out with original articles available in Portuguese, English and Spanish, published in the scientific electronic library online (SCIELO) and Latin American literature in health sciences (LILACS) databases, from 2015 to 2021 with the following descriptors: nursing care, mental disorders and postpartum period.Results:Fifty-eight articles were found, of which 17 were selected at the end of the process. 10 studies showed factors associated with mental disorder, 4 studies described protective measures and 3 addressed health care actions in the intervention of mental disorders in the puerperium.Conclusions:After analyzing the literature, we observed that low social and family support were shown to be the main risk factors associated with mental disorders for the puerperal. On the other hand, the protective factors were related to increased family and care support through health services, as well as the importance of nursing in the implementation of preventive strategies for mental disorders in the puerperium (AU).
En el puerperio, la mujer sufre intensos cambios de orden familiar y social, así como adaptaciones psicológicas y biológicas, que se caracterizan por complejas alteraciones metabólicas y hormonales, siendo la fase de mayor riesgo para el desarrollo de algún trastorno mental.Objetivo:Realizar una revisión de la literatura para identificar la atención médica en los trastornos mentales en el período posparto. Metodología: Estudio descriptivo en la modalidad de revisión integradora, realizado con artículos originales disponibles en portugués, inglés y español, publicados en las bases de datos de la biblioteca científica electrónica en línea (SCIELO) y de la literatura latinoamericana en ciencias de la salud (LILACS), de 2015 a 2021 con los siguientes descriptores: cuidados de enfermería, trastornos mentales y puerperio.Resultados: Se encontraron cincuenta y ocho artículos, de los cuales 17 fueron seleccionados al final del proceso. 10 estudios mostraron factores asociadosal trastorno mental, 4 estudios describieron medidas de protección y 3 abordaron acciones de atención sanitaria en la intervención de los trastornos mentales en el puerperio.Conclusiones: Después de analizar la literatura, observamos que el bajo apoyo social y familiar demostró ser el principal factor de riesgo asociado a los trastornos mentales para el puerperal. Por otro lado, los factores protectores se relacionaron con el aumento del apoyo familiar y asistencial a través de los servicios de salud, asícomo la importancia de la enfermería en la implementación de estrategias preventivas para los trastornos mentales en el puerperio (AU).
Asunto(s)
Humanos , Femenino , Periodo Posparto/psicología , Atención a la Salud Mental , Trastornos Mentales/patología , Atención de Enfermería/psicología , Humanización de la Atención , Servicios de SaludRESUMEN
AIMS: During illnesses caused by infectious diseases, a suite of brain-mediated responses called sickness syndrome occurs, triggering behavioral and physiological changes. This study investigated whether ghrelin modulates sickness syndrome induced by systemic administration of lipopolysaccharide (LPS). MAIN METHODS: Male Wistar rats were pretreated with vehicle or [D-lys3]-GHRP-6, a ghrelin receptor GHS-R1 antagonist (20 nmol, i.c.v), 30 min before injection of LPS (200 µg/kg, i.p.) or sterile saline. We investigated the behavioral effects in male rats after LPS administration by screening for depressive-like behavior, locomotor activity alterations, and corticosterone release. Changes in body temperature were measured using a biotelemetry probe preimplanted in the peritoneal cavity to evaluate the effect of ghrelin on the thermoregulatory response during immunological challenge. KEY FINDINGS: Pretreatment with [D-lys3]-GHRP-6 blunted most of the assessed parameters related to sickness syndrome, including social withdrawal, anhedonia, depressive-like behavior, and anorexia, reduced the activation of the HPA axis, but did not alter LPS-induced fever. SIGNIFICANCE: Our findings suggest that ghrelin centrally mediates the sickness behavior and activation of HPA, as a ghrelin receptor antagonist attenuates social withdrawal, anhedonia, depressive-like behavior, anorexia, and HPA activation in response to LPS.
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Sistema Hipotálamo-Hipofisario/fisiología , Conducta de Enfermedad/efectos de los fármacos , Lipopolisacáridos/toxicidad , Trastornos Mentales/prevención & control , Oligopéptidos/farmacología , Receptores de Ghrelina/antagonistas & inhibidores , Animales , Temperatura Corporal , Sistema Hipotálamo-Hipofisario/efectos de los fármacos , Conducta de Enfermedad/fisiología , Locomoción , Masculino , Trastornos Mentales/inducido químicamente , Trastornos Mentales/metabolismo , Trastornos Mentales/patología , Ratas , Ratas WistarRESUMEN
Mesial temporal lobe epilepsy (MTLE) is the most common type of focal epilepsy in adults, and hippocampal sclerosis (HS) is a frequent histopathological feature in patients with MTLE. Pharmacoresistance is present in at least one-third of patients with MTLE with HS (MTLE+HS). Several hypotheses have been proposed to explain the mechanisms of pharmacoresistance in epilepsy, including the effect of genetic and molecular factors. In recent years, the increased knowledge generated by high-throughput omic technologies has significantly improved the power of molecular genetic studies to discover new mechanisms leading to disease and response to treatment. In this review, we present and discuss the contribution of different omic modalities to understand the basic mechanisms determining pharmacoresistance in patients with MTLE+HS. We provide an overview and a critical discussion of the findings, limitations, new approaches, and future directions of these studies to improve the understanding of pharmacoresistance in MTLE+HS. However, it is important to point out that, as with other complex traits, pharmacoresistance to anti-seizure medications is likely a multifactorial condition in which gene-gene and gene-environment interactions play an important role. Thus, studies using multidimensional approaches are more likely to unravel these intricate biological processes.
Asunto(s)
Epilepsia del Lóbulo Temporal , Epilepsia , Trastornos Mentales , Adulto , Epilepsia del Lóbulo Temporal/tratamiento farmacológico , Hipocampo/patología , Humanos , Trastornos Mentales/patología , Esclerosis/patologíaRESUMEN
Oxytocin (OT) and vasopressin (AVP) are hypothalamic neuropeptides classically associated with their regulatory role in reproduction, water homeostasis, and social behaviors. Interestingly, this role has expanded in recent years and has positioned these neuropeptides as therapeutic targets for various neuropsychiatric diseases such as autism, addiction, schizophrenia, depression, and anxiety disorders. Due to the chemical-physical characteristics of these neuropeptides including short half-life, poor blood-brain barrier penetration, promiscuity for AVP and OT receptors (AVP-R, OT-R), novel ligands have been developed in recent decades. This review summarizes the role of OT and AVP in neuropsychiatric conditions, as well as the findings of different OT-R and AVP-R agonists and antagonists, used both at the preclinical and clinical level. Furthermore, we discuss their possible therapeutic potential for central nervous system (CNS) disorders.
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Enfermedades del Sistema Nervioso Central/tratamiento farmacológico , Trastornos Mentales/tratamiento farmacológico , Oxitocina/uso terapéutico , Vasopresinas/uso terapéutico , Animales , Enfermedades del Sistema Nervioso Central/metabolismo , Enfermedades del Sistema Nervioso Central/patología , Agonismo de Drogas , Antagonismo de Drogas , Humanos , Trastornos Mentales/metabolismo , Trastornos Mentales/patología , Oxitócicos/uso terapéutico , Vasoconstrictores/uso terapéuticoRESUMEN
Maternal inflammation during pregnancy causes later-in-life alterations of the offspring's brain structure and function. These abnormalities increase the risk of developing several psychiatric and neurological disorders, including schizophrenia, intellectual disability, bipolar disorder, autism spectrum disorder, microcephaly, and cerebral palsy. Here, we discuss how astrocytes might contribute to postnatal brain dysfunction following maternal inflammation, focusing on the signaling mediated by two families of plasma membrane channels: hemi-channels and pannexons. [Ca2+]i imbalance linked to the opening of astrocytic hemichannels and pannexons could disturb essential functions that sustain astrocytic survival and astrocyte-to-neuron support, including energy and redox homeostasis, uptake of K+ and glutamate, and the delivery of neurotrophic factors and energy-rich metabolites. Both phenomena could make neurons more susceptible to the harmful effect of prenatal inflammation and the experience of a second immune challenge during adulthood. On the other hand, maternal inflammation could cause excitotoxicity by producing the release of high amounts of gliotransmitters via astrocytic hemichannels/pannexons, eliciting further neuronal damage. Understanding how hemichannels and pannexons participate in maternal inflammation-induced brain abnormalities could be critical for developing pharmacological therapies against neurological disorders observed in the offspring.
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Astrocitos/metabolismo , Canales Iónicos/metabolismo , Trastornos Mentales , Complicaciones del Embarazo , Efectos Tardíos de la Exposición Prenatal , Astrocitos/patología , Transporte Biológico Activo , Femenino , Humanos , Inflamación/metabolismo , Inflamación/patología , Trastornos Mentales/etiología , Trastornos Mentales/metabolismo , Trastornos Mentales/patología , Trastornos del Neurodesarrollo/etiología , Trastornos del Neurodesarrollo/metabolismo , Trastornos del Neurodesarrollo/patología , Embarazo , Complicaciones del Embarazo/metabolismo , Complicaciones del Embarazo/patología , Efectos Tardíos de la Exposición Prenatal/etiología , Efectos Tardíos de la Exposición Prenatal/metabolismo , Efectos Tardíos de la Exposición Prenatal/patologíaRESUMEN
Autophagy is a process of degradation and recycling of cytoplasmatic components by the lysosomes. In the central nervous system (CNS), autophagy is involved in cell surveillance, neuroinflammation, and neuroplasticity. Neuropsychiatric conditions are associated with functional disturbances at molecular and cellular levels, causing significant impairments in cell homeostasis. Additionally, emerging evidence supports that dysfunctions in autophagy contribute to the pathophysiology of neurological diseases. However, the studies on autophagy in psychiatric disorders are highly heterogeneous and have several limitations, mainly to assess causality and determine the autophagy flux in animals and human samples. Besides, the role of this mechanism in non-neuronal cells in the CNS is only recently being explored. Thus, this review summarizes and discusses the changes in the autophagy pathway in animal models of psychiatric disorders and the limitations underlying the significant findings. Moreover, we compared these findings with clinical studies. Understanding the involvement of autophagy in psychiatric conditions, and the limitation of our current models may contribute to the development of more effective research approaches and possibly pharmacological therapies.
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Autofagia/fisiología , Encéfalo/metabolismo , Modelos Animales de Enfermedad , Trastornos Mentales/metabolismo , Estrés Oxidativo/fisiología , Transducción de Señal/fisiología , Animales , Encéfalo/patología , Humanos , Mediadores de Inflamación/metabolismo , Trastornos Mentales/patología , Trastornos Mentales/psicologíaRESUMEN
BACKGROUND: Evidence suggests that the single-disease paradigm does not accurately reflect the individual experience, with increasing prevalence of chronic disease multimorbidity, and subtle yet important differences in types of co-occurring diseases. Knowledge of multimorbidity patterns can aid clarification of individual-level burden and needs, to inform prevention and treatment strategies. This study aimed to estimate the prevalence of multimorbidity in Jamaica, identify population subgroups with similar and distinct disease profiles, and examine consistency in patterns identified across statistical techniques. METHODS: Latent class analysis (LCA) was used to examine multimorbidity patterns in a sample of 2,551 respondents aged 15-74 years, based on data from the nationally representative Jamaica Health and Lifestyle Survey 2007/2008 and self-reported presence/absence of 11 chronic conditions. Secondary analyses compared results with patterns identified using exploratory factor analysis (EFA). RESULTS: Nearly one-quarter of the sample (24.1%) were multimorbid (i.e. had ≥2 diseases), with significantly higher burden in females compared to males (31.6% vs. 16.1%; p<0.001). LCA revealed four distinct classes, including a predominant Relatively Healthy class, comprising 52.7% of the sample, with little to no morbidity. The remaining three classes were characterized by varying degrees and patterns of multimorbidity and labelled Metabolic (30.9%), Vascular-Inflammatory (12.2%), and Respiratory (4.2%). Four diseases determined using physical assessments (obesity, hypertension, diabetes, hypercholesterolemia) were primary contributors to multimorbidity patterns overall. EFA identified three patterns described as "Vascular" (hypertension, obesity, hypercholesterolemia, diabetes, stroke); "Respiratory" (asthma, COPD); and "Cardio-Mental-Articular" (cardiovascular disease, arthritis, mental disorders). CONCLUSION: This first study of multimorbidity in the Caribbean has revealed a high burden of co-existing conditions in the Jamaican population, that is predominantly borne by females. Consistency across methods supports the validity of patterns identified. Future research into the causes and consequences of multimorbidity patterns can guide development of clinical and public health strategies that allow for targeted prevention and intervention.
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Análisis de Clases Latentes , Multimorbilidad , Adolescente , Adulto , Anciano , Asma/complicaciones , Asma/epidemiología , Asma/patología , Enfermedades Cardiovasculares/complicaciones , Enfermedades Cardiovasculares/epidemiología , Enfermedades Cardiovasculares/patología , Femenino , Humanos , Hipertensión/complicaciones , Hipertensión/epidemiología , Hipertensión/patología , Jamaica/epidemiología , Masculino , Trastornos Mentales/complicaciones , Trastornos Mentales/epidemiología , Trastornos Mentales/patología , Persona de Mediana Edad , Prevalencia , Autoinforme , Factores Sexuales , Adulto JovenRESUMEN
Objetivou-se avaliar a assistência às pessoas com transtornos mentais em conflito com a lei. Trata-se de um estudo de avaliação realizado em duas etapas: Estudo Metodológico e Estudo de Caso. O estudo metodológico, desenvolvido de fevereiro a dezembro de 2019, delineou a construção e validação do modelo lógico e da matriz de critérios para avaliação da assistência ao grupo estudado, a partir dos três procedimentos sugeridos pelo referencial da Psicometria de Pasquali: 1) teóricos- composto por ensaio teórico, scoping review e estudo de avaliabilidade, a fim de identificar os conteúdos que compuseram o modelo lógico e a matriz de critérios; 2) empíricos compreenderam a construção do instrumento de coleta através do Google Forms e a seleção de 44 experts para o processo de validação do instrumento de avaliação proposto; e 3) analíticos- realizado a partir de duas etapas Delphi, em que se considerou válido o item avaliado como adequado que obteve 70% de concordância entre os experts. O estudo de caso ocorreu no âmbito do Hospital de Custódia e Tratamento Psiquiátrico do estado do Rio Grande do Norte. Foram entrevistados, em janeiro de 2020, três gestores e sete profissionais de saúde que atuavam no cenário pesquisado. O conteúdo textual decorrente das entrevistas foi submetido à análise textual lexicográfica, com auxílio do software Interface de R pour Analyses Multidimensionnelles de Textes et de Questionneires e a análise dos dados foi realizada a partir de literatura pertinente. O ensaio teórico refletiu sobre a existência de muros (in) visíveis que cerceiam as pessoas com transtornos mentais em conflito com a lei. A scoping review identificou que as pesquisas acerca da assistência à saúde mental ofertada aos internos dos Institutos de Psiquiatria Forense no Brasil eram predominantemente dissertações, com abordagem qualitativa, na área da Psicologia e Direito, publicadas em 2014, realizadas na região sudeste do Brasil, com ênfase nas falas dos profissionais de saúde e sem especificar a metodologia da análise de dados. Ademais, indicou que a assistência ofertada aos internos destas instituições tem caráter punitivo, pauta-se na medicalização excessiva e diverge da legislação vigente, o que dificulta a reintegração social desses sujeitos. O estudo de avaliabilidade resultou: na elaboração e pactuação do modelo lógico; na análise e comparação entre a realidade da política e o modelo lógico; e na elaboração da matriz de critérios. O modelo lógico foi validado pela Técnica de Grupo Nominal. A adequabilidade do conteúdo da matriz de critérios foi avaliada por 16 experts na etapa Delphi 1 e por 12 na etapa Delphi 2. A matriz de critérios teve seu conteúdo validado mediante Coeficiente de Validade de Conteúdo de 0,93. Para gestores e profissionais de saúde entrevistados na etapa de campo, a assistência no cenário estudado é permeada por carências estruturais, mas mudanças no âmbito da gestão institucional têm permitido avanços no processo de desinstitucionalização dos internos. Recomenda-se o estabelecimento de metas exequíveis, bem como que a matriz de critérios proposta nesse estudo direcione a avaliação contínua e sistemática, capaz de incidir em melhorias na assistência prestada a esta clientela (AU).
The objective was to evaluate the assistance to people with mental disorders in conflict with the law. It is an evaluation study carried out in two stages: Methodological Study and Case Study. The methodological study, developed in February 2019, outlines a construction and validation of the logical model and the matrix of criteria for assessing assistance to the studied group, based on the three procedures suggested by Pasquali's psychometric framework: 1) theoristscomposed of theoretical essay, scope review and availability study, in order to identify the contents that make up the logical model and the criteria matrix; 2) empirical - understand the construction of a collection instrument using Google Forms and the selection of 44 specialists for the validation process of the analyzed evaluation instrument; and 3) analytical - carried out using two Delphi steps, in which the item evaluated as adequate is considered valid, which recovered 70% of agreement between the specialists. The case study took place at the Hospital of Custody and Psychiatric Treatment of the State of Rio Grande do Norte. In January 2020, three managers and seven health professionals who worked in the surveyed scenario were interviewed. The textual content resulting from the interviews was subjected to lexicographic textual analysis, with the aid of the software Interface de R pour Analyzes Multidimensionnelles de Textes et de Questionneires and the data analysis was performed from the relevant literature. The theoretical essay reflected on the existence of (in) visible walls that surround people with mental disorders in conflict with the law. The scoping review identified that research on mental health care offered to interns at the Institutes of Forensic Psychiatry in Brazil was predominantly dissertations, with a qualitative approach, in the area of Psychology and Law, published in 2014, carried out in the southeastern region of Brazil, with emphasis on the speeches of health professionals and without specifying the methodology of data analysis. In addition, he indicated that the assistance offered to the interns of these institutions has a punitive character, is based on excessive medicalization and diverges from the current legislation, which hinders the social reintegration of these subjects. The evaluability study resulted in: the elaboration and agreement of the logical model; in the analysis and comparison between the reality of politics and the logical model; and in the elaboration of the criteria matrix. The logical model was validated by the Nominal Group Technique. The content adequacy of the criteria matrix was assessed by 16 experts in the Delphi 1 stage and by 12 in the Delphi 2 stage. The content matrix had its content validated by 0.93 Content Validity Coefficient. For managers and health professionals interviewed in the field stage, assistance in the scenario studied is permeated by structural deficiencies, but changes in the scope of institutional management have allowed advances in the process of deinstitutionalization of inmates. It is recommended to establish achievable goals, as well as the criteria matrix proposed in this study to direct continuous and systematic assessment, capable of focusing on improvements in the assistance provided to this cliente (AU).
Asunto(s)
Humanos , Prisioneros/psicología , Evaluación en Salud/métodos , Evaluación de Programas y Proyectos de Salud , Atención a la Salud Mental , Trastornos Mentales/patología , Salud Mental , Estudio de Validación , Investigación CualitativaRESUMEN
Clarifying the relationships between neuropsychiatric symptoms and Alzheimer's disease (AD)-related pathology may open avenues for effective treatments. Here, we investigate the odds of developing neuropsychiatric symptoms across increasing burdens of neurofibrillary tangle and amyloid-ß pathology. Participants who passed away between 2004 and 2014 underwent comprehensive neuropathologic evaluation at the Biobank for Aging Studies from the Faculty of Medicine at the University of São Paulo. Postmortem interviews with reliable informants were used to collect information regarding neuropsychiatric and cognitive status. Of 1,092 cases collected, those with any non-Alzheimer pathology were excluded, bringing the cohort to 455 cases. Braak staging was used to evaluate neurofibrillary tangle burden, and the CERAD neuropathology score was used to evaluate amyloid-ß burden. The 12-item neuropsychiatric inventory was used to evaluate neuropsychiatric symptoms and CDR-SOB score was used to evaluate dementia status. In Braak I/II, significantly increased odds were detected for agitation, anxiety, appetite changes, depression, and sleep disturbances, compared to controls. Increased odds of agitation continue into Braak III/IV. Braak V/VI is associated with higher odds for delusions. No increased odds for neuropsychiatric symptoms were found to correlate with amyloid-ß pathology. Increased odds of neuropsychiatric symptoms are associated with early neurofibrillary tangle pathology, suggesting that subcortical neurofibrillary tangle accumulation with minimal cortical pathology is sufficient to impact quality of life and that neuropsychiatric symptoms are a manifestation of AD biological processes.
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Envejecimiento/patología , Envejecimiento/psicología , Enfermedad de Alzheimer/patología , Enfermedad de Alzheimer/psicología , Trastornos Mentales/patología , Trastornos Mentales/psicología , Anciano , Anciano de 80 o más Años , Enfermedad de Alzheimer/epidemiología , Brasil/epidemiología , Femenino , Humanos , Masculino , Trastornos Mentales/epidemiología , Persona de Mediana EdadRESUMEN
Biochemical imbalances, provoked by aging or a secondary illness, might directly affect the brain, causing severe problems, such as loss of memory or alteration of behavior patterns. Brain disorders are usually classified as injuries (such as stroke, hematomas, and concussions), tumors, and neurodegenerative (such as Parkinson's and Alzheimer's diseases) and mental (such as depression, bipolar disorder, schizophrenia) diseases. As the pathophysiology of these illnesses is not completely established and multiple factors are involved, metallomics, a bioanalytical strategy that allows the detection of metal ions and metalloproteins in diverse biological matrices, is of extreme relevance in identifying which elements are affected by a disease and/or treatment. Thus, determining which element ions suffer disturbances in their homeostasis during the disease progress is relevant to understand the biochemical changes and propose new drug targets. In addition, it is well known that oxidative stress plays an important role in the development of pathological neurodegenerative and mental diseases, which may be caused by metal ion dyshomeostasis, so it is also important to understand endogenous antioxidant metalloprotein and metalloenzyme mechanisms in this regard. In this context, recent applications of metallomics in the study of neurodegenerative and mental disorders are discussed in this chapter, as well as future trends in this research area.
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Antioxidantes/metabolismo , Homeostasis , Trastornos Mentales/metabolismo , Metaloproteínas/metabolismo , Metales/metabolismo , Enfermedades Neurodegenerativas/metabolismo , Animales , Humanos , Trastornos Mentales/tratamiento farmacológico , Trastornos Mentales/patología , Enfermedades Neurodegenerativas/tratamiento farmacológico , Enfermedades Neurodegenerativas/patologíaRESUMEN
Alzheimer's disease (AD) is the most frequent type of dementia in the elderly, severely affecting functional and executive skills of subjects suffering from this disease. Moreover, the distress of caregivers as well as the social implications constitute a critical issue for families. Furthermore, cognitive impairment, along with behavioral disorders and neuropsychiatric symptoms are characteristics of AD. Although these are present with variations in prevalence, intensity, and progression, an important core of them is visible before cognitive impairment, especially depression and apathy, which affect at least 50% of patients. The most updated literature shows that depression and/or behavioral and neuropsychiatric symptoms (BNS) are part of the initial phase of the disease rather than just a risk factor. Thus, mood disorders are associated with anomalies in specific brain regions that disturb the normal balance of neurotransmission. This in turn is linked with an inflammatory pathway that leads to microglial activation and aggregated neurofibrillary tangle formation, finally triggering neuronal loss, according to our neuroimmunomodulation theory. Altogether, inflammation and tau aggregation are observed in preclinical stages, preceding the BNS of patients, which in turn are exhibited earlier than cognitive and functional impairment detected in AD. This review is focused on the latest insights of cellular and molecular processes associated with BNS in asymptomatic early-onset stages of AD. An important medical research focus is to improve quality of life of patients, through prevention and treatments of AD, and the study of behavioral disorders and early event in AD pathogenesis has a major impact.
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Enfermedad de Alzheimer/complicaciones , Trastornos Mentales/etiología , Afecto , Encefalitis/etiología , Humanos , Trastornos Mentales/patología , Microglía/metabolismo , Microglía/patología , Pruebas Neuropsicológicas , Escalas de Valoración PsiquiátricaRESUMEN
It could be argued that one of the few unifying qualities all human beings share is the ability to appreciate beauty. While the object of beauty may change from one person to another, the awe and the thrill experienced by an enthralled beholder remains the same. Sometimes, this experience can be so overwhelming it can bring someone to the edge of existence. A very rare condition, known as aesthetic syndrome and, more commonly, Stendhal syndrome, entails a clinical phenomenon in which the presence of a beautiful piece of work or architecture causes dysautonomic symptoms such as tachycardia, diaphoresis, chest pains and loss of consciousness. We present an historical and clinical review of this condition.
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Arte , Trastornos Mentales , Trastornos Psicofisiológicos , Historia del Siglo XIX , Humanos , Trastornos Mentales/historia , Trastornos Mentales/patología , Trastornos Mentales/terapia , Trastornos Psicofisiológicos/historia , Trastornos Psicofisiológicos/patología , Trastornos Psicofisiológicos/terapia , Factores de Riesgo , SíndromeRESUMEN
BACKGROUND: The Renin-Angiotensin System (RAS) is a key regulator of cardiovascular and renal homeostasis, but also plays important roles in mediating physiological functions in the central nervous system (CNS). The effects of the RAS were classically described as mediated by angiotensin (Ang) II via angiotensin type 1 (AT1) receptors. However, another arm of the RAS formed by the angiotensin converting enzyme 2 (ACE2), Ang-(1-7) and the Mas receptor has been a matter of investigation due to its important physiological roles, usually counterbalancing the classical effects exerted by Ang II. OBJECTIVE: We aim to provide an overview of effects elicited by the RAS, especially Ang-(1-7), in the brain. We also aim to discuss the therapeutic potential for neuropsychiatric disorders for the modulation of RAS. METHOD: We carried out an extensive literature search in PubMed central. RESULTS: Within the brain, Ang-(1-7) contributes to the regulation of blood pressure by acting at regions that control cardiovascular functions. In contrast with Ang II, Ang-(1-7) improves baroreflex sensitivity and plays an inhibitory role in hypothalamic noradrenergic neurotransmission. Ang-(1-7) not only exerts effects related to blood pressure regulation, but also acts as a neuroprotective component of the RAS, for instance, by reducing cerebral infarct size, inflammation, oxidative stress and neuronal apoptosis. CONCLUSION: Pre-clinical evidence supports a relevant role for ACE2/Ang-(1-7)/Mas receptor axis in several neuropsychiatric conditions, including stress-related and mood disorders, cerebrovascular ischemic and hemorrhagic lesions and neurodegenerative diseases. However, very few data are available regarding the ACE2/Ang-(1-7)/Mas receptor axis in human CNS.
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Sistema Nervioso Central/metabolismo , Trastornos Mentales/patología , Sistema Renina-Angiotensina/fisiología , Angiotensina I/metabolismo , Enzima Convertidora de Angiotensina 2 , Humanos , Trastornos Mentales/metabolismo , Enfermedades Neurodegenerativas/metabolismo , Enfermedades Neurodegenerativas/patología , Fragmentos de Péptidos/metabolismo , Peptidil-Dipeptidasa A/metabolismo , Receptor de Angiotensina Tipo 1/metabolismoRESUMEN
Neurological and psychiatric disorders are leading contributors to the global disease burden, having a serious impact on the quality of life of both patients and their relatives. Although the molecular events underlying these heterogeneous diseases remain poorly understood, some studies have raised the idea of common mechanisms involved. In excitotoxicity, there is an excessive activation of glutamate receptors by excitatory amino acids, leading to neuronal damage. Thus, the excessive release of glutamate can lead to a dysregulation of Ca2+ homeostasis, triggering the production of free radicals and oxidative stress, mitochondrial dysfunction and eventually cell death. Although there is a consensus in considering excitotoxicity as a hallmark in most neurodegenerative diseases, increasing evidence points to the relevant role of this pathological mechanism in other illnesses affecting the central nervous system. Consequently, antagonists of glutamate receptors are used in current treatments or in clinical trials in both neurological and psychiatric disorders. However, drugs modulating other aspects of the excitotoxic mechanism could be more beneficial. This review discusses how excitotoxicity is involved in the pathogenesis of different neurological and psychiatric disorders and the promising strategies targeting the excitotoxic insult.
Asunto(s)
Trastornos Mentales/patología , Enfermedades del Sistema Nervioso/patología , Animales , Ácido Glutámico/metabolismo , Humanos , Trastornos Mentales/metabolismo , Enfermedades del Sistema Nervioso/metabolismo , Neuronas/metabolismo , Neuronas/patología , Receptores de Glutamato/metabolismoRESUMEN
ABSTRACT It could be argued that one of the few unifying qualities all human beings share is the ability to appreciate beauty. While the object of beauty may change from one person to another, the awe and the thrill experienced by an enthralled beholder remains the same. Sometimes, this experience can be so overwhelming it can bring someone to the edge of existence. A very rare condition, known as aesthetic syndrome and, more commonly, Stendhal syndrome, entails a clinical phenomenon in which the presence of a beautiful piece of work or architecture causes dysautonomic symptoms such as tachycardia, diaphoresis, chest pains and loss of consciousness. We present an historical and clinical review of this condition.
RESUMO Podría decirse que una de las pocas cualidades comunes a todos los seres humanos es la capacidad de apreciar la belleza. Si bien, es cierto que el objeto considerado como bello cambia de una persona a otra, la admiración y profunda emoción que experimenta un espectador en trance, es la misma. En ocasiones, esta experiencia puede llevar una persona hasta el borde mismo de la existencia. Una condición muy rara, conocida como síndrome estético, y en algunos casos, síndrome de Stendhal, comprende un cuadro clínico en el que la presencia de una magnífica y bella pieza de arte o arquitectura, produce síntomas disautonómicos como taquicardia, diaforesis, dolor torácico y pérdida de la consciencia. Presentamos aquí una revisión clínica e histórica de esta condición.
Asunto(s)
Humanos , Historia del Siglo XIX , Arte , Trastornos Psicofisiológicos/historia , Trastornos Psicofisiológicos/patología , Trastornos Mentales/historia , Trastornos Mentales/patología , Trastornos Mentales/terapia , Trastornos Psicofisiológicos/terapia , Síndrome , Factores de RiesgoRESUMEN
The Apolipoprotein E (APOE) gene is one of the main candidates in neuropsychiatric genetics, with hundreds of studies carried out in order to explore the possible role of polymorphisms in the APOE gene in a large number of neurological diseases, psychiatric disorders, and related endophenotypes. In the current article, we provide a comprehensive review of the structural and functional aspects of the APOE gene and its relationship with brain disorders. Evidence from genome-wide association studies and meta-analyses shows that the APOE gene has been significantly associated with several neurodegenerative disorders. Cellular and animal models show growing evidence of the key role of APOE in mechanisms of brain plasticity and behavior. Future analyses of the APOE gene might find a possible role in other neurological diseases and psychiatric disorders and related endophenotypes. © 2016 Wiley Periodicals, Inc.
Asunto(s)
Apolipoproteínas E/genética , Trastornos Mentales/genética , Animales , Apolipoproteínas E/metabolismo , Encéfalo/metabolismo , Encéfalo/patología , Endofenotipos , Estudio de Asociación del Genoma Completo , Genotipo , Humanos , Trastornos Mentales/metabolismo , Trastornos Mentales/patología , Enfermedades Neurodegenerativas/genética , Enfermedades Neurodegenerativas/metabolismo , Enfermedades Neurodegenerativas/patología , Polimorfismo GenéticoRESUMEN
BACKGROUND: The brain-derived neurotrophic factor (BDNF) Val66Met polymorphism (rs6265) has been associated with several neuropsychiatric disorders and regional structural brain changes in adults, but little is known about Val66Met's effect on brain morphology during typical or atypical neurodevelopment. Windows of vulnerability to psychopathology may be associated with the different alleles of the Val66Met polymorphism during childhood and adolescence. METHODOLOGY: We investigated the effect of Val66Met on cortical thickness in MRI scans of 718 children and adolescents (6-12 years old) with typical development, and in those meeting DSM criteria for a psychiatric disorder. RESULTS: Val66Met had a significant effect on cortical thickness. Considering the typically developing group, Met-carriers presented thicker parietal and occipital lobes and prefrontal cortices compared to Val homozygotes. Met-carriers with psychiatric disorders presented thicker medial and lateral temporal cortices than Val homozygotes. Furthermore, a significant genotypeâ¯×â¯psychiatric diagnosis interaction was found: Met-carriers with a psychiatric diagnosis presented thinner bilateral prefrontal cortices than Val homozygotes. CONCLUSION: This study provides evidence that Val66Met is associated with cortical maturation in children and adolescents with and without psychiatric disorders.
Asunto(s)
Factor Neurotrófico Derivado del Encéfalo/genética , Corteza Cerebral/anatomía & histología , Corteza Cerebral/crecimiento & desarrollo , Desarrollo Infantil/fisiología , Trastornos Mentales/genética , Trastornos Mentales/patología , Brasil , Corteza Cerebral/diagnóstico por imagen , Corteza Cerebral/patología , Niño , Estudios de Cohortes , Femenino , Humanos , Imagen por Resonancia Magnética , Masculino , Trastornos Mentales/diagnóstico por imagen , Polimorfismo de Nucleótido SimpleRESUMEN
Embora exista um corpo de pesquisa dedicado a investigar as relações entre família e adoecimento psíquico, ainda faltam muitas informações sobre como se dão estas interações. Os transtornos mentais apresentam um impacto significativo sobre as famílias e, ao mesmo tempo, podem ser afetados por características da mesma. Além disto, a depender dessas características, a família pode apresentar-se como fator de proteção (suporte, apoio) ou risco ao desenvolvimento do portador de transtorno mental, em especial na infância. Neste contexto, o objetivo deste estudo foi caracterizar as famílias de crianças com transtorno mental em relação ao funcionamento familiar e os recursos ambientais que estas famílias oferecem para suas crianças, buscando identificar associações entre o funcionamento familiar, a disponibilização de recursos no ambiente familiar e as variáveis sociodemográficas. Responsáveis por 33 pacientes de um serviço de Psiquiatria foram entrevistados para o preenchimento de um questionário sociodemográfico, o Questionário de Capacidades e Dificuldades - SDQ, o Inventário de Recursos do Ambiente Familiar - RAF, e a Escala de Avaliação da Coesão e Adaptabilidade Familiar - FACES IV. Foram realizadas análises descritivas e aplicados o teste de correlação de Spearman para verificar associações entre as dimensões de funcionamento familiar e os recursos do ambiente familiar; as variáveis sociodemográficas foram categorizadas e submetidas a análises comparativas, utilizando o teste de Mann Whitney (variáveis dicotômicas) e teste de Kruskal Wallis (variáveis com três categorias). A maioria dos pacientes investigados eram do sexo masculino (69,7%) e frequentavam escola (78,8%). Os diagnósticos mais frequentes foram Transtorno do Déficit de Atenção e Hiperatividade (39,4%) e Transtorno do Espectro Autista (39,4%). Apenas 12,1% das famílias foram consideradas disfuncionais. Os recursos mais presentes no ambiente foram brinquedos (6,9 ±2,0), a família estar reunida para atividades de rotina (6,6 ±2,3), realização de atividades conjuntas com os pais em casa (6,0 ±2,1) e organização dos horários/rotina (5,9 ±2,5). Variáveis sociodemográficas como frequência à escola, o responsável exercer atividade profissional, percepção familiar sobre a gravidade das dificuldades da criança, escolaridade do responsável e classe social mostraram influência sobre funcionamento familiar. Frequência da criança à escola, responsável trabalhar fora, presença de comorbidades, escolaridade do responsável e classe socioeconômica também influenciaram a oferta de recursos pela família. A subescala emaranhada (disfuncional) de funcionamento familiar mostrou associação positiva com sintomas emocionais (r= 0,376; p<0,01) e a subescala satisfação familiar correlacionou-se negativamente com os mesmos sintomas (r=-0,365; p<0,05). As subescalas desequilibradas (desengajada, emaranhada e caótica) apresentaram correlações negativas fracas ou moderadas com os recursos ambientais (variando de r=-0,348 a r=-0,484). As subescalas equilibradas (coesão, flexibilidade, comunicação e satisfação familiar) correlacionaram-se positivamente (variando de r=0,348 a r=0,515) com a maioria dos recursos investigados pelo RAF. A presença de sintomas de hiperatividade e de sintomas emocionais mostrou-se negativamente correlacionada com os recursos investigados. De modo geral, as famílias investigadas apresentam um bom funcionamento, entretanto, há indicadores de disfuncionalidade presentes. Os resultados evidenciam que crianças com transtorno mental têm poucos recursos disponíveis no ambiente familiar que possam promover seu desenvolvimento afetivo, cognitivo e social. Além disto, os achados sugerem que quanto mais dificuldades a criança apresenta, menor é seu acesso a estes recursos. Apesar das dificuldades, recursos pessoais e familiares estão presentes
Although there is a body of research dedicated to investigate the relationship between family and mental illness, still lack a lot of information about these interactions. Mental disorders have a significant impact on families and, at the same time, may be affected by family characteristics. In addition, depending on these characteristics, the family can present itself as a protective or risk factor to the development of the bearer of mental disorder, especially in childhood. In this context, the objective of this study was to characterize the families of children with mental disorder in relation to family functioning and the environmental resources that these families provide for their children, seeking to identify associations between family functioning, the availability of resources in the family environment and sociodemographic variables. Parents of 33 patients from a Psychiatry service were interviewed to complete a sociodemographic questionnaire, the Capacities and Difficulties Questionnaire - SDQ, the Family Environment Resource Inventory - RAF, and the Family Adaptability and Cohesion Evaluation Scale IV (FACES IV). Descriptive analyzes were performed and the Spearman correlation test was applied to verify associations between the dimensions of family functioning and the resources of the family environment; the sociodemographic variables were categorized and submitted to comparative analysis using the Mann Whitney test (dichotomous variables) and Kruskal Wallis test (variables with three categories). The majority of the patients investigated were males (69.7%) and attended school (78.8%). The most frequent diagnoses were Attention Deficit Hyperactivity Disorder (39.4%) and Autism Spectrum Disorder (39.4%). Only 12.1% of the families considered were dysfunctional. The resources more present in the environment were toys (6.9 ±2.0), the family be gathered for routine activities (6.6 ±2.3), carrying out joint activities with parents at home (6.0 ±2.1) and the organization of schedules /routine (5.9 ±2.5). Sociodemographic variables such as attendance at school, the respondent engage in professional activity, family perception about the severity of the child's difficulties, schooling of the respondent and social class showed influence on family functioning. Frequency of the child to school, respondent work outside, presence of comorbidities, schooling of the respondent and socioeconomic class also influenced the supply of resources by the family. The enmeshed subscale (unbalanced) showed a positive association with emotional symptoms (r = 0.376, p <0.01) and the family satisfaction subscale correlated negatively with the same symptoms (r = -0.365, p <0.05). Unbalanced subscales (disengaged, enmeshed and chaotic) showed weak or moderate negative correlations with environmental resources (ranging from r = 0.348 to r = -0.484). The balanced subscales (cohesion, flexibility, communication and family satisfaction) correlated positively (ranging from r = 0.348 to r = 0.515) with the majority of the resources investigated by the RAF. The presence of hyperactivity and emotional symptoms were negatively correlated with the investigated resources. In general, families investigated have a good functioning; however, indicators of dysfunction are present. The results show that children with mental disorders have few resources available in the family environment that can promote their affective, cognitive and social development. In addition, the findings suggest that the more difficulties the child presents, the less is the access to these resources. Despite difficulties, personal and family resources are present
Asunto(s)
Humanos , Niño , Familia/psicología , Factores Protectores , Apoyo Familiar/psicología , Trastornos Mentales/patologíaRESUMEN
Este estudo objetivou verificar, por meio de uma revisão sistemática da literatura e da realização de uma meta-análise, a prevalência do transtorno dismórfico corporal em pacientes candidatos e/ou submetidos a procedimentos estéticos na especialidade da Cirurgia Plástica. Para cumprir com o objetivo proposto, foram analisados os mais relevantes estudos publicados originalmente em qualquer idioma, porém, que estivessem indexados às bases de dados National Library of Medicine (MEDLINE), Cochrane e Scielo, nas quais as buscas foram realizadas, por meio do uso de descritores associados ao tema e de critérios de inclusão e exclusão. Sendo assim, a amostra final deste estudo foi composta por 15 publicações, as quais foram submetidas a uma meta-análise, podendo-se verificar que 12,5% dos pacientes que são candidatos/submetidos a procedimentos estéticos na especialidade da Cirurgia Plástica possuem transtorno dismórfico corporal. Destes, a maioria é do gênero feminino (75,7%) e possui média de idade de 30 (± 10,5) anos. Devido ao alto índice de pacientes com transtorno dismórfico corporal atendidos na especialidade, ressalta-se a importância de os cirurgiões plásticos atentarem-se para o adequado atendimento dos pacientes, com vistas à identificação dos indivíduos potencialmente portadores desse transtorno e, consequentemente, à solicitação de um acompanhamento interdisciplinar com a participação de psicólogos e psiquiatras.
This study aimed at showing the prevalence of body dysmorphic disorder (BDD) in patients who are candidates and/or are submitted to aesthetic procedures in the specialty of plastic surgery via a systematic review of the literature and a meta-analysis. To comply with the proposed objective, we analyzed the most relevant studies originally published in any language that were available in the National Library of Medicine (MEDLINE), Cochrane, and SciELO databases. Searches were performed using keywords associated with the theme and inclusion and exclusion criteria. Thus, the final sample of this study was composed of 15 publications, which were submitted to a meta-analysis. It can be confirmed that 12.5% of the patients who were candidates/submitted to aesthetic procedures in the specialty of plastic surgery had BDD. Of these, the majority were women (75.7%) with a mean age of 30 (± 10.5) years. Given the high number of patients with BDD attended to in the specialty, it is important that plastic surgeons focus on providing patients with adequate care to identify individuals who potentially have BDD and consequently conduct an interdisciplinary follow-up with the participation of psychologists and psychiatrists.
Asunto(s)
Humanos , Historia del Siglo XXI , Cirugía Plástica , Estética , Trastorno Dismórfico Corporal , Revisión Sistemática , Trastornos Mentales , Trastorno Dismórfico Corporal/patología , Trastornos Mentales/patologíaRESUMEN
The mechanisms underlying the pathophysiology of psychiatric disorders are still poorly known. Most of the studies about these disorders have been conducted on postmortem tissue or in limited preclinical models. The development of human induced pluripotent stem cells (iPSCs) has helped to increase the translational capacity of molecular profiling studies of psychiatric disorders through provision of human neuronal-like tissue. This approach consists of generation of pluripotent cells by genetically reprogramming somatic cells to produce the multiple neural cell types as observed within the nervous tissue. The finding that iPSCs can recapitulate the phenotype of the donor also affords the possibility of using this approach to study both the disease and control states in a given medical area. Here, we present a protocol for differentiation of human pluripotent stem cells to neural progenitor cells followed by subcellular fractionation which allows the study of specific cellular organelles and proteomic analysis.